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Pharmacology of Ionic Channel Function: Activators and Inhibitors pp 27–51Cite as

Sodium Channel Blockers and Activators

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 147))

Abstract

Impulse conduction in brain and peripheral nerves, skeletal and cardiac muscle is sustained by transient increases in membrane permeability to sodium ions. This function resides in a family of integral membrane proteins, the voltage-gated Na+ channels. Sodium channel blockers are an important class of therapeutic agents as anticonvulsants, local anesthetics, and antiarrhythmic drugs. The blockers have also proved to be important tools for structure-function studies of the Na+ channel. The activators of Na+ channels are potentially useful tools to study the mechanism of activation and inactivation. They may also form the basis for the development of novel positive inotropic agents and insecticides.

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  1. A. O. Grant
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Editors and Affiliations

  1. Saitama Medical School, 38 Morohongo, Moroyama Iruma-Gun, Saitama, 350-0495, Japan

    Makato Endo M.D., Ph.D.

  2. Department of Pharmacology II Graduate School of Medicine and Faculty of Medicine, Osaka University, 2-2 Yamada-oka, Suita, Osaka, 565-0871, Japan

    Yoshihisa Kurachi

  3. Department of Molecular Neurobiology and Pharmacology School of Medicine, University of Tokyo, Hongo 7-3-1, Bukyo-ku, Tokyo, 113-0033, Japan

    Masayoshi Mishina

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Grant, A.O. (2000). Sodium Channel Blockers and Activators. In: Endo, M., Kurachi, Y., Mishina, M. (eds) Pharmacology of Ionic Channel Function: Activators and Inhibitors. Handbook of Experimental Pharmacology, vol 147. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-57083-4_2

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