Abstract
This chapter is devoted to the pharmacological actions of nicotine relevant for its dependence liability. As most, if not all, of the central actions of nicotine might, in principle, concur to its dependence liability, a chapter on this topic would have required a review of the whole psychopharmacology of nicotine, a task far beyond the limits of this chapter. However, some aspects of nicotine psychopharmacology, such as its effects on cognition, learning and performance, as well as the genetics of its central actions are covered in specific chapters of this volume. Therefore, these topics will be discussed when necessary but will not be specifically reviewed in this chapter.
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References
Abood LG, Reynolds DT, Booth H, Bidlack JM (1981) Sites and mechanisms of nicotine’s action in the brain. Neurosci Biobehav Rev 5:479–86
Acquas E, Di Chiara G (1992) Depression of mesolimbic dopamine transmission and sensitization to morphine during opiate abstinence. J Neurochem 58:1620–1625
Acquas E, Di Chiara G (1994) D1 receptors blockade stereospecifically impairs the acquisition of drug-conditioned place-preference and place-aversion. Behav Pharmacol 5:555–569
Acquas E, Carboni E, Leone P, Di Chiara G (1989) SCH23390 blocks drug-conditioned place-preference and place-aversion: anhedonia (lack of reward) or apathy (lack of motivation) after dopamine receptor blockade?. Psychopharmacology 99: 151–155
Acri JB, Morse DE, Popke EJ, Grunberg NE (1994) Nicotine-increases sensory gating measured as inhibition of the acoustic startle reflex in rats. Psychopharmacology 114:369–374
Ahmed SH, Koob GF (1997) Cocaine-but not food-seeking behavior is reinstated by stress after extinction. Psychopharmacology 32:289–295
Ahmed SH, Koob GF (1998) Transition from moderate to excessive drug intake: change in hedonic set point. Science 282:298–300
Alkondon M, Albuquerque EX (1993) Diversity of nicotinic acetylcholine receptors in rat hippocampal neurons. 1. Pharmacological and functional evidence for distinct structural subtypes. J Pharmacol Exp Ther 265:1455–1473
Alkondon M, Reinhardt S, Lobron C, Hermsen B, Maelicke A, Albuquerque EX (1994) Diversity of nicotinic acetylcholine receptors in rat hippocampal neurons. II. The rundown and inward rectification of agonist-elicited whole-cell currents and identification of receptor subunits by in situ hybridization. J Pharmacol Exp Ther 271:494–506
Allan LM, Williams JH, Wellman NA, Tonin J, Taylor E, Rawlins JNP (1995) Effects of tobacco smoking, schizotypy and number of pre-exposure on latent inhibition in healthy subjects. Person Individ Diff 19:893–902
Altar CA, Boyar WC, Wasley A, Gerhardt SC, Liebman JM, Wood PL (1988) Dopamine neurochemical profile of atypical antipsychotics resembles that of D-l antagonists. Naunyn Schmiedeberg Arch Pharmacol 338:162–168
Altman J, Everitt BJ, Glautier S, Markou A, Nutt D, Oretti R, Phillips GD, Robbins TW (1996) The biological, social, and clinical bases of drug addiction: commentary and debate. Psychopharmacology 125:285–345
Amador M, Dani JA (1995) Mechanism for modulation of nicotinic acetylcholine receptors that can influence synaptic transmission. J Neurosci 15:4525–532
American Psychiatric Association (1980) Diagnostic and statistical manual of mental disorders, 3rd edn American Psychiatric Association, Washington DC
American Psychiatric Association (1987) Diagnostic and statistical manual of mental disorders, 3rd edn, revised. American Psychiatric Association, Washington DC
American Psychiatric Association (1994) Diagnostic and statistical manual of mental disorders, 4th edn. American Psychiatric Association, Washington DC
Anda RF, Williamson DF, Escobedo LG, Mast EE, Giovino GA, Remington PL (1990) Depression and the dynamics of smoking: A national perspective. J Am Med Assoc 26:1541–1545
Anderson K, Fuxe K, Agnati LF (1981) Effects of single injections of nicotine on the ascending dopamine pathways in the rat. Evidence for increases of dopamine turnover in the mesostriatal and mesolimbic dopamine neurons. Acta Physiol Scand 112(3):345–347
Ando K, Yanagita T (1978) The discriminative stimulus properties of intravenously administered cocaine in rhesus monkeys. In: Colpaert FC, Rosecrans JA (eds) Stimulus properties of drugs: ten years of progress. Elsevier, Amsterdam, pp 125–136
Ando K, Yanagita T (1981) Cigarette smoking in Rhesus monkeys. Psychopharmacology 72:117–127
Ando K, Miyata H, Hironaka N, Tsuda T, Yanagita T (1993) The discriminative effects of nicotine and their central sites in rats. Jpn J Psychopharm 13:129–136
Armitage AK, Hall GH, Morrison CF (1968) Pharmacological basis for the tobacco smoking habit. Nature 217:331–334
Armitage AK, Dollery CT, Houseman TH, Lewis PJ, Turner DM (1975) Absorption and metabolism of nicotine from cigarettes. Br Med J 4:313–316
Arnold JM, Roberts DCS (1997) A critique of fixed and progressive ratio schedules used to examine the neural substrates of drug reinforcement. Pharmacol Biochem Behav 57:441–447
Arnold B, Allison K, Ivanova S, Paetsch PR, Paslawski T, Greenshaw AJ (1995) 5HT3 receptor antagonists do not block nicotine induced hyperactivity in rats. Psychopharmacology 119:213–221
Arqueros L, Naquira D, Zunino E (1978) Nicotine-induced release of catecholamines from rat hippocampus and striatum. Biochem Pharmacol 27:2661–2614
Arroyo-Jimenez MM, Bourgeois J-P, Marubio LM, Le Sourd AM, Ottersenn OP, Rinvik P, Faire A, Changeux J-P (1999) Ultrastructural localization of the a4-subunit of the neuronal acetylcholine nicotinic receptor in the rat substantia nigra. J Neurosci 19:6475–6487
Ator NA, Griffiths RR (1983) Nicotine self-administration in baboons. Pharmacol Biochem Behav 19:993–1003
Azam L, Castaneda D, Chen Y, Leslie FM (1999) Expression of neuronal nicotinic acetylcholine receptor subunit mRNAS within rat midbrain. Soc Neurosci 25:187
Badio B, Padgett WL, Daly JW (1997) Ibogaine: a potent noncompetitive blocker of ganglionic/neuronal nicotinic receptors. Mol Pharmacol 51:1–5
Baker TB, Tiffany ST (1985) Morphine tolerance as habituation. Psychol Rev 92:78–108
Baidinger B, Hasenfratz M, Bättig K (1995) Switching to ultralow nicotine cigarettes: effects of different tar yields and blocking of olfactory cues. Pharmacol Biochem Behav 50:233–239
Balfour DJK (1984) The effects of nicotine on brain neurotransmitter systems. In: Balfour DJK (ed) Nicotine and the Tobacco Smoking Habit. Pergamon Press, Oxford, England, pp 61–74
Balfour DJK (1990) A comparison of the effects of nicotine and ± amphetamine on rat behavior in an unsignalled Sidman avoidance schedule. J Pharm Pharmacol 42:257–260
Balfour DJK (1994) Neural mechanisms underlying nicotine dependence. Addiction 89:1419–1423
Balfour DJK, Birrell CE, Moran RJ, Benwell MEM (1996) Effects of acute D-CPPene on mesoaccumbens dopamine responses to nicotine in the rat. Eur J Pharmacol 316:153–156
Balfour DJK, Benwell MEM, Birrel CE, Kelly RJ, Al-Aloul M (1998) Sensitization of mesoaccumbens dopamine response to nicotine. Pharmacol Biochem Behav 4:1021–1030
Balster RL, Schuster CR (1973) Fixed-interval schedule of cocaine reinforcement: Effects of dose and infusion duration. J Exp Anal Behav 20:119–129
Bardo MT, Bevins RA, Klebaur JE, Crooks PA, Dwoskin LP (1997) (-)-Nornicotine partially substitutes for (+)-amphetamine in a drug discrimination paradigm in rats. Pharmacol Biochem Behav 58:1083–1087
Baruch I, Hemsley DR, Gray JA (1988) Differential performance of acute and chronic schizophrenics in a latent inhibition task. J Nerv Ment Dis 176:598–606
Bassareo V, Di Chiara G (1997) Differential influence of associative and nonassociative learning mechanisms on the responsiveness of prefrontal and accumbal dopamine transmission to food stimuli in rats fed ad libitum. J Neurosci 17:851–861
Bassareo V, Di Chiara G (1999) Differential responsiveness of dopamine transmission to food-stimuli in nucleus accumbens shell/core compartments. Neuroscience 89:637–641
Bassareo V, Tanda G, Di Chiara G (1995) Increase of extracellular dopamine in the medial prefrontal cortex during spontaneous and naloxone-precipitated opiate abstinence. Psychopharmacol 122:202–205
Bassareo V, Tanda G, Petromilli P, Giua C, Di Chiara G (1996) Non-psychostimulant drugs of abuse and anxiogenic drugs activate with differential selectivity dopamine transmission in the nucleus accumbens and in the medial prefrontal cortex. Psychopharmacology 124:293–299
Bauco P, Wise RA (1994) Potentiation of lateral hypothalamic and midline mesencephalic brain stimulation reinforcement by nicotine: Examination of repeated treatment. J Pharmacol Exp Ther 271:294–301
Behm FM, Rose JE (1994) Reducing craving for cigarettes while decreasing smoke intake using capsaicin-enhanced low-tar cigarettes. Exp Clin Psychopharmacol 2:143–153
Behm F, Levin ED, Lee YK, Rose JE (1990) Low-nicotine smoke aerosol reduces desire for cigarettes. J Subst Abuse 2:237–247
Bencherif M, Fowler K, Lukas RJ, Lippiello PM (1995) Mechanisms of up-regulation of neuronal nicotinic acetylcholine receptors in clonal cell lines and primary cultures of fetal rat brain. J Pharmacol Exp Ther 275:987–994
Beninger RJ (1983) The role of dopamine in locomotor activity and learning. Brain Res 6:173–196
Benowitz NL (1986) The human pharmacology of nicotine. In: Kappell H (ed) Research Advances in Alcohol and Drug Problems. Vol 9. Plenum Press, New York, pp 1–52
Benowitz NL, Jacob PHI (1990) Intravenous nicotine replacement suppresses nicotine intake from cigarette smoking. J Pharmacol Exp Ther 254:1000–1005
Benowitz NL, Jacob P (1993) Nicotine and cotinine elimination kinetics in smokers and non smokers. Clin Pharmacol Ther 53:316–323
Benowitz NL, Jacob P, Jones RT, Rosenberg J (1982) Interindividual variability in the metabolism and cardiovascular effects of nicotine in man. J Pharmacol Exp Ther 221:368–372
Benowitz NL, Porchet H, Jacob PIII (1990) Pharmacokinetics, metabolism, and pharmacodynamics of nicotine. In: Wonnacott S, Russell MAH, Stolerman IP (eds) Nicotine psychopharmacology. Oxford University Press, Oxford, pp 112–157
Benwell MEM, Balfour DJK (1979) Effects of nicotine administration and its withdrawal on plasma corticosterone and brain 5-hydroxyindoles. Psychopharmacology 63:7–11
Benwell MEM, Balfour DJK (1992) The effects of acute and repeated nicotine treatment on nucleus accumbens dopamine and locomotor activity. Br J Pharmacol 105:849–856
Benwell MEM, Balfour DJ (1997) Regional variation in the effects of nicotine on catecholamine overflow in rat brain. Eur J Pharmacol 325:13–20
Benwell MEM, Balfour DJK, Anderson JM (1988) Evidence that tobacco smoking increases the density of (-)3H-nicotine binding site in human brain. J Neurochem 50:1243–1247
Benwell MEM, Balfour DJK, Lucchi HM (1993) The influence of tetrodotoxin and calcium on the stimulation of mesolimbic dopamine activity evoked by systemic nicotine. Psychopharmacology 112:467–471
Benwell ME, Balfour DJ, Birrell CE (1995) Desensitization of the nicotine-induced mesolimbic dopamine responses during constant infusion with nicotine. Br J Pharmacol 144:454–460
Berger BD, Wise CD, Stein L (1973) Area posterma damage and bait shyness. J Comp Physiol Psychol 82:475–479
Bhargava HN (1995) Attenuation of tolerance to, and physical dependence on, morphine in the rat by inhibition of nitric oxide synthase. Gen Pharmacol 26:1049–1053
Bindra D (1974) A motivational view of learning, performance, and behavior modification. Psychol Rev 81:199–213
Birrell CE, Balfour DJK (1998) The influence of nicotine pretreatment on mesoaccumbens dopamine overflow and locomotor responses to D-amphetamine. Psychopharmacology 140:142–149
Boring EG (1945) The use of operational definitions in science. Psychol Rev 52:243–245
Boyd ND (1987) Two distinct kinetic phases of desensitization of acetylcholine receptors of clonal rat PC12 cells. J Physiol 389:45–67
Bozarth MA, Wise RA (1985) Toxicity associated with long-term intravenous heroin and cocaine self-administration in the rat. JAMA 254:81–83
Bozarth MA, Pudiak CM, KuoLee R (1998a) Effect of chronic nicotine on brain stimulation reward. I. Effect of daily injections. Behav Brain Res 96:185–188
Bozarth MA, Pudiak CM, KuoKee R (1998b) Effect of chronic nicotine on brain stimulation reward. II. An escalating dose regimen. Behav Brain Res 96:189–194
Brady JV, Lukas SE (1984) (eds) Testing drugs for physical dependence potential and abuse liability. National Institute on Drug Abuse Research Monograph 52, US Gov’t Printing Office, Washington, DC
Brazell MP, Mitchell SN, Joseph MH, Gray JA (1990) Acute administration of nicotine increases the in vivo extracellular levels of dopamine, 3,4-dihydroxyphenylacetic acid and ascorbic acid preferentially in the nucleus accumbens of the rat: comparison with caudate-putamen. Neuropharmacology 29:1177–1185
Brazell MP, Mitchell SN, Gray JA (1991) Effect of acute administration of nicotine on in vivo release of noradrenaline in the hippocampus of freely moving rats: a doseresponse and antagonist study. Neuropharmacology 30:823–833
Breese CR, Marks MJ, Logel J, Adams CE, Sullivan B, Collins AC, Leonard S (1997) Effects of smoking history on [3H]-nicotine binding in human post-mortem brain. J Pharmacol Exp Ther 282:7–13
Breslau N, Kilbey M, Andreski P (1993a) Vulnerability to psychopathology in nicotine-dependent smokers: An epidemiologic study of young adults. Am J Psychiatry 150:941–946
Breslau N, Kilbey M, Andreski P (1993b) Nicotine dependence and major depression. New evidence from a prospective investigation. Arch Gen Psychiatry 50:31–35
Breslau N, Peterson EL, Schultz LR, Chilcoat HD, Andreski P (1998) Major depression and stages of smoking. A longitudinal investigation. Arch Gen Psychiatry 55:161–166
Brioni JD, Kim DJ, O’Neill AB, Williams JE, Decker MW (1994) Clozapine attenuates the discriminative stimulus properties of (-)-nicotine. Brain Res 643:1–9
Brioni JD, Kim DJ, O’Neill AB (1996) Nicotine cue: lack of effect of the a7 nicotinic receptor antagonist methyllycaconitine. Eur J Pharmacol 301:1–5
Buczek Y, Lê AD, Wang A, Stewart J (1999) Stress reinstates nicotine seeking but not sucrose solution seeking in rats. Psychopharmacology 144:183–188
Butschky MF, Bailey D, Henningfield JE, Pickworth WB (1995) Smoking without nicotine delivery decreases withdrawal in 12-hour abstinent smokers. Pharmacol Biochem Behav 50:91–96
Cabeza de Vaca S, Carr KD (1998) Food restriction enhances the central rewarding effect of abused drugs. J Neurosci 18:7502–7510
Cadoni C, Di Chiara G (1999) Reciprocal changes in dopamine responsiveness in the nucleus accumbens shell and core and in the dorsal caudate-putamen in rats sensitized to morphine. Neuroscience 90:447–455
Cadoni C, Di Chiara G (2000) Differential changes in accumbens shell and core dopamine in behavioural sensitization to nicotine. Eur J Pharmacol 387:R23–R25
Cador M, Robbins TW, Everitt BJ (1989) Involvement of amygdala in stimulus-reward association: interaction with the ventral striatum. Neuroscience 30:77–86
Caggiula AR, Epstein LH, Stiller R (1989) Changing environmental cues reduces tolerance to nicotine-induced anorexia. Psychopharmacology 99:389–392
Caggiula AR, Epstein LH, Antelman SM, Saylor SS, Perkins KA, Knopf S, Stiller R (1991) Conditioned tolerance to the anorectic and corticosterone-elevating effects of nicotine. Pharmacol Biochem Behav 40:53–59
Caggiula AR, Epstein LH, Antelman SM, Knopf S, Perkins KA, Saylor S, Donny E, Stiller R (1995) Conditioned tolerance to nicotine in rats. In: Clarke P, Quik K, Thurau K, Adhofer F (eds) The effects of nicotine on biological systems II. Birkhäuser, Basel Boston Berlin, pp 101–107
Caine SB, Koob GF (1994) Effects of mesolimbic dopamine depletion on responding maintained by cocaine and food. J Exp Anal Behav 61:213–221
Calabresi P, Lacey MG, North RA (1989) Nicotine excitation of rat ventral tegmental neurons in vitro studied by intracellular recording. Br J Pharmacol 98:135–140
Calcagnetti DJ, Schechter MD (1991) Conditioned place aversion following the central administration of a novel dopamine release inhibitor CGS 10746B. Pharmacol Biochem Behav 40:255–259
