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Gelenkpathologie pp 61–140Cite as

Reaktionsformen des organisierten Bindegewebes

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Zusammenfassung

Zur Vermeidung von Mehrfachdarstellungen sollen häufige Reaktionen artikularer Gewebe auf „Schädigungen“ beschrieben werden. Damit wird auch „Nichtmorphologen“ ein Einblick in ihre Morphogenese gegeben, vergleichbar der Situation in der Radiologie:„... wie z. B. das Verständnis für bestimmte Röntgenphänomene, nur erreichbar [ist], wenn man diese auch von der pathologisch-anatomischen Scite her erklärt“ [151].

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Literatur

  1. Abbink JJ, Kamp AM, Nieuwenhuys EJ, Nuijens JH, Swaak AJG, Hack CE (1991) Predominant role of neutrophils in the inactivation of α2—macroglobulin in arthritic joints. Arthritis Rheum 34:1139–1150

    Article  PubMed  CAS  Google Scholar 

  2. Acrel O (1780) Historia tumorum rariorum circa carpum et in vola manus obvenientium, qui, simillimi licet facie, qua indolem tarnen et sanandi methodum prorsus discrepant. In: Commentationes societatis regiae scientiarum Gottingensis per Annum 1779. Volumen II. Joan. Christ. Dieterich, Göttingen, S 112–138

    Google Scholar 

  3. Adams DO (1976) The granulomatous inflammatory response. A review. Am J Pathol 84:164–192

    PubMed  CAS  Google Scholar 

  4. Adams DO, Hamilton TA (1989) The activated macrophage and granulomatous inflammation. In: Iversen OH (ed) Cell kinetics of the inflammatory reaction. Current topics in pathology 79. Springer, Berlin Heidelberg New York London Paris Tokyo, pp 151–176

    Google Scholar 

  5. Aherne MJ, Bacon PA, Blake DR, Gallagher PJ, Jones DB, Morris CJ, Potter AR (1985) Immunohistochemical findings in rheumatoid nodules. Virchows Arch [Pathol Anat] 407:191–202

    Article  CAS  Google Scholar 

  6. Aigner T, Dudhia J (1997) Phenotypic modulation of chondrocytes as a potential therapeutic target in osteoarthritis: a hypothesis. Ann Rheum Dis 56:287–291

    Article  PubMed  CAS  Google Scholar 

  7. Aigner T, Dietz U, Stöß H, von der Mark K (1995) Differential expression of collagen types I, II, III, and X in human osteophytes. Lab Invest 73:236–243

    PubMed  CAS  Google Scholar 

  8. Aigner T, Haag J, von der Mark K, Kirchner T (1995) Phänotypisierung von Chondrozyten bei der Gelenkknorpeldegeneration. Verh Dtsch Ges Pathol 79:598

    Google Scholar 

  9. Aigner T, Glückert K, von der Mark K (1997) Activation of fibrillar collagen synthesis and phenotypic modulation of chondrocytes in early human osteoarthritic cartilage lesions. Osteoarthr Cartilage 5:183–189

    Article  CAS  Google Scholar 

  10. Aikman H (1997) The association between arthritis and the weather. Int J Biometeorol 40:192–199

    Article  PubMed  CAS  Google Scholar 

  11. Al-Dabbagh AI, Al-Irhayim B (1983) Eosinophilic transient synovitis. Ann Rheum Dis 42:462–465

    Article  PubMed  CAS  Google Scholar 

  12. Albertini A von (1943) Zum Begriff der fibrinoiden Degeneration. Schweiz Z Pathol Bact 6:417–436

    Google Scholar 

  13. Albrecht M, Marinetti GV, Jacox RF, Vaughan JH (1965) A biochemical and electron microscopy study of rice bodies from rheumatoid patients. Arthritis Rheum 8:1053–1063

    Article  PubMed  CAS  Google Scholar 

  14. Allain J, Le Mouel S, Voiçin MC, Delepine G, Goutallier D (1998) The importance of systematic histological examination after loosening of an implant. J Bone Joint Surg [Br] 80:591–594

    Article  CAS  Google Scholar 

  15. Allard SA, Muirden KD, Camplejohn KL, Maini RN (1987) Chondrocyte-derived cells and matrix at the rheumatoid cartilage-pannus junction identified with monoclonal antibodies. Rheumatol Int 7:153–159

    Article  PubMed  CAS  Google Scholar 

  16. Allard SA, Muirden KD, Maini RN (1990) Die Beteiligung von Chondrozyten an der Pannusbildung. In: Mohr W, Emmert KH (Hrsg) Gelenkzerstörung bei entzündlichen rheumatischen Erkrankungen. Basismechanismen und deren Beeinflussung durch Therapie. Steinkopff, Darmstadt, S 131–135

    Google Scholar 

  17. Aloe L, Tuveri MA, Levi-Montalcini, R (1992) Nerve growth factor and distribution of mast cells in the synovium of adult rats. Clin Exp Rheumatol 10:203–204

    PubMed  CAS  Google Scholar 

  18. Alonge TO, Oni OOA, Fenwick S (1998) Collagen expression in osteophytes. Examination of decalcified material. J Bone Joint Surg [Br] (Suppl II) 80:180

    Article  Google Scholar 

  19. Alsalameh S, Firestein GS, Oez S, Kurrle R, Kalden JR, Burmester GR (1994) Regulation of granulocyte macrophage colony stimulating factor production by human articular chondrocytes. Induction by both tumor necrosis factor-a and interleukin 1, downregulation by transforming growth factor β and upregulation by fibroblast growth factor. J Rheumatol 21:993–1002

    PubMed  CAS  Google Scholar 

  20. Anderson PN, Potter M (1979) Induction of plasma cell tumours in BALB/c mice with 2,6,10,14-tetramethyl-pentadecane (pristane). Nature 222:994–995

    Article  Google Scholar 

  21. Annunziato EJ, Pressman MM, Gorecki GA (1984) Frostbite arthritis of the foot. J Foot Surg 23:116–120

    PubMed  CAS  Google Scholar 

  22. Apley AG (1989) Malignancy and joint replacement: The tip of an iceberg? J Bone Joint Surg [Br] 71:1

    CAS  Google Scholar 

  23. Aractingi S, Janin A, Zini JM et al. (1996) Specific mucosal erosions in hypereosinophilic syndrome. Evidence for eosinophil protein deposition. Arch Dermatol 132:535–541

    Article  PubMed  CAS  Google Scholar 

  24. Arnason JA, Malone DG (1995) Role of mast cells in arthritis. In: Marone G (ed) Human basophils and mast cells: Clinical aspects. Chem Immunol. Basel, Karger 62:204–238

    CAS  Google Scholar 

  25. Aschoff L (1925) Über den Entzündungsbegriff. Vorträge über Pathologie gehalten an den Universitäten und Akademien Japans im Jahre 1924. Fischer, Jena

    Google Scholar 

  26. Atanes A, Fernandez V, Nunez R et al. (1996) Idiopathic eosinophilic synovitis. Case report and review of the literature. Scand J Rheumatol 25:183–185

    Article  PubMed  CAS  Google Scholar 

  27. Athanasou NA (1996) Cellular biology of bone-resorbing cells. J Bone Joint Surg [Am] 78:1096–1112

    CAS  Google Scholar 

  28. Athanasou NA, Quinn J, Woods CG, McGee JO’D (1988) Immunohistology of rheumatoid nodules and rheumatoid synovium. Ann Rheum Dis 47:398–403

    Article  PubMed  CAS  Google Scholar 

  29. Aufdermaur M (1972) Die Synovialis bei der progredient chronischen Polyarthritis. Histologische Kriterien und ihre Beziehungen zur Rheumaserologie. Dtsch Med Wochenschr 97:448–453

    Article  PubMed  CAS  Google Scholar 

  30. Averbuch SD (1993) New bisphosphonates in the treatment of bone metastases. Cancer 72:3443–3452

    Article  PubMed  CAS  Google Scholar 

  31. Bacon PA, Kitas GD (1994) The significance of vascular inflammation in rheumatoid arthritis. Ann Rheum Dis 53:621–623

    Article  Google Scholar 

  32. Baker DG, Schumacher HR (1993) Acute monoarthritis. N Engl J Med 329:1013–1020

    Article  PubMed  CAS  Google Scholar 

  33. Ball J (1969) Pathological aspects of rheumatoid arthritis. In: Hijmans W, Paul WD, Herschel H (eds) Early synovectomy in rheumatoid arthritis. Excerpta Medica Foundation, S 23–31

    Google Scholar 

  34. Barnhart MI, Riddle JM, Bluhm GB, Quintana C (1967) Fibrin promotion and lysis in arthritic joints. Ann Rheum Dis 26:206–218

    Article  PubMed  CAS  Google Scholar 

  35. Baron R, Vignery A, Horowitz M (1983) Lymphocytes, macrophages and the regulation of bone remodeling. In: Peck WA (ed) Bone and mineral research. Annual 2. Elsevier Science Publishers B. V., Amsterdam, pp 175–243

    Google Scholar 

  36. Barrie HJ (1981) Histologic changes in rheumatoid disease of the metacarpal and metatarsal heads as seen in surgical material. J Rheumatol 8:246–257

    PubMed  CAS  Google Scholar 

  37. Bates RR, Klein M (1966) Importance of a smooth surface in carcinogenesis by plastic film. J Natl Cancer Inst 37:145–151

    PubMed  CAS  Google Scholar 

  38. Bell AL, Magill MK, McKane R, Irvine AE (1995) Human blood and synovial fluid neutrophils cultured in vitro undergo programmed cell death which is promoted by the addition of synovial fluid. Ann Rheum Dis 54:910–915

    Article  PubMed  CAS  Google Scholar 

  39. Ben-Chetrit E, Enk C, Rubinow A (1992) Palmar rheumatoid nodulosis associated with local pressure. Ann Rheum Dis 51:1005–1006

    Article  PubMed  CAS  Google Scholar 

  40. Bendele AM, Hulman JF (1988) Spontaneous cartilage degeneration in Guinea pigs. Arthritis Rheum 31:561–565

    Article  PubMed  CAS  Google Scholar 

  41. Bendele AM, Hulman JF (1991) Effects of body weight restriction on the development and progression of spontaneous osteoarthritis in Guinea pigs. Arthritis Rheum. 34:1180–1184

    Article  PubMed  CAS  Google Scholar 

  42. Bendele AM, White SL, Hulman JF (1989) Osteoarthrosis in Guinea pigs: Histopathologic and scanning electron microscopic features. Lab Anim Sci 39:115–121

    PubMed  CAS  Google Scholar 

  43. Beneke G, Paulini K, Mohr W, Mohing W (1973) Die Entstehung der Synovialzellnekrose bei rheumatoider Arthritis. Z Rheumaforsch 32:416–427

    PubMed  CAS  Google Scholar 

  44. Berg E, Wainwright R, Barton B, Puchtler H, McDonald T (1977) On the nature of rheumatoid rice bodies. An immunologic, histochemical, and electron microscope study. Arthritis Rheum 20:1343–1349

    Article  PubMed  CAS  Google Scholar 

  45. Bhawan J, Dayal Y, Gonzalez-Serva A, Eisen R (1990) Cutaneous metaplastic synovial cyst. J Cutan Pathol 17:22–26

    Article  PubMed  CAS  Google Scholar 

  46. Bissonnette B, Beaudet F (1983) Reactive arthritis with eosinophilic synovial infiltration. Ann Rheum Dis 42:466–468

    Article  PubMed  CAS  Google Scholar 

  47. Bjurholm A, Kreicbergs A, Brodin E, Schultzberg M (1988) Substance P-and CGRP-immunoreactive nerves in bone. Peptides 9:165–171

    Article  PubMed  CAS  Google Scholar 

  48. Black J (1988) Does corrosion matter? J Bone Joint Surg [Br] 70:517–519

    CAS  Google Scholar 

  49. Blanco FJ, Ochs RL, Schwarz H, Lotz M (1995) Chondrocyte apoptosis induced by nitric oxide. Am J Pathol 146:75–85

    PubMed  CAS  Google Scholar 

  50. Blanco FJ, Guitian R, Vázquez-Martul E, de Toro FJ, Galdo F (1998) Osteoarthritis chondrocytes die by apoptosis. A possible pathway for osteoarthritis pathology. Arthritis Rheum 41:284–289

    Article  PubMed  CAS  Google Scholar 

  51. Bluestone R, Bywaters EGL, Hartog M, Holt PJL, Hyde S (1971) Acromegalic arthropathy. Ann Rheum Dis 30:243–258

    Article  PubMed  CAS  Google Scholar 

  52. Borregaard N (1996) Current concepts about neutrophil granule physiology. Curr Opin Hematol 3:11–18

    Article  PubMed  CAS  Google Scholar 

  53. Borregaard N, Cowland JB (1997) Granules of the human neutrophilic polymorphonuclear leukocyte. Blood 89: 3503–3521

    PubMed  CAS  Google Scholar 

  54. Boyde A (1980) Evidence against „ osteocytic osteolysis “. In: Jee WSS, Parfit AM (eds) Bone Histomorphometry. 3. International workshop, May 1980, Elkhorn, ID. Metabolic Bone Disease and Related Research (Paris) Suppl 12, pp 239–255

    Google Scholar 

  55. Brem H, Folkman J (1975) Inhibition of tumor angiogenesis mediated by cartilage. J Exp Med 141:427–439

    Article  PubMed  CAS  Google Scholar 

  56. Bremell T, Lange S, Yacoub A, Rydén C, Tarkowski A (1991) Experimental Staphylococcus aureus arthritis in mice. Infect Immun 59:2615–2623

    PubMed  CAS  Google Scholar 

  57. Bremell T, Lange S, Holmdahl R, Rydén C, Hansson GK, Tarkowski A (1994) Immunopathological features of rat Staphylococcus aureus arthritis. Infect Immun 62: 2334–2344

    PubMed  CAS  Google Scholar 

  58. Bridges AJ, Malone DG, Jicinsky J, Chen M, Ory P, Engber W, Graziano FM (1991) Human synovial mast cell involvement in rheumatoid arthritis and osteoarthritis. Arthritis Rheum 34:1116–1124

    Article  PubMed  CAS  Google Scholar 

  59. Broide DH, Humber D, Sriramarao P (1998) Inhibition of eosinophil rolling and recruitment in P-selectin-and intracellular adhesion molecule-1-deficient mice. Blood 91:2847–2856

    PubMed  CAS  Google Scholar 

  60. Brown KA, Perry ME, Mustafa Y, Wood SK, Crawley M, Taub N, Dumonde DC (1995) The distribution and abnormal morphology of plasma cells in rheumatoid synovium. Scand J Immunol 41:509–517

    Article  PubMed  CAS  Google Scholar 

  61. Bunim JJ, Sokoloff L, Williams RR, Black RL (1955) Rheumatoid arthritis: A review of recent advances in our knowledge concerning pathology, diagnosis, and treatment. J Chron Dis 1:168–210

