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Overview of Potassium Channel Families: Molecular Bases of the Functional Diversity

  • Chapter
Pharmacology of Ionic Channel Function: Activators and Inhibitors

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 147))

Abstract

The structural and functional diversity is one of the most characteristic features of K+ channels among other ion channels. In the K+ channel superfamily there are some distinctly different families, and each family consists of many subfamilies. As the number of members in each subfamily is also large in number, total numbers of genes for K+ channels are vast. The electrophysiological properties of each member are different and the function is also highly diversified. This functional diversity enables fine regulation of membrane potential and electrical excitability of cells.

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  1. Y. Kubo
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Editors and Affiliations

  1. Saitama Medical School, 38 Morohongo, Moroyama Iruma-Gun, Saitama, 350-0495, Japan

    Makato Endo M.D., Ph.D.

  2. Department of Pharmacology II Graduate School of Medicine and Faculty of Medicine, Osaka University, 2-2 Yamada-oka, Suita, Osaka, 565-0871, Japan

    Yoshihisa Kurachi

  3. Department of Molecular Neurobiology and Pharmacology School of Medicine, University of Tokyo, Hongo 7-3-1, Bukyo-ku, Tokyo, 113-0033, Japan

    Masayoshi Mishina

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Kubo, Y. (2000). Overview of Potassium Channel Families: Molecular Bases of the Functional Diversity . In: Endo, M., Kurachi, Y., Mishina, M. (eds) Pharmacology of Ionic Channel Function: Activators and Inhibitors. Handbook of Experimental Pharmacology, vol 147. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-57083-4_6

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  • DOI: https://doi.org/10.1007/978-3-642-57083-4_6

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