Calcagnetti DJ, Schechter MD (1992) Psychostimulant-induced activity is attenuated by two putative dopamine release inhibitors. Pharmacol Biochem Behav 43: 1023–1031
Calcagnetti DJ, Schechter MD (1993) Place preference for the psychostimulant cathinone is blocked by pretreatment with a dopamine release inhibitor. Prog Neuropsychopharmacol Biol Psychiatry 17:637–649
Calcagnetti DJ, Schechter MD (1994) Nicotine place preference using the biased method of conditioning. Prog Neuro-Psychopharmacol&Biol Psychiat 18:925–933
Cappendijk SLT, Dzoljic MR (1993) Inhibitory effects of ibogaine on cocaine selfadministration in rats. Eur J Pharmacol 241:261–265
Carboni E, Acquas E, Leone P, Di Chiara G (1989a) 5HT3 receptor antagonists block morphine-and nicotine-but not amphetamine-induced reward. Psychopharmacology 97:175–178
Carboni E, Acquas E, Frau R, Di Chiara G (1989b) Differential inhibitory effects of a 5HT3 antagonist on drug-induced stimulation of dopamine release. Eur J Pharmacol 164:515–519
Carboni E, Bortone L, Giua C, Di Chiara G (2000a) Dissociation of physical abstinence signs from changes in extracellular dopamine in the nucleus accumbens and in the prefrontal cortex of nicotine dependent rats. Drug Alcohol Dep 58:93–102
Carboni E, Silvagni A, Rolando MTP, Di Chiara G (2000b) Stimulation of in vivo dopamine transmission in the bed nucleus of stria terminalis by addictive drugs. J Neuroscience (in press)
Carmelli D, Swan GE, Robinette D, Fabsitz R (1992) Genetic influence on smoking a study of male twins. N Engl J Med 327:829–833
Carr GD, Fibiger HC, Phillips AG (1989) Conditioned place preference as a measure of drug reward. In: Liebman JM, Cooper SJ (eds) The Neuropharmacological basis of reward. Oxford University Press, New York, pp 264–319
Carroll ME, Lac ST, Asencio M, Keenan RM (1989) Nicotine dependence in rats. Life Sci 45:1381–1388
Chance WT, Murfin D, Krynock GM, Rosecrans JA (1977) A description of the nicotine stimulus and tests of its generalization to amphetamine. Psychopharmacology 55:19–26
Chance WT, Kallman MD, Rosecrans JA, Spencer RM (1978) A comparison of nicotine and structurally related compounds as discriminative stimuli. Br J Pharmacol 63:609–616
Chandler CJ, Stolerman IP (1997) Discriminative stimulus properties of the nicotinic agonist cytisine. Psychopharmacology 129:257–264
Changeux JP, Bertrand D, Corringer PJ, Dehaene S, Edelstein S, Lena C, Le Novere N, Marubio L, Picciotto M, Zoli M (1998) Brain nicotinic receptors: structure and regulation, role in learning and reinforcement. Brain Res Rev 26:198–216
Chen Z, Engberg G (1989) The rat nucleus paragigantocellularis as a relay station to mediate peripherally induced effects of nicotine. Neurosci Lett 101:67–71
Chen J, Kelz MB, Hope BT, Nakabeppu Y, Nestler EJ (1997) Chronic fos-related antigens: stable variants of deltaFosB induced in brain by chronic treatments. J Neurosci 17:4933–4941
Chernick V (1983) The brain’s own morphine and cigarette smoking: the junkie in disguise?. Chest 83:2–4
Chiamulera C, Borgo C, Falchetto S, Valerio E, Tessari M (1996) Nicotine reinstatement of nicotine self-administration after long-term extinction. Psychopharmacology 127:102–107
Church RE (1989) Smoking and the human EEG. In: Ney T, Gale A (eds) Smoking and human behavior. Wiley, Chichester, pp 115–140
Clark MSG (1969) Self-administered nicotine solutions preferred to placebo by the rat. Br J Pharmacol 35:367
Clarke PBS (1984) Chronic nicotinic blockade after a single administration of the bisquaternary ganglion-blocking drug chlorisondamine. Br J Pharmacol 83: 527–535
Clarke PBS, Fibiger HC (1987) Apparent absence of nicotine-induced conditioned place preference in rats. Psychopharmacology 92:84–88
Clarke PBS, Kumar R (1983a) The effects of nicotine on locomotor activity in nontolerant and tolerant rats. Br J Pharmacol 78:329–337
Clarke PBS, Kumar R (1983b) Characterization of the locomotor stimulant action of nicotine in tolerant rats. Br. J Pharmacol 80:587–594
Clarke PBS, Kumar R (1984) Effects of nicotine and d-amphetamine on intracranial self-stimulation in a shuttle box test in rats. Psychopharmacology 84(l):109–114
Clarke PBS, Pert A (1985) Autoradiographic evidence for nicotine receptors on nigrostriatal and mesolimbic dopaminergic neurons. Brain Res 348:355–358
Clarke PBS, Reuben M (1996) Release of [3H]-noradrenaline from rat hippocampal synaptosomes by nicotine: mediation by different nicotinic receptor subtypes from striatal [3H]-dopamine release. Br J Pharmacol 117:595–606
Clarke PBS, Pert CB, Pert A (1984) Autoradiographic distribution of nicotine receptors in rat brain. Brain Res 323(2):390–395
Clarke PBS, Schwartz RD, Paul SM, Pert CB, Pert A (1985) Nicotinic binding in rat brain: autoradiographic comparison of [3H]acetylcholine, [3H]nicotine, and [125I]alpha-bungarotoxin. J Neurosci 5(5):1307–1315
Clarke PBS, Hamill GS, Nadi NS, Jacobwitz DM, Pert A (1986) 3H-Nicotine and 125I-alpha-bungarotoxin labeled nicotinic receptors in the interpeduncular nucleus of rats. II. Effects of habenular deafferentation. J comp Neurol 251:407–413
Clarke PBS, Fu DS, Jakubovic A, Fibiger HC (1988a) Evidence that mesolimbic dopaminergic activation underlies the locomotor stimulant action of nicotine in rats. J Pharmacol Exp Ther 246:701–708
Clarke PBS, Jakubovic A, Fibiger HC (1988b) Anatomical analysis of the involvement of mesolimbic dopamine in the locomotor stimulant actions of d-amphetamine and apomorphine. Psychopharmacology 96:511–520
Collins RJ, Weeks JR, Cooper MM, Good PI, Russell RR (1984) Prediction of abuse liability of drugs using i.v. self-administration by rats. Psychopharmacology 82: 6–13
Collins AC, Roman E, Wehner JM (1988) Nicotine tolerance: an analysis of the time course of its development and loss in the rat. Psychopharmacology 96:7–14
Collins AC, Romm E, Wehner JM (1990) Dissociation of the apparent relationship between nicotine tolerance and upregulation on nicotinic receptors. Brain Res Bull 25:373–379
Connelly MS, Littleton JM (1983) Lack of stereoselectivity in ability of nicotine to release dopamine from rat synaptosomal preparations. J Neurochem 41:1297–1302
Corrigall WA (1999) Nicotine self-administration in animal as a dependence model. Nicotine&Tobacco Res 1:11–20
Corrigall WA, Coen KM (1989) Nicotine maintains self-administration in rats on a limited-access schedule. Psychopharmacology 99:473–478
Corrigall WA, Coen KM (1991a) Opiate antagonists reduce cocaine but not nicotine self-administration. Psychopharmacology 104:167–170
Corrigall WA, Coen KM (1991b) Selective dopamine antagonists reduce nicotine selfadministration. Psychopharmacology 104:171–176
Corrigall WA, Coen KM (1994a) Dopamine mechanisms play at best a small role in the nicotine discriminative stimulus. Pharmacol Biochem Behav 48:817–820
Corrigall WA, Coen KM (1994b) Nicotine self-administration and locomotor activity are not modified by the 5-HT3 antagonists ICS 205-930 and MDL 72222. Pharmacol Biochem Behav 49:67–71
Corrigall WA, Herling S, Coen KM (1989) Evidence for a behavioral deficit during withdrawal from chronic nicotine treatment. Pharmacol Biochem Behav 33:559–562
Corrigall WA, Franklin KB, Coen KM, Clarke PB (1992) The mesolimbic dopaminergic system is implicated in the reinforcing effects of nicotine. Psychopharmacology 107:285–289
Corrigall WA, Coen KM, Adamson KL (1994) Self-administered nicotine activates the mesolimbic dopamine system through the ventral tegmental area. Brain Res 653:278–284
Costall B, Kelly ME, Naylor RJ, Onaivi RJ (1989) The actions of nicotine and cocaine in a mouse model of anxiety. Pharmacol Biochem Behav 33:197–203
Costall B, Jones BJ, Kelly ME, Naylor RJ, Onaivi ES, Tyers MB (1990a) Sites of action of ondansetron to inhibit withdrawal from drugs of abuse. Pharmacol Biochem Behav 36:97–104
Costall B, Jones BJ, Kelly ME, Naylor RJ, Onaivi ES, Tyers MB (1990b) Ondansetron inhibits a behavioural consequence of withdrawing from drugs of abuse. Pharmacol Biochem Behav 36:339–344
Court JA, Lloyd S, Thomas N, Piggot MA, Marshall EF, Morris CM, Lamb H, Perry RH, Johnson M, Perry EK (1998) Dopamine and nicotinic receptor binding and the level of dopamine and homovanillic acid in human brain related to tobacco use. Neuroscience 87:63–78
Cox BM, Goldstein A, Nelson WT (1984) Nicotine self-administration in rats. Br J Pharmacol 83:49–55
Curzon P, Kim DJ, Decker MW (1994) Effect of nicotine, lobeline, and mecamylamine on sensory gating in the rat. Pharmacol Biochem Behav 49:877–882
Damaj MI, Creasy KR, Grove AD, Rosecrans JA, Martin BR (1994) Pharmacological effects of epibatidine optical enantiomers. Brain Res 664:34–40
Damaj MI, Welch SP, Martin BR (1996) Characterization and modulation of acute tolerance to nicotine in mice. J Pharmacol Exp Ther 277:454–461
Damaj MI, Slemmer JE, Carroll FI, Martin BR (1999) Pharmacological characterization of nicotine’s interaction with cocaine and cocaine analogs. J Pharmacol Exp Ther 289:1229–1236
Damsma G, Day J, Fibiger HC (1989) Lack of tolerance to nicotine-induced dopamine release in the nucleus accumbens. Eur J Pharmacol 168:363–368
Dani JA, Heinemann S (1996) Molecular and cellular aspects of nicotine abuse. Neuron 16:905–908
Davis TRA, Kensler CJ, Dews PB (1973) Comparison of behavioral effects of nicotine, d-amphetamine, caffeine and dimethylheptyltetrahydrocannabinol in squirrel monkeys. Psychopharmacologia 32:51–65
Dawe S, Gerada C, Russell MA, Gray JA (1995) Nicotine intake in smokers increases following a single dose of haloperidol. Psychopharmacology 117:110–115
De la Garza R, Johanson CE (1983) The discriminative stimulus properties of cocaine in the rhesus monkey. Pharmacol Biochem Behav 19:145–148
De la Garza R, Johanson CE (1985) Discriminative stimulus properties of cocaine in pigeons. Psychopharmacology 85:23–30
De la Garza R, Johanson CE (1989) The effects of food deprivation on the self-administration of psychoactive drugs. Drug Alcohol Dep 19:17–27
Delia Casa V, Höffer I, Weiner I, Feldon J (1998) The effects of smoking on acoustic prepulse inhibition in healthy men and women. Psychopharmacology 137:362–368
Deneau GA, Inoki R (1967) Nicotine self-administration in monkeys. Ann NY Acad Sci 142:227–279
Deneris ES, Boulter J, Swanson LW, Patrick J, Heinemann S (1989) B3: a new member of nicotinic acetylcholine receptor gene family is expressed in brain. J Biol Chem 264:6268–6272
Deutch AY, Holliday J, Roth RR, Chun LLY, Hawrot E (1987) Immunohistochemical localization of a neuronal nicotinic acetylcholine receptor in mammalian brain. Proc Natl Acad Sci USA 84:8697–8701
Dewey SL, Brodie JD, Gerasimov BM, Horan B, Gardner EL, Ashby CR (1999) A Pharmacologie strategy for the treatment of nicotine addiction. Synapse 31: 76–86
Dews P, Wenger G (1977) Rate dependency of the behavioral effects of amphetamine. In: Thompson T, Dews PB (eds) Advances in Behavioral Pharmacology. Academic Press, New York, vol 1, pp 167–227
De Wit H, Stewart J (1981) Reinstatement of cocaine-reinforced responding in the rat. Psychopharmacology 75:134–143
De Wit H, Stewart J (1983) Drug reinstatement of heroin-reinforced responding in the rat. Psychopharmacology 79:29–31
De Wit H, Zacny J (1995) Abuse potential of nicotine replacement therapies. CNS Drugs 4:456–468
Dhatt RK, Gudehithlu KP, Wemlinger TA, Tejwani GA, Neff NH, Hadjiconstantinou M (1995) Preproenkephalin mRNA and methionine-enkephalin content are increased in mouse striatum after treatment with nicotine. J Neurochem 64: 1878–1883
Di ChiaraG (1995) The role of dopamine in drug abuse viewed from the perspective of its role in motivation. Drug Alcohol Dep 38:95–137
Di ChiaraG (1998) A motivational learning hypothesis of the role of dopamine in compulsive drug use. J Psychopharmacol 12:54–67
Di ChiaraG (1999) Drug addiction as dopamine-dependent associative learning disorder. Eur J Pharmacol 375:13–30
Di Chiara G, Imperato A (1988) Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. Proc Natl Acad Sci USA 85:5274–5278
Dickinson A (1994) Instrumental conditioning. In: Mackintosh N (ed) Animal learning and cognition. Academic Press, San Diego, pp 45–79
Dickinson A, Balleine B (1995) Motivational control of instrumental action. Curr Dir Psychol Sci 4:162–167
Dineley-Miller K, Patrick J (1992) Gene transcripts for the nicotinic acetylcholine receptor subunit β4 are distributed in multiple areas of the rat central nervous system. Mol Brain Res 16:339–344
Dominguez del Toro E, Juiz JM, Peng X, Lindstrom J, Criado M (1994) Immunocyto-chemical localization of the a7 subunit of the nicotinic acetylcholine receptor in the rat central nervous system. J comp Neurol 349:325–342
Domino EF (1973) Neuropsychopharmacology of nicotine and tobacco smoking. In: Dunn WL (ed) Smoking behavior: motives and incentives. Winston/Wiley, New York, pp 5–32
Domino EF (1997) Tobacco smoking and nicotine neuropsychopharmacology: some future research directions. Neuropsychopharmacology 18:456–468
Domino EF, Lutz MP (1973) Tolerance to the effects of daily nicotine on rat bar pressing behavior for water reinforcement. Pharmacol Biochem Behav 1:445–448
Domino EF, Hall GH, Morrison CF (1968) Pharmacological basis for the smoking habit. Nature 217:331–334
Donny EC, Caggiula AR, Knopf S, Brown C (1995) Nicotine self-administration in rats. Psychopharmacology 122:390–394
Donny EC, Caggiula AR, Mielke MM, Jacobs KS, Rose C, Sved AF (1998) Acquisition of nicotine self-administration in rats: the effects of dose, feeding schedule, and drug contingency. Psychopharmacology 136:83–90
Dougherty J, Miller D, Todd G, Kostengauder HB (1981) Reinforcing and other behavioral effects of nicotine. Neurosci Biobehav Rev 5:487–495
Druhan J, Fibiger HC, Phillips AG (1989) Differential effects of cholinergic drugs on discriminative cues and self-stimulation produced by electrical stimulation of the ventral tegmental area. Psychopharmacology 97:331–338
Duka T, Tasker R, Russell K, Stephens DN (1998) Discriminative stimulus properties of nicotine at low doses: the effects of caffeine preload. Behav Pharmacol 9: 219–229
Dworkin SI, Vrana SL, Broadbent J, Robinson JH (1993) Comparing the reinforcing effects of nicotine, caffeine, methylphenidate and cocaine. Med Chem Res 2:593–602
Dwoskin LP, Crooks PA, Teng L-H, Green TA, Bardo MT (1999) Acute and chronic effects of nornicotine on locomotor activity in rats: altered response to nicotine. Psychopharmacology 145:442–451
Edwards G, Arif A, Hodgson R (1981) Nomenclature and classification of drug-and alcohol-related disorders: a WHO Memorandum. Bull World Health Organization 59:225–242
Egan TM, North RA (1986) Actions of acetylcholine and nicotine on rat locus coeruleus neurons in vitro. Neuroscience 19:565–571
Eissenberg T, Griffiths RG, Stitzer ML (1996) Mecamylamine does not precipitate withdrawal in cigarette smokers. Psychopharmacology 127:328–336
El-Bizri H, Clarke PBS (1994) Blockade of nicotine receptor-mediated release of dopamine from striatal synaptosomes by chlorisondamine and other nicotinic antagonists administered in vitro. Br J Pharmacol 111:406–413
Engberg G (1989) Nicotine induced excitation of locus coeruleus neurons is mediated via release of excitatory amino acids. Life Sci 44:1535–1540
Engberg G, Svensson TH (1980) Pharmacological analysis of a cholinergic regulation of brain norepinephrine neurons. J Neural Transm 49:137–150
Epping-Jordan MP, Watkins SS, Koob GF, Markou A (1998) Dramatic decreases in brain reward function during nicotine withdrawal. Nature 393:76–79
Epstein LH, Dickson BE, McKenzie S, Russell PO (1984) The effect of smoking on perception of music tension. Psychopharmacology 83:107–113
Epstein LH, Caggiula AR, Stiller R (1989) Environment-specific tolerance to nicotine. Psychopharmacology 97:235–237
Epstein LH, Caggiula AR, Perkins KA, McKenzie SJ, Smith JA (1991) Conditioned tolerance to the heart rate effects of smoking. Pharmacol Biochem Behav 39(1): 15–19
Erb S, Shaham Y, Stewart J (1996) Stress reinstates cocaine-seeking behavior after prolonged extinction and drug-free periods. Psychopharmacology 128:408–412