    Article  PubMed  CAS  Google Scholar 

  62. Burkhardt H (1990) Der Beitrag der Synovialflüssigkeit zur entzündlichen Gelenkdestruktion in der Pathogenese der chronischen Polyarthritis. In: Mohr W, Emmert KH (Hrsg) Gelenkzerstörung bei entzündlichen rheumatischen Erkrankungen. Basismechanismen und deren Beeinflussung durch Therapie. Steinkopff, Darmstadt, S 49–55

    Google Scholar 

  63. Burkhardt H, Schwingel M, Menninger H, Macartney HW, Tschesche H (1986) Oxygen radicals as effectors of cartilage destruction. Arthritis Rheum 29:379–387

    Article  PubMed  CAS  Google Scholar 

  64. Burkl W (1952) Ueber Mastzellen und ihre Aufgaben. Wien Klin Wochenschr 64:411–415

    PubMed  CAS  Google Scholar 

  65. Burmester GR, Locher P, Koch B, Winchester RJ, Dimitriu-Bona A, Kalden JR, Mohr W (1983) The tissue architecture of synovial membranes in inflammatory and noninflammatory joint diseases. I. The localization of the major synovial cell populations as detected by monoclonal reagents directed towards Ia and monocyte-macrophage antigens. Rheumatol Int 3:173–181

    Article  PubMed  CAS  Google Scholar 

  66. Burns WA, Kanhouwa S, Tillman L, Saini N, Herrmann JB (1972) Fibrosarcoma occurring at the site of a plastic vascular graft. Cancer 29:66–72

    Article  PubMed  CAS  Google Scholar 

  67. Burry HC, Caughey DE, Palmer DG (1979) Benign rheumatoid nodules. Aust NZ J Med 9:697–701

    Article  CAS  Google Scholar 

  68. Byers RJ, Marshall DAS, Freemont AJ (1997) Pericardial involvement in systemic sclerosis. Ann Rheum Dis 56:393–394

    Article  PubMed  CAS  Google Scholar 

  69. Bywaters EGL (1976) Vasculitis in rheumatoid arthritis. In: Feltkamp TEW (ed) Non-articular forms of rheumatoid arthritis. Proc IV I. S. R. A. Symposium, The Hague, Oct. 20–21, 1976. Netherlands League Against Rheumatism, Staffen Sci, pp 82–84

    Google Scholar 

  70. Calabro JJ (1970) Diskussionsbemerkung zu Sturgill B. C. und J. H. Allan: Nr. 492a. Arthritis Rheum 13:178–179

    Article  Google Scholar 

  71. Calafat J, Janssen H, Ståhle-Bäckdahl M, Zuurbier AEM, Knol EF, Egesten A (1997) Human monocytes and neutrophils store transforming growth factor-a in a subpopulation of cytoplasmic granules. Blood 90:1255–1266

    PubMed  CAS  Google Scholar 

  72. Calvo W (1968) The innervation of the bone marrow in laboratory animals. Am J Anat 123:315–328

    Article  PubMed  CAS  Google Scholar 

  73. Cantagrel A, Roubinet F, Lassoued S et al. (1988) The transsynovial lymphocyte ratio. Characterization of blood and synovial fluid lymphocytes from patients with arthritic diseases. J Rheumatol 15:899–904

    PubMed  CAS  Google Scholar 

  74. Carmassi F, de Negri F, Morale M, Puccetti R, Chung SI (1994) Ekstase-and plasmin-mediated fibrinolysis in rheumatoid arthritis. Int J Tissue React 16:89–93

    PubMed  CAS  Google Scholar 

  75. Carter RL, Roberts JDB (1971) Macrophages and multinucleate giant cells in nitrosoquinoline-induced granulomata in rats: an autoradiographic study. J Pathol 105:285–288

    Article  PubMed  CAS  Google Scholar 

  76. Cassatella MA (1995) The production of cytokines by polymorphonuclear neutrophils. Immunol Today 16:21–26

    Article  PubMed  CAS  Google Scholar 

  77. Caulfield JP. Hein A, Helfgott SM, Brahn E, Dynesius-Trentham RA, Trentham DE (1988) Intraarticular injection of arthritogenic factor causes mast cell degranulation, inflammation, fat necrosis, and synovial hyperplasia. Lab Invest 59:82–95

    PubMed  CAS  Google Scholar 

  78. Caux C, Dezutter-Dambuyant C, Schmitt D, Banchereau J (1992) GM-CSF and TNF-a cooperate in the generation of dendritic Langerhans cells. Nature 360:258–261

    Article  PubMed  CAS  Google Scholar 

  79. Chanez P, Lacoste J-Y, Guillot B et al. (1993) Mast cells’ contribution to the fibrosing alveolitis of the scleroderma lung. Am Rev Respir Dis 147:1497–1502

    PubMed  CAS  Google Scholar 

  80. Chang JS, Quinn JM, Demaziere A, Bulstrode CJ, Francis MJ, Duthie RB, Athanasou NA (1992) Bone resorption by cells isolated from rheumatoid synovium. Ann Rheum Dis 51:1223–1229

    Article  PubMed  CAS  Google Scholar 

  81. Chatham WW, Blackburn WD, Heck LW (1990) Activation of latent neutrophil collagenase by oxidative and proteolytic mechanisms. Arthritis Rheum (Suppl) 33:R18 (Abstr 28 S)

    Google Scholar 

  82. Chatham WW, Heck LW, Blackburn WD (1990) Ligand-dependent release of active neutrophil collagenase. Arthritis Rheum 33:228–234

    Article  PubMed  CAS  Google Scholar 

  83. Chatham WW, Heck LW, Blackburn WD (1990) Lysis of fibrillar collagen by PMN in synovial fluid-A role for surface bound immunoglobulins. Arthritis Rheum (Suppl) 33:R18 (Abstr 26 S)

    Google Scholar 

  84. Chatham WW, Frohsin H, Blackburn WD, Miller EJ (1991) Neutrophil mediated degradation of collagens in intact articular cartilage. Arthritis Rheum (Suppl) 34:R34 (Abstr 55 S)

    Google Scholar 

  85. Chatham WW, Heck LW, Blackburn WD (1992) Ligand dependent release of activated neutrophil collagenase—a role for surface bound IgG in the degradation of articular collagens. In: Birkedal-Hansen H, Werb Z, Welgus HG, van Wart HE (eds) MATRIX. Metalloproteinases and inhibitors. Gustav Fischer, Stuttgart Jena New York, S 207–208

    Google Scholar 

  86. Chen K-R, Pittelkow MR, Su WPD, Gleich GJ, Newman W, Leiferman KM (1994) Recurrent cuteaneous necrotizing eosinophilic vasculitis. A novel eosinophil-mediated syndrome. Arch Dermatol 130:1159–1166

    Article  PubMed  CAS  Google Scholar 

  87. Chen SC, Helal B, Revell PA, Brocklehurst R, Currey HLF (1986) Experimental cryo-irrigation of the knee joint. Ann Rheum Dis 45:865–872

    Article  PubMed  CAS  Google Scholar 

  88. Chu CQ, Field M, Abney E, Zheng RQH, Allard S, Feldmann M, Maini RN (1991) Transforming growth factor-βl in rheumatoid synovial membrane and cartilage/pannus junction. Clin Exp Immunol 86:380–386

    Article  PubMed  CAS  Google Scholar 

  89. Coleman DL, King RN, Andrade JD (1974) The foreign body reaction: A chronic inflammatory response. J Biomed Mater Res 8:199–211

    Article  PubMed  CAS  Google Scholar 

  90. Collier DH, Achten MI, Levine JD (1984) The role of the peripheral nervous system in experimental arthritis. Arthritis Rheum 27:S22 (Abstr 42)

    Article  Google Scholar 

  91. Collins DH (1949) The pathology of articular and spinal diseases. Edward Arnold, London

    Google Scholar 

  92. Colville-Nash PR, Scott DL (1992) Angiogenesis and rheumatoid arthritis: pathogenic and therapeutic implications. Ann Rheum Dis 51:919–925

    Article  PubMed  CAS  Google Scholar 

  93. Cooke TDV, Scudamore RA (1990) Der Abbau des Knorpels bei der chronischen Polyarthritis: Die Bedeutung von Immunkomplexen. In: Mohr W, Emmert KH (Hrsg) Gelenkzerstörung bei entzündlichen rheumatischen Erkrankungen. Basismechanismen und deren Beeinflussung durch Therapie. Steinkopff, Darmstadt, S 101–107

    Google Scholar 

  94. Cottier H (1980) Pathogenese. Ein Handbuch für die ärztliche Fortbildung. Springer, Berlin Heidelberg New York

    Google Scholar 

  95. Creamer P, Hunt M, Dieppe P (1996) Pain mechanisms in Osteoarthritis of the knee: Effect of intraarticular anesthetic. J Rheumatol 23:1031–1036

    PubMed  CAS  Google Scholar 

  96. Crisp AJ, Chapman CM, Kirkham SE, Schiller AL, Krane SM (1984) Articular mastocytosis in rheumatoid arthritis. Arthritis Rheum 27:845–851

    Article  PubMed  CAS  Google Scholar 

  97. Damiano VV, Tsang A, Kucich U et al. (1986) Immuno-localization of elastase in human emphysematous lungs. J Clin Invest 78:482–493

    Article  PubMed  CAS  Google Scholar 

  98. Dämmrich K (1996) Zur Pathogenese der nichtentzündlichen Erkrankungen des Fesselgelenks. In: Hertsch B (Hrsg) Internationales Symposion „Gelenkerkrankungen beim Pferd“. 2. Band der Reihe: Internationales Symposion der Gesellschaft für Pferdemedizin e. V. FN-Verlag der Reiterlichen Vereinigung Warendorf und Gesellschaft für Pferdemedizin e. V., München, S 115–126

    Google Scholar 

  99. Danger J (1982) Die Abhängigkeit der Proliferation synovialer Zellen von der Struktur der Synovialmembran. Med Diss, Universität Ulm

    Google Scholar 

  100. Davies ME, Horner A, Franz B (1994) Intercellular adhesion molecule-1 (ICAM-1) and MHC class II on chondrocytes in arthritic joints from pigs experimentally infected with Erysipelothrix rhusiopathiae. FEMS Immunol Med Microbiol 9:265–272

    Article  PubMed  CAS  Google Scholar 

  101. Dawson MH, Pappenheimer AM (1930) Subcutaneous nodules in chronic infectious arthritis. Am J Pathol 6:625–626

    Google Scholar 

  102. DeHaven KE, Arnoczky SP (1994) Meniscal repair. Part I: Basic science, indications for repair, and open repair. J Bone Joint Surg [Am] 76:140–152

    Google Scholar 

  103. Delbarre F, Kahan A, Amor B, Krassinine G (1964) Le ragocyte synovial. Son intérêt pour le diagnostic des maladies rhumatismales. Presse Med 72:2129–2132

    PubMed  CAS  Google Scholar 

  104. Deleuran B, Lemche P, Kristensen M et al. (1994) Localisation of interleukin 8 in the synovial membrane, cartilagepannus junction and chondrocytes in rheumatoid arthritis. Scand J Rheumatol 23:2–7

    Article  PubMed  CAS  Google Scholar 

  105. Dieppe PA, Bacon PA, Bamji AN, Watt I (1986) Atlas of clinical rheumatology. Lea&Febiger, Philadelphia, Gower Medical Publishing, London New York

    Google Scholar 

  106. Dingle JT (1979) Recent studies on the control of joint damage: the contribution of the Strangeways Research Laboratory. Ann Rheum Dis 38:201–214

    Article  PubMed  CAS  Google Scholar 

  107. Dodds RA, Gowen M (1994) The growing osteophyte: A model system for the study of human bone development and remodeling in situ. J Histotechnol 17:37–45

    Google Scholar 

  108. Dodds RA, Merry K, Littlewood A, Gowen M (1994) Expression of mRNA for ILlβ, IL6 and TGFβl in developing human bone and cartilage. J Histochem Cytochem 42:733–744

    Article  PubMed  CAS  Google Scholar 

  109. Dodge GR, Poole AR (1989) Immunohistochemical detection and immunochemical analysis of type II collagen degradation in human normal, rheumatoid, and osteoarthritic articular cartilages and in expiants of bovine articular cartilage cultured with interleukin 1. J Clin Invest 83:647–661

    Article  PubMed  CAS  Google Scholar 

  110. Dodge GR, Pidoux I, Poole AR (1991) The degradation of type II collagen in rheumatoid arthritis: An immunoelectron microscopic study. Matrix 11:330–338

    PubMed  CAS  Google Scholar 

  111. Dogterom AA, Huber-Bruning O, Vernooy JE, Wilbrink B, den Otter W, Huber J (1985) Matrix depletion of young and old human articular cartilage by cultured autologous synovium fragments: a chondrocyte-independent effect. Rheumatol Int 5:169–173

    Article  PubMed  CAS  Google Scholar 

  112. Dolan AL (1995) Asymmetric rheumatoid vasculitis in a hemiplegic patient. Ann Rheum Dis 54:532

    Article  PubMed  CAS  Google Scholar 

  113. Dolhain RJEM, van der Heiden AN, TerHaar NT, Breedveld FC, Miltenburg AMM (1996) Shift toward T lymphocytes with a T helper 1 cytokine-secretion profile in the joints of patients with rheumatoid arthritis. Arthritis Rheum 39:1961–1969

    Article  PubMed  CAS  Google Scholar 

  114. Donohue JM, Buss D, Oegeman TR, Thompson RC (1983) The effects of indirect blunt trauma on adult canine articular cartilage. J Bone Joint Surg [Am] 65:948–957

    CAS  Google Scholar 

  115. Doran A, Rushton N, Law FC (1990) Neoplastic transformation of cells by orthopaedic metals in vitro. J Bone Joint Surg [Br] 72:163 (Abstr)

    Google Scholar 

  116. Draheim JH, Johnson LC, Helwig EB (1959) A clinicopathologic analysis of „rheumatoid“ nodules occurring in 54 children. Am J Pathol 35:678 (Abstr)

    Google Scholar 

  117. Duke OL, Hobbs S, Panayi GS, Poulter LW, Rasker JJ, Janossy G (1984) A combined immunohistological and histochemical analysis of lymphocyte and macrophage subpopulations in the rheumatoid nodule. Clin Exp Immunol 56:239–246

    PubMed  CAS  Google Scholar 

  118. Dupuytren G (1839) Des kystes séreux contenant des petits corps blancs, ou hydatides.-Des tumeurs hydatiques.-De leur diagnostic et de leur traitement. In: Leçons orales de clinique chirurgicale faites a l’hôtel de Dieu, Paris, 2e ed, Baillière, Paris, pp 148–174

    Google Scholar 

  119. Dvorak AM, Tepper RI, Weller PF, Morgan ES, Estrella P, Monahan-Earley RA, Galli SJ (1994) Piecemeal degranulation of mast cells in the inflammatory eyelid lesions of interleukin-4 transgenic mice. Evidence of mast cell histamine release in vivo by diamine oxidase-gold enzyme-affinity ultrastructural cytochemistry. Blood 83:3600–3612

