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P2X Receptors for ATP: Classification, Distribution, and Function

  • Chapter
Pharmacology of Ionic Channel Function: Activators and Inhibitors

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 147))

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Abstract

P2 receptors for ATP may be subclassified into ligand gated P2X receptor cation channels and metabotropic G-protein coupled P2Y receptors. ATP can be released from a variety of cell types including neurons (VON KUGELGEN and STARKE 1991; SILINSKY and REDMAN1996) and endothelial cells (YANGet al. 1994; BODIN and BURNSTOCK 1996) or as a result of local tissue damage and cell lysis (BURNSTOCK 1996). P2X receptors mediate fast synaptic transmission between neurons in the periphery (EVANS et al. 1992; GALLIGAN and BERTRAND 1995), the central nervous system (EDWARDS et al.1992), and between sympathetic nerves and smooth muscle (EVANS and SURPRENANT 1992). In addition P2X receptors are expressed in a variety of cell types ranging from immune cells to cochlear hair cells (BUELL et al. 1996a; RAYBOULD and HOUSLEY 1997). The aim of this chapter is to give an overview of the properties and distribution of cloned P2X receptors and how this corresponds to native P2X receptor phenotypes.

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  1. R. J. Evans
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Editors and Affiliations

  1. Saitama Medical School, 38 Morohongo, Moroyama Iruma-Gun, Saitama, 350-0495, Japan

    Makato Endo M.D., Ph.D.

  2. Department of Pharmacology II Graduate School of Medicine and Faculty of Medicine, Osaka University, 2-2 Yamada-oka, Suita, Osaka, 565-0871, Japan

    Yoshihisa Kurachi

  3. Department of Molecular Neurobiology and Pharmacology School of Medicine, University of Tokyo, Hongo 7-3-1, Bukyo-ku, Tokyo, 113-0033, Japan

    Masayoshi Mishina

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Evans, R.J. (2000). P2X Receptors for ATP: Classification, Distribution, and Function. In: Endo, M., Kurachi, Y., Mishina, M. (eds) Pharmacology of Ionic Channel Function: Activators and Inhibitors. Handbook of Experimental Pharmacology, vol 147. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-57083-4_20

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  • DOI: https://doi.org/10.1007/978-3-642-57083-4_20

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