Etscorn F (1980) Sucrose aversions in mice as a result of injected nicotine or passive tobacco smoke inhalation. Bull Psychon Soc 15:54–56
Etscorn F, Moore GA, Hagen LS, Caton TM, Sanders DL (1986) Saccharin aversions in hamsters as a result of nicotine injections. Pharmacol Biochem Behav 24: 567–570
Etscorn F, Moore GA, Scott EP, Hagen LS, Caton TM, Sanders DL, Divine KK (1987) Conditioned saccharin aversions in rats as a result of cutaneous nicotine or intraperitoneal nicotine administered in divided doses. Pharmacol Biochem Behav 28:495–502
Ettenberg A (1989) Dopamine, neuroleptics and reinforced behavior. Neurosci Biobehav Rev 13:105–111
Fagerström KO (1978) Measuring degree of physical dependence to tobacco smoking with reference to individualization of treatment. Addict Behav 3:235–241
Fagerström KO (1988) Efficacy of nicotine chewing gum: a review. In: Pomerleau O, Pmerleau C (eds) Nicotine replacement in the treatment of smoking. Liss, New York, pp 109–128
Fagerström KO, Säwe U, Tönnesen P (1992) Therapeutic use of nicotine patches: efficacy and safety. J Smok Rel Disord 3:247–261
Fagerström KO, Schneider NG, Lunell E (1993) Effectiveness of nicotine patch and nicotine gum as individual versus combined treatments for tobacco withdrawal symptoms. Psychopharmacology 111:271–277
Falk JL (1971) The nature and determinants of adjunctive behavior. Physiol Behav 6:577–588
Falkeborn Y, Larsson C, Nordberg A (1981) Chronic nicotine exposure in the rat: a behavioral and biochemical study of tolerance. Drug Alcohol Depend 8:51–60
Fant RV, Schuh KJ, Stitzer ML (1995) Response to smoking as a function of prior smoking amounts. Psychopharmacology 119:385–390
Feigl (1945) Operationism and scientific method. Psychol Rev 52:250–259
Fenster CP, Rains MF, Noerager B, Quick MW, Lester RA (1997) Influence of subunit composition on desensitization of neuronal acetylcholine receptors at low concentrations of nicotine. J Neurosci 17:5747–5759
Fenster CP, Whitworth TL, Sheffield EB, Quick MW, Lester RA (1999a) Upregulation of surface alpha4beta2 nicotinic receptors is initiated by receptor desensitization after chronic exposure to nicotine. J Neurosci 19:4804–4814
Fenster CP, Beckman ML, Parker JC, Sheffield EB, Whitworth TL, Quick MW, Lester RA (1999b) Regulation of alpha4beta2 nicotinic receptor desensitization by calcium and protein kinase C. Mol Pharmacol 55:432–443
Ferster CB, Skinner BF (1957) Schedules of reinforcement. Appleton-Century-Crofts, New York
Fischman MW (1989) Relationship between self-reported drug effects and their reinforcing effects: studies with stimulant drugs. NIDA Res Monogr 92:211–230
Flores CM, Rogers SW, Pabreza LA, Wolfe BB, Kellar KJ (1992) A subtype of nicotinic cholinergic receptor in rat brain is composed of α4 and β2 subunits and is up-regulated by chronic nicotine treatment. Mol Pharmacol 41:31–37
Flores CM, Davila-Garcia MI, Ulrich YM, Kellar KJ (1997) Differential regulation of neuronal nicotinic receptor binding sites following chronic nicotine administration. J Neurochem 69:2216–2219
Flynn FW, Webster M, Ksir C (1989) Chronic voluntary nicotine drinking enhances nicotine palatability. Behav Neurosci 103:356–364
Foulds J, Stapleton J, Feyerabend C, Vesey C, Jarvis M, Russell MAH (1992) Effect of transdermal nicotine patches on cigarette smoking: a double blind crossover study. Psychopharmacology 106:421–27
Foulds J, Stapleton JA, Bell N, Swettenham J, Jarvis MJ, Russell MA (1997) Mood and physiological effects of subcutaneous nicotine in smokers and never-smokers. Drug Alcohol Depend 44:105–115
French D, Witkin JM (1993) Effects of the dopamine release inhibitor, CGS 10746B, on the locomotor stimulant and discriminative stimulus effects of cocaine and methamphetamine. Pharmacol Biochem Behav 46:989–993
Fu Y, Matta SG, James TJ, Sharp BM (1998a) Nicotine-induced norepinephrine release in the rat amygdala and hippocampus in mediated through brainstem nicotinic cholinergic receptors. J Pharmacol Exp Ther 284:1188–1196
Fu Y, Matta SG, Valentine JD, Sharp BM (1998b) Desensitization and resensitization of norepinephrine release in the rat hippocampus with repeated nicotine administration. Neurosci Lett 241:147–150
Fu Y, Matta SG, Sharp BM (1999a) Local alpha-bungarotoxin (α-BTX)-sensitive nicotinic receptors modulate nicotine-induced dopamine (DA) release in the nucleus accumbens (NACC). Soc Neurosci 25:187
Fu Y, Matta SG, Sharp BM (1999b) Local α-bungarotoxin-sensitive nicotinic receptors modulate hippocampal norepinephrine release by systemic nicotine. JPET 289: 133–139
Fudala PJ, Teoh KW, Iwamoto ET (1985) Pharmacologic characterization of nicotineinduced conditioned place preference. Pharmacol Biochem Behav 22:237–241
Fudala PJ, Iwamoto ET (1986) Further studies on nicotine-induced conditioned place preference in the rat. Pharmacol Biochem Behav 25:1041–1049
Fudala PJ, Iwamoto ET (1987) Conditioned aversion after delay place conditioning with nicotine. Psychopharmacology 92:376–381
Fung YK (1989) Effects of chronic nicotine pretreatment on (+)amphetamine and nicotine-induced synthesis and release of 3H-dopamine from 3H-tyrosine in rat nucleus accumbens. J Pharm Pharmacol 41:66–68
Fung YK, Schmid MJ, Anderson TM, Lau Y-S (1996) Effects of nicotine withdrawal on central dopaminergic systems. Pharmacol Biochem Behav 53:635–640
Fuxe K, Andersson K, Harfstrand A, Agnati LF (1986) Increases in dopamine utilization in certain limbic dopamine terminal populations after a short period of intermittent exposure of male rats to cigarette smoke. J Neural Transm 67:15–29
Garcha HS, Thomas P, Spivak CE, Wonnacott S, Stolerman IP (1993) Behavioural and ligand-binding studies in rats with l-acetyl-4-methylpiperazine, a novel nicotinic agonist. Psychopharmacology 110:347–354
Garcia-Munoz M, Patino P, Young SJ, Groves PM (1996) Effects of nicotine on dopaminergic nigrostriatal axons requires stimulation of presynaptic glutamatergic receptors. J Pharmacol Exp Ther 277:1685–1693
Gasior M, Shoaib M, Yasar S, Jaszyna M, Goldberg SR (1999) Acquisition of nicotine discrimination and discriminative stimulus effects of nicotine in rats chronically exposed to caffeine. J Pharmacol Exp Ther 288:1053–1073
George TP, Verrico CD, Roth RH (1998) Effects of repeated nicotine pre-treatment on mesoprefrontal dopaminergic and behavioral responses to acute footshock stress. Brain Res 801:36–49
Gerber GJ, Stretch R (1975) Drug-induced reinstatement of extinguished selfadministration behavior in monkeys. Pharmacol Biochem Behav 3:1055–1061
Gilbert RM (1978) Schedule-induced self-administration of drugs. In: Blackman DE, Sanger DJ (eds) Contemporary Research in Behavioral Pharmacology. Plenum Press, New York
Gilbert DG (1996) Depression, smoking and nicotine: toward a bioinformational situation by trait model. Drug Dev Res 38:267–277
Gilbert DG, Gilbert BO (1995) Personality, psychopathology, and nicotine response as mediators of the genetics of smoking. Behav Genet 25:133–147
Giorguieff-Chesselet MF, Kernel ML, Wandsheer D, Glowinski J (1979) Regulation of dopamine release by presynaptic nicotinic receptors in rat striatal slices: Effect of nicotine in a low concentrations. Life Sci 25:1257–1262
Glassman AH (1993) Cigarette smoking: implications for psychiatric illness. Am J Psychiatry 150:546–553
Glassman AH, Heizer JE, Covey LS, Cotrler LB, Stetner F, Tipp JE, Johnson J (1990) Smoking, smoking cessation, and major depression. J Am Med Assoc 264: 1546–1549
Glick SD, Jarvik ME, Nakamura RK (1970) Inhibition by drugs of smoking behaviour in monkeys. Nature 227:969–971
Glick SD, Zimmerberg B, Jarvik ME (1971) Titration of oral nicotine intake with smoking behaviour in monkeys. Nature 233:207–208
Glick SD, Rossman K, Steindorf S, Maisonneuve IM, Carlson JN (1991) Effects and aftereffects of ibogaine on morphine self-administration in rats. Eur J Pharmacol 195:341–345
Glick SD, Kuehne ME, Raucci J, Wilson TE, Larson D, Keller RW Jr, Carlson JN (1994) Effects of iboga alkaloids on morphine and cocaine self-administration in rats: relationship to tremorigenic effects and to effects on dopamine release in nucleus accumbens and striatum. Brain Res 657:14–22
Glick SD, Visker KE, Maisonneuve IM (1996) An oral self-administration model of nicotine preference in rats: effects of mecamylamine. Psychopharmacology 128: 426–431
Glick SD, Maisonneuve IM, Visker KE, Fritz KA, Bandarage UK, Kuehne ME (1998) 18-Methoxycoronardine attenuates nicotine-induced dopamine release and nicotine preferences in rats. Psychopharmacology 139:274–280
Goldberg SR, Spealman RD (1982) Maintenance and suppression of behavior by intravenous nicotine injections in squirrel monkeys. Fed Proceed 41:216–220
Goldberg SR, Spealman RD (1983) Suppression of behavior by intravenous injection of nicotine or by electric shock in squirrel monkeys: effects of chlordiazepoxide and mecamylamine. J Pharmacol Exp Therap 224:334–340
Goldberg SR, Henningfield JE (1988) Reinforcing effects of nicotine in humans and experimental animals responding under intermittent schedules of IV drug injection. Pharmacol Biochem Behav 30:227–234
Goldberg SR, Spealman RD, Goldberg DM (1981) Persistent behavior at high rates maintained by intravenous self-administration of nicotine. Science 214:573–575
Goldberg SR, Risner ME, Stolerman IP, Reavill C, Garcha HS (1989) Nicotine and some related compounds: effects on schedule-controlled behavior and discriminative properties in rats. Psychopharmacology 97:295–302
Goldner F, Dineley K, Patrick J (1997) Immunohistochemical localization of the nicotinic acetylcholine receptor subunit α6 dopaminergic neurons in the substantia nigra and ventral tegmental area. NeuroReport 8:2739–2742
Goodman FR (1974) Effects of nicotine on distribution and release of 14C-norepinephrine and 14C-dopamine in rat brain striatum and hypothalamus slices. Neuropharmacology 13:1025–1032
Gorelick DA, Rose JE, Jarvik ME (1989) Effect of naloxone on cigarette smoking. J Subst Abuse 1:153–159
Gourlay SG, Benowitz NL (1997) Arteriovenous differences in plasma concentration of nicotine and catecholamines and related cardiovascular effects after smoking, nicotine nasal spray, and intravenous nicotine. Clin Pharmacol Ther 62:453–463
Grady SR, Marks MJ, Wonnacott S, Collins AC (1992) Characterization of nicotinic receptor-mediated [3H]dopamine release from synaptosomes prepared from mouse striatum. J Neurochem 59:848–856
Grady SR, Marks MJ, Collins AC (1994) Desensitization of nicotine-stimulated 3H-dopamine release from mouse striatal synaptosomes. J Neurochem 62:1390–1398
Grady SR, Lu Y, Picciotto MR, Changeux J-P, Collins AC (1998) Nicotine-stimulated synaptosomal neurotransmitter release from βl null mutant mice. Soc for Neurosci 94:1342
Gray JA, Joseph MH, Hemsley DR, Young AMJ, Warburton EC, Boulenguez P, et al (1995) The role of mesolimbic dopaminergic and retrohippocampal afférents to the nucleus accumbens in latent inhibition: implications for schizophrenia. Behav Brain Res 71:19–31
Gray NS, Hemsley DR, Gray JA (1992a) Abolition of latent inhibition in acute but not chronic schizophrenics. Neurol Psychiatry Brain Res 1:83–89
Gray NS, Pickering AD, Hemsley DR, Dawling S, Gray JA (1992b) Abolition of latent inhibition by a single 5 mg dose of d-amphetamine in man. Psychopharmacology 107:425–30
Grenhoff J, Aston-Jones G, Svensson TH (1986) Nicotinic effects on the firing pattern of midbrain dopamine neurons. Acta Physiol Scand 128:351–358
Grenhoff J, Svensson TH (1988) Selective stimulation of limbic dopamine activity by nicotine. Acta Physiol Scand 133:595–596
Griffiths RR, Brady JV, Bradford LD (1979) Predicting the abuse liability of drugs with animal drugs self-administration procedures: Psychomotor stimulants and hallucinogens. In: Thompson T, Dews PB (eds) Advances in Behavioral Pharmacology. Academic Press, New York, vol 2, pp 163–208
Griffiths RR, Henningfield JE (1982) Pharmacology of cigarette smoking behavior. Trends Pharmacol Sci 3:260–263
Griffiths RR, Henningfield JE, Bigelow GE (1982) Human cigarette smoking: manipulation of number of puffs, interbout interval and nicotine dose. J Pharmacol Exp Ther 220:256–265
Gritz ER (1980) Smoking behavior and tobacco use. In: Mello NK (ed) Advances in Substance Abuse. Volume 1. CT: JAI Press, Greenwich, pp 91–158
Gross J, Lee J, Stitzer ML (1997) Nicotine-containing versus denicotinised cigarettes: effects on craving and withdrawal. Pharmacol Biochem Behav 57:159–165
Grün EU, Pauly JR, Collins AC (1992) Adrenalectomy reverses chronic injectioninduced tolerance to nicotine. Psychopharmacology 109:299–304
Grün EU, Pauly JR, Bullock AE, Collins AC (1995) Corticosterone reversibly alters brain a-bungarotoxin binding and nicotine sensitivity. Pharmacol Biochem Behav 52:629–636
Grunberg NE, Bowen DJ, Morse DE (1984) Effects of nicotine on body weight and food consumption in rats. Psychopharmacology 83:93–98
Grunberg NE, Bowen DJ, Maycock VA, Nespor SM (1985) The importance of sweet taste and caloric content in the effects of nicotine on specific food consumption. Psychopharmacology 87:198–203
Grunberg NE, Bowen DJ, Winders SE (1986) Effects of nicotine on body weight, food and water consumption in female rats. Psychopharmacology 90:101–105
Hakan RL, Ksir CJ (1988) Nicotine induced locomotor activity in rats: the role of Pavlovian conditioning. Pharmacol Biochem Behav 29:661–665
Hakan RL, Ksir C (1991) Acute tolerance to the locomotor stimulant effects of nicotine in the rat. Psychopharmacology 104:386–390
Haikala H, Karmalahti T, Ahtee L (1986) The nicotine-induced changes in striatal dopamine metabolism of rats depend on body temperature. Brain Res 375:313–319
Hajos M, Engberg G (1988) Role of primary sensory neurons in the central effects of nicotine. Psychopharmacology 94:468–470
Hakan RL, Hart C, Eyl C (1993) Specific neurophysiological effects of systemic nicotine on neurons in the nucleus accumbens. Synapse 15:191–197
Hall GH, Morrison CF (1973) New evidence for a relationship between tobacco smoking, nicotine dependence and stree. Nature 243:199–201
Hall GH, Turner DM (1972) Effects of nicotine on the release of 3H-noradrenaline from the hypothalamus. Biochem Pharmac 21:1829–1838
Hall SM, Havassy BE, Wassermann DA (1990) Commitment to abstinence and acute stress in relapse to alcohol, opiates and nicotine. J Consult Clin Psychol 58:175–181
Hanson HM, Ivester CA, Morton BR (1979) Nicotine self-administration in rats. In: Krasnegor NA (ed) Cigarette smoking as a dependence process. National Institute on Drug Abuse Research Monograph, US Government Printing Office, Washington, DC, vol 23, pp 70–90
Harlan RE, Garcia MM (1998) Drug of abuse and immediate-early genes in the forebrain. Mol Neurobiol 16:221–267
Harris CM, Emmett-Oglesby MW, Robinson NG, Lal H (1986) Withdrawal from chronic nicotine substitutes partially for the interoceptive stimulus produced by pentylenetetrazol (PTZ). Psychopharmacology 90:85–89
Harsing LG, Jr, Sershen H, Lajtha A (1992) Dopamine efflux from striatum after chronic nicotine: evidence for autoreceptor desensitization. J Neurochem 59:48–54
Hart C, Ksir C (1996) Nicotine effects on dopamine clearance in rat nucleus accumbens. J Neurochem 66:216–221
Harvey SC, Luetje CW (1996) Determinants of competitive antagonist sensitivity on neuronal nicotinic receptor β subunits. J Neurosci 16:3798–3806
Hasenfratz M, Baldinger B, Battig K (1993) Nicotine or tar titration in cigarette smoking behavior?. Psychopharmacology 112:253–258
Hatchell PC, Collins AC (1977) Influences of genotype and sex on behavioral tolerance to nicotine in mice. Pharmacol Biochem Behav 6:25–30
Hatchell PC, Collins AC (1980) The influence of genotype and sex on behavioral sensitivity to nicotine in mice. Psychopharmacology 71:46–49
Hatsukami DK, Gust SW, Keenan RM (1987) Physiologic and subjective changes from smokeless tobacco withdrawal. Clin Pharmacol Ther 41:103–107
Hatsukami DK, Dahlgren L, Zimmerman K, et al (1988) Symptoms of tobacco withdrawal from total cigarette cessation vs partial cigarette reduction. Psychopharmacology 94:242–247