    PubMed  CAS  Google Scholar 

  120. Dvorak HF, Brown LF, Detmar M, Dvorak AM (1995) Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. Am J Pathol 146:1029–1039

    PubMed  CAS  Google Scholar 

  121. Edelson R, Burks RT, Bloebaum RD (1995) Short-term effects of knee washout for osteoarthritis. Am J Sports Med 23:345–349

    Article  PubMed  CAS  Google Scholar 

  122. Edwards JCW, Sedgwick AD, Willoughby DA (1981) The formation of a structure with the features of synovial lining by subcutaneous injection of air: An in vivo tissue culture system. J Pathol 134:147–156

    Article  PubMed  CAS  Google Scholar 

  123. Edwards JCW, MacKay AR, Sedgwick ED, Willoughby DA (1983) Mode of formation of synovial villi. Ann Rheum Dis 42:585–590

    Article  PubMed  CAS  Google Scholar 

  124. Edwards JCW, Wilkinson LS, Pitsillides AA (1993) Palisading cells of rheumatoid nodules: Comparison with synovial initimal cells. Ann Rheum Dis 52:801–805

    Article  PubMed  CAS  Google Scholar 

  125. Edwards SW, Hallett MB (1997) Seeing the wood for the trees: the forgotten role of neutrophils in rheumatoid arthritis. Immunology Today 18:320–324

    Article  PubMed  CAS  Google Scholar 

  126. Eisenstein R, Sorgente N, Soble LW, Miller A, Kuettner KE (1973) The resistance of certain tissues to invasion. Penetrability of explanted tissues by vascularized mesenchyme. Am J Pathol 73:765–774

    PubMed  CAS  Google Scholar 

  127. Elliott S, Cooke TDV (1986) Scanning electron microscopy of antigen induced arthritic joints. I. Inflammatory cell interactions at synovial-meniscal surfaces during the Arthus response. J Rheumatol 13:401–407

    PubMed  CAS  Google Scholar 

  128. Ely LW, Coleman Mensor M (1933) Studies on the immobilization of the normal joints. Surg Gynec Obstet 57:212–215

    Google Scholar 

  129. Endresen GKM (1981) Investigation of blood platelets in synovial fluid from patients with rheumatoid arthritis. Scand J Rheumatol 10:204–208

    Article  PubMed  CAS  Google Scholar 

  130. Enneking WF, Horowitz M (1972) The intra-articular effects of immobilization on the human knee. J Bone Joint Surg [Am] 54:973–985

    CAS  Google Scholar 

  131. Evans EB, Eggers GWN, Butler JK, Blumel J (1960) Experimental immobilization and remobilization of rat knee joints. J Bone Joint Surg [Am] 42:737–758

    Google Scholar 

  132. Farr M, Wainwright A, Salmon M, Hollywell CA, Bacon PA (1984) Platelets in the synovial fluid of patients with rheumatoid arthritis. Rheumatol Int 4:13–17

    Article  PubMed  CAS  Google Scholar 

  133. Fassbender HG (1984) Is pannus a residue of inflammation? Arthritis Rheum 27:956–957

    Article  PubMed  CAS  Google Scholar 

  134. Fassbender H-G (1994) Inflammatory reactions in arthritis. In: Davies ME, Dingle JT (eds) Immunopharmacology of joints and connective tissue. Academic Press, Harcourt Brace and Comp., Publishers. London San Diego New York Boston Sydney Tokyo Toronto, pp 165–198

    Google Scholar 

  135. Fava RA, Olsen NJ, Spencer-Green G et al. (1994) Vascular permeability factor/endothelial growth factor (VPF/ VEGF): Accumulation and expression in human synovial fluids and rheumatoid synovial tissue. J Exp Med 180:341–346

    Article  PubMed  CAS  Google Scholar 

  136. Fenwick SA, Gregg P, Rooney P (1997) The loss of avascularity in human osteoarthritic cartilage. J Bone Joint Surg [Br] (Suppl III) 79:363 (Abstr)

    Google Scholar 

  137. Ferguson DJ (1977) Cellular attachment to implanted foreign bodies in relation to tumorigenesis. Cancer Res 37:4367–4371

    PubMed  CAS  Google Scholar 

  138. Fernandes JC, Martel-Pelletier J, Lascau-Coman V, Moldovan F, Jovanovic D, Raynauld J-P, Pelletier J-P (1998) Collagenase-1 and collagenase-3 synthesis in normal and early experimental osteoarthritic canine cartilage: An immunohistochemical study. J Rheumatol 25:1585–1594

    PubMed  CAS  Google Scholar 

  139. Firestein GS (1996) Invasive fibroblast-like synoviocytes in rheumatoid arthritis. Passive responders or transformed aggressors? Arthritis Rheum. 39:1781–1790

    Article  PubMed  CAS  Google Scholar 

  140. Firestein GS, Yeo M, Zvaifler NJ (1995) Apoptosis in rheumatoid arthritis synovium. J Clin Invest 96:1631–1638

    Article  PubMed  CAS  Google Scholar 

  141. Fischer R (1996) Immunhistochemische Untersuchungen zur Identifikation, zum Verteilungsmuster, zur Häufigkeit und Aktivierung wesentlicher Zellpopulationen bei rheumatoider Synovialitis. Med Diss, Universität Leipzig

    Google Scholar 

  142. Flechtenmacher J, Rohe K, Cotta H (1993) Ist die pathohistologische Untersuchung bei der klinischen Differentialdiagnose chronischer Arthritiden hilfreich? Z Orthop 131:32–36

    Article  PubMed  CAS  Google Scholar 

  143. Foerster A (1854-1859) Atlas der mikroskopischen pathologischen Anatomie. Voss, Leipzig

    Google Scholar 

  144. Formigli L, Lombardo LD, Adembri C, Brunelleschi S, Ferrari E, Novelli GP (1992) Neutrophils as mediators of human skeletal muscle ischemia-reperfusion syndrome. Hum Pathol 23:627–634

    Article  PubMed  CAS  Google Scholar 

  145. Fowler JK (1884) Subcutaneous nodules occurring in an adult not the subject of rheumatism. Br Med J 1:107

    Google Scholar 

  146. Fraedrich G, Kracht J, Scheid HH, Jundt G, Mulch J (1984) Sarcoma of the lung in a pacemaker pocket-simple coincidence or oncotaxis? Thorac Cardiovasc Surg 32:67–69

    Article  PubMed  CAS  Google Scholar 

  147. Freemont AJ, Denton J (1985) Disease distribution of synovial fluid mast cells and cytophagocytic mononuclear cells in inflammatory arthritis. Ann Rheum Dis 44:312–315

    Article  PubMed  CAS  Google Scholar 

  148. Freemont AJ, Jones CJP, Bromley M, Andrews P (1983) Changes in vascular endothelium related to lymphocyte collections in diseased synovia. Arthritis Rheum 26:1427–1433

    Article  PubMed  CAS  Google Scholar 

  149. Freund E (1925) Die Gelenkerkrankung der Bluter. Virchows Arch 256:158–188

    Article  Google Scholar 

  150. Freund E (1927) Über Abstoßungs-und Implantationserscheinungen in erkrankten Gelenken. Virchows Arch 263:515–522

    Article  Google Scholar 

  151. Freyschmidt J (1996) Buchbesprechung. Radiologe 36: 676

    Google Scholar 

  152. Fritz P, Müller J, Reiser H et al. (1984) Distribution of mast cells in human synovial tissue of patients with osteoarthritis and rheumatoid arthritis. Z Rheumatol 43:294–298

    PubMed  CAS  Google Scholar 

  153. Frost HM (1964) Dynamics of bone remodeling. In: Frost HM (ed) Bone biodynamics. Little, Brown and Company, Boston, Massachusetts, pp 315–333

    Google Scholar 

  154. Fujikawa Y, Sabokbar A, Neale S, Athanasou NA (1996) Human osteoclast formation and bone resorption by monocytes and synovial macrophages in rheumatoid arthritis. Ann Rheum Dis 55:816–822

    Article  PubMed  CAS  Google Scholar 

  155. Furukawa T, Eyre DR, Koide S, Glimcher MJ (1980) Biochemical studies on repair of cartilage resurfacing experimental defects in the rabbit knee. J Bone Joint Surg [Am] 62:79–89

    CAS  Google Scholar 

  156. Gaechter A, Alroy J, Andersson GBJ, Galante J, Rostoker W, Schajowicz F (1977) Metal carcinogenesis. J Bone Joint Surg [Am] 59:622–624

    CAS  Google Scholar 

  157. Galasko CSB (1976) Mechanisms of bone destruction in the development of skeletal metastases. Nature 263: 507–508

    Article  PubMed  CAS  Google Scholar 

  158. Galli SJ, Wershil BK (1996) The two faces of the mast cell. Nature 381:21–22

    Article  PubMed  CAS  Google Scholar 

  159. Gangl A, Horak W, Richter H, Thumb N, Weidinger P (1969) Die Synovialflüssigkeit bei verschiedenen rheumatischen Erkrankungen. Wien Z Inn Med 50:382–390

    PubMed  CAS  Google Scholar 

  160. Garrett NE, Mapp PI, Cruwys SC, Kidd BL, Blake DR (1992) Role of substance P in inflammatory arthritis. Ann Rheum Dis 51:1014–1018

    Article  PubMed  CAS  Google Scholar 

  161. Gaudry M, Brégerie O, Andrieu V, El Benna J, Pocidalo M-A, Hakim J (1997) Intracellular pool of vascular endothelial growth factor in human neutrophils. Blood 90:4153–4161

    PubMed  CAS  Google Scholar 

  162. Gauger M, Mohr W (1995) Cartilage destruction in septic arthritis-electron microscopy and historical considerations. Z Rheumatol 54:241–249

    PubMed  CAS  Google Scholar 

  163. Gauger M, Mohr W (1995) Neutrophil Granulozyten bei der rheumatischen Gewebsdestruktion. VII. Eine lichtund elektronenmikroskopische Studie an der pannusfreien Knorpeloberfläche. Aktuel Rheumatol. 20:49–54

    Article  Google Scholar 

  164. Gay CV (1996) Role of microscopy in elucidating the mechanism and regulation of the osteoclast resorptive apparatus. Microsc Res Tech 33:165–170

    Article  PubMed  CAS  Google Scholar 

  165. Gay S (1990) Molekulare Basis und Onkogenexpression bei der rheumatischen Gelenkzerstörung. In: Mohr W, Emmert KH (Hrsg) Gelenkzerstörung bei entzündlichen rheumatischen Erkrankungen. Basismechanismen und deren Beeinflussung durch Therapie. Steinkopff, Darmstadt, S 111–114

    Google Scholar 

  166. Gay S, Müller PK, Lemmen C, Remberger K, Matzen K, Kühn K (1976) Immunohistological study on collagen in cartilage-bone metamorphosis and degenerative osteoarthrosis. Klin Wochenschr 54:969–979

    Article  PubMed  CAS  Google Scholar 

  167. Gédéon P, Mazières B, Ficat P (1978) Un nouveau modèle d’arthrose expérimentale: la contusion du cartilage. Rev Rhum 45:401–408

    PubMed  Google Scholar 

  168. Geiler G, Mehlhorn U (1989) Vaskulitis mit anämischen Zotteninfarkten an der Synovialmembran bei Rheumatoid-Arthritis. Z. Rheumatol. 48:63–6

    PubMed  CAS  Google Scholar 

  169. Geiler G, Richter A-K, Mehlhorn U (1990) Die Bedeutung von Vaskulitis und fibrinöser Entzündung der Synovialmembran für die Gelenkdestruktion bei Rheumatoid-Arthritis. In: Mohr W, Emmert KH (Hrsg) Gelenkzerstörung bei entzündlichen rheumatischen Erkrankungen. Basismechanismen und deren Beeinflussung durch Therapie. Steinkopff, Darmstadt, S 115–122

    Google Scholar 

  170. Geiler T, Kriegsmann J, Keyszer GM, Gay RE, Gay S (1994) A new model for rheumatoid arthritis generated by engraftment of rheumatoid synovial tissue and normal human cartilage into SCID mice. Arthritis Rheum 37:1664–1671

    Article  PubMed  CAS  Google Scholar 

  171. Ghadially FN, Wedge JH, Lalonde J-MA (1986) Experimental methods of repairing injured menisci. J Bone Joint Surg [Br] 68:107–110

    Google Scholar 

  172. Ghadially JA, Ghadially FN (1975) Evidence of cartilage flow in deep defects in articular cartilage. Virchows Arch B Cell Pathol 18:193–204

    PubMed  CAS  Google Scholar 

  173. Gieseking R (1965) Die hyaline Umwandlung des kollagenen Fasergewebes im elekoptischen Bild. Zentralbl Allg Pathol Anat 107:579–580 (Abstr)

    Google Scholar 

  174. Goddard NJ, Gosling PT (1988) Intra-articular fluid pressure and pain in osteoarthritis of the hip. J Bone Joint Surg [Br] 70:52–55

    CAS  Google Scholar 

  175. Godfrey HP, Ilardi C, Engber W, Graziano FM (1984) Quantitation of human synovial mast cells in rheumatoid arthritis and other rheumatic diseases. Arthritis Rheum 27:852–856

    Article  PubMed  CAS  Google Scholar 

  176. Goldmann R (1991) Die Reparation von synovialen Strukturen bei Patienten mit chronischer Polyarthritis nach operativer Synovialektomie. Med Diss, Universität Ulm

    Google Scholar 

  177. Goldstein IM (1976) Polymorphonuclear leukocyte lysosomes and immune tissue injury. Prog Allergy 20: 301–340

    Article  PubMed  CAS  Google Scholar 

  178. Gonzalez JG, Ghiselli RW, Santa Cruz DJ (1987) Synovial metaplasia of the skin. Am J Surg Pathol 11:343–350

    Article  PubMed  CAS  Google Scholar 

  179. Goodfellow J (1992) Malignancy and joint replacement. J Bone Joint Surg [Br] 74:645

    CAS  Google Scholar 

  180. Goodsir J, Goodsir HDS (1845) The process of ulceration in articular cartilages. In: Anatomical and pathological observations. Myles Macphail, Edinburgh, Simpkin, Marshall and Comp., London, pp 17–19

    Google Scholar 

  181. Gordon JR, Burd PR, Galli SJ (1990) Mast cells as a source of multifunctional cytokines. Immunol Today 11: 458–464

    Article  PubMed  CAS  Google Scholar 

  182. Gotis-Graham I, McNeil HP (1997) Mast cell responses in rheumatoid synovium. Association of the MGrc subset with matrix turnover and clinical progression. Arthritis Rheum 40:479–489

    Article  PubMed  CAS  Google Scholar 

  183. Grabow D (1999) Die Rolle der Natürlichen Killerzellen bei der Rheumatoid-Arthritis. Immunhistochemische Untersuchungen an Synovialmembranen. Med Diss, Universität Leipzig

