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Pharmacology of Ionic Channel Function: Activators and Inhibitors pp 333–345Cite as

Potassium Channels with Two Pore Domains

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 147))

Abstract

Among ion channels, the K+-selective channels form the largest family and probably the most puzzling. Electrophysiological studies have revealed a wide variety of K+ currents which differ by their gating properties, their unitary conductance, their pharmacology and their regulations (RUDY 1988; HILLE 1992). A probable explanation for this diversity is to offer to each excitable cell the repertoire of K+ currents that is the most suitable for its function. Molecular characterization of K+ channels is recent. From the original cloning of the Shaker gene from the Drosophila in 1987, a deluge of data concerning the structure of K+ channels has occurred. Today, more than 100 pore-forming K+ channel subunits as well as a variety of auxiliary subunits have been cloned. Heterologous expression of these proteins has allowed to reconstitute voltage-gated (Kv), Ca2+-activated (KCa), inwardly rectifying (IRK), Gprotein-coupled (GIRK) and ATP-sensitive (KATP) K+ channels and to determine their biophysical, pharmacological, and regulation properties (for reviews see CHANDY et al. 1995; ROEPER et al. 1996; IsoMoTo et al. 1997; JAN et al. 1997; NICHOLS et al. 1997). On the other hand, the association of site-directed mutagenesis and electrophysiology techniques has allowed us to define structural features that are associated with particular K+ functional properties.

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Authors
  1. F. Lesage
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  2. M. Lazdunski
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Editor information

Editors and Affiliations

  1. Saitama Medical School, 38 Morohongo, Moroyama Iruma-Gun, Saitama, 350-0495, Japan

    Makato Endo M.D., Ph.D.

  2. Department of Pharmacology II Graduate School of Medicine and Faculty of Medicine, Osaka University, 2-2 Yamada-oka, Suita, Osaka, 565-0871, Japan

    Yoshihisa Kurachi

  3. Department of Molecular Neurobiology and Pharmacology School of Medicine, University of Tokyo, Hongo 7-3-1, Bukyo-ku, Tokyo, 113-0033, Japan

    Masayoshi Mishina

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© 2000 Springer-Verlag Berlin Heidelberg

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Lesage, F., Lazdunski, M. (2000). Potassium Channels with Two Pore Domains. In: Endo, M., Kurachi, Y., Mishina, M. (eds) Pharmacology of Ionic Channel Function: Activators and Inhibitors. Handbook of Experimental Pharmacology, vol 147. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-57083-4_13

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  • DOI: https://doi.org/10.1007/978-3-642-57083-4_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-63030-9

  • Online ISBN: 978-3-642-57083-4

  • eBook Packages: Springer Book Archive

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