Hatsukami DK, Anton DJ, Keenan R, et al (1992) Smokeless tobacco abstinence effects and nicotine gum dose. Psychopharmacology 106:60–66
Heimer L, Zahm DS, Churchill L, Kalivas PW, Wohltman C (1991) Specificity in the projection patterns of accumbal core and shell in the rat. Neuroscience 41:89–125
Heimer L, Alheid GF, Zahm DS (1993) Basal forebrain organization: an anatomical framework for motor aspects of drive and motivation. In: Kalivas PW, Barnes CD (eds) Limbic Motor Circuits and Neuropsychiatry. CRC Press, Boca Raton, Florida, pp 1–43
Heishman SJ, Taylor RC, Henningfield JE (1994) Nicotine and smoking: a review of effects on human performance. Exp Clin Psychopharmacol 2:345–395
Helton DR, Modlin DL, Tizzano JP, Rasmussen K (1994) Nicotine withdrawal: a behavioral assessment using schedule controlled responding, locomotor activity, and sensorimotor reactivity. Psychopharmacology 113:205–210
Hendry JS, Rosecrans JA (1982a) The development of pharmacological tolerance to the effect of nicotine on schedule-controlled responding in mice. Psychopharmacology 77:339–343
Hendry JS, Rosecrans JA (1982b) Effects of nicotine on conditioned and unconditioned behaviors in experimental animals. Pharmacol Ther 17:431–454
Henningfield JE (1984) Behavioral pharmacology of cigarette smoking. In: Thompson T, Dews PB, Barrett JE (eds) Advances in Behavioral Pharmacology, vol 4, pp 131–2
Henningfield JE, Goldberg SR (1983a) Control of behavior by intravenous nicotine injections in human subjects. Pharmacol Biochem Behav 19:1021–1026
Henningfield JE, Goldberg SR (1983b) Nicotine as a reinforcer in human subjects and laboratory animals. Pharmacol Biochem Behav 19(6):989–992
Henningfield JE, Keenan R (1993) Nicotine delivery kinetics and abuse liability. J Consulting Clin Psychol 61:743–750
Henningfield JE, Heishman SJ (1995) The addictive role of nicotine in tobacco use. Psychopharmacology 117:11–13
Henningfield JE, Miyasato K, Jasinski DR (1983) Cigarette smokers self-administer intravenous nicotine. Pharmacol Biochem Behav 19:887–890
Henningfield JE, Miyasato K, Jasinski DR (1985) Abuse liability and pharmacodynamic characteristics of intravenous and inhaled nicotine. J Pharmacol Exp Ther 234:1–11
Henningfield JE, Strickler G, King D, Higgins ST, Fenwick JW, Gulliver SB, Mireault G (1989) Smoking history, instructions and the effects of nicotine: two pilot studies. Pharmacol Biochem Behav 34:149–155
Henningfield JE, Stapleton JM, Benowitz NL, Grayson RF, London ED (1993) Higher levels of nicotine in arterial than in venous blood after cigarette smoking. Drug Alcohol Depend 33:23–29
Herberg LJ, Montgomery AMJ, Rose IC (1993) Tolerance and sensitization to stimulant and depressant effects of nicotine in intracranial self-stimulation in the rat. Behav Pharmacol 4:419–427
Herning RI, Jones RT, Bachman J (1983) EEG changes during tobacco withdrawal. Psychophysiology 20:507–512
Herrera DG, Robertson HA (1996) Activation of c-fos in the brain. Prog Neurobiol 50:83–107
Herskovic JE, Rose JE, Jarvik ME (1986) Cigarette desirability and nicotine preference in smokers. Pharmacol Biochem Behav 24:171–175
Hexum TD, Russett LR (1987) Plasma enkephalin-like peptide response to chronic nicotine infusion in guinea pig. Brain Res 406:370–372
Hildebrand BE, Nomikos GG, Bondjers C, Nisell M, Svensson TH (1997a) Behavioral manifestations of the nicotine abstinence syndrome in the rat: peripheral versus central mechanisms. Psychopharmacology 129:348–356
Hildebrand BE, Nomikos GG, Hertel P, Schilstrom B, Svensson TH (1997b) Reduced dopamine output in the nucleus accumbens but not in the medial prefrontal cortex in rats displaying a mecamylamine-precipitated nicotine withdrawal syndrome. Brain Res 779:214–225
Hill Jr JA, Zoli M, Bourgeois JP, Changeux JP (1993) Immunocytochemical localization of a neuronal nicotinic receptor: the β2 subunit. J Neurosci 13:1551–1568
Himmelsbach CK (1943) Morphine, with reference to physical dependence. Fed Proc Fed Am Soc Exp Biol 2:201–203
Hindmarch I, Kerr JS, Sherwood N (1990) Effects of nicotine gum on psychomotor performance in smokers and non-smokers. Psychopharmacology 100:535–541
Ho BT, Huang J-T (1975) Role of dopamine in d-amphetamine induced discriminative responding. Pharmacol Biochem Behav 3:1085–1092
Hoffman DC (1989) The use of place conditioning in studying the neuropharmacology of drug reinforcement. Brain Res Bull 23:373–387
Holland PC, Sträub JJ (1979) Differential effects of two ways of devaluing the unconditioned stimulus after Pavlovian appetitive conditioning. J Exp Psychol Anim Behav 5:65–78
Hollt V, Horn G (1992) Effect of nicotine on mRNA levels encoding opioid peptides, vasopressin and alpha 3 nicotinic receptor subunit in the rat. Clin Investig 70: 224–231
Hope BT, Nye HE, Kelz MB, Self DW, Iadarola MJ, Nakabeppu Y, Duman RS, Nestler EJ (1994) Induction of a long-lasting AP-1 complex composed of altered Fos-like proteins in brain by chronic cocaine and other chronic treatment. Neuron 13: 1235–1244
Horan B, Smith M, Gardner EL, Lepore M, Ashby CR Jr (1997) (-)-Nicotine produces conditioned place preference in Lewis, but not Fischer 344 rats. Synapse 26:93–94
Houdi AA, Pierzchala K, Marson L, Palkovits M, Van Loon GR (1991) Nicotineinduced alteration in tyr-gly-gly and met-en-kephalin in discrete brain nucleic reflects altered enkephalin neuron activity. Peptides 12:161–166
Houdi AA, Dasgupta R, Kindy MS (1998) Effect of nicotine use and withdrawal on brain preproenkephalin A mRNA. Brain Res 799:257–263
Hsu Y, Amin J, Weiss D, Wecker L (1996) Sustained nicotine exposure differentially affects α3β2 and α4β2 neuronal nicotinic receptors expressed in Xenopus oocytes. J Neurochem 66:667–775
Hughes JR (1991) Distinguishing withdrawal relief and direct effects of smoking. Psychopharmacology 104:409–410
Hughes JR (1992) The nicotine withdrawal syndrome: a brief review and Update. Int J Smoking Cessation 1:21–26
Hughes JR, Hatsukami D (1986) Signs and symptoms of tobacco withdrawal. Arch Gen Psychiatry 43:289–294
Hughes P, Dragunow M (1995) Induction of immediate-early genes and the control of neurotransmitter-regulated gene expression within the nervous system. Pharmacol Rev 47:133–178
Hughes JR, Hatsukami DK, Pickens RW, Krahn D, Malin S, Luknic A (1984) Effect of nicotine on the tobacco withdrawal syndrome. Psychopharmacology 83:82–87
Hughes JR, Hatsukami DK, Skoog K (1986) Physical dependence on nicotine gum: a placebo-substitution trial. J Am Med Ass 255:3277–3279
Hughes JR, Higgins ST, Hatsukami DK (1990) Effects of abstinence from tobacco: a critical review. In: Kozlowski LT, Annis H, Cappell HD et al (eds) Research Advances in Alcohol and Drug Problems. Plenum Press, New York, vol 10, pp 317–398
Hughes JR, Higgins ST, Bickel WK (1994) Nicotine withdrawal versus other drug withdrawal syndromes: similarities and dissimilarities. Addiction 89:1461–1470
Hulihan-Giblin BA, Lumpkin MD, Kellar KJ (1990a) Acute effects of nicotine on prolactin release in the rat: agonist and antagonist effects of a single injection of nicotine. J Pharmacol Exp Ther 252:15–20
Hulihan-Giblin BA, Lumpkin MD, Kellar KJ (1990b) Effects of chronic administration of nicotine on prolactin release in the rat: inactivation of prolactin response by repeated injections of nicotine. J Pharmacol Exp Ther 252:21–25
Huston-Lyons D, Kornetsky C (1992) Effects of nicotine on the threshold for rewarding brain stimulation in rats. Pharmacol Biochem Behav 41:755–759
Huston-Lyons D, Sarkar M, Kornetsky C (1993) Nicotine and brain-stimulation reward: interactions with morphine, amphetamine and pimozide. Pharmacol Biochem Behav 46:453–457
Hutchisond RR, Emley GS (1985) Aversive stimulation produces nicotine ingestion in squirrel monkeys. Psychol Rec 35:491–502
Imperato A, Mulas A, Di Chiara G (1986) Nicotine preferentially stimulates dopamine release in the limbic system of freely moving rats. Eur J Pharmacol 132:337–338
Ismail Z, el-Guebaly N (1998) Nicotine and endogenous opioids: toward specific pharmacotherapy. Can J Psychiatry 43:37–42
Ivanova S, Greenshaw AJ (1997) Nicotine-induced decreases in VTA electrical selfstimulation thresholds: blockade by haloperidol and mecamylamine but not scopolamine or ondansetron. Psychopharmacology 134:187–192
Iwamoto ET (1990) Nicotine conditions place preference after intracerebral administration in rats. Psychopharmacology 100:251–257
Iwamoto ET, Williamson EC (1984) Nicotine-induced taste aversion: characterization and preexposure effects in rats. Pharmacol Biochem Behav 21:527–532
Izenwasser S, Jacocks HM, Rosenberger JG, Cox BM (1991) Nicotine indirectly inhibits [3H] dopamine uptake at concentrations that do not directly promote [3H]dopamine release in rat striatum. J Neurochem 56:603–610
Izenwasser S, Cox BM (1992) Inhibition of dopamine uptake by cocaine and nicotine: Tolerance to chronic treatments. Brain Res 573:119–125
Jaffe JH (1990) Drug addiction and drug abuse. In: Gilman AG, Rail TW, Nies AS, Taylor P (eds) Goodman and Gilman’s the pharmacological basis of therapeutics. Pergamon, New York, pp 522–573
Jaffe JH (1995) Commentary on the nicotine IS/IS not addictive debate. Psychopharmacology 117:21–22
James JR, Villanueva HF, Johnson JH, Arezo S, Rosecrans JA (1994) Evidence that nicotine can acutely desensitise central nicotinic acetylcholinergic receptors. Psychopharmacology 114:456–462
Jarvik M (1968) The role of nicotine in the smoking habit. In: Hunt WA (ed) Learning Mechanisms in Smoking. Chicago, Aldine, pp 155–190
Jarvik ME (1967) Tobacco smoking in monkeys. Ann NY Acad Sci 142:280–294
Jarvik ME (1995) Commentary. Psychopharmacology 117:18–20
Jarvik ME, Glick SD, Nakamura RK (1970) Inhibition of cigarette smoking by orally administered nicotine. Clin Pharmacol Ther 11:574–576
Jaszyna M, Gasior M, Shoaib M, Yasar S, Goldberg SR (1998) Behavioral effects of nicotine, amphetamine and cocaine under a fixed-interval schedule of food reinforcement in rats chronically exposed to caffeine. Psychopharmacology 140: 257–271
Jensen RA, Gilbert DG, Meliska CJ, Landrum TA, Szary AB (1990) Characterization of a dose-response curve for nicotine-induced conditioned taste aversion in rats: relationship to elevation of plasma beta-endorphin concentration. Behav Neural Biol 53:428–440
Johanson CE (1978) Drugs as reinforcers. In: Blackman DE, Sanger DJ (eds) Contemporary research in behavioral pharmacology. Plenum, New York, pp 325–390
Johnson DH, Svensson AI, Engel JA, Söderpalm B (1995) Induction but not expression of behavioural sensitization to nicotine in the rat is dependent on glucocorticoids. Eur J Pharmacol 276:155–164
Johnston LM (1942) Tobacco smoking and nicotine. Lancer 2:742
Jones RT, Farrell TR, Herning RI (1978) Tobacco smoking and nicotine tolerance. In: Krasnegor NA (ed) Self-administration of abuse substances: methods for study. US Govt Printing Office, Washington DC, pp 202–208
Jorenby DE, Steinpreis RE, Sherman JE, Baker TB (1990) Aversion instead of preference learning indicated by nicotine place conditioning in rats. Psychopharmacology 101:533–538
Joseph MH, Peters SL, Gray JA (1993) Nicotine blocks latent inhibition in rats: evidence for a critical role of increased functional activity of dopamine in the mesolimbic system at conditioning rather than pre-exposure. Psychopharmacology 110:187–192
Kaiser SA, Soliakov L, Harvey SC, Luetje CW, Wonnacott S (1998) Differential inhibition by alpha-conotoxin-MH of the nicotinic stimulation of [3H]dopamine release from rat striatal synaptosomes and slices. J Neurochem 70:1069–1076
Kallman WM, Kallman MJ, Harry GJ, Woodson PP, Rosecrans JA (1982) Nicotine as a discriminative stimulus in human subjects. In: Colpaert FC, Slangen JL (eds) Drug discrimination: Applications in CNS Pharmacology. Else vier Biomedical Press, Amsterdam, pp 211–218
Karras A, Kane JM (1980) Naloxone reduces cigarette smoking. Life Sci 27:1541–1545
Katz B, Thesleff S (1957) A study of desensitization produced by acetylcholine at the motor end plate. J Physiol 138:63–80
Keenan A, Johnson FN (1972) Development of behavioural tolerance to nicotine in the rat. Experientia 28:428–429
Kiba H, Jayaraman A (1994) Nicotine induced c-fos expression in the striatum is mediated mostly by dopamine Dl-receptor and is dependent on NMDA stimulation. Mol Brain Res 23:1–13
Kogan MJ, Verebey K, Jaffee JH, Mule SJ (1981) Simultaneous determination of nicotine and cotinine in human plasma by nitrogen detection gas-liquid chromatography. J Forensic Sci 26:6–11
Kolesnikov YA, Pick CG, Ciszewska G, Pasternak GW (1993) Blockade of tolerance to morphine but not to k opioids by a nitric oxide synthase inhibitor. Proc Natl Acad Sci USA 90:5162–5166
Koob GF, LeMoal M (1997) Drug abuse: hedonic homeostatic disregulation. Science 278:52–58
Koob GF, Le HT, Creese I (1987) The D-l dopamine receptor antagonist SCH 23390 increase cocaine self-administration in the rat. Neurosci Lett 79:315–320
Koob GF, Stinus L, Le Moal M, Bloom FE (1989) Opponent process theory of motivation: neurobiological evidence from studies of opiate dependence. Neurosci Biobehav Rev 13:135–140
Koob GF, Heinrichs SC, Menzaghi F, Merlo-Pich E, Britton KT (1994) Corticotropin-releasing factor, stress and behavior. Semin Neurosci 6:221–229
Koob GF, Rocio M, Carrera A, Gold LH, Heyser CJ, Maldonado-Irizarry C, Markou A, Parsons LH, Roberts AJ, Schulteis G, Stinus L, Walker JR, Weissenborn R, Weiss F (1998) Substance dependence as a compulsive behavior. J Psychophar-macology 12:39–48
Kreek MJ, Koob GF (1998) Drug dependence: stress and disregulation of brain reward pathways. Drug&Alcohol Dep 51:23–47
Ksir C (1983) Taste and nicotine as determinants of voluntary tobacco use by hamsters. Pharmacol Biochem Behav 19:605–608
Ksir C, Hakan R, Hall Jr DP, Kellar KJ (1985) Exposure to nicotine enhances the behavioral stimulant effect of nicotine and increases binding of [3H] acetylcholine to nicotinic receptors. Neuropharmacology 24:527–531
Ksir C, Hakan RL, Kellar KJ (1987) Chronic nicotine and locomotor activity: influences of exposure dose and test dose. Psychopharmacology 92:25–29
Ksir C, Mellor G, Hart C, Gerhardt GA (1995) Nicotine enhances dopamine clearance in rat nucleus accumbens. Prog Neuropsychopharmacol Biol Psychiatry 19: 151–156
Kulak JM, Nguyen TA, Olivera BM, Mclntosh JM (1997) α-Conotoxin Mil blocks nicotine-stimulated dopamine release in rat striatal synaptosomes. J Neurosci 17:5263–5270
Kumar R, Cooke EC, Lader MH, Russell MAH (1977) Is nicotine important in tobacco-smoking?. Clin Pharmac Ther 21:520–529
Kumar R, Pratt JA, Stolerman IP (1983) Characteristics of conditioned taste aversion produced by nicotine in rats. Br J Pharmacol 79:245–253
Kumar R, Reavill C, Stolerman IP (1987) Nicotine cue in rats: effects of central administration of ganglion-blocking drugs. Br J Pharmacol 90:239–246
Kumari V, Checkley SA, Gray JA (1996) Effect of cigarette smoking on prepulse inhibition of the acoustic startle reflex in healthy male smokers. Psychopharmacology 128:54–60
Kumari V, Cotter PA, Checkley SA, Gray JA (1997) Effect of acute subcutaneous nicotine on prepulse inhibition of the acoustic startle reflex in healthy male nonsmokers. Psychopharmacology 132:389–395
Kumari V, Gray JA (1999) Smoking withdrawal, nicotine dependence and prepulse inhibition of the acoustic startle reflex. Psychopharmacology 141:11–15
Lamb RJ, Preston KL, Schindler CW, Meisch RA, Davis F, Katz JL, Henningfield JE, Goldberg SR (1991) The reinforcing and subjective effects of morphine in postaddicts: a dose-response study. J Pharmacol Exp Ther 259:1165–1173
Lang WJ, Latiff AA, McQueen A, Singer G (1977) Self-administration of nicotine with and without a food delivery schedule. Pharmacol Biochem Behav 7:65–70
Langley JN (1905) On the reaction of cells and of nerve-endings to certain poisons, chiefly as regards the reaction of striated muscle to nicotine and to curari. J Physiol 4:374–13
Lapchak PA, Araujo DM, Quirion R, Collier B (1989) Effect of chronic nicotine treatment on nicotinic autoreceptorfunction and N-[3H]methylcarbamylcholine binding sites in the rat brain. J Neurochem 52:483–191