    Google Scholar 

  184. Graf J, Bernd L, Pauschert R, Niethard FU (1991) Der besondere Fall: Das seltene Auftreten einer villonodulären Synovialitis an beiden Schultergelenken. Z Rheumatol 50:46–48

    PubMed  CAS  Google Scholar 

  185. Graziano FM, Ilardi C, Godfrey H, Engber W (1983) The occurrence of mast cells in the synovium of patients with active rheumatoid arthritis (RA). Arthritis Rheum (Suppl 4) 26:S52 (Abstr B16)

    Google Scholar 

  186. Grimley PM, Sokoloff L (1966) Synovial giant cells in rheumatoid arthritis. Am J Pathol 49:931–954

    PubMed  CAS  Google Scholar 

  187. Gristina AG, Giridhar G, Gabriel BL, Naylor PT, Myrvik QN (1993) Cell biology and molecular mechanisms in artificial device infections. Int J Artif Organs 16:755–764

    PubMed  CAS  Google Scholar 

  188. Grober JS, Bowen BL, Ebling H, Athey B, Thompson CB, Fox DA, Stoolman LM (1993) Monocyte-endothelial adhesion in chronic rheumatoid arthritis. In situ detection of selectin and integrin-dependent interactions. J Clin Invest 91:2609–2619

    Article  PubMed  CAS  Google Scholar 

  189. Gross V, Leser H-G, Heinisch A, Schölmerich J (1993) Inflammatory mediators and cytokines-new aspects of the pathophysiology and assessment of severity of acute pancreatitis? Hepato-Gastroenterol 40:522–530

    CAS  Google Scholar 

  190. Gruber B, Poznansky M, Boss E, Partin J, Gorevic P, Kaplan AP (1986) Characterization and functional studies of rheumatoid synovial mast cells. Activation by secretagogues, anti-IgE, and a histamine-releasing lymphokine. Arthritis Rheum 29:944–955

    Article  PubMed  CAS  Google Scholar 

  191. Grumbles RM, Howell DS, Howard GA et al. (1995) Cartilage metalloproteases in disuse atrophy. J Rheumatol (Suppl 43) 22:146–148

    Google Scholar 

  192. Gryfe A, Sanders PM, Gardner DL (1971) The mast cell in early rat adjuvant arthritis. Ann Rheum Dis 30:24–30

    Article  PubMed  CAS  Google Scholar 

  193. Guedj D, Weinberger A (1990) Effect of weather conditions on rheumatic patients. Ann Rheum Dis 49:158–159

    Article  PubMed  CAS  Google Scholar 

  194. Hachicha M, Rathanaswami P, Schall TJ, McColl SR (1993) Production of monocyte chemotactic protein-1 in human type B synoviocytes. Synergistic effect of tumor necrosis factor a and interferon-y. Arthritis Rheum 36:26–34

    Article  PubMed  CAS  Google Scholar 

  195. Hall MC (1964) Articular changes in the knee of the adult rat after prolonged immobilization in extension. Clin Orthop 34:184–195

    PubMed  CAS  Google Scholar 

  196. Halla JT, Hardin JG, Fallahi S (1987) The nature of the onset of rheumatoid arthritis: a reassessment. Rheumatol Int 7:169–171

    Article  PubMed  CAS  Google Scholar 

  197. Hambach L, Neureiter D, Zeiler G, Kirchner T, Aigner T (1998) Severe disturbance of the distribution and expression of type VI collagen chains in osteoarthritic articular cartilage. Arthritis Rheum 41:986–996

    Article  PubMed  CAS  Google Scholar 

  198. Hameed MR, Erlandson R, Rosen PP (1995) Capsular synovial-like hyperplasia around mammary implants similar to detritic synovitis. A morphologic and immunohisto-chemical study of 15 cases. Am J Surg Pathol 19:433–438

    Article  PubMed  CAS  Google Scholar 

  199. Hamilton S (1983) Unilateral rheumatoid arthritis in hemiplegia. J Can Assoc Radiol 34:49–50

    PubMed  CAS  Google Scholar 

  200. Hansch A, Stiehl P, Geiler G (1996) Quantifizierung der Makrophagen und Granulozyten an der Gelenkknorpel-Pannus-Grenze bei Rheumatoid-Arthritis. Z Rheumatol 55:401–409

    PubMed  CAS  Google Scholar 

  201. Harada T, Scudamore RA, Cooke TDV, Smith JT (1992) Deleterious interactions of immune complexes with cartilage in inflammatory arthritis. IV. Role of polymorphonuclear neutrophils. Eur J Exp Musculoskel Res 1:19–24

    CAS  Google Scholar 

  202. Harris ED, Glauert AM, Murley AHG (1977) Intracellular collagen fibers at the pannus-cartilage junction in rheumatoid arthritis. Arthritis Rheum 20:657–665

    Article  PubMed  Google Scholar 

  203. Harrison JW, McLain DL, Hohn RB, Wilson GP, Chaiman JA, MacGowan KN (1976) Osteosarcoma associated with metallic implants. Clin Orthop 116:253–257

    PubMed  Google Scholar 

  204. Hart DNJ (1997) Dendritic cells: Unique leukocyte populations which control the primary immune response. Blood 90:3245–3287

    PubMed  CAS  Google Scholar 

  205. Hart DNJ, McKenzie JL (1988) Isolation and characterization of human tonsil dendritic cells. J Exp Med 168:157–170

    Article  PubMed  CAS  Google Scholar 

  206. Hashimoto S, Ochs RL, Komiya S, Lotz M (1998) Linkage of chondrocyte apoptosis and cartilage degradation in human osteoarthritis. Arthritis Rheum 41:1632–1638

    Article  PubMed  CAS  Google Scholar 

  207. Hashimoto S, Takahashi K, Amiel L, Coutis RD, Lotz M (1998) Chondrocyte apoptosis and nitric oxide production during experimentally induced osteoarthritis. Arthritis Rheum 41:1266–1274

    Article  PubMed  CAS  Google Scholar 

  208. Haslett C (1992) Resolution of acute inflammation and the role of apoptosis in the tissue fate of granulocytes. Clin Sci 83:639–648

    PubMed  CAS  Google Scholar 

  209. Hasselbacher P, Schumacher HR (1978) Synovial fluid eosinophilia following arthrography. J Rheumatol 5: 173–176

    PubMed  CAS  Google Scholar 

  210. atano Y, Kasama T, Iwabuchi H et al. (1999) Macrophage inflammatory protein 1 alpha expression by synovial fluid neutrophils in rheumatoid arthritis. Ann Rheum Dis 58:297–302

    Article  Google Scholar 

  211. Häuselmann HJ, Flechtenmacher J, Michal L, Thonar EJ-MA, Shinmei M, Kuettner KE, Aydelotte MB (1996) The superficial layer of human articular cartilage is more susceptible to interleukin-1-induced damage than the deeper layers. Arthritis Rheum 39:478–488

    Article  PubMed  Google Scholar 

  212. Hawkins RA, Claman HN, Clark RAF, Steigerwald JC (1985) Increased dermal mast cell populations in progressive systemic sclerosis: A link in chronic fibrosis? Ann Intern Med 102:182–186

    PubMed  CAS  Google Scholar 

  213. Hedfors E (1989) The clinical use of immunohistopathology. Br J Rheumatol 28:278–280

    Article  PubMed  CAS  Google Scholar 

  214. Heide S (1997) Die Proliferation der Zellen der Synovialmembran bei Rheumatoid-Arthritis unter Einwirkung von exsudiertem Fibrin. Med Diss, Universität Leipzig

    Google Scholar 

  215. Heile (1901) Ueber die Zerstörung des hyalinen Gelenkund Epiphysenknorpels bei Tuberkulose und Eiterung, insbesondere über die dabei stattfindende Zeil-Einwanderung. Arch Pathol Anat Phys Klin Med 163:265–286

    Article  Google Scholar 

  216. Helal B (1965) The pain in primary osteoarthritis of the knee. Its causes and treatment by osteotomy. Postgrad Med J 41:172–181

    Article  PubMed  CAS  Google Scholar 

  217. Hendler PL, Lavoie PE, Werb Z, Chan J, Seaman WE (1985) Human synovial dendritic cells. Direct observation of transition to fibroblasts. J Rheumatol 12:660–664

    PubMed  CAS  Google Scholar 

  218. Henson PM (1971) The immunologic release of constituents from neutrophil leukocytes. I. The role of antibody and complement on nonphagocytosable surfaces or phagocytosable particles. J Immunol 107:1535–1546

    PubMed  CAS  Google Scholar 

  219. Henson PM (1971) The immunologic release of constituents from neutrophil leukocytes. II. Mechanisms of release during phagocytosis, and adherence to nonphagocytosable surfaces. J Immunol 107:1547–1557

    PubMed  CAS  Google Scholar 

  220. Hermann G, Miescher PA (1965) Differentiation of leukocytic fibrinolytic enzymes from plasmin by the use of plasmatic proteolytic inhibitors. Int Arch Allergy 27:346–354

    Article  PubMed  CAS  Google Scholar 

  221. Hernanz A, de Miguel E, Romera N, Perez-Ayala C, Gijon J, Arnalich F (1993) Calcitonin gene-related peptide II, substance P and vasoactive intestinal peptide in plasma and synovial fluid from patients with inflammatory joint disease. Br J Rheumatol 32:31–35

    Article  PubMed  CAS  Google Scholar 

  222. Herterich B (1991) Proliferation synovialer Zellen bei der chronischen Polyarthritis. Med Diss, Universität Ulm

    Google Scholar 

  223. Highton J, Palmer DG, Smith M, Hessian PA (1990) Phenotypic markers of lymphocyte and mononuclear phagocyte activation within rheumatoid nodules. J Rheumatol 17:1130–1136

    PubMed  CAS  Google Scholar 

  224. Hirohata K, Kobayashi I (1964) Fine structure of the synovial tissues in rheumatoid arthritis. Kobe J Med Sci 10:195–225

    PubMed  CAS  Google Scholar 

  225. Hollander AP, Atkins RM, Eastwood DM, Dieppe PA, Elson CJ (1991) Human cartilage is degraded by rheumatoid arthritis synovial fluid but not by recombinant cytokines in vitro. Clin Exp Immunol 83:52–57

    Article  PubMed  CAS  Google Scholar 

  226. Hollander AP, Dieppe PA, Atkins RM, Elson CJ (1993) Hypothesis: Cartilage catabolic cofactors in human arthritis. J Rheumatol 20:223–224

    PubMed  CAS  Google Scholar 

  227. Hollander AP, Heathfield TF, Webber C, Iwata Y, Bourne R, Rorabeck C, Poole AR (1994) Increased damage to type II collagen in osteoarthritic articular cartilage detected by a new immunoassay. J Clin Invest 93:1722–1732

    Article  PubMed  CAS  Google Scholar 

  228. Hollander AP, Pidoux I, Reiner A, Rorabeck C, Bourne R, Poole AR (1995) Damage to type II collagen in aging and osteoarthritis starts at the articular surface, originates around chondrocytes, and extends into the cartilage with progressive degeneration. J Clin Invest 96: 2859–2869

    Article  PubMed  CAS  Google Scholar 

  229. Hollander JL, McCarty DJ, Astorga G, Castro-Murillo E (1965) Studies on the pathogenesis of rheumatoid joint inflammation. I. The „RA-cell“ and a working hypothesis. Ann Int Med 62:271–280

    PubMed  CAS  Google Scholar 

  230. Hollingsworth JW, Siegel ER, Creasey WA (1967) Granulocyte survival in synovial exudate of patients with rheumatoid arthritis and other inflammatory joint diseases. Yale J Biol Med 39:289–296

    PubMed  CAS  Google Scholar 

  231. Homandberg GA, Meyers R, Aydelotte M, Tripier D, Kuettner KE (1992) Isolation and characterization of an abundant elastase inhibitor from NaCl extracts of bovine nasal septa and articular cartilage. Connect Tissue Res 28:289–305

    Article  PubMed  CAS  Google Scholar 

  232. Honma T, Hamasaki T (1996) Ultrastructure of multinucleated giant cell apoptosis in foreign-body granuloma. Virchows Arch 428:165–176

    Article  PubMed  CAS  Google Scholar 

  233. Höpker W-W (1984) Gelenkzwischenscheiben. In: Doerr W, Scifert G (Hrsg) Pathologie der Gelenke und Weichteiltumoren IL Springer, Berlin Heidelberg New York Tokyo, S 723–921

    Google Scholar 

  234. Horner A, Davies ME, Franz B (1995) Chondrocyte-peripheral blood mononuclear cell interactions: the role of ICAM-1. Immunology 86:584–590

    PubMed  CAS  Google Scholar 

  235. Hukkanen M, Grönblad M, Rees R et al. (1991) Regional distribution of mast cells and peptide containing nerves in normal and adjuvant arthritic rat synovium. J Rheumatol 18:177–183

    PubMed  CAS  Google Scholar 

  236. Hunter W (1743) Of the structure and diseases of articulating cartilages. Phil Trans Roy Soc London 42:514–521

    Google Scholar 

  237. Hunziker EB, Kapfinger E (1998) Removal of proteoglycans from the surface of defects in articular cartilage transiently enhances coverage by repair cells. J Bone Joint Surg [Br] 80:144–150

    Article  CAS  Google Scholar 

  238. Hunziker EB, Rosenberg LC (1996) Repair of partialthickness defects in articular cartilage: Cell recruitment from the synovial membrane. J Bone Joint Surg [Am] 78:721–733

    CAS  Google Scholar 

  239. Imhof BA, Dunon D (1995) Leukocyte migration and adhesion. Adv Immunol 58:345–416

    Article  PubMed  CAS  Google Scholar 

  240. Inman RD, Harpel PC (1986) a2-plasmin inhibitor-plasmin complexes in synovial fluid. J Rheumatol 13:535–537

    PubMed  CAS  Google Scholar 

  241. Isdale AH, Helliwell PS (1992) An infiltrating rheumatoid nodule? Ann Rheum Dis 51:688–689

    Article  PubMed  CAS  Google Scholar 

  242. Ishido B (1923) Über den Kniegelenksmeniscus. Virchow Arch 244:429–438

    Article  Google Scholar 

  243. Ishikawa H, Ohno O, Jamasaki K, Ikuta S, Hirohata K (1986) Arthritis presumably caused by chlamydia in Reiter syndrome. J Bone Joint Surg [Am] 68:777–779

    CAS  Google Scholar 

  244. Ishikawa H, Hirata S, Andoh Y, Kubo H, Nakagawa N, Nishibayashi Y, Mizuno K (1996) An immunohistochemical and immunoelectron microscopic study of adhesion molecules in synovial pannus formation in rheumatoid arthritis. Rheumatol Int 16:53–60

    Article  PubMed  CAS  Google Scholar 

  245. Iwasaki Y, Matsubara T, Hirohata K (1988) A mechanism of cartilage destruction in immunologically mediated inflammation: increased superoxide anion release from chondrocytes in response to interleukin 1 and interferons. Orthop Trans 12:438–439

