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The Role of Nitric Oxide in Cardiac Ischaemia-Reperfusion

  • Chapter
Nitric Oxide

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 143))

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Abstract

Myocardial ischaemia, resulting mainly from atherosclerotic coronary artery disease, is the most common pathology in clinical cardiology and is a major cause of mortality and morbidity in the developed world. Iatrogenic myocardial ischaemia is also commonly encountered clinically, especially in the context of cardiac surgery and interventional cardiology procedures, such as percutaneous balloon angioplasty. There have been great advances in the clinical management of myocardial ischaemia over the last 2–3 decades. In particular, the benefits of early reperfusion following coronary occlusion have become well established. Such reperfusion is usually achieved in the clinical setting with thrombolytic drugs (or with balloon angioplasty, in recent years) and translates into a substantial improvement in patient survival (GISSI 1986; ISIS 1988). However, it has also been realised that reperfusion of ischaemic myocardium may itself cause detrimental effects in the tissue to which blood flow is being restored (BRAUNWALD and KLONER 1985).

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  1. P. A. MacCarthy
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  2. A. M. Shah
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  1. Department of Pharmacology and Toxicology, Karl-Franzens-University of Graz, Universitätsplatz 2, 8010, Graz, Austria

    Bernd Mayer

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© 2000 Springer-Verlag Berlin Heidelberg

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MacCarthy, P.A., Shah, A.M. (2000). The Role of Nitric Oxide in Cardiac Ischaemia-Reperfusion. In: Mayer, B. (eds) Nitric Oxide. Handbook of Experimental Pharmacology, vol 143. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-57077-3_22

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  • DOI: https://doi.org/10.1007/978-3-642-57077-3_22

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-63026-2

  • Online ISBN: 978-3-642-57077-3

  • eBook Packages: Springer Book Archive

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