Lapin EP, Maker HS, Sershen H, Lajtha A (1989) Action of nicotine on accumbens dopamine and attenuation with repeated administration. Eur J Pharmacol 160:53–59
Lapin EP, Maker HS, Bhardwaj A (1995) Ethanol enhancement of the motorstimulating effect of nicotine in the rat. Alcohol 12:217–220
Larsson C, Nilsson L, Halen A, Nordberg A (1986) Subchronic treatment of rats with nicotine: effects on tolerance and on [3H]acetylcholine and [3H]nicotine binding in the brain. Drug Alcohol Depend 17:37–45
Latiff AA, Smith LA, Lang WJ (1980) Effects of changing dosage and urinary pH in rats self-administering nicotine on a food delivery schedule. Pharmacol Biochem Behav 13:209–213
Lau CE, Spear DJ, Falk JL (1994) Acute and chronic nicotine effects on multiple-schedule behavior: oral and SC routes. Pharmacol Biochem Behav 48:209–215
Le AD, Quan B, Juzystcg W, Fletcher PJ, Joharchi N, Shaham Y (1998) Reinstatement of alcohol-seeking by priming injections of alcohol and exposure to stress in rats. Psychopharmacology 135:169–174
Lee L-Y, Gerhardstein DC, Wang AL, Burki NK (1993) Nicotine is responsible for the airway irritation evoked by cigarette smoke inhalation in men. J Appl Physiol 75:1955–1961
Le Houezec J, Martin C, Cohen C, Molimard R (1989) Failure of behavioral dependence induction and oral nicotine bioavailability in rats. Physiol Behav 45:103–108
Leikola-Pelho T, Heinämäki J, Laakso I, Ahtee L (1990) Chronic nicotine treatment changes differentially the effects of acute nicotine on the three main dopamine metabolites in mouse striatum. Naunys Schmiedeberg’s Arch Pharmacol 342: 400–406
Leikola-Pelho T, Jackson DM (1992) Preferential stimulation of locomotor activity by ventral tegmental microinjections of (-)-Nicotine. Pharmacol Toxicol 70:50–52
LeNovere N, Zoli M, Changeux JP (1996) Neuronal nicotinic receptors alpha 6 subunit mRNA is selectively concentrated in cathecolaminergic nuclei of the rat brain. Eur J Neurosci 8:2428–2439
Lerman C, Caproso N, Audrain J, Main D, Bowman ED, Lockshin B, Boyd NR, Shields P (1999) Evidence suggesting the role of specific genetic factors in cigarette smoking. Health Psychol 18:14–20
Lester R, Dani J (1994) Time-dependent changes in central nicotinic acetylcholine channel kinetics in excised patches. Neuropharmacology 33:27–34
Levin ED, Morgan MM, Galvez C, Ellison GD (1987) Chronic nicotine and withdrawal effects on body weight and food and water consumption in female rats. Physiol Behav 39:441–444
Levin ED, Briggs SJ, Christopher NC, Rose JE (1992) Persistence of chronic nicotineinduced cognitive facilitation. Behav Neural Biol 58:152–158
Li X, Rainnie DG, McCarley RW, Greene RW (1998) Presynaptic nicotinic receptors facilitate monoaminergic transmission. J Neurosci 18:1904–1912
Lichtensteiger W, Hefti F, Felix D, Huwyler T, Melamed E, Schlumpf M (1982) Stimulation of nigrostriatal dopamine neurones by nicotine. Neuropharmacology 21:963–968
Louis M, Clarke PB (1998) Effect of ventral tegmental 6-hydroxydopamine lesions on the locomotor stimulant action of nicotine in rats. Neuropharmacology 37:1503–1513
Lubow RE (1989) Latent inhibition and conditioned attention theory. Cambridge University Press, Cambridge
Lubow RE, Moore AU (1959) Latent inhibition: the effects of non-reinforced preexposure to the conditioned stimulus. J Comp Physiol Psychol 52:415–419
Lucchesi BR, Schuster CR, Emley GS (1967) The role of nicotine as a determinant of cigarette smoking in man with observations of certain cardiovascular effects associated with the tobacco alkaloid. Clin Pharmac Ther 8:789–796
Luetje CW, Patrick J (1991) Both α-and β-subunits contribute to the agonist sensitivity of neuronal nicotinic acetylcholine receptors. J Neurosci 11:837–845
Lukas RJ (1991) Effects of chronic nicotinic ligand exposure on functional activity of nicotinic acetylcholine receptors expressed by cells of the PC12 rat pheochromocytoma or the TE6/1/RD human clonal line. J Neurochem 56:1134–1145
Luo S, Kulak JM, Cartier GE, Jacobsen RB, Yoshikami D, Olivera BM, Mclntosh JM (1998) α-Conotoxin AuIB selectively blocks α3/β4 nicotinic acetylcholine receptors and nicotine-evoked norepinephrine release. J Neurosci 18:8571–8579
Marlatt GA, Baer JS, Donovan DM, Klivahan DR (1988) Addictive behaviors: Etiology and treatment. Ann Rev Psychology 39:223–252
Maisonneuve IM, Glick SD (1992) Interactions between ibogaine and cocaine in rats: in vivo microdialysis and motor behavior. Eur J Pharmacol 212:263–266
Maisonneuve IM, Keller RW Jr, Glick SD (1991) Interactions between ibogaine, a potential anti-addictive agent, and morphine: an in vivo microdialysis study. Eur J Pharmacol 199:35–2
Maisonneuve IM, Keller RW Jr, Glick SD (1992) Interactions of ibogaine and D-amphetamine: in vivo microdialysis and motor behavior in rats. Brain Res 579: 87–92
Maisonneuve IM, Mann GL, Deibel CR (1997) Ibogaine and the dopaminergic response to nicotine. Psychopharmacology 129:249–256
Malin DH, Lake JR, Newlin-Maultsby P, Roberts LK, Lanier JG, Carter VA, Cunningham JS, Wilson OB (1992) Rodent model of nicotine abstinence syndrome. Pharmacol Biochem Behav 43:779–784
Malin DH, Lake JR, Carter VA, Cunningham JS, Wilson OB (1993) Naloxone precipitates nicotine abstinence syndrome in the rat. Psychopharmacology 112:339–342
Malin DH, Lake JR, Carter VA, Cunningham JS, Hebert KM, Conrad DL, Wilson OB (1994) The nicotinic antagonist mecamylamine precipitates nicotine abstinence syndrome in the rat. Psychopharmacology 115:180–184
Malin DH, Lake JR, Payne MC, Short PE, Carter VA, Cunningham JS, Wilson OB (1996a) Nicotine alleviation of nicotine abstinence syndrome is naloxonereversible. Pharmacol Biochem Behav 53:81–85
Malin DH, Lake JR, Short PE, Blossman JB, Lawless BA, Schopen CK, Sailer EE, Burgess K, Wilson OB (1996b) Nicotine abstinence syndrome precipitated by an analog of neuropeptide FF. Pharmacol Biochem Behav 54:581–585
Malin DH, Lake JR, Schopen CK, Kirk JW, Sailer EE, Lawless BA, Upchurch TP, Shenoi M, Rajan N (1997) Nicotine abstinence syndrome precipitated by central but not peripheral hexamethonium. Pharmacol Biochem Behav 58:695–699
Malin DH, Lake JR, Upchurch TP, Shenoi M, Rajan N, Schweinle WE (1998a) Nicotine abstinence syndrome precipitated by the competitive nicotinic antagonist dihydro-α-erythroidine. Pharmacol Biochem Behav 60:609–613
Malin DH, Lake JR, Shenoi M, Upchurch TP, Johnson SC, Schweinle WE, Cadle CD (1998b) The nitric oxide synthesis inhibitor nitro-L-arginine (L-NNA) attenuates nicotine abstinence syndrome in the rat. Psychopharmacology 140:371–377
Mansbach RS, Rovetti CC, Freedland CS (1998) The role of monoamine neurotransmitter systems in the nicotine discriminative stimulus. Drug Alcohol Dep 52: 125–134
Marien M, Brien J, Jhamandas K (1983) Regional release of [3H]dopamine from rat brain in vitro: effects of opioids on release induced by potassium, nicotine, and L-glutamic acid. Can J Pharmacol 61:43–60
Markou A, Weiss F, Gold LH, Caine SB, Schulteis G, Koob GF (1993) Animal models of drug craving. Psychopharmacology 112:163–182
Markou A, Kosten TR, Koob GF (1998) Neurobiological similarities in depression and drug dependence: a self-medication hypothesis. Neuropsychopharmacology 18:135–174
Marks MJ, Burch JB, Collins AC (1983) Effects of chronic nicotine infusion on tolerance development and nicotinic receptors. J Pharmacol Exp Ther 226:817–825
Marks MJ, Stitzel JA, Collins AC (1985) Time course study of the effects of chronic nicotine infusion on drug responses and brain receptors. J Pharmacol Exp Ther 235:619–628
Marks MJ, Romm E, Gaffney DK, Collins AC (1986a) Nicotine-induced tolerance and receptor changes in four mouse strains. J Pharmacol Exp Ther 237:809–819
Marks MJ, Stitzel JA, Collins AC (1986b) A dose-response analysis of nicotine tolerance and receptor changes in two inbred mouse strains. J Pharmacol Exp Ther 239:358–364
Marks MJ, Stitzel JA, Collins AC (1987) Influence of kinetics of nicotine administration on tolerance development and receptor levels. Pharmacol Biochem Behav 27:505–512
Marks MJ, Campbell SM, Romm E, Collins AC (1991) Genotype influences the development of tolerance to nicotine in the mouse. J Pharmacol Exp Ther 259:392–02
Marks MJ, Paualy JR, Gross SD, Deneris ES, Hermans-Borgmeyer I, Collins AC (1992) Nicotine binding and nicotinic receptor subunit RNA after chronic nicotine treatment. J Neurosci 12:2765–2784
Marks MJ, Grady SR, Collins AC (1993) Downregulation of nicotinic receptor function after chronic infusion. J Pharmacol Exp Ther 266:1268–1276
Marks MJ, Grady SR, Yang JM, Lippiello PM, Collins AC (1994) Desensitization of nicotine-stimulated 86RB efflux from mouse brain synaptosome. J Neurochem 63:2125–2135
Marshall D, Soliakov L, Redfern P, Wonnacott S (1996) Tetrodotoxin-sensitivity of nicotine-evoked dopamine release from rat striatum. Neuropharmacology 35:1531–1536
Marshall DL, Redfern PH, Wonnacott S (1997) Presynaptic nicotinic modulation of dopamine release in the three ascending pathways studied by in vivo microdialysis: comparison of naive and chronic nicotine-treated rats. J Neurochem 68:1511–1519
Martellotta MC, Kuzmin A, Zvartau E, Cossu G, Gessa GL, Fratta W (1995) Isradipine inhibits nicotine intravenous self-administration in drug-naive mice. Pharmacol Biochem Behav 52:271–274
Mathieu AM, Caboche J, Besson MJ (1996) Distribution of preproenkephalin, preprotachykinin A, and preprodynorphin mRNAs in the rat nucleus accumbens: effect of repeated administration of nicotine. Synapse 23:94–106
Mathieu-Kia AM, Besson MJ (1998a) Repeated administration of cocaine, nicotine and ethanol: effects on preprodynorphin, preprotachykinin A and preproenkephalin mRNA expression in the dorsal and the ventral striatum of the rat. Brain Res Mol Brain Res 54:141–151
Mathieu-Kia AM, Pages C, Besson MJ (1998b) Inducibility of c-Fos protein in visuomotor system and limbic structures after acute and repeated administration of nicotine in the rat. Synapse 29:343–354
Matta SG, Foster CA, Sharp BM (1993) Nicotine stimulates the expression of cFos protein in the parvocellular paraventricular nucleus and brainstem catecholaminergic regions. Endocrinology 132:2149–2156
McEvoy JP, Freudenreich O, Levin ED, Rose JE (1995) Haloperidol increases smoking in patients with schizophrenia. Psychopharmacology 119:124–126
McGehee DS, Role LW (1995) Physiological diversity of nicotinic acetylcholine receptors expressed by vertebrate neurons. Annu Rev Physiol 57:521–546
McMorrow MJ, Foxx RM (1983) Nicotine’s role in smoking: an analysis of nicotine regulation. Psych Bull 93:302–327
Meehan SM, Schechter MD (1996) Discriminative stimulus properties of CGS 10746B: Similarity to dopamine Dl receptor antagonists. Behav Brain Res 74:199–205
Meltzer LT, Rosecrans JA, Aceto MD, Harris LS (1980) Discriminative stimulus properties of the optical isomers of nicotine. Psychopharmacology 68:283–286
Mereu G, Yoon K-WP, Boi V, Gessa GL, Naes L, Westfall TC (1987) Preferential stimulation of ventral tegmental area dopaminergic neurons by nicotine. Eur J Pharmacol 141:395–399
Merlo Pich M, Pagliusi SR, Tessari M, Talabot-Ayer D, Hooft van Huijsduijnen R, Chiamulera C (1997) Common neural substrates for the addictive properties of nicotine and cocaine. Science 275:83–86
Mifsud JC, Hernandez L, Hoebel BG (1989) Nicotine infused into the nucleus accumbens increases synaptic dopamine as measured by in vivo microdialysis. Brain Res 478:365–368
Miner LL, Collins AC (1989) Strain comparison of nicotine-induced seizure sensitivity and nicotinic receptors. Pharmac Biochem Behav 33:469–475
Mirza NR, Pei Q, Stolerman JP, Zetterström TSC (1996) The nicotinic receptor agonists (-)-nicotine and isoarecolone differ in their effects on dopamine release in the nucleus accumbens. Eur J Pharmacol 295:207–210
Mitchell SN, Brazell MP, Joseph MH, Alavijeh MS, Gray JA (1989) Regionally specific effects of acute and chronic nicotine on rates of catecholamine and 5-hydroxytryptamine synthesis in rat brain. Eur J Pharmacol 167:311–322
Mitchell SN, Brazell MP, Schugens MM, Gray JA (1990) Nicotine-induced catecholamine synthesis after lesions to the dorsal or ventral noradrenergic bundle. Eur J Pharmacol 179:383–391
Mitchell SN, Smith KM, Joseph MH, Gray JA (1993) Increases in tyrosine hydroxylase messenger RNA in the locus coeruleus after a single dose of nicotine are followed by time-dependent increases in enzyme activity and noradrenaline release. Neuroscience 56:989–997
Miyata H, Ando K, Yanagita T (1999) Medial prefrontal cortex is involved in the discriminative stimulus effects of nicotine in rats. Psychopharmacology 145:234–236
Mogg AJ, Kaiser SA, Wonnacott S (1999) Indirect modulation of dopamine release in the rat striatum by anatoxin-A and nicotine evoked glutamate release. In: “Neuronal Nicotinic Receptors: From Structure to Therapeutics.” Venice, 1-4 October
Molinari HH, Maisonneuve IM, Glick SD (1996) Ibogaine neurotoxicity: a reevaluation. Brain Res 737:255–262
Montgomery AM, Rose IC, Herberg LJ (1993) The effect of a 5-HT3 receptor antagonist, ondansetron, on brain stimulation reward, and its interaction with direct and indirect stimulants of central dopaminergic transmission. J Neural Transm Gen Sect 91:1–11
Moratalla R, Elibol B, Vallejo M, Graybiel AM (1996a) Network-level changes in expression of inducible Fos-Jun proteins in the striatum during chronic cocaine treatment and withdrawal. Neuron 17:147–156
Moratalla R, Vallejo M, Elibol B, Graybiel AM (1996b) Dl-class dopamine receptors influence cocaine-induced persistent expression of Fos-related proteins in striatum. Neuroreport 8:1–5
Morrison CF (1967) Effects of nicotine on opérant behaviour of rats. Int J Neuropharmacol 6:229–240
Morrison CF (1969) Effects of nicotine on operant behaviour of rats. Int J Neuropharmacol 6:229–240
Morrison CF (1974) Effects of nicotine and its withdrawal on the performance of rats on signalled avoidance schedules. Psychopharmacology 38:25–35
Morrison CF, Armitage AK (1967) Effects of nicotine upon the free operant behavior of rats and spontaneous motor activity of mice. Ann NY Acad Sci 142:268–276
Morrison CF, Stephenson JA (1969) Nicotine injections as the conditioned stimulus in discrimination learning. Psychopharmacologia 15:351–360
Morrison CF, Stephenson JA (1972) The occurrence of tolerance to a central depressant effect of nicotine. Br J Pharmacol 46:151–156
Museo E, Wise RA (1990a) Microinjection of a nicotinic agonist into dopamine terminal fields: effects on locomotion. Pharmacol Biochem Behav 37:113–116
Museo E, Wise RA (1990b) Locomotion induced by ventral tegmental microinjections of a nicotinic agonist. Pharmacol Biochem Behav 37:735–737
Museo E, Wise RA (1995) Cytisine-induced behavioral activation: delineation of neuroanatomical locus of action. Brain Res 670:257–263
Nemeth-Coslett R, Griffiths RR (1986) Naloxone does not affect cigarette smoking. Psychopharmacology 89:261–264
Nemeth-Coslett R, Henningfield JE, O’Keeffe MK, Griffiths RR (1986) Effects of mecamylamine on human cigarette smoking and subjective ratings. Psychopharmacology 88:420–25
Newman LM (1972) Effects of cholinergic agonists on self-stimulation behavior in the rat. J Comp Physiol Psychol 79:394–413
Nil R, Bättig K (1989) Separate effects of cigarette smoke yield and smoke taste on smoking behavior. Psychopharmacology 99:54–59
Nisell M, Nomikos GG, Svensson TH (1994a) Infusion of nicotine in the ventral tegmental area or the nucleus accumbens of the rat differentially affects accumbal dopamine release. Pharmac Toxicol 75:348–352
Nisell M, Nomikos GG, Svensson TH (1994b) Systemic nicotine-induced dopamine release in the rat nucleus accumbens is regulated by nicotinic receptors in the ventral tegmental area. Synapse 16:36–44
Nisell M, Nomikos GG, Hertel P, Panagis G, Svensson TH (1996) Condition-independent sensitization of locomotor stimulation and mesocortical dopamine release following chronic nicotine treatment in the rat. Synapse 22:369–381