    Google Scholar 

  246. Iwata Y, Mort JS, Tateishi H, Lee ER (1997) Macrophage cathepsin L, a factor in the erosion of subchondral bone in rheumatoid arthritis. Arthritis Rheum 40:499–509

    Article  PubMed  CAS  Google Scholar 

  247. Janes J, McDonald JR (1948) Mast cells. Their distribution in various human tissues. Arch Pathol 45:622–634

    Google Scholar 

  248. Janoff A (1985) Ekstase in tissue injury. Ann Rev Med 36:207–216

    Article  PubMed  CAS  Google Scholar 

  249. Jeffery AK (1975) Osteophytes and the osteoarthritic femoral head. J Bone Joint Surg [Br] 57:314–324

    CAS  Google Scholar 

  250. Jennings TA, Peterson L, Axiotis CA, Friedlaender GE, Cooke RA, Rosai J (1988) Angiosarcoma associated with foreign body material. Cancer 62:2436–2444

    Article  PubMed  CAS  Google Scholar 

  251. Jortikka MO, Inkinen RI, Tammi MI et al. (1997) Immoblisation causes longlasting matrix changes both in the immobilised and contralateral joint cartilage. Ann Rheum Dis 56:255–261

    Article  PubMed  CAS  Google Scholar 

  252. Junqueira LCU, Zugaib M, Montes GS, Toledo OMS, Krisztán RM, Shigihara KM (1980) Morphologic and histochemical evidence for the occurrence of collagenolysis and for the role of neutrophilic polymorphonuclear leukocytes during cervical dilation. Am J Obstet 138:273–281

    CAS  Google Scholar 

  253. Kahn AJ, Stewart CC, Teitelbaum SL (1978) Contactmediated bone resorption by human monocytes in vitro. Science 199:988–989

    Article  PubMed  CAS  Google Scholar 

  254. Kanis JA, McCloskey EV (1997) Bone turnover and biochemical markers in malignancy. Cancer 80:1538–1545

    Article  PubMed  CAS  Google Scholar 

  255. Kawakami A, Eguchi K, Matsuoka N, Tsuboi M, Kawabe Y, Aoyagi T, Nagataki S (1996) Inhibition of FAS antigenmediated apoptosis of rheumatoid synovial cells in vitro by transforming growth factor βl. Arthritis Rheum 39:1267–1276

    Article  PubMed  CAS  Google Scholar 

  256. Kawanami O, Ferrans VJ, Fulmer JD, Crystal RG (1979) Ultrastructure of pulmonary mast cells in patients with fibrotic lung disorders. Lab Invest 40:717–734

    PubMed  CAS  Google Scholar 

  257. Kaye BR, Kaye RL, Bobrove A (1984) Rheumatoid nodules. Review of the spectrum of associated conditions and proposal of a new classification, with a report of four seronegative cases. Am J Med 76:279–292

    Article  PubMed  CAS  Google Scholar 

  258. Keefer CS, Parker F, Myers WK (1934) Histological changes in the knee joint in various infections. Arch Pathol 18:199–215

    Google Scholar 

  259. Keel M, Ungethüm U, Steckholzer U, Niederer E, Hartung T, Trentz O, Ertel W (1997) Interleukin-10 counterregulates proinflammatory cytokine-induced inhibition of neutrophil apoptosis during severe sepsis. Blood 90:3356–3363

    PubMed  CAS  Google Scholar 

  260. Key JA (1925) The reformation of synovial membrane in the knees of rabbits after synovectomy. J Bone Joint Surg 7:793–813

    Google Scholar 

  261. Kiely PDW (1998) The Th1-Th2 model-what relevance to inflammatory arthritis? Ann Rheum Dis 57:328–330

    Article  PubMed  CAS  Google Scholar 

  262. Kiener HP, Baghestanian M, Dominkus M et al. (1998) Expression of the C5a receptor (CD88) on synovial mast cells in patients with rheumatoid arthritis. Arthritis Rheum 41:233–245

    Article  PubMed  CAS  Google Scholar 

  263. Kienzle G, von Kempis J (1998) Vascular cell adhesion molecule 1 (CD 106) on primary human articular chondrocytes. Functional regulation of expression by cytokines and comparison with intercellular adhesion molecule 1 (CD54) and very late activation antigen 2. Arthritis Rheum 41:1296–1305

    Article  PubMed  CAS  Google Scholar 

  264. Kim HKW, Kerr RG, Cruz TF, Salter RB (1995) Effects of continuous passive motion and immobilization on synovitis and cartilage degradation in antigen induced arthritis. J Rheumatol 22:1714–1721

    PubMed  CAS  Google Scholar 

  265. Kinne R, Vorderwülbecke U, Weseloh G, Glückert K, Emmrich F (1990) In: Mohr W, Emmert KH (Hrsg) Gelenkzerstörung bei entzündlichen rheumatischen Erkrankungen. Basismechanismen und deren Beeinflussung durch Therapie. Steinkopff, Darmstadt, S 83–89

    Google Scholar 

  266. Kita H, Gleich GJ (1997) Eosinophils and IgE receptors: A continuing controversy. Blood 89:3497–3501

    PubMed  CAS  Google Scholar 

  267. Kjeldsen L, Bainton DF, Sengeløv H, Borregaard N (1993) Structural and functional heterogeneity among peroxidase-negative granules in human neutrophils: Identification of a distinct gelatinase-containing granule subset by combined immunocytochemistry and subcellular fractionation. Blood 82:3183–3191

    PubMed  CAS  Google Scholar 

  268. Kjeldsen L, Bainton DF, Sengeløv H, Borregaard N (1994) Identification of neutrophil gelatinase-associated lipocalin as a novel matrix protein of specific granules in human neutrophils. Blood 83:799–807

    PubMed  CAS  Google Scholar 

  269. Kjeldsen L, Sengeløv H, Lollike K, Nielsen MH, Borregaard N (1994) Isolation and characterization of gelatinase granules from human neutrophils. Blood 83: 1640–1649

    PubMed  CAS  Google Scholar 

  270. Klareskog L, Forsum U, Wigren A, Wigzell H (1982) Relationships between HLA-DR-expressing cells and T lymphocytes of different subsets in rheumatoid synovial tissue. Scand J Immunol 15:501–507

    Article  Google Scholar 

  271. Klofkorn RW, Lehman TJA (1982) Eosinophilic synovial effusions complicating chronic urticaria and angioedema. Arthritis Rheum 25:708–709

    Article  PubMed  CAS  Google Scholar 

  272. Kobayashi I, Ziff M (1975) Electron microscopic studies of the cartilage-pannus junction in rheumatoid arthritis. Arthritis Rheum 18:475–483

    Article  PubMed  CAS  Google Scholar 

  273. Koch AE, Kunkel SL, Harlow LA et al. (1992) Enhanced production of monocyte chemoattractant protein-1 in rheumatoid arthritis. J Clin Invest 90:772–779

    Article  PubMed  CAS  Google Scholar 

  274. Koch AE, Halloran MM, Hosaka S et al. (1996) Hepatocyte growth factor. A cytokine mediating endothelial migration in inflammatory arthritis. Arthritis Rheum 39: 1566–1575

    Article  PubMed  CAS  Google Scholar 

  275. Kopicky-Burd JA, Kagey-Sobotka A, Peters SP, Dvorak AM, Lennox DW, Lichtenstein LM, Wigley FM (1988) Characterization of human synovial mast cells. J Rheumatol 15:1326–1333

    PubMed  CAS  Google Scholar 

  276. Kopsch K-P (1997) Immunhistochemische Analyse synovialer Riesenzellen bei Rheumatoid Arthritis und ihre Beziehungen zur morphologischen Aktivität der Synovial-membran (Aktuelle Aktivität und Basisaktivität) Med Diss, Universität Leipzig

    Google Scholar 

  277. Kowanko IC, Ferrante A (1996) Adhesion and TNF priming in neutrophil-mediated cartilage damage. Clin Immunol Immunopathol 79:36–42

    Article  PubMed  CAS  Google Scholar 

  278. Krenn V, Schalhorn N, Greiner A, Molitoris R, König A, Gohlke F, Müller-Hermelink HK (1995/96) Immuno-histochemical analysis of proliferating and antigenpresenting cells in rheumatoid synovial tissue. Rheumatol Int 15:239–247

    Article  Google Scholar 

  279. Kriegsmann J, Müller-Ladner U, Franklin BN et al. (1996) Synoviale Fibroblasten von Patienten mit Rheumatoid-Arthritis (RA) transplantiert in SCID-Mäuse destruieren normalen Knorpel und exprimieren VCAM-1 und Kathepsine. Verh Dtsch Ges Pathol 80:281

    PubMed  CAS  Google Scholar 

  280. Kuettner KE, Pauli BU, Soble L (1978) Morphological studies on the resistance of cartilage to invasion by osteosarcoma cells in vitro and in vivo. Cancer Res 38:277–287

    PubMed  CAS  Google Scholar 

  281. Lalor PA, Mapp PI, Hall PA, Revell PA (1987) Proliferative activity of cells in the synovium as demonstrated by a monoclonal antibody, Ki67. Rheumatol Int 7:183–186

    Article  PubMed  CAS  Google Scholar 

  282. Lam S-M (1998) Sparing effect of monoparesis on tophaceous gout in a patient with poliomyelitis. J Rheumatol (Suppl 52) 25:87 (Abstr W88)

    Google Scholar 

  283. Langemak O (1903) Die Entstehung der Hygrome. Arch Klin Chir 70:946–972

    Google Scholar 

  284. Larbre J-P, Moore AR, Da Silva JAP, Iwamura H, Ioannou Y, Willoughby DA (1994) Direct degradation of articular cartilage by rheumatoid synovial fluid: contribution of proteolytic enzymes. J Rheumatol 21:1796–1801

    PubMed  CAS  Google Scholar 

  285. Laschner W, Fritz P, Mischlinski A et al. (1988) Klinische Wertigkeit der histomorphologischen Untersuchungen von Gelenkkapseln. Z Rheumatol 47:195–200

    PubMed  CAS  Google Scholar 

  286. Lawrence T, Moskal JT, Diduch DR (1999) Analysis of routine histological evaluation of tissues removed during primary hip and knee arthroplasty. J Bone Joint Surg [Am] 81:926–931

    Article  CAS  Google Scholar 

  287. Leder LD (1967) Der Blutmonozyt. Springer, Berlin Heidelberg New York

    Google Scholar 

  288. Lee DA, Archer CW (1991) The control of chondrocyte division in matrix depleted articular cartilage. Trans Orthop Res Soc 16:305

    Google Scholar 

  289. Lefkoe TP, Nalin AM, Clark JM, Reife RA, Sugai J, Sandell LJ (1997) Gene expression of collagen types IIA and IX correlates with ultrastructural events in early osteoarthrosis: new applications of the rabbit meniscectomy model. J Rheumatol 24:1155–1163

    PubMed  CAS  Google Scholar 

  290. Leidy J (1849) On the intimate structure and history of the articular cartilages. Am J Med Sci 17:277–294

    Article  Google Scholar 

  291. Lemaire V, Peltier A, Jouvent C, Ryckewaert A (1981) Résultats de l’examen cytologique du liquide synovial dans diverses arthropathies. Rev Rhum 48:229–234

    PubMed  CAS  Google Scholar 

  292. Lindner J (1968) Der rheumatische Bindegewebs-Stoffwechsel und die pathologische Struktur der Bindegewebe bei rheumatoider Arthritis. Verh Dtsch Ges Inn Med 74:1315–1349

    Google Scholar 

  293. Lindner J (1976) Morphology of organic manifestations and complications in rheumatoid arthritis. In: Eberl R, Rosenthal M (eds) Organic manifestations and complications in rheumatoid arthritis. Schattauer, Stuttgart New York, pp 15–50

    Google Scholar 

  294. Lipton SA, Chol Y-B, Pan Z-H et al. (1993) A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds. Nature 364:626–632

    Article  PubMed  CAS  Google Scholar 

  295. Lotz M, Carson DA, Vaughan JH (1987) Substance P activation of rheumatoid synoviocytes: Neural pathway in pathogenesis of arthritis. Science 235:893–895

    Article  PubMed  CAS  Google Scholar 

  296. Lundberg C, Åsberg I, Ionescu M, Reiner A, Smedegård G, Poole AR (1996) Changes in cartilage proteoglycan aggrecan after intra-articular injection of interleukin-1 in rabbits: studies of synovial fluid and articular cartilage. Ann Rheum Dis 55:525–534

    Article  PubMed  CAS  Google Scholar 

  297. Luzar MJ, Friedman BM (1982) Acute synovial fluid eosinophilia. J Rheumatol 9:961–962

    PubMed  CAS  Google Scholar 

  298. Majno G, Joris I (1995) Apoptosis, oncosis, and necrosis. An overview of cell death. Am J Pathol 146:3–15

    PubMed  CAS  Google Scholar 

  299. Malech HL, Gallin JI (1987) Neutrophils in human diseases. N Engl J Med 317:687–694

    Article  PubMed  CAS  Google Scholar 

  300. Malone DG, Irani A-M, Schwartz LB, Barrett KE, Metcalfe DD (1986) Mast cell numbers and histamine levels in synovial fluids from patients with diverse arthritides. Arthritis Rheum 29:956–963

    Article  PubMed  CAS  Google Scholar 

  301. Malone DG, Wilder RL, Saavedra-Delgado AM, Metcalfe DD (1987) Mast cell numbers in rheumatoid synovial tissues. Correlations with quantitative measures of lymphocytic infiltration and modulation by antiinflammatory therapy. Arthritis Rheum 30:130–137

    Article  PubMed  CAS  Google Scholar 

  302. Mankin HJ (1973) Biochemical and metabolic abnormalities in osteoarthritic human cartilage. Fed Proc 32:1478–1480

    PubMed  CAS  Google Scholar 

  303. Mankin HJ, Dorfman H, Lippiello L, Zarins A (1971) Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips. II. Correlation of morphology with biochemical and metabolic data. J Bone Joint Surg [Am] 53:523–537

    CAS  Google Scholar 

  304. Mannik M, Person RE (1994) Deep penetration of antibodies into the cartilage of patients with rheumatoid arthritis. Rheumatol Int 14:95–102

    Article  PubMed  CAS  Google Scholar 

  305. Mariano M, Spector WG (1974) The formation and properties of macrophage polykaryons (inflammatory giant cells). J Pathol 113:1–19

    Article  PubMed  CAS  Google Scholar 

  306. Maroudas NG, O’Neill CH, Stanton MF (1973) Fibroblast anchorage in carcinogenesis by fibres. Lancet 1:807–809

    Article  PubMed  CAS  Google Scholar 

  307. Mathur AK, Schumacher HR, Gatter RA (1988) Synovial mast cell numbers in early inflammatory arthritis. Arthritis Rheum (Suppl 1) 31:R35 (Abstr 9 S)

