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Structure of the Voltage-Dependent L-Type Calcium Channel

  • Chapter
Book cover Pharmacology of Ionic Channel Function: Activators and Inhibitors

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 147))

Abstract

Voltage-activated L-type calcium channels regulate the intracellular concentration of calcium and contribute thereby to calcium signaling in numerous cells. These channels are widely distributed in the animal kingdom and are an essential part of many excitatory and non-excitatory mammalian cells. The opening of these channels is primarily regulated by the membrane potential, but is also modulated by a wide variety of hormones, protein kinases, protein phosphatases, toxins, and drugs. Site directed mutagenesis has identified sites on these channels which interact specifically with other proteins, inhibitors, and ions. This chapter will focus on these recent developments. The older findings have been summarized in several excellent reviews (STRIESSNIG et al.1993; HOFMANN et al. 1994; CATTERALL 1995; DE WAARD et al. 1996a).

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Authors
  1. F. Hofmann
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  2. N. Klugbauer
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Editors and Affiliations

  1. Saitama Medical School, 38 Morohongo, Moroyama Iruma-Gun, Saitama, 350-0495, Japan

    Makato Endo M.D., Ph.D.

  2. Department of Pharmacology II Graduate School of Medicine and Faculty of Medicine, Osaka University, 2-2 Yamada-oka, Suita, Osaka, 565-0871, Japan

    Yoshihisa Kurachi

  3. Department of Molecular Neurobiology and Pharmacology School of Medicine, University of Tokyo, Hongo 7-3-1, Bukyo-ku, Tokyo, 113-0033, Japan

    Masayoshi Mishina

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Hofmann, F., Klugbauer, N. (2000). Structure of the Voltage-Dependent L-Type Calcium Channel. In: Endo, M., Kurachi, Y., Mishina, M. (eds) Pharmacology of Ionic Channel Function: Activators and Inhibitors. Handbook of Experimental Pharmacology, vol 147. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-57083-4_4

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