Nisell M, Marcus M, Nomikos GG, Svensson TH (1997a) Differential effects of acute and chronic nicotine on dopamine output in the core and shell of the rat nucleus accumbens. J Neural Transm 104:1–10
Nisell M, Nomikos GG, Chergui K, Grillner P, Svensson TH (1997b) Chronic nicotine enhances basal and nicotine-induced Fos immunoreactivity preferentially in the medial prefrontal cortex of the rat. Neuropsychopharmacology 17:151–161
Noble EP, St Jeor ST, Ritchie T, Syndulko K, St Jeor SC, Fitch RJ, Brunner RL, Sparkes RS (1994) D2 dopamine receptor gene and cigarette smoking: a reward gene?. Med Hypotheses 42:257–260
Nye HE, Hope BT, Kelz MB, Iadarola M, Nestler EJ (1995) Pharmacological studies of the regulation of chronic Fos-related antigen induction by cocaine in the striatum and nucleus accumbens. J Pharmacol Exp Ther 275:1671–1680
O’Brien CP (1996) Drug addiction and drug abuse. In: Goodman LS, Gilman A (eds) The Pharmacological Basis of Therapeutics. mMe Graw Hill, New York
Ochoa EL, Li L, McNamee MG (1990) Desensitization of central cholinergic mechanisms and neuroadaptation to nicotine. Mol Neurobiol 4:251–287
Oglesby MW, Epping-Jordan MP, Pich EM, Picciotto MR, Changeux J-P (1998) Attenuated nicotine discrimination in mice lacking high affinity nicotine receptors. Soc Neurosci Abstr 24:1196
Olale F, Gerzanich V, Kuryatov A, Wang F, Lindstrom J (1997) Chronic nicotine exposure differentially affects the function of human α3, α4, and α7 neuronal nicotinic receptor subtypes. J Pharmacol Exp Ther 283:675–683
Olds ME, Domino EF (1969a) Comparison of muscarinic and nicotinic cholinergic agonists on self-stimulation behavior. J Pharmacol Exp Ther 166:189–204
Olds ME, Domino EF (1969b) Differential effects of cholinergic agonists on selfstimulation and escape behavior. J Pharmacol Exp Ther 170:157–167
O’Neill MF, Dourish CT, Iversen SD (1991) Evidence for an involvement of D1 and D2 dopamine receptors in mediating nicotine-induced hyperactivity in rats. Psychopharmacology 104:343–350
Ossenkopp KP, Giugno L (1990) Nicotine-induced conditioned taste aversions are enhanced in rats with lesions of the area postrema. Pharmacol Biochem Behav 36:625–630
Overton DA (1969) Control of T-maze choice by nicotinic, antinicotinic, and antimuscarinic drugs. Proceedings, 77th Ann Convention, Am Psychol Ass, pp 869–870
Overton DA (1984) State dependent learning and drug discrimination. In: Iversen LL, Iversen SD, Snyder SH (eds) Handbook of Psychopharmacology. Plenum Press, New York, vol 18, pp 60–127
Pagliusi SR, Tessari M, DeVevey S, Chiamulera C, Merlo Pich E (1996) The reinforcing properties of nicotine are associated with a specific patterning of c-fos expression in the rat brain. Eur J Neurosci 8:2247–2256
Panagis G, Nisell M, Nomikos GG, Chergui K, Svensson TH (1996) Nicotine injections into the ventral tegmental area increase locomotion and Fos-like immunostaining in the nucleus accumbens of the rat. Brain Res 730:133–142
Pang Y, Kiba H, Jayaraman A (1993) Acute nicotine injections induce c-fos mostly in non-dopaminergic neurons of the midbrain of the rat. Mol Brain Res 20:162–170
Papke RL, Heinemann SF (1994) Partial agonist properties of cytisine on neuronal nicotinic receptors containing the βl subunit. Mol Pharmacol 45:142–149
Parker LA (1992) Place conditioning in a three-or four-choice apparatus: role of stimulus novelty in drug-induced place conditioning. Behav Neurosci 106:294–306
Parker LA (1995) Rewarding drugs produce taste avoidance, but not taste aversion. Neurosci Biobehav Rev 19:143–157
Parker LA, Doucet K (1995) The effects of nicotine and nicotine withdrawal on taste reactivity. Pharmacol Biochem Behav 52:125–129
Patton GC, Ilibbert M, Rosier MJ, Carlin JB, Caust J, Bowes G (1996) Is smoking associated with depression and anxiety in teenagers?. Am J Public Health 86:225–230
Pauly JR, Grün EU, Collins AC (1990) Chronic corticosterone administration modulates nicotine sensitivity and brain nicotinic receptor binding in C3H mice. Psychopharmacology 101:310–316
Pauly JR, Marks MJ, Gross SD, Collins AC (1991) An autoradiographic analysis of cholinergic receptors in mouse brain after chronic nicotine treatment. J Pharmac Exp Ther 258:1127–1136
Pauly JR, Grün EU, Collins A (1992) Tolerance to nicotine following chronic treatment by injections: a potential role for corticosterone. Psychopharmacology 108:33–39
Payne TJ, Share ML, Levis DJ, Coletri G (1991) Exposure to smoking-relevant cues: effects on desire to smoke and topographical components of smoking behavior. Addictive Behav 16:467–479
Peng X, Gerzanich V, Anand R, Whiting PJ, Lindstrom J (1994) Nicotine-induced increase in neuronal receptors results from a decrease in the rate of receptor turnover. Mol Pharmacol 46:523–530
Perkins KA (1995) Individual variability in responses to nicotine. Behav Gen 25: 119–132
Perkins KA (1999) Baseline dependency of nicotine effects: a review. Behav Pharmacol (in press)
Perkins KA, Sexton JE (1995) Influence of aerobic fitness, activity level, and smoking history on the acute thermic effect of nicotine. Physiol Behav 57(6):1097–1102
Perkins KA, Stitzer M (1998) Behavioral pharmacology of nicotine. In: Tarter R, Ammerman RT, Ott P (eds) Handbook of substance abuse: neurobehavioral pharmacology. New York, Plenum Press, pp 299–317
Perkins KA, Epstein LH, Stiller RL, Marks BL, Jacob RG (1989) Chronic and acute tolerance to the heart rate effects of nicotine. Psychopharmacology 97:529–534
Perkins KA, Grobe JE, Stiller RL, Fonte C, Goettler JE (1992a) Nasal spray nicotine replacement suppresses cigarette smoking desire and behavior. Clin Pharmacol Ther 52:627–634
Perkins KA, Grobe JE, Fonte C, Breus M (1992b) “Paradoxical” effects of smoking on subjective stress versus cardiovascular arousal in males and females. Pharmacol Biochem Behav 42:301–311
Perkins KA, Grobe JE, Epstein LH, Caggiula A, Stiller RL, Jacob RG (1993) Chronic and acute tolerance to subjective effects of nicotine. Pharmacol Biochem Behav 45(2):375–381
Perkins KA, DiMarco A, Grobe JE, Scierka A, Stiller RL (1994a) Nicotine discrimination in male and female smokers. Psychopharmacology 116(4):407–413
Perkins KA, Grobe JE, Fonte C, Goettler J, Caggiula AR, Reynolds WA, Stiller RL, Scierka A, Jacob RG (1994b) Chronic and acute tolerance to subjective, behavioral and cardiovascular effects of nicotine in humans. J Pharmacol Exp Ther 270(2):628–638
Perkins KA, Epstein LH, Grobe J, Fonte C (1994c) Tobacco abstinence, smoking cues, and the reinforcing value of smoking. Pharmacol Biochem Behav 47:107–112
Perkins KA, Sexton JE, Reynolds WA, Grobe JE, Fonte C, Stiller RL (1994d) Comparison of acute subjective and heart rate effects of nicotine intake via tobacco smoking vs. nasal spray. Pharmacol Biochem Behav 47:295–299
Perkins KA, Sexton JE, Stiller RL, Fonte C, Di Marco A, Goettler J, Scierka A (1994e) Subjective and cardiovascular responses to nicotine combined with caffeine during rest and casual activity. Psychopharmacology 113:438–444
Perkins KA, Epstein LH, Fonte C, Mitchell SL, Grobe JE (1995a) Gender, dietary restraint, and smoking’s influence on hunger and the reinforcing value of food. Physiol Behav 57:675–680
Perkins KA, Grobe JE, Mitchell SL, Goettler J, Caggiula A, Stiller RL, Scierka A (1995b) Acute tolerance to nicotine in smokers: lack of dissipation within 2 hours. Psychopharmacology 118:164–170
Perkins KA, Grobe JE, Weiss D, Fonte C, Caggiula A (1996a) Nicotine preference in smokers as a function of smoking abstinence. Pharmacol Biochem Behav 55:257–263
Perkins KA, D’Amico D, Sanders M, Grobe JE, Wilson A, Stiller RL (1996b) Influence of training dose on nicotine discrimination in humans. Psychopharmacology 126:132–139
Perkins KA, Grobe JE, Caggiula A, Wilson AS, Stiller RL (1997a) Acute reinforcing effects of low-dose nicotine nasal spray in humans. Pharmacol Biochem Behav 56(2):235–241
Perkins KA, Sanders M, D’Amico D, Wilson A (1997b) Nicotine discrimination and self-administration in humans as a function of smoking status. Psychopharmacology 131(4):361–370
Perkins KA, Grobe JE, Fonte C (1997c) Influence of acute smoking exposure on the subsequent reinforcing value of smoking. Exp Clin Psychopharm 5:277–285
Perkins KA, Sanders M, Fonte C, Wilson AS, White W, Stiller R, McNamara D (1999) Effects of central and peripheral nicotinic blockade on human nicotine discrimination. Psychopharmacology 142:158–164
Picciotto MR, Zoli M, Rimondini R, Lena C, Marubio LM, Pich EM, Fuxe K, Changeux JP (1998) Acetylcholine receptors containing the beta2 subunit are involved in the reinforcing properties of nicotine. Nature 391:173–177
Pickworth WB, Herning RI, Henningfield JE (1989) Spontaneous EEG changes during tobacco abstinence and nicotine substitution. J Pharmacol Exp Ther 251:976–982
Pickworth WB, Heishman SJ, Henningfield JE (1995) Relationships between EEG and performance during nicotine withdrawal and administration. In: Domino EF (ed) Brain imaging of nicotine and tobacco smoking. NPP Books, Ann Arbor, Mich, pp 275–287
Pidoplichko VI, DeBiasi M, Williams JT, Dani JA (1997) Nicotine activates and desensitizes midbrain dopamine neurons. Nature 390:401–404
Pierzchala K, Houdi AA, Van Loon GR (1987) Nicotine-induced alterations in brain regional concentrations of native and crytic met-and leu-enkephalin. Peptides 8:1035–1043
Pietilä K, Salminen O, Leikola-Pelho T, Ahtee L (1996) Tolerance to nicotine’s effects on striatal dopamine metabolism in nicotine-withdrawn mice. Eur J Pharmacol 318:17–22
Pomerleau OF (1995) Individual differences in sensitivity to nicotine: implications for genetic research on nicotine dependence. Behav Genet 25:161–177
Pomerleau OF, Pomerleau CS (1984) Neuroregulators and the reinforcement of smoking: towards a biobehavioral explanation. Neurosci Biobehav Rev 8:503–513
Pomerleau CS, Pomerleau OF (1992) Euphoriant effects of nicotine in smokers. Psychopharmacology 108:460–465
Pomerleau OF, Fertig JF, Seyler LE, Jaffe J (1983) Neuroendocrine reactivity to nicotine in smokers. Psychopharmacology 81:61–67
Pomerleau CS, Pomerleau OF, Majchrzak MJ (1987) Mecamylamine pretreatment increases subsequent nicotine self-administration as indicated by changes in plasma nicotine level. Psychopharmacology 91:391–393
Pontieri FE, Tanda G, Di Chiara G (1995) Intravenous cocaine, morphine and amphetamine preferentially increase extracellular dopamine in the “shell” as compared with the “core” of the rat nucleus accumbens. Proc Natl Acad Sci USA 92: 12304–12308
Pontieri FE, Tanda G, Orzi F, Di Chiara G (1996) Effects of nicotine on the nucleus accumbens and similarities to those of addictive drugs. Nature 382:255–257
Porchet HC, Benowitz NL, Sheiner LB, Copeland JR (1987) Apparent tolerance to the acute effect of nicotine results in part from distribution kinetics. J Clin Invest 80:1466–1471
Porchet HC, Benowitz NL, Sheiner LB (1988) Pharmacodynamic model of tolerance: application to nicotine. J Pharmacol Exp Ther 244:231–236
Pradhan SN (1970) Effects of nicotine on several schedules of behaviour in rats. Arch Int Pharmacodyn 183:127–138
Pradhan SN, Bowling C (1971) Effects of nicotine on self-stimulation in rats. J Pharmacol Exp Ther 176:229–243
Pratt JA, Stolerman IP, Garcha HS, Giardini V, Feyerabend C (1983) Discriminative stimulus properties of nicotine: further evidence for mediation at a cholinergic receptor. Psychopharmacology 81:54–60
Preston KL, Bigelow GE (1991) Subjective and discriminative effects of drugs. Behav Pharmacol 2:293–313
Rang HP (1982) The action of ganglionic blocking drugs on the synaptic responses of rat submandibular ganglion cells. Br J Pharmacol 75:151–168
Rapier C, Lunt GG, Wonnacott S (1988) Stero-selective nicotine-induced release of dopamine from striatal synaptosomes: concentration dependence and repetitive stimulation. J Neurochem 50:1123–1130
Rasmussen T, Czachura JF (1995) Nicotine withdrawal leads to increased firing rates of midbrain dopamine neurons. NeuroReport 7:329–332
Rasmussen T, Swedberg MD (1998) Reinforcing effects of nicotinic compounds: intravenous self-administration in drug-naive mice. Pharmacol Biochem Behav 60(2):567–573
Rasmussen K, Kallman MJ, Helton DR (1997) Serotonin-1A antagonists attenuate the effects of nicotine withdrawal on the auditory startle response. Synapse 27:145–152
Reavill C, Stolerman IP (1987) Interaction of nicotine with dopaminergic mechanisms assessed through drug discrimination and rotational behaviour in rats. J Psychopharmacol 1:264–273
Reavill C, Stolerman IP (1990) Locomotor activity in rats after administration of nicotinic agonists intracerebrally. Brit J Pharmacol 99:273–278
Reavill C, Stolerman IP, Kumar R, Garcha HS (1986) Chlorisondamine blocks acquisition of the conditioned taste aversion produced by (-)-nicotine. Neuropharmacology 25:1067–1069
Reavill C, Walther B, Stolerman IP, Testa B (1990) Behavioural and pharmacokinetic studies on nicotine, cytisine and lobeline. Neuropharmacology 29:619–624
Reid MS, Ho LB, Berger SP (1996) Effects of environmental conditioning on the development of nicotine sensitization: behavioral and neurochemical analysis. Psychopharmacology 126(4):301–310
Reid MS, Ho LB, Berger SP (1998) Behavioral and neurochemical components of nicotine sensitization following 15-day pretreatment: studies on contextual conditioning. Behav Pharmacol 9(2): 137–148
Ren T, Sagar SM (1992) Induction of c-fos immunostaining in the rat brain after the systemic administration of nicotine. Brain Res Bull 29:589–597
Rezvani AH, Overstreet DH, Lee YW (1995) Attenuation of alcohol intake by ibogaine in three strains of alcohol-preferring rats. Pharmacol Biochem Behav 52: 615–620
Richardson NR, Roberts DCS (1996) Progressive ratio schedules in drug administration studies in rats: a method to evaluate reinforcing efficacy. J Neurosci Meth 66:1–11
Risner ME, Goldberg SR (1983) A comparison of nicotine and cocaine selfadministration in the dog: fixed-ratio and progressive-ratio schedules of intravenous drug infusion. J Pharmacol Exp Therap 224:319–326
Risner ME, Goldberg SR, Prada JA, Cone EJ (1985) Effects of nicotine, cocaine and some of their metabolites on schedule-controlled responding by beagle dogs and squirrel monkeys. J Pharmacol Exp Therap 234:113–119
Robbins TW (1981) Behavioural determinants of drug action: rate-dependency revisited. In: Cooper SJ (ed) Theory in Psychopharmacology. Academic Press, New York, pp 2–63
Robbins TW, Koob GF (1980) Selective disruption of displacement behaviour by lesions of the mesolimbic dopamine system. Nature 285:409–12
Robinson JH, Pritchard WS (1992) The role of nicotine in tobacco use. Psychopharmacology 108:397–407
Robinson TE, Berridge KC (1993) The neural basis of drug craving: an incentive-sensitization theory of addiction. Brain Res Rev 18:247–291
Robinson SF, Pauly JR, Marks MJ, Collins AC (1994) An analysis of response to nicotine infusion using an automated radiotelemetry system. Psychopharmacology 115:115–120
Robinson SF, Grün EU, Pauly JR, Collins AC (1996) Regulation of sensitivity to nicotine and brain nicotinic receptors by chronic nicotine and corticosterone treatment. Pharmacol Biochem Behav 54:1–7
Romano C, Goldstein A, Jewell NP (1981) Characterization of the receptor mediating the nicotine discriminative stimulus. Psychopharmacology 74(4): 310–315
Rose JE (1984) Discriminability of nicotine in tobacco smoke: Implications for titration. Addictive Behav 9:189–193
Rose JE, Levin ED (1991) Inter-relationships between conditioned and primary reinforcement in the maintenance of cigarette smoking. In: West R, Grunberg NE (eds) British Journal of Addiction. Carfax, London, pp 605–610
Rose JE, Behm FM (1995) There is more to smoking than the CNS effects of nicotine. In: Clarke PBS, Quik M, Adlkofer F, Thurau K (eds) Effects of nicotine on biological systems II. Birkhäuser Verlag, Basel, pp 9–16
Rose JE, Corrigall WA (1997) Nicotine self-administration in animals and humans: similarities and differences. Psychopharmacology 130(1):28–40
Rose J, Jarvik M, Ananda S (1983) Nicotine preference increases after cigarette deprivation. Pharmacol Biochem Behav 20:55–58