    Google Scholar 

  308. McCarty DJ, Cheung HS (1982) Origin and significance of rice bodies in synovial fluid. Lancet 2:715–716

    Article  Google Scholar 

  309. McCurdy L, Chatham WW, Blackburn WD (1995) Rheumatoid synovial fibroblast adhesion to human articular cartilage. Arthritis Rheum 38:1694–1700

    Article  PubMed  CAS  Google Scholar 

  310. McDonald PP, Bald A, Cassatella MA (1997) Activation of the NF-KB pathway by inflammatory stimuli in human neutrophils. Blood 89:3421–3433

    PubMed  CAS  Google Scholar 

  311. McDonnell J, Lobner JM, Knight WB, Lark MW, Green B, Poe M, Moore VL (1993) Comparison of the proteoglycanolytic activities of human leukocyte elastase and human cathepsin G in vitro and in vivo. Connect Tissue Res 30:1–9

    Article  PubMed  CAS  Google Scholar 

  312. Meininger CJ, Zetter BR (1992) Mast cells and angiogenesis. Semin Cancer Biol 3:73–79

    PubMed  CAS  Google Scholar 

  313. Mellbye OJ, Forre O, Mollnes TE, Kvarnes L (1991) Immunopathology of subcutaneous rheumatoid nodules. Ann Rheum Dis 50:909–912

    Article  PubMed  CAS  Google Scholar 

  314. Menninger H, Putzier R, Mohr W, Wessinghage D, Tillmann K (1980) Granulocyte elastase at the site of cartilage erosion by rheumatoid synovial tissue. Z Rheumatol 39:145–156

    PubMed  CAS  Google Scholar 

  315. Menzel A (1871) Ueber die Erkrankung der Gelenke bei dauernder Ruhe derselben. Arch Klin Chir 12:990–1009

    Google Scholar 

  316. Mesara BW, Brody GL, Oberman HA (1966) „Pseudorheumatoid“ subcutaneous nodules. Am J Clin Pathol 45:684–691

    PubMed  CAS  Google Scholar 

  317. Millroy SA, Poole AR (1974) Pig articular cartilage in organ culture. Ann Rheum Dis 33:500–508

    Article  PubMed  CAS  Google Scholar 

  318. Mitchell N, Blackwell P (1968) The electron microscopy of regenerating synovium after subtotal synovectomy in rabbits. J Bone Joint Surg [Am] 50:675–686

    CAS  Google Scholar 

  319. Mitchell N, Shepard N (1972) The effect of synovectomy on synovium and cartilage in early rheumatoid arthritis. Clin Orthop 89:178–196

    PubMed  CAS  Google Scholar 

  320. Mitrovic D (1985) The mechanism of cartilage destruction in rheumatoid arthritis. Arthritis Rheum. 28:1192–1193

    Article  PubMed  CAS  Google Scholar 

  321. Mitrovic DR, Garcia F, Front P, Guillermet V (1985) Histochemical and cellular changes induced in the rabbit knee joint by an intraarticular implantation of a sheet of polyethylene. Lab Invest 53:228–239

    PubMed  CAS  Google Scholar 

  322. Miwa M, Saura R, Hirata S, Ishikawa H, Mizuno K (1996) Apoptosis of bovine articular chondrocytes induced by prostaglandin E2. Arthritis Rheum (Suppl) 39:S269 (Abstr 1449)

    Google Scholar 

  323. Mohr W (1984) Arthropathien. In: Doerr W, Scifert G (Hrsg) Spezielle pathologische Anatomie, 18/I. Pathologie der Gelenke und Weichteiltumoren I. Springer, Berlin Heidelberg New York Tokyo, S 373–547

    Google Scholar 

  324. Mohr W (1984) Arthrosis deformans. In: Doerr W, Scifert G (Hrsg) Spezielle pathologische Anatomie, Band 18/I. Pathologie der Gelenke und Weichteiltumoren I. Springer, Berlin Heidelberg New York Tokyo, S 257–372

    Google Scholar 

  325. Mohr W (1984) Gelenkkrankheiten. Diagnostik und Pathogenese makroskopischer und histologischer Strukturveränderungen. Thieme, Stuttgart New York

    Google Scholar 

  326. Mohr W (1986) Die Reaktion des subchondralen Knochens und „Knochenmarkes“ bei der chronischen Polyarthritis. In: Dietsch P, Keck E, Kruse H-P, Kuhlencordt F (Hrsg) Osteologia 1. Aktuelle Ergebnisse der Osteologie. de Gruyter, Berlin New York, S 134–139

    Google Scholar 

  327. Mohr W (1987) Pathologie des Bandapparates. Sehnen, Sehnenscheiden, Faszien, Schleimbeutel. In: Doerr W, Scifert G (Hrsg) Spezielle pathologische Anatomie, Band 19. Springer, Berlin Heidelberg New York London Paris Tokyo

    Google Scholar 

  328. Mohr W (1990) Basismechanismen der Gelenkzerstörung aus der Sicht des Pathologen. In: Mohr W, Emmert KH (Hrsg) Gelenkzerstörung bei entzündlichen rheumatischen Erkrankungen. Basismechanismen und deren Beeinflussung durch Therapie. Steinkopff, Darmstadt, S 21–31

    Google Scholar 

  329. Mohr W (1991) Juxtaartikuläre Knochendestruktion bei Arthritiden. In: Werner E, Matthiaß HH (Hrsg) Osteologie-interdisziplinär. Springer, Berlin Heidelberg New York London Paris Tokyo Hong Kong Barcelona Budapest, S 161–171

    Google Scholar 

  330. Mohr W (1991) Kommentar zu der Publikation J. Graf, L. Bernd, R. Pauschert und F. U. Niethard: „Der besondere Fall: Das seltene Auftreten einer villonodulären Synovialitis an beiden Schultergelenken“. Z Rheumatol 50:46–48

    Google Scholar 

  331. Mohr W (1991) Morphologie der Manifestation der chronischen Polyarthritis am Radiusköpfchen und der Bursa olecrani. In:Stahl C, Zeidler H, Koebke J, Lorenz R (Hrsg) Klinische Arthrologie. Diagnostik-Klinik-Behandlung. Handbuch und Atlas für Klinik und Praxis, II-4.4.3. ecomed, Landsberg/Lech, S 1–10

    Google Scholar 

  332. Mohr W (1995) Cartilage destruction via the synovial fluid in rheumatoid arthritis. J Rheumatol 22:1436–1437

    PubMed  CAS  Google Scholar 

  333. Mohr W (1995) Pathomorphologie der Bewegungsorgane bei der Spondylitis ankylosans. Aktuel Rheumatol 20:162–170

    Article  Google Scholar 

  334. Mohr W (1996) Pathogenese der Gelenkzerstörung bei der chronischen Polyarthritis. Radiologe 36:593–599

    Article  PubMed  CAS  Google Scholar 

  335. Mohr W (1997) Gelenke, Sehnen und Sehnengleitgewebe, Bursen, Faszien. In: Remmele W. (Hrsg) Pathologie 5, 2. Aufl. Springer, Berlin Heidelberg New York Barcelona Budapest Hongkong London Mailand Paris Santa Clara Singapur Tokio, S 383–482

    Chapter  Google Scholar 

  336. Mohr W, Galle J (1986) To the editor. J Bone Joint Surg [Am] 68:1066

    Google Scholar 

  337. Mohr W, Hummler N (1986) Zerstört das Pannusgewebe bei der chronischen Polyarthritis einen Knorpel mit vitalen Chondrozyten? Aktuel Rheumatol 11:162–168

    Article  Google Scholar 

  338. Mohr W, Kirkpatrick CJ (1981) Biokompatibilität von Polymeren. In: Burri C, Claes L (Hrsg) Alloplastischer Bandersatz. Aktuelle Probleme in Chirurgie und Orthopädie, Band 25. Huber, Bern Stuttgart Wien, S 20–29

    Google Scholar 

  339. Mohr W, Lehmann H (1992) Osteoarthrosis of the ankle joint in old rats. Z Rheumatol 51:35–40

    PubMed  CAS  Google Scholar 

  340. Mohr W, Menninger H (1980) Polymorphonuclear granulocytes at the pannus-cartilage junction in rheumatoid arthritis. Arthritis Rheum 32:1413–1414

    Article  Google Scholar 

  341. Mohr W, Regel E (1985) Die Entwicklung der Randexostosen bei der Koxarthrose. Aktuel Rheumatol 10:119–124

    Article  Google Scholar 

  342. Mohr W, Wessinghage D (1978) The relationship between polymorphonuclear granulocytes and cartilage destruction in rheumatoid arthritis. Z Rheumatol 37:81–86

    PubMed  CAS  Google Scholar 

  343. Mohr W, Wessinghage D (1981) Zur Ultrastruktur der Detritus-Synovitis („Hydroxylapatit-Synovitis?.“). Z Orthop 119:463–468

    Article  PubMed  CAS  Google Scholar 

  344. Mohr W, Wild A (1977) Autoradiographische Untersuchungen zur Pannusentwicklung bei der Adjuvansarthritis der Ratte. Wien Klin Wochenschr 89:756–765

    PubMed  CAS  Google Scholar 

  345. Mohr W, Beneke G, Carl H (1971) Proliferation von Peritonealflüssigkeitszellen in implantierten Diffusionskammern. Beitr Pathol 144:63–79

    PubMed  CAS  Google Scholar 

  346. Mohr W, Carl H, Beneke G (1972) Untersuchungen zur Herkunft von Fibroblasten in Kulturen (Diffusionskammern) von Peritonealflüssigkeitszellen der Ratte. Res Exp Med 158:251–267

    Article  CAS  Google Scholar 

  347. Mohr W, Beneke G, Mohing W (1975) Proliferation of synovial lining cells and fibroblasts. Ann Rheum Dis 34:219–224

    Article  PubMed  CAS  Google Scholar 

  348. Mohr W, Wild A, Paulini K (1975) Proliferation of synovial tissue cells in rats with adjuvant disease. Pathol Microbiol 43:1–9

    CAS  Google Scholar 

  349. Mohr W, Wild A, Wolf HP (1978) Incorporation of 3Hproline into hyaline articular cartilage. An autoradiographic study in rats with and without adjuvant-induced arthritis. Virchows Arch B Cell Pathol 28:1–12

    PubMed  CAS  Google Scholar 

  350. Mohr W, Wessinghage D, Heimstädt P (1979) Morphologie des Knorpels bei der alkaptonurischen Arthropathie. Aktuel Rheumatol 4:205–212

    Google Scholar 

  351. Mohr W, Wild A, Wolf HP (1980) Untersuchungen zur Pathogenese der entzündlichen Knorpelzerstörung bei der Adjuvansarthritis der Ratte. Z Rheumatol 39:212–222

    PubMed  CAS  Google Scholar 

  352. Mohr W, Wessinghage D, Köhler G (1980) Neutrophile Granulozyten bei der rheumatischen Gewebsdestruktion. Z. Rheumatol. 39:322–330

    PubMed  CAS  Google Scholar 

  353. Mohr W, Wessinghage D, Putzier R, Menninger H (1980) Corpora oryzoidea (Reiskörperchen). Aktuel Rheumatol 5:207–216

    Article  Google Scholar 

  354. Mohr W, Westerhellweg H, Wessinghage D (1981) Neutrophile Granulozyten bei der rheumatischen Gewebsdestruktion. IV. Die Häufigkeit neutrophiler Granulozyten an der Pannus-Knorpel-Grenze. Aktuel Rheumatol 6:54–58

    Article  Google Scholar 

  355. Mohr W, Westerhellweg H, Wessinghage D (1981) Polymorphonuclear granulocytes in rheumatic tissue destruction. III. An electron microscopic study of PMNs at the pannus-cartilage junction in rheumatoid arthritis. Ann Rheum Dis 40:396–399

    Article  PubMed  CAS  Google Scholar 

  356. Mohr W, Köhler G, Wessinghage D (1981) Polymorphonuclear granulocytes in rheumatic tissue destruction. II. Demonstration of PMNs in rheumatoid nodules by electron microscopy. Rheumatol. Int. 1:21–28

    Article  PubMed  CAS  Google Scholar 

  357. Mohr W, Maschek H, Wessinghage D (1984) Nekrotisierte Vaskulitiden und Rheumagranulome in der Synovialmembran verschiedener Gelenke bei Patienten mit chronischer Polyarthritis. Aktuel Rheumatol 9:73–78

    Article  Google Scholar 

  358. Mohr W, Kuhn C, Pelster B, Wessinghage D (1985) S-100 protein in normal, osteoarthrotic and arthritic cartilage. Rheumatol Int 5:273–277

    Article  PubMed  CAS  Google Scholar 

  359. Mohr W, Pelster B, Wessinghage D (1985) Polymorphonuclear granulocytes in rheumatic tissue destruction. VI. The occurrence of PMNs in menisci of patients with rheumatoid arthritis. Rheumatol Int 5:39–44

    Article  Google Scholar 

  360. Mohr W, Doms E, Wessinghage D (1989) Ultrastruktur des Reparationskollagens und seine Beziehungen zum residualen hyalinen Gelenkknorpel bei der entzündlichen Knorpeldestruktion. Z Rheumatol 48:30–38

    PubMed  CAS  Google Scholar 

  361. Mohr W, Doms E, Wessinghage D (1990) Reparative Vorgänge bei der pannösen Knorpeldestruktion. In: Mohr W, Emmert KH (Hrsg) Gelenkzerstörung bei entzündlichen rheumatischen Erkrankungen. Basismechanismen und deren Beeinflussung durch Therapie. Steinkopff, Darmstadt, S 149–156

    Google Scholar 

  362. Moore AR, Appelboam A, Kawabata K, Da Silva JAP, D’Cruz D, Gowland G, Willoughby DA (1999) Destruction of articular cartilage bei alpha2 macroglobulin elastase complexes: role in rheumatoid arthritis. Ann Rheum Dis 58:109–113

    Article  PubMed  CAS  Google Scholar 

  363. Moore GE (1991) Foreign body carcinogenesis. Cancer 67:2731–2732

    Article  PubMed  CAS  Google Scholar 

  364. Moore GE, Palmer WN (1977) Money causes cancer: Ban it. JAMA 238:397

    Article  PubMed  CAS  Google Scholar 

  365. Morales-Ducret J, Wayner E, Elices MJ, Alvaro-Gracia JM, Zvaifler NJ, Firestein GS (1992) α4/β1 Integrin (VLA-4) ligands in arthritis. Vascular cell adhesion molecule-1 expression in synovium and on fibroblast-like synoviocytes. J Immunol 149:1424–1431

    PubMed  CAS  Google Scholar 

  366. Moritz AR (1928) Tabische Arthropathie. Histologische Studie. Virchows Arch 267:746–855

    Article  Google Scholar 

  367. Morris R, Winyard PG, Brass LF, Blake DR, Morris CJ (1996) Thrombin receptor expression in rheumatoid and osteoarthritic synovial tissue. Ann Rheum Dis 55:841–843

