Abstract
This chapter has the objective of furnishing the reader with some understanding of non-competitive antagonism. A simple version is first discussed; this will then be followed by a specific case applied to N-methyl-D-aspartate (NMDA) receptors. Since the latter is a particular system that is activated by the simultaneous presence of two agonists, it will be seen that competitive antagonists for one agonist-binding site appear to be non-competitive for the other agonist.
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Trist, D.G., Corsi, M. (2000). Mechanisms of Non-Competitive Antagonism and Co-Agonism. In: Kenakin, T., Angus, J.A. (eds) The Pharmacology of Functional, Biochemical, and Recombinant Receptor Systems. Handbook of Experimental Pharmacology, vol 148. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-57081-0_10
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DOI: https://doi.org/10.1007/978-3-642-57081-0_10
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