Rose JE, Herskovic JE, Trilling Y, Jarvik ME (1985) Transdermal nicotine reduces cigarette craving and nicotine preference. Clin Pharmacol Ther 38:450–456
Rose JE, Sampson A, Levin ED, Henningfield JE (1989) Mecamylamine increases nicotine preference and attenuates nicotine discrimination. Pharmacol Biochem Behav 32(4):933–938
Rose JE, Behm FM, Levin ED (1993) The role of nicotine dose and sensory cues in the regulation of smoke intake. Pharmacol Biochem Behav 44:891–900
Rose JE, Westman EC, Behm FM, Johnson MP, Goldberg JS (1999) Blockade of smoking satisfaction using the peripheral nicotinic antagonist trimethaphan. Pharmacol Biochem Behav 62(1):165–172
Rosecrans JA (1989) Nicotine as a discriminative stimulus: A neurobiobehavioral approach to studying central cholinergic mechanisms. J Subs Abuse Treat 1: 287–300
Rosecrans JA, Meltzer LT (1981) Central sites and mechanisms of action of nicotine. Neurosci Biobehav Rev 5:497–501
Rosecrans JA, Kallman MJ, Glenon R (1978) The nicotine cue: An overview. In: Colpaert FC, Rosecrans JA (eds) Stimulus Properties of Drugs: Ten Years of Progress. Elsevier, Amsterdam, pp 69–81
Rosecrans JA, Hendry JS, Hong JS (1985) Biphasic effects of chronic nicotine treatment on hypothalamic immunoreactive beta-endorphin in the mouse. Pharmacol Biochem Behav 23:141–143
Rosenberg J, Benowitz NL, Jacob P, Wilson KM (1980) Disposition kinetics and effects of intravenous nicotine. Clin Pharmacol Ther 28:517–522
Rossing MA (1998) Genetic influences on smoking: candidate genes. Environment Health Perspect 106:231–238
Rowell PP (1995) Nanomolar concentrations of nicotine increase the release of [3H]dopamine from rat striatal synaptosomes. Neurosci Lett 189:171–175
Rowell PP, Duggan DS (1998) Long-lasting inactivation of nicotine receptor function in vitro by treatment with high concentrations of nicotine. Neuropharmacology 37:103–111
Rowell PP, Hillebrand JA (1994) Desensitization of nicotine stimulated dopamine release from rat striatal synaptosomes. J Neurochem 63:561–569
Rowell PP, Li M (1997) Dose response relationship for nicotine-induced up-regulation of rat brain nicotinic receptors. J Neurochem 68:1982–1989
Rowell PP, Wonnacott S (1990) Evidence for functional activity of up-regulated nicotine binding sites in rat striatal synaptosomes. J Neurochem 55:2105–2110
Rowell PP, Carr LA, Garner AC (1987) Stimulation of 3H-dopamine release by nicotine in rat nucleus accumbens. J Neurochem 49:1449–1454
Russell MAH (1971) Cigarette smoking: natural history of dependence disorder. Br J Psychol 44:1–16
Russell MAH (1976) Tobacco smoking and nicotine dependence. In: Gibbons RJ, Israel Y, Kalant H, Popham RE, Schmidt W, Smart RG (eds) Research Advances i8n Alcohol and Drug Problems. Wiley, New York, pp 1–46
Russell MAH (1979) Tobacco dependence: Is nicotine rewarding or aversive?. In: Krasnegor N (ed) Cigarette Smoking as a Dependence Process. US Government Printing Office, Washington, DC, pp 100–122
Russell M AH (1990) Nicotine intake and its control over smoking. In: Wonnacott S, Russell MAH, Stolerman IP (eds) Nicotine psychopharmacology: molecular, cellular, and behavioural aspects. Oxford University Press, New York, pp 374–427
Russell MAH, Feyerabend C (1978) Cigarette smoking: a dependence on highnicotine boli. Drug Metab Rev 8:29–57
Russell MAH, Jarvis M, Iyer R, Feyrabend C (1980) Relation of nicotine yield of cigarettes to blood nicotine concentrations in smokers. Br Med J 280:972–976
Russell MAH, Jarvis MJ, Jones G, Feyerabend C (1990) Non-smokers show acute tolerance to subcutaneous nicotine. Psychopharmacology 102(1):56–58
Russell PO, Epstein LH, Sittenfield SL, Block DR (1986) The effects of nicotine chewing gum on the sensitivity to muscle tension. Psychopharmacology 89:230–233
Rusted JM, Mackee A, Williams R, Willner P (1998) Deprivation state but not nicotine content of the cigarette affects responding by smokers on a progressive ratio task. Psychopharmacology 140:411–417
Sacaan AL, Dunlop JL, Lloyd GK (1995) Pharmacological characterisation of neuronal acetylcholine gated ion channel-receptor mediated hippocampal norepinephrine and striatal dopamine release from rat brain slices. J Pharmacol Exp Ther 274: 224–230
Sachs DPL (1991) Advances in smoking cessation treatment. Curr Pulmonol 12:139–198
Sakurai Y, Takano Y, Kohjimoto Y, Honda K, Kamiya HO (1982) Enhancement of [3H]dopamine release and its [3H]metabolites in rat striatum by nicotinic drugs. Brain Res 242:99–106
Salminen O, Lahtinen S, Ahtee L (1996) Expression of Fos protein in various rat brain areas following acute nicotine and diazepam. Pharmacol Biochem Behav 54:241–248
Salminen O, Seppä T, Gäddnäs H, Ahtee L (1999) The effects of acute nicotine on the metabolism of dopamine and the expression of Fos protein in striatal and limbic brain areas of rats during chronic nicotine infusion and its withdrawal. J Neurosci 19:8145–8151
Sanderson EM, Drasdo AL, McCrea K, Wonnacott S (1993) Upregulation of nicotinic receptors following continuous infusion of nicotine is brain-region-specific. Brain Res 617:349–352
Sanger DJ (1978) Nicotine and schedule-induced drinking in rats. Pharmacol Biochem Behav 8:343–346
Sanger DJ (1986) Drug taking as adjunctive behavior. In Behavioural Analysis of Drug Dependence, ed. Goldberg SA and Stolerman J, Academic Press, New York, pp 123–160
Sannerud CA, Prada J, Goldberg DM, Goldberg SR (1994) The effects of sertraline on nicotine self-administration and food-maintained responding in squirrel monkeys. Eur J Pharmacol 271:461–469
Schachter S, Singer JE (1962) Cognitive, social, and psychological determinants of emotional states. Psychol Rev 69:379–399
Schaefer GJ, Michael RP (1986) Task-specific effects of nicotine in rats: Intracranial self-stimulation and locomotor activity. Neuropharmacology 25:125–131
Schaefer GJ, Michael RP (1992) Interactions between alcohol and nicotine on intracranial self-stimulation and locomotor activity in rats. Drug Alcohol Dep 30:37–47
Schechter MD (1993) Cocaine discrimination is attenuated by isradipine and CGS 10746B. Pharmacol Biochem Behav 44:661–664
Schechter MD, Meehan SM (1992) Further evidence for the mechanisms that may mediate nicotine discrimination. Pharmacol Biochem Behav 41:807–812
Schechter MD, Meehan SM (1993) Dopaminergic mediation of the stimulant generalization of nicotine. Prog Neuropsychopharmacol Biol Psychiatry 17:835–845
Schechter MD, Meehan SM (1994) Conditioned place aversion produced by dopamine release inhibition. Eur J Pharmacol 260:133–137
Schechter MD, Rosecrans JA (1971) C.N.S. effect of nicotine as the discriminative stimulus for the rat in a T-maze. Life Sci [I] 10(14):821–832
Schechter MD, Rosecrans JA (1972a) Nicotine as a discriminative cue in rats: inability of related drugs to produce a nicotine-like cueing effect. Psychopharmacologia 27:379–387
Schechter MD, Rosecrans JA (1972b) Effect of mecamylamine on discrimination between nicotine-and arecoline-produced cues. Eur J Pharmacol 17:179–182
Schechter MD, Rosecrans JA (1973) d-Amphetamine as a discriminative cue: drugs with similar stimulus properties. Eur J Pharmacol 21:212–216
Schenk S, Snow S, Horger BA (1991) Pre-exposure to amphetamine but not nicotine sensitizes rats to the motor activating effect of cocaine. Psychopharmacology 103:62–66
Scherer G (1999) Smoking behaviour and compensation: a review of the literature. Psychopharmacology 145:1–20
Schiffman SM, Jarvik ME (1976) Smoking withdrawal symptoms in two weeks of abstinence. Psychopharmacology 50:35–39
Schilström B, Nomikos GG, Nisell M, Hertel P, Svensson TH (1998a) N-methyl-D-aspartate receptor antagonism in the ventral tegmental area diminishes the systemic nicotine-induced dopamine release in the nucleus accumbens. Neuroscience 82:781–789
Schilström B, Svensson HM, Svensson TH, Nomikos GG (1998b) Nicotine and food induced dopamine release in the nucleus accumbens of the rat: putative role of α7 nicotinic receptors in the ventral tegmental area. Neuroscience 85:1005–1009
Schneiria TC (1959) An evolutionary and developmental theory of biphasic processes underlying approach and withdrawal. In: Jones MR (ed) Nebraska Symposium on Motivation. Univ of Nebraska Press, Lincoln, pp 1–42
Schulz DW, Zigmond RE (1989) Neuronal bungarotoxin blocks the nicotinic stimulation of endogenous dopamine release from rat striatum. Neurosci Lett 98:310–316
Schuster CR, Thompson T (1969) Self-administration of and behavioral dependence on drugs. Annu Rev Pharmacol 9:483–502
Schwartz RD, Kellar KJ (1983) Nicotinic cholinergic receptor binding sites in the brain: regulation in vivo. Science 220:214–216
Schwartz RD, Kellar KJ (1985) In vivo regulation of [3H]acetylcholine recognition sites in brain by nicotinic cholinergic drugs. J Neurochem 45:427–433
Schwartz RD, Lehmann J, Kellar KJ (1984) Presynaptic nicotinic cholinergic receptors labeled by [3H]acetylcholine on catecholamine and serotonin axons in brain. J Neurochem 42:1495–1498
Seguela P, Wadiche J, Dineley-Miller K, Dani JA, Patrick JW (1993) Molecular cloning, functional properties and distribution of rat brain a7: a nicotinic cation channel highly permeable to calcium. J Neurosci 13:596–604
Sershen H, Balla A, Lajtha A, Vizi ES (1997) Characterization of nicotinic receptors involved in the release of noradrenaline from the hippocampus. Neuroscience 77:121–130
Shaham Y, Stewart J (1995) Stress reinstates heroin self-administration behavior in drug-free animals: an effect mimicking heroin, not withdrawal. Psychopharmacology 119:334–341
Shaham Y, Stewart J (1996) Effects of opioid and dopamine receptor antagonists on relapse induced by stress and reexposure to heroin in rats. Psychopharmacology 125:385–391
Shaham Y, Adamson LK, Grocki S, Corrigall WA (1997) Reinstatement and spontaneous recovery of nicotine seeking in rats. Psychopharmacology 130:396–403
Sharp BM, Beyer SH (1986) Rapid desensitization of the acute stimulatory effects of nicotine on rat plasma adrenocorticotropin and prolactin. J Pharmacol Exp Ther 238:486–491
Sharp BM, Beyer HS, McAllen M, Hart D, Matta SG (1993) Induction and desensitization of the c-fos mRNA response to nicotine in the rat brain. Mol Cell Neurosci 4:199–208
Shiffman SM (1979) The tobacco withdrawal syndrome. In: Krasnegor NA (ed) Cigarette smoking as a dependence process, NIDA Research Monograph 23. US Department of Health and Human Services, HEW Pub No (ADM) Washington DC, pp 79–800
Shiffman SM, Jarvik ME (1976) Smoking withdrawal symptoms in two weeks of abstinence. Psychopharmacology 50:35–39
Shiffman S (1986) A cluster-analytic classification of smoking relapse episodes. Addictive Behav 11:295–307
Shiffman S (1989) Tobacco “chippers”-individual differences in tobacco dependence. Psychopharmacology 97:539–547
Shiffman S (1995) Comments on nicotine addiction. Psychopharmacology 117:14–15
Shiffman S, Zettler-Segal M, Kassel J, Paty J, Benowitz NL, O’Brien G (1992) Nicotine elimination and tolerance in non-dependent cigarette smokers. Psychopharmacology 109:449–456
Shoaib M, Stolerman IP (1992) MK801 attenuates behavioural adaptation to chronic nicotine administration in rats. Br J Pharmacol 105:514–515
Shoaib M, Stolerman IP (1996) Brain sites mediating the discriminative stimulus effects of nicotine in rats. Behav Brain Res 78(2):183–188
Shoaib M, Stolerman IP (1999) Plasma nicotine and cotinine levels following intravenous nicotine self-administration in rats. Psychopharmacology 143(3):318–321
Shoaib M, Stolerman IP, Kumar RC (1994a) Nicotine-induced place preferences following prior nicotine exposure in rats. Psychopharmacology 113:445–452
Shoaib M, Benwell ME, Akbar MT, Stolerman IP, Balfour DJ (1994b) Behavioural and neurochemical adaptations to nicotine in rats: influence of NMDA antagonists. Br J Pharmacol 111(4):1073–1080
Shoaib M, Schindler CW, Goldberg SR (1997a) Nicotine self-administration in rats: strain and nicotine pre-exposure effects on acquisition. Psychopharmacology 129(1):35–43
Shoaib M, Thorndike E, Schindler CW, Goldberg SR (1997b) Discriminative stimulus effects of nicotine and chronic tolerance. Pharmacol Biochem Behav 56:167–173
Siegel S (1983) Classical conditioning, drug tolerance, and drug dependence. In: Israel Y, Glaser FB, Kalant H, Popham RE, Schmidt W, Smart RG (eds) Research advances in alcohol and drug problems. Plenum Press, New York, vol 7, pp 207–246
Singer G, Simpson F, Lang WJ (1978) Schedule induced self injections of nicotine with recovered body weight. Pharmacol Biochem Behav 9:387–389
Singer G, Oei TP, Wallace M (1982a) Schedule-induced self-injection of drugs. Neurosci Biobehav Rev 6:77–83
Singer G, Wallace M, Hall R (1982b) Effects of dopaminergic nucleus accumbens lesions on the acquisition of schedule induced self injection of nicotine in the rat. Pharmacol Biochem Behav 17:579–581
Skinner BF (1935) Two types of conditioned reflex and a pseudotype. J Gen Psychol 12:66–77
Slifer BL (1983) Schedule-induction of nicotine self-administration. Pharmacol Biochem Behav 19:1005–1009
Slifer BL, Balster RL (1985) Intravenous self-administration of nicotine: with and without schedule-induction. Pharmacol Biochem Behav 22:61–69
Smith A, Roberts DCS (1995) Oral self-administration of sweetened nicotine solutions by rats. Psychopharmacology 120:341–346
Smith KM, Mitchell SN, Joseph MH (1991) Effects of chronic and subchronic nicotine on tyrosine hydroxylase activity in noradrenergic and dopaminergic neurones in the rat brain. J Neurochem 57:1750–1756
Smith LA, Lang WJ (1980) Changes occurring in self administration of nicotine by rats over a 28-day period. Pharmacol Biochem Behav 13:215–220
Snell LD, Johnson KM (1989) Effects of nicotinic agonists and antagonists on N-methyl-D-aspartate-induced 3H-norepinephrine release and H-l-[l-(2-thienyl)cyclohexyl]-piperidine binding in rat hippocampus. Synapse 3:129–135
Snyder FR, Davis FC, Henningfield JE(1989) The tobacco withdrawal syndrome: performance decrements assessed on a computerized test battery. Drug Alcohol Depend 23(3):259–266
Soliakov L, Gallagher T, Wonnacott S (1995) Anatoxin-a-evoked [3H]dopamine release from rat striatal synaptosomes. Neuropharmacology 34:1535–1541
Soliakov L, Wonnacott S (1996) Voltage-sensitive Ca2+ channels involved in nicotinic receptor-mediated 3H-dopamine release from rat striatal synaptosomes. J Neurochem 67:163–170
Solomon RL, Corbit JD (1973) An opponent-process theory of motivation. II. Cigarette addiction. J Abnorm Psychol 81:158–171
Solomon RL, Corbit JD (1974) An opponent-process theory of motivation. I: Temporal dynamics of affect. Psychol Rev 81:119–145
Sorenson EM, Shiroyama T, Kitai ST (1998) Postsynaptic nicotinic receptors on dopaminergic neurons in the substantia nigra pars compacta of the rat. Neuroscience 87:659–673
Soria R, Stapleton JM, Gilson SF, Sampson-Cone A, Henningfield JE, London ED (1996) Subjective and cardiovascular effects of intravenous nicotine in smokers and non-smokers. Psychopharmacology 128(3):221–226
Sparks JA, Pauly JR (1999) Effects of continuous oral nicotine administration on brain nicotinic receptors and responsiveness to nicotine in C57BI/6 mice. Psychopharmacology 141:145–153
Spealman RD (1983) Maintenance of behavior by postponement of scheduled injections of nicotine in squirrel monkeys. J Pharmacol Exp Ther 227(1):154–159
Spealman RD, Goldberg SR (1982) Maintenance of schedule-controlled behavior by intravenous injections of nicotine in squirrel monkeys. J Pharmacol Exp Ther 223:402–08
Spealman RD, Goldberg SR, Gardner ML (1981) Behavioral effects of nicotine: schedule-controlled responding by squirrel monkeys. J Pharmacol Exp Ther 216: 484–491
Srivastava ED, Russell MAH, Feyerabend C, Masterson JG, Rhodes J (1991) Sensitivity and tolerance to nicotine in smokers and non-smokers. Psychopharmacology 105:63–68
Stafford D, LeSage MG, Glowa JR (1998) Progressive-ratio schedules of drug delivery in the analysis of drug self-administration: a review. Psychopharmacology 139: 169–184
Stein EA, Pankiewicz J, Harsch HH, Cho JK, Fuller SA, Hoffmann RG, Hawkins M, Rao SM, Bandettini PA, Bloom AS (1998) Nicotine-induced limbic cortical activation in the human brain: a functional MRI study. Am J Psychiatry 155:1009–1015