    Article  PubMed  CAS  Google Scholar 

  368. Moses MA, Sudhalter J, Langer R (1990) Identification of an inhibitor of neovascularization from cartilage. Science 248:1408–1410

    Article  PubMed  CAS  Google Scholar 

  369. Moskowitz RW, Goldberg VM (1987) Osteophyte evolution: Studies in an experimental partial meniscectomy model. J Rheumatol (Suppl 14) 14:116–118

    Google Scholar 

  370. Möst J, Spötl L, Mayr G, Gasser A, Sarti A, Dierich MP (1997) Formation of multinucleated giant cells in vitro is dependent on the stage of monocyte to macrophage maturation. Blood 89:662–671

    PubMed  Google Scholar 

  371. Muguruma Y, Lee MY (1998) Isolation and characterization of murine clonogenic osteoclast progenitors by cell surface phenotype analysis. Blood 91:1272–1279

    PubMed  CAS  Google Scholar 

  372. Muirden KD (1970) Giant cells, cartilage and bone fragments within rheumatoid synovial membrane: Clinicopathological correlations. Aust Ann Med 2:105–110

    Google Scholar 

  373. Müller F (1902) Ueber die Bedeutung der Selbstverdauung bei einigen krankhaften Zuständen. Verh Congr Inn Med 20:192–204

    Google Scholar 

  374. Mundy GR (1989) Local factors in bone remodeling. Recent Progr Hormone Res 45:507–531

    PubMed  CAS  Google Scholar 

  375. Murray J, Barbara JAJ, Dunkley SA et al. (1997) Regulation of neutrophil apoptosis by tumor necrosis factor-a: Requirement for TNFR55 and TNFR75 for induction of apoptosis in vitro. Blood 90:2772–2783

    PubMed  CAS  Google Scholar 

  376. Murrell GAC, Dolan MM, Jang D, Szabo C, Warren RF, Hannafin JA (1996) Nitric oxide: an important articular free radical. J Bone Joint Surg [Am] 78:265–274

    CAS  Google Scholar 

  377. Nade S, Speers DJ (1987) Staphylococcal adherence to chicken cartilage. Acta Orthop Scand 58:351–353

    Article  PubMed  CAS  Google Scholar 

  378. Nagashima M, Yoshino S, Ishiwata T, Asano G (1995) Role of vascular endothelial growth factor in angiogenesis of rheumatoid arthritis. J Rheumatol 22:1624–1630

    PubMed  CAS  Google Scholar 

  379. Namba RS, Meuli M, Sullivan KM, Le AX, Adzick NS (1998) Spontaneous repair of superficial defects in articular cartilage in a fetal lamb model. J Bone Joint Surg [Am] 80:4–10

    CAS  Google Scholar 

  380. Neumann E (1880) Die Picrocarminfärbung und ihre Anwendung auf die Entzündungslehre. Arch Mikrosk Anat 18:130–150

    Article  Google Scholar 

  381. Neumann E (1896) Zur Kenntnis der fibrinoiden Degeneration des Bindegewebes bei Entzündungen. Arch Pathol Anat Physiol Klin Med 144:201–238

    Article  Google Scholar 

  382. Neumann E (1918) Zur Verständigung über Fragen der Entzündungslehre. I. Über das Verhältnis der Entzündung zur Regeneration. Beitr Pathol Anat 64:1–17

    Google Scholar 

  383. Nichols EH, Richardson FL (1909) Arthritis deformans. J Med Res 21:149–221

    PubMed  CAS  Google Scholar 

  384. Nimni M, Deshmukh K (1973) Differences in collagen metabolism between normal and osteoarthritic human articular cartilage. Science 181:751–752

    Article  PubMed  CAS  Google Scholar 

  385. Nothdurft H (1956) Experimentelle Sarkomau slösung durch eingeheilte Fremdkörper. Strahlentherapie 100: 192–210

    PubMed  CAS  Google Scholar 

  386. Noyori K, Jasin HE (1994) Inhibition of human fibroblast adhesion by cartilage surface proteoglycans. Arthritis Rheum 37:1656–1663

    Article  PubMed  CAS  Google Scholar 

  387. Ochi M, Kanda T, Sumen Y, Ikuta Y (1997) Changes in the permeability and histologic findings of rabbit menisci after immobilization. Clin Orthop 334:305–315

    PubMed  Google Scholar 

  388. Oda T, Hotta O, Taguma Y et al. (1997) Involvement of neutrophil elastase in crescentic glomerulonephritis. Hum Pathol 28:720–728

    Article  PubMed  CAS  Google Scholar 

  389. Ogrinc G, Kampalath B, Tomashefski JF (1998) Destruction and loss of bronchial cartilage in cystic fibrosis. Hum Pathol 29:65–73

    Article  PubMed  CAS  Google Scholar 

  390. Ohba T, Takase Y, Ohhara M, Kasukawa R (1996) Thrombin in the synovial fluid of patients with rheumatoid arthritis mediates proliferation of synvoial fibroblast-like cells by induction of platelet derived growth factor. J Rheumatol 23:1505–1511

    PubMed  CAS  Google Scholar 

  391. Okada Y (1973) The mast cell in synovial membrane of the patients with joint diseases. J Jap Orthop Ass 47:657–674

    Google Scholar 

  392. Okada Y, Nakanishi I (1989) Activation of matrix metalloproteinase 3 (stromelysin) and matrix metalloproteinase 2 (’gelatinase’) by human neutrophil elastase and cathepsin G. FEBS Lett 249:353–356

    Article  PubMed  CAS  Google Scholar 

  393. Okada Y, Watanabe S, Nakanishi I et al. (1988) Inactivation of tissue inhibitor of metalloproteinases by neutrophil elastase and other serin proteinases. FEBS Lett 229:157–160

    Article  PubMed  CAS  Google Scholar 

  394. Okazaki R, Sakai A, Nakamura T, Kunugita N, Norimura T, Suzuki K (1996) Effects of transforming growth factor ßs and basic fibroblast growth factor on articular chondrocytes obtained from immobilised rabbit knees. Ann Rheum Dis 55:181–186

    Article  PubMed  CAS  Google Scholar 

  395. Olivé A, Maymo J, Lloreta J, Corominas J, Carbonell J (1987) Evolution of benign rheumatoid nodules into rheumatoid arthritis after 50 years. Ann Rheum Dis 46:624–625

    Article  PubMed  Google Scholar 

  396. Opie EL (1906) The enzymes in phagocytic cells of inflammatory exudates. J Exp Med 8:410–436

    Article  PubMed  CAS  Google Scholar 

  397. Oppenheimer BS, Oppenheimer ET, Stout AP (1948) Sarcomas induced in rats by implanting cellophane. Proc Soc Exp Biol Med 67:33–34

    PubMed  CAS  Google Scholar 

  398. Oppenheimer BS, Oppenheimer ET, Stout AP (1952) Sarcomas induced in rodents by imbedding various plastic films. (19380). Proc Soc Exp Biol Med 79:366–

    PubMed  CAS  Google Scholar 

  399. Paleolog EM (1996) Angiogenesis: A critical process in the pathogenesis of RA-a role for VEGF? Br J Rheumatol 35:917–920

    Article  PubMed  CAS  Google Scholar 

  400. Palmer DG (1995) The anatomy of the rheumatoid lesion. Br Med Bull 51:286–295

    PubMed  CAS  Google Scholar 

  401. Palmer DG, Hogg N, Revell PA (1986) Lymphocytes, polymorphonuclear leukocytes, macrophages and platelets in synovium involved by rheumatoid arthritis. A study with monoclonal antibodies. Pathology 18:431–437

    Article  PubMed  CAS  Google Scholar 

  402. Palmer DG, Hogg N, Highton J, Hessian PA, Denholm I (1987) Macrophage migratio n and maturation within rheumatoid nodules. Arthritis Rheum 30:729–736

    Article  Google Scholar 

  403. Palmer DG, Hogg N, Denholm I, Allen CA, Highton J, Hessian PA (1987) Comparison of phenotype expression by mononuclear phagocytes within subcutaneous gouty tophi and rheumatoid nodules. Rheumatol Int 7:187–193

    Article  PubMed  CAS  Google Scholar 

  404. Palmoski MJ, Brandt KD (1982) Immobilization of the knee prevents osteoarthritis after anterior cruciate ligament transection. Arthritis Rheum 25:1201–1208

    Article  PubMed  CAS  Google Scholar 

  405. Palmoski MJ, Colyer RA, Brandt KD (1980) Joint motion in the absence of normal loading does not maintain normal articular cartilage. Arthritis Rheum 23:325–334

    Article  PubMed  CAS  Google Scholar 

  406. Panagides J, Landes MJ, Sloboda AE (1980) Destruction of articular cartilage by arthritic synovium in vitro: mechanism of breakdown and effect of indomethacin and prednisolone. Agents Actions 10:22–30

    Article  PubMed  CAS  Google Scholar 

  407. Panush RS, Franco AE, Schur PH (1971) Rheumatoid arthritis associated with eosinophilia. Ann Intern Med 75:199–205

    PubMed  CAS  Google Scholar 

  408. Papachristou G, Mandrecas J, Liapi G (1997) Healing of the meniscus in the avascular area. J Bone Joint Surg [Br] Suppl II, 79:S 193, Abstr O230

    Google Scholar 

  409. Parfitt AM (1977) The cellular basis of bone turnover and bone loss. A rebuttal of the osteocytic resorption-bone flow theory. Clin Orthop 127:236–247

    PubMed  Google Scholar 

  410. Patberg WR, Nienhuis RLF, Veringa F (1985) Relation between meteorological factors and pain in rheumatoid arthritis in a marine climate. J Rheumatol 12:711–715

    PubMed  CAS  Google Scholar 

  411. Patterson JW (1988) Rheumatoid nodule and subcutaneous granuloma annulare. A comparative histologic study. Am J Dermatopathol 10:1–8

    Article  PubMed  CAS  Google Scholar 

  412. Pattrick M, Doherty M, Dieppe P (1984) Unilateral exacerbation of rheumatoid arthritis by hemiparesis. Br J Rheumatol 23:107–109

    Article  PubMed  CAS  Google Scholar 

  413. Paukkonen K, Jurvelin J, Helminen HJ (1986) Effects of immobilization on the articular cartilage in young rabbits. A quantitative light microscopic stereological study. Clin Orthop 206:270–280

    PubMed  Google Scholar 

  414. Perry ME, Mustafa Y, Wood SK, Cawley MID, Dumonde DC, Brown KA (1997) Binucleated and multinucleated forms of plasma cells in synovia from patients with rheumatoid arthritis. Rheumatol Int 17:169–174

    Article  PubMed  CAS  Google Scholar 

  415. Pettipher ER, Henderson B, Moncada S, Higgs GA (1988) Leucocyte infiltration and cartilage proteoglycan loss in immune arthritis in the rabbit. Br J Pharmacol 95:169–176

    PubMed  CAS  Google Scholar 

  416. Pettipher ER, Henderson B, Hardingham T, Ratcliffe A (1989) Cartilage proteoglycan depletion in acute and chronic antigen-induced arthritis. Arthritis Rheum 32:601–607

    Article  PubMed  CAS  Google Scholar 

  417. Pfander D, Rahmanzadeh R, Scheller EE (1999) Presence and distribution of collagen II, collagen I, fibronectin, and tenascin in rabbit normal and osteoarthritic cartilage. J Rheumatol 26:386–394

    PubMed  CAS  Google Scholar 

  418. Pillinger MH, Abramson SB (1995) The neutrophil in rheumatoid arthritis. Rheum Dis Clin North Am 21:691–714

    PubMed  CAS  Google Scholar 

  419. Plow EF, Edgington TS (1975) An alternative pathway for fibrin olysis. I. The cleavage of fibrinogen by leukocyte proteases at physiologic pH. J Clin Invest 56:30–38

    Article  PubMed  CAS  Google Scholar 

  420. Podell TE, Ault M, Sullam P, Klinenberg JR (1980) Synovial fluid eosinophilia. Arthritis Rheum 23:1060–1061

    Article  PubMed  CAS  Google Scholar 

  421. Poole CA, Matsuoka A, Schofield JR (1991) Chondrons from articular cartilage. III. Morphologic changes in the cellular microenvironment of chondrons isolated from osteoarthritic cartilage. Arthritis Rheum 34:22–35

    Article  PubMed  CAS  Google Scholar 

  422. Postlethwait RW, Willigan DA, Ulin AW (1975) Human tissue reaction to sutures. Ann Surg 181:144–150

    Article  PubMed  CAS  Google Scholar 

  423. Potenza AD, Herte MC (1982) The synovial cavity as a „tissue culture in situ“-Science or nonsense? J Hand Surg 7:196–199

    CAS  Google Scholar 

  424. Potter M, Wax J, Jones GM (1997) Indomethacin is a potent inhibitor of pristane and plastic disc induced plasmacytomagenesis in a hypersusceptible BALB/c congenic strain. Blood 90:260–269

    PubMed  CAS  Google Scholar 

  425. Pournaras J, Gibson AAM (1971) „Pseudorheumatoid“ nodules in children. J Bone Joint Surg [Br] 53:724–728

    CAS  Google Scholar 

  426. Pritchett JW (1997) Substance P level in synovial fluid may predict pain relief after knee replacement. J Bone Joint Surg [Br] 79:114–116

    Article  CAS  Google Scholar 

  427. Puhl W, Weber M (1978) Die Bedeutung der Frühsynovektomie. Morphologische Untersuchungen zur Pathogenese der Gelenkflächenschädigung durch Pannus. Z Rheumatol (Suppl 5) 37:72–76

    Google Scholar 

  428. Qu Z, Hernandez Garcia C, O’Rourke LM, Planck SR, Kohli M, Rosenbaum JT (1994) Local proliferation of fibroblast-like synoviocytes contributes to synovial hyperplasia. Results of proliferating cell nuclear antigen/cyclin, c-myc, and nucleolar organizer region staining. Arthritis Rheum 37:212–220

    Article  PubMed  CAS  Google Scholar 

  429. Qu Z, Liebler JM, Powers MR et al. (1995) Mast cells are a major source of basic fibroblast growth factor in chronic inflammation and cutaneous hemangioma. Am J Pathol 147:564–573

    PubMed  CAS  Google Scholar 

  430. Raab SS, Slagel DD, Robinson RA (1998) The utility of histological examination of tissue removed during elective joint replacement. J Bone Joint Surg [Am] 80:331–335

    CAS  Google Scholar 

  431. Ranki A, Paavonen T, Tolvanen E, Kankaanpää U, Häyry P (1984) T lymphocyte subclasses in rheumatoid synovia as analysed with monoclonal antibodies and functional in vitro tests. Scand J Rheumatol 13:67–76

    Article  PubMed  CAS  Google Scholar 

  432. Rasker JJ, Kuipers FC (1983) Are rheumatoid nodules caused by vasculitis?. A study of 13 early cases. Ann Rheum Dis 42:384–388