Stellar JR, Stellar E (1985) The neurobiology of motivation and reward. Springer-Verlag, New York
Stewart J, de Wit H (1987) Reinstatement of drug-taking behavior as a method of assessing incentive motivational properties of drugs. In: Bozarth MA (ed) Methods of assessing the reinforcing properties of abused drugs. Springer, New York, pp 211–227
Stitzer M, Morrison J, Domino EF (1970) Effects of nicotine on fixed-interval behavior and their modification by cholinergic antagonists. J Pharmacol Exp Ther 171:166–177
Stolerman IP (1986) Could nicotine antagonists be used in smoking cessation. Br J Addiction 81:47–53
Stolerman IP (1987) Psychopharmacology of nicotine: stimulus effects and receptor mechanisms. In: Iversen LL, Iversen SD, Snyder SH (eds) Handbook of psychopharmacology, vol 19. Plenum, New York, pp 421–465
Stolerman IP (1989) Discriminative stimulus effects of nicotine in rats trained under different schedules of reinforcement. Psychopharmacology 97:131–138
Stolerman IP (1992) Drugs of abuse: behavioural principles, methods and terms. Trends Pharmacol Sci 13:170–176
Stolerman IP, Jarvis MJ (1995) The scientific case that nicotine is addictive. Psychopharmacology 117:2–10
Stolerman IP, Fink R, Jarvik ME (1973a) Acute and chronic tolerance to nicotine measured by activity in rats. Psychopharmacology 30:329–342
Stolerman IP, Goldfarb T, Fink R, Jarvik ME (1973b) Influencing cigarette smoking with nicotine antagonists. Psychopharmacologia 28(3):247–259
Stolerman IP, Bunker P, Jarvik ME (1974) Nicotine tolerance in rats; role of dose and dose interval. Psychopharmacologia 34(4):317–324
Stolerman IP, Pratt JA, Garcha HS, Giardini V, Kumar R (1983) Nicotine cue in rats analysed with drugs acting on cholinergic and 5-hydroxytryptamine mechanisms. Neuropharmacology 22(9):1029–1037
Stolerman IP, Garcha HS, Pratt JA, Kumar R (1984) Role of training dose in discrimination of nicotine and related compounds by rats. Psychopharmacology 84(3):413–419
Stolerman IP, Albuquerque EX, Garcha HS (1992) Behavioural effects of anatoxin, a potent nicotinic agonist, in rats. Neuropharmacology 31:311–314
Stolerman IP, Garcha HS, Mirza NR (1995a) Dissociations between the locomotor stimulant and depressant effects of nicotinic agonists in rats. Psychopharmacology 117:430–437
Stolerman IP, Mirza NR, Shoaib M (1995b) Nicotine psychopharmacology: addiction, cognition and neuroadaptation. Med Res Rev 15:47–52
Stolerman IP, Chandler CJ, Garcha HS, Newton JM (1997) Selective antagonism of behavioural effects of nicotine by dihydro-beta-erythroidine in rats. Psychopharmacology 129(4):390–397
Stolerman IP, Naylor C, Elmer GI, Goldberg SR (1999) Discrimination and selfadministration of nicotine by inbred strains of mice. Psychopharmacology 141(3):297–306
Stretch R, Gerber GJ (1973) Drug-induced reinstatement of amphetamine self-administration in monkeys. Can J Psychol 27:168–177
Stretch R, Gerber GJ, Wood SM (1971) Factors affecting behavior maintained by response-contingent intravenous infusions of amphetamine in squirrel monkeys. Can J Physiol Pharmacol 49:581–589
Suemaru K, Gomita Y, Furuno K, Araki Y (1993) Chronic nicotine treatment potentiates behavioral responses to dopaminergic drugs in rats. Pharmacol Biochem Behav 46:135–139
Sutherland G, Stapleton JA, Russell MAH (1995) Naltrexone, smoking behaviour and cigarette withdrawal. Psychopharmacology 120:418–25
Sutton SR, Russell MAH (1982) Relationship between cigarette yields, puffing patterns, and smoke intake: evidence for tar compensation?. BMJ 285:600–603
Suzuki T, Ise Y, Tsuda M, Maeda J, Misawa M (1996) Mecamylamine-precipitated nicotine-withdrawal aversion in rats. Eur J Pharmacol 314(3):281–284
Suzuki T, Ise Y, Mori T, Misawa M (1997) Attenuation of mecamylamine-precipitated nicotine-withdrawal aversion by the 5-HT3 receptor antagonist ondansetron. Life Sci 61:PL249-254
Svensson TH, Engberg G (1980) Peripheral, autonomie regulation of locus coeruleus noradrenergic neurons in brain: putative implications for psychiatry and psychopharmacology. Psychopharmacology 92:1–7
Svensson TH, Mathe JM, Nomikos GG, Schilstrom B (1998) Role of excitatory amino acids in the ventral tegmental area for central actions of non-competitive NMDA-receptor antagonists and nicotine. Amino Acids 14:51–56
Swanson LW, Simmons DM, Whiting PJ, Lindstrom J (1987) Immunohistochemical localization of neuronal nicotinic receptors in the rodent central nervous system. J Neurosci 7:3334–3342
Swedberg MDB, Henningfield JE, Goldberg SR (1990) Nicotine dependency: animal studies. In: Wonnacott S, Russell MAH, Stolerman IP (eds) Nicotine psychopharmacology: molecular, cellular and behavioural aspects. Oxford Science Publications, Oxford, pp 38–76
Swerdlow MR, Caine SB, Braff DL, Geyer MA (1992) The neural substrates of sensorimotor gating of the startle reflex: a review of recent findings and their implications. J Psychopharmacol 6:176–190
Swerdlow MR, Braff DL, Taaid N, Geyer MA (1994) Assessing the validity of an animal model of deficient sensorimotor gating in schizophrenic patients. Arch Gen Psychiatry 51:139–154
Takada K, Hagen TJ, Cook JM, Goldberg SR, Katz JL (1988) Discriminative stimulus effects of intravenous nicotine in squirrel monkeys. Pharmacol Biochem Behav 30(1):243–247
Takada K, Swedberg MD, Goldberg SR, Katz JL (1989) Discriminative stimulus effects of intravenous 1-nicotine and nicotine analogs or metabolites in squirrel monkeys. Psychopharmacology 99(2):208–212
Takano Y, Sakurai Y, Kohjimoto Y, Honda K, Kamiya H-O (1983) Presynaptic modulation of the release of dopamine from striatal synaptosomes: differences in the effects of high K+ stimulation, methamphetamine and nicotinic drugs. Brain Res 279:330–334
Tanda G, Pontieri FE, Di Chiara G (1997) Cannabinoid and heroin activation of mesolimbic dopamine transmission by a common μm1 opioid receptor mechanism. Science 276:2048–2050
Tanda G, Di Chiara G (1998) A dopamine-μ1 opioif link in the rat ventral tegmentum shared by palatable food (Fonzies) and non psychostimulant drugs of abuse. Eur J Neurosci 10:1179–1187
Tessari M, Valerio E, Chiamulera C, Beardsley PM (1995) Nicotine reinforcement in rats with histories of cocaine self-administration. Psychopharmacology 121: 282–283
Thorndike EL (1898) Animal intelligence: An experimental study of the associative processes in animals. Macmillan, New York
Thornton JC, Dawe S, Lee C, Capstick C, Corr PJ, Cotter P, Frangou S, Gray NS, Russell MAH, Gray JA (1996) Effects of nicotine and amphetamine on latent inhibition in human subjects. Psychopharmacology 127:164–173
Tiffany ST (1990) A cognitive model of drug urges and drug use behavior: Role of automatic and nonautomatic processes. Psychol Rev 97:147–168
Tiffany ST, Carter BL (1998) Is craving the source of compulsive drug use?. J Psychopharmacology 12:23–30
Toates F (1986) Motivational systems. Cambridge: Cambridge University Press
Tobin MJ, Jenouri G, Sachner MA (1982) Effect of naloxone on change in breathing pattern with smoking: a hypothesis on the addictive nature of cigarette smoking. Chest 82:530–537
Toth E, Vizi ES, Lajtha A (1993) Effect of nicotine on levels of extracellular amino acids in regions of the rat brain in vivo. Neuropharmacology 32:827–832
Tripathi HL, Martin BR, Aceto MD (1982) Nicotine-induced antinociception in rats and mice: Correlation with nicotine brain levels. J Pharmacol Exp Ther 221:91–96
US Department of Health, Education and Welfare (1964) Smoking and Health. Report of the Advisory Committee to the Surgeon General of the Public Health Service. US Department of Health, Education and Welfare, Washington, DC
US Department of Health and Human Services (1988) The health consequences of smoking: nicotine addiction. A Report of the Surgeon General. Office on Smoking and Health, Maryland
US Department of Health and Human Services (1990) Psychological and behavioral consequences and correlates of smoking cessation. In: Samiet JM, Davis RM, Grunberg NE, et al (eds) Health benefits of smoking cessation: A report of the US Surgeon General. Printing Office, US Govt, Washington, pp 521–531
Valentine JD, Hokanson JS, Matta SG, Sharp BM (1997) Self-administration in rats allowed unlimited access to nicotine. Psychopharmacology 133(3):300–304
Varvel SA, James JR, Bowen S, Rosecrans JA, Karan LD (1999) Discriminative stimulus (DS) properties of nicotine in the C57BL/6 mouse. Pharmacol Biochem Behav 63(1):27–32
Vezina P, Blanc G, Glowinski J, Tassin JP (1991) Opposed behavioural outputs of increased dopamine transmission in prefrontocortical and subcortical areas: A role for cortical Dl receptor. Eur J Neurosci 3:1001–1007
Vezina P, Blanc G, Glowinski J, Tassin JP (1992) Nicotine and morphine differentially activate brain dopamine in prefrontocortical and subcortical terminal fields: effects of acute and repeated injections. J Pharmacol Exp Therap 261:484–490
Vezina P, Hervé D, Glowinski J, Tassin JP (1994) Injections of 6-hydroxydopamine into the ventral tegmental area destroy mesolimbic dopamine neurons but spare the locomotor activating effects of nicotine in the rat. Neurosci Lett 168:111–114
Villanueva HF, Arezo S, James JR, Rosecrans JA (1992) A characterization of nicotine-induced tolerance: Evidence of pharmacological tolerance in the rat. Behav Pharmacol 3:255–260
Wada E, Wada K, Boulter J, Deneris E, Heinemann S, Patrick J, Swanson LW (1989) Distribution of alpha2, alpha3, alpha4, and beta2 neuronal nicotinic receptor subunit mRNAs in the central nervous system: A hybridization histochemical study in the rat. J Comp Neurol 284:314–335
Wada E, McKinnon D, Heinemann S, Patrick J, Swanson LW (1990) The distribution of mRNA encoded by a new member of the neuronal nicotinic acetylcholine receptor gene family (α5) in the rat central nervous system. Brain Res 526:45–53
Wakasa Y, Takada K, Yhnngita T (1995) Reinforcing effect as a function of infusion speed in intravenous self-administration of nicotine in rhesus monkeys. Jap J Psychopharmacology 15:53–59
Walter S, Kuschinsky K (1989) Conditioning of nicotine effects on motility and behaviour in rats. Naunyn Schmiedebergs Arch Pharmacol 339(1-2):208–213
Wang F, Nelson ME, Kuryatov A, Olale F, Cooper J, Keyser K, Lindstrom J (1998) Chronic nicotine treatment up-regulates human α3β2 but not α3β4 acetylcholine receptors stably transfected in human embryonic kidney cells. J Biol Chem 273:28721–28732
Warpman U, Friberg L, Gillespie A, Hellström-Lindahl E, Zhang X, Nordberg A (1998) Regulation of nicotinic receptor subtypes following chronic nicotinic agonist exposure in M10 and SH-SY5Y neuroblastoma cells. J Neurochem 70:2028–2037
Watkins SS, Epping-Jordan MP, Koob GF, Markou A (1999) Blockade of nicotine selfadministration with nicotinic antagonists in rats. Pharmacol Biochem Behav 62(4): 743–751
Weiner I (1990) Neural substrates of latent inhibition: the switching model. Psychol Bull 10:442–161
West RJ, Russell MAH (1985) Effects of withdrawal from long-term nicotine gum use. Psychol Med 15:891–893
West RJ, Russell MAH (1987) Cardiovascular and subjective effects of smoking before and after 24h of abstinence from cigarettes. Psychopharmacology 92(1):118–121
West RJ, Jarvis MJ, Russell MAH, Carruthers ME, Feyerbend C (1984) Effect of nicotine replacement on the cigarette withdrawal syndrome. Br J Addict 79:215–219
West RJ, Russell MAH, Jarvis MS, et al (1984) Does switching to an ultra-low nicotine withdrawal effects?. Psychopharmacology 84:120–123
Westfall TC (1974) Effect of nicotine and other drugs on the release of 3H-norepinephrine and 3H-dopamine from rat brain slices. Neuropharmacology 13: 693–700
Westfall TC, Perry H (1986) The nicotinic-induced release of endogenous dopamine from rat striatal slices from animals chronically exposed to dimethylphenylpiperazinium (DMPP). Neurosci Lett 71:340–344
Westfall TC, Grant H, Perry H (1983) Release of dopamine and 5-hydroxytryptamine from rat striatal slices following activation of nicotinic cholinergic receptors. Gen Pharmacol 14:321–325
Westfall TC, Mereu G, Vickery L, Perry H, Naes L, Yoon KP (1989) Regulation of midbrain dopamine neurons. Prog Brain Res 79:173–185
White JM (1988) Behavioral interactions between nicotine and caffeine. Pharmacol Biochem Behav 29:63–66
White NM (1996) Addictive drugs as reinforcers: multiple partial actions on memory system. Addiction 91:921–946
White JM, Ganguzza CC (1985) Effects of nicotine on schedule-controlled behavior. Neuropharmacology 24:75–82
Whiteaker P, Garcha HS, Wonnacott S, Stolerman IP (1995) Locomotor activation and dopamine release produced by nicotine and isoarecolone in rats. Br J Pharmacol 116:2097–2105
Whiteaker P, Sharpies C, Wonnacott S (1998) Agonist-induced upregulation of α4β2 nicotine acetylcholine receptors in M10 cells: pharmacological and spatial definition. Mol Pharmacol 53:950–962
Willner P (1984) The validity of animal models of depression. Psychopharmacology 83:1–16
Wise RA (1982) Neuroleptics and opérant behavior: the anhedonia hypothesis. Behav Brain Sci 5:39–87
Wise RA (1988) The neurobiology of craving: implications for understanding and treatment of addiction. J Abnormal Psychol 97:147–168
Wise RA, Murray A, Bozarth MA (1990) Bromocriptine self-administration and bromocriptine-reinstatement of cocaine-trained and heroin-trained lever-pressing in rats. Psychopharmacology 100:355–360
Wonnacott S (1990) The paradox of nicotinic acetylcholine receptor upregulation by nicotine. Trends Pharmacol Sci 11:216–219
Wonnacott S (1997) Presynaptic nicotinic ACh receptors. Trends Neurosci 20:92–98
Wonnacott S, Soliakov L, Wilkle G, Redfern P, Marshall D (1996) Presynaptic nicotinic acetylcholine receptors in the brain. Drug Develop Res 38:149–159
Woodman G, Newman SP, Pavia D, Clarke SW (1987) The separate effects of tar and nicotine on the cigarette smoking manoeuvre. Eur J Respir Dis 70:316–321
Woolverton WL, Virus RM (1989) The effects of a Dl and D2 dopamine antagonist on behavior maintained by cocaine or food. Pharmacol Biochem Behav 32:691–697
World Health Organization (1969) World Health Organization Technical Report Series No 407. WHO, Geneva
World Health Organization (1978) International classification of diseases, 9th edn. WHO, Geneva
Yanagita T (1976) Some methodological problems in assessing dependence-producing properties of drugs in animals. Pharmacol Rev 27:503–509
Yanagita T, Ando K, Oinuma N, Ishida K (1974) Intravenous self-administration of nicotine and an attempt to produce smoking behavior in monkeys. Proceedings of the 36th Annual Scientific Meeting. Committee on Problems of Drug Dependence, National Academy of Sciences, pp 567–578
Yeomans JS (1990) Principles of brain stimulation. University Press, Oxford, New York Yoshida K, Kato Y, Imura H (1980) Nicotine-induced release of noradrenaline from hypothalamic synaptosomes. Brain Res 182:361–368
Young AM, Herling S (1986) Drugs as reinforcers: studies in laboratory animals. In: Goldberg SR, Stolerman IP (eds) Behavioral analysis of drug dependence. Academic Press, Orlando, Florida, pp 9–67
Yu YJ, Wecker L (1994) Chronic nicotine administration differentially affects neurotransmitter release from rat striatal slices. J Neurochem 63:186–194
Zacny JP, Stitzer ML (1985) Effects of smoke deprivation interval on puff topography. Clin Pharmacol Ther 38:109–115
Zacny JP, Apfelbaum JL, Lichtor JL, Zaragoza JG (1993) Effects of 5-hydroxytryptamine3 antagonist, ondansetron, on cigarette smoking, smoke, exposure, and mood in humans. Pharmacol Biochem Behav 44:387–391
Zoli M, Lena C, Picciotto M, Changeux J-P (1998) Identification of four classes of brain nicotinic receptors using α2 mutant mice. J Neurosci 18:4461–4472
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Di Chiara, G. (2000). Behavioural Pharmacology and Neurobiology of Nicotine Reward and Dependence. In: Clementi, F., Fornasari, D., Gotti, C. (eds) Neuronal Nicotinic Receptors. Handbook of Experimental Pharmacology, vol 144. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-57079-7_24
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