    Article  PubMed  CAS  Google Scholar 

  433. Raso DS, Crymes LW, Metcalf JS (1994) Histological assessment of fifty breast capsules from smooth and textured augmentation and reconstruction mammoplasty prostheses with emphasis on the role of synovial metaplasia. Modern Pathol 7:310–316

    CAS  Google Scholar 

  434. Ravaud P, Moulinier L, Giraudeau B et al. (1999) Effects of joint lavage and steroid injection in patients with osteoarthritis of the knee. Result of a multicenter, randomized, controlled trial. Arthritis Rheum 42:475–482

    Article  PubMed  CAS  Google Scholar 

  435. Redfern P (1851) On the healing of wounds in articular cartilages, and on the removal of these structures after amputations at the joints, with remarks on the relation which exists between the diseases of cartilage and ulceration and inflammation in other textures. Monthly J Med Sci 13:201–215

    Google Scholar 

  436. Remmele W (1999) Grundlagen der diagnostischen Pathologie an Biopsie und Operationspräparat. In: Remmele W (Hrsg) Pathologie 1, 2. Aufl. Springer, Berlin Heidelberg New York Barcelona Hongkong London Mailand Paris Singapur Tokio, S 25–49

    Google Scholar 

  437. Renkel J (1992) Zellularität des Gewebes und DNS-Gehalt der Reparationszellen zu unterschiedlichen Zeiten nach Meniscusrissen. Med Diss, Universität Ulm

    Google Scholar 

  438. Resnick D (1983) Osteophytosis of the femoral head and neck. Arthritis Rheum 26:908–913

    Article  PubMed  CAS  Google Scholar 

  439. Revell PA (1982) Examination of synovial fluid. In: Berry CL (ed) Bone and joint disease. Current Topics in Pathology 71. Springer, Berlin Heidelberg New York, pp 1–24

    Google Scholar 

  440. Revell PA (1990) Basismechanismen der Knochendestruktion in rheumatischen Gelenken. In: Mohr W, Emmert KH (Hrsg) Gelenkzerstörung bei entzündlichen rheumatischen Erkrankungen. Basismechanismen und deren Beeinflussung durch Therapie. Steinkopff, Darmstadt, S 39–44

    Google Scholar 

  441. Reyher C (1873) Ueber die Veränderungen der Gelenke bei dauernder Ruhe. Dtsch Z Chir 3:189–255

    Article  Google Scholar 

  442. Ribatti D, Contino R, Tursi A (1988) Do mast cells intervene in the vasoproliferative processes of the rheumatoid synovitis? J Submicrosc Cytol Pathol 20:635–637

    PubMed  CAS  Google Scholar 

  443. Ricker G (1901) Die Verflüssigung der Bindegewebsfasern. Zugleich ein Beitrag zur Kenntniss der fibrinoiden Degeneration. Virchows Arch 163:44–75

    Article  Google Scholar 

  444. Riddle JM, Barnhart MI (1964) Ultrastructural study of fibrin dissolution via emigrated polmorphonuclear neutrophils. Am J Pathol 45:805–823

    PubMed  CAS  Google Scholar 

  445. Riese H (1896) Die Reiskörperchen in tuberculös erkrankten Synovialsäcken. Dtsch Z Chir 42:1–100

    Article  Google Scholar 

  446. Roberts CR, Dean RT (1986) Degradation of cartilage by macrophages in culture: Evidence for the involvement of an enzyme which is associated with the cell surface. Connect Tissue Res 14:199–212

    Article  PubMed  CAS  Google Scholar 

  447. Rohe K, Bierther M, Becker W, Sarvestani M (1980) Das Bindegewebe in Pseudarthrosen und Nearthrosen langer Röhrenknochen-Teil I: Pseudogelenkkapsel beim Hund. Z Orthop 118:937–949

    Article  PubMed  CAS  Google Scholar 

  448. Rosenberg L (1971) Chemical basis for the histological use of Safranin O in the study of articular cartilage. J Bone Joint Surg [Am] 53:69–82

    CAS  Google Scholar 

  449. Rötzer A, Mohr W (1992) 3H-Thymidin-Inkorporation in Chondrozyten arthrotischen Knorpels. Z. Rheumatol. 51:172–1

    PubMed  Google Scholar 

  450. Rowland RE (1964) Resorption and bone physiology. In: Frost HM (ed) Bone biodynamics. Little, Brown and Company, Boston, Massachusetts, pp 335–507

    Google Scholar 

  451. Roy S (1970) Ultrastructure of articular cartilage in experimental immobilization. Ann Rheum Dis 29:634–642

    Article  PubMed  CAS  Google Scholar 

  452. Rubin LR, Bromberg BE, Waiden RH (1971) Long term human reaction to synthetic plastics. Surg Gynecol Obstet 132:603–608

    PubMed  CAS  Google Scholar 

  453. Rush PJ, Bernstein BH, Smith CR, Shore A (1985) Chronic arthritis following benign rheumatoid nodules of childhood. Arthritis Rheum 28:1175–1178

    Article  PubMed  CAS  Google Scholar 

  454. Rutishauser E, Taillard W (1966) L’ischémie articulaire en pathologie humaine et expérimentale. La notion de pannus vasculaire. Rev Chir Orthop Reparatrice Appar Mot. 52:197–2

    PubMed  CAS  Google Scholar 

  455. Saari H, Santavirta S, Nordström D, Paavolainen P, Konttinen YT (1993) Hyaluronate in total hip replacement. J Rheumatol 20:87–90

    PubMed  CAS  Google Scholar 

  456. Sabokbar A, Fujikawa Y, Neale S, Murray DW, Athanasou NA (1997) Human arthroplasty derived macrophages differentiate into osteoclastic bone resorbing cells. Ann Rheum Dis 56:414–420

    Article  PubMed  CAS  Google Scholar 

  457. Sack U, Stiehl P, Geiler G (1994) Distribution of macrophages in rheumatoid synovial membrane and its association with basic activity. Rheumatol Int 13:181–186

    Article  PubMed  CAS  Google Scholar 

  458. Saklatvala J (1990) Der Beitrag von Zytokinen zur Gelenkzerstörung. In: Mohr W, Emmert KH (Hrsg) Gelenkzerstörung bei entzündlichen rheumatischen Erkrankungen. Basismechanismen und deren Beeinflussung durch Therapie. Steinkopff, Darmstadt, S 75–81

    Google Scholar 

  459. Salter RB, Field P (1960) The effect of continous compression on living articular cartilage. J Bone Joint Surg [Am] 42:31–49

    Google Scholar 

  460. Satsuma S, Scudamore RA, Cooke TDV, Aston WP, Saura R (1993) Toxicity of complement for chondrocytes. A possible source of cartilage degradation in inflammatory arthritis. Rheumatol Int 13:71–75

    Article  PubMed  CAS  Google Scholar 

  461. Saura R, Cooke TDV, Scudamore RA (1991) Superoxide anion (O2-) generation by chondrocytes following stimulation by heat-aggregated IgG. Orthop Trans 15:177–178

    Google Scholar 

  462. Schalkwijk J, Joosten LAB, van den Berg WB, van de Putte LBA (1988) Elastase secreted by activated polymorphonuclear leukocytes causes chondrocyte damage and matrix degradation in intact articular cartilage. Agents Actions 23:58–59

    Article  PubMed  CAS  Google Scholar 

  463. Schalkwijk J, Joosten LAB, van den Berg WB, van de Putte LBA (1988) Degradation of cartilage proteoglycans by elastase is dependent on charge-mediated interactions. Rheumatol Int 8:27–33

    Article  PubMed  CAS  Google Scholar 

  464. Schalkwijk J, Joosten LAB, van den Berg WB, van de Putte LBA (1990) Antigen induced arthritis in beige (Chediak-Higashi) mice. Ann Rheum Dis 49:607–610

    Article  PubMed  CAS  Google Scholar 

  465. Schaser K, Kinne RW, Beil H, Kladny B, Stöss H (1996) Proliferation von T-Zellen, Makrophagen, neutrophile Granulozyten und Fibroblasten-ähnliche Zellen in der Synovialmembran von Patienten mit rheumatoider Arthritis. Verh Dtsch Ges Pathol 80:276–280

    PubMed  CAS  Google Scholar 

  466. Schenck P, Schneider S, Miehlke R, Prehm P (1995) Synthesis and degradation of hyaluronate by synovia from patients with rheumatoid arthritis. J Rheumatol 22: 400–405

    PubMed  CAS  Google Scholar 

  467. Schuchard K (1890) Die Entstehung der subkutanen Hygrome. Virchows Arch 121:305–321

    Article  Google Scholar 

  468. Schuchardt K (1894) Tuberculose und Syphilis der Sehnenscheiden. Beiträge zur Kenntniss der fibrinoiden Entartung des Bindegewebes. Virchows Arch 15:394–432

    Google Scholar 

  469. Schulitz KP, Becker W (1971) Die Kapselregeneration nach Synovektomie arthrotischer Gelenke. Arch Orthop Unfall-Chir 70:14–25

    Article  CAS  Google Scholar 

  470. Schulte E, Fisseler-Eckhoff A, Müller K-M (1994) Differentialdiagnose der Synovialitis. Korrelation von arthroskopisch-bioptischen zu klinischen Befunden. Pathologe 15:22–27

    Article  PubMed  CAS  Google Scholar 

  471. Schweigerer L, Neufeld G, Friedman J, Abraham JA, Fiddes JC, Gospodarowicz D (1987) Capillary endothelial cells express basic fibroblast growth factor, a mitogen that promotes their own growth. Nature 325:257–258

    Article  PubMed  CAS  Google Scholar 

  472. Seed MP, Ismaiel S, Cheung CY, Thomson TA, Gardner CR, Atkins RM, Elson CJ (1993) Inhibition of interleukin lβ induced rat and human cartilage degradation in vitro by the metalloproteinase inhibitor U27391. Ann Rheum Dis 52:37–43

    Article  PubMed  CAS  Google Scholar 

  473. Segal R, Caspi D, Tishler M, Fishel B, Yaron M (1988) Accelerated nodulosis and vasculitis during methotrexate therapy for rheumatoid arthritis. Arthritis Rheum 31:1182–1185

    Article  PubMed  CAS  Google Scholar 

  474. Segale C (1913) Ueber die Regeneration der Synovialmembran und der Gelenkkapsel. Bruns Beitr Klin Chir 87:259–298

    Google Scholar 

  475. Seibold JR, Giorno RC, Claman HN (1990) Dermal mast cell degranulation in systemic sclerosis. Arthritis Rheum 33:1702–1709

    Article  PubMed  CAS  Google Scholar 

  476. Selye H (1953) On the mechanism through which hydrocortisone affects the resistance of tissues to injuries. An experimental study with the granuloma pouch technique. JAMA 152:1207–1213

    CAS  Google Scholar 

  477. Shapiro F, Koide S, Glimcher MJ (1993) Cell origin and differentiation in the repair of full-thickness defects of articular cartilage. J Bone Joint Surg [Am] 75:532–553

    CAS  Google Scholar 

  478. Sharma A, Baethge BA, Acebes JC, Lisse JR (1996) Arthroscopic lavage treatment in rheumatoid arthritis of the knee. J Rheumatol 23:1872–1874

    PubMed  CAS  Google Scholar 

  479. Sheppeard H, Couchman KG (1987) What’s happened to catabolin? Rheumatol Int 7:141–145

    Article  PubMed  CAS  Google Scholar 

  480. Shiozawa S, Yoshihara R, Kuroki Y, Fujita T, Shiozawa K, Imura S (1992) Pathogenic importance of fibronectin in the superficial region of articular cartilage as a local factor for the induction of pannus extension on rheumatoid articular cartilage. Ann Rheum Dis 51:869–873

    Article  PubMed  CAS  Google Scholar 

  481. Sibley JT (1985) Weather and arthritis symptoms. J Rheumatol 12:707–710

    PubMed  CAS  Google Scholar 

  482. Simon MA, Hecht JD (1982) Invasion of joints by primary bone sarcomas in adults. Cancer 50:1649–1655

    Article  PubMed  CAS  Google Scholar 

  483. Simon WH (1978) Experimental degenerative joint disease: freezing of rabbit articular cartilage in vivo. In: Simon WH (ed) The human joint in health and disease. University of Pennsylvania Press, Philadelphia, pp 122–131

    Google Scholar 

  484. Simons FER, Schaller JG (1975) Benign rheumatoid nodules. Pediatrics 56:29–33

    PubMed  CAS  Google Scholar 

  485. Sinibaldi K, Rosen H, Liu S-K, DeAngelis M (1976) Tumors associated with metallic implants in animals. Clin Orthop 118:257–266

    PubMed  Google Scholar 

  486. Smith RL, Schurman DJ (1986) Bacterial arthritis. A staphylococcal proteoglycan-releasing factor. Arthritis Rheum 29:1378–1386

    Article  PubMed  CAS  Google Scholar 

  487. Snider GL (1981) Pathogenesis of emphysema and chronic bronchitis. Med Clin North Am 65:647–665

    PubMed  CAS  Google Scholar 

  488. Sokoloff L (1974) Cell biology and the repair of articular cartilage. J Rheumatol 1:9–16

    PubMed  CAS  Google Scholar 

  489. Sokoloff L, Bunim JJ (1957) Vascular lesions in rheumatoid arthritis. J Chron Dis 5:668–687

    Article  PubMed  CAS  Google Scholar 

  490. Sorgente N, Kuettner KE, Soble LW, Eisenstein R (1975) The resistance of certain tissues to invasion. II. Evidence for extractable factors in cartilage which inhibit invasion by vascularized mesenchyme. Lab Invest 32:217–222

    PubMed  CAS  Google Scholar 

  491. Spector WG (1975) The dynamics of granulomas and the significance of epithelioid cells. Path Biol 23:437–439

    CAS  Google Scholar 

  492. Sporn LA, Bunce LA, Francis CW (1995) Cell proliferation on fibrin: Modulation by fibrinopeptide cleavage. Blood 86:1802–1810

    PubMed  CAS  Google Scholar 

  493. Sporn MB, Harris ED (1981) Proliferative diseases. Am J Med 70:1231–1236

    Article  PubMed  CAS  Google Scholar 

  494. Sporn MB, Roberts AB (1986) Peptide growth factors and inflammation, tissue repair, and cancer. J Clin Invest 78:329–332

    Article  PubMed  CAS  Google Scholar 

  495. Steinman RM (1991) The dendritic cell system and its role in immunogenicity. Annu Rev Immunol 9:271–296

    Article  PubMed  CAS  Google Scholar 

  496. Stolpmann H-J (1967) Elektronenmikroskopische Untersuchung des Hyalins der Pleura und Milzkapsel. Frankfurt Z Pathol 77:213–221

    CAS  Google Scholar 

  497. Sturgill BC, Allan JH (1970) Rheumatoid-like nodules presenting as “pump bumps“ in a patient without rheumatoid arthritis. Arthritis Rheum 13:175–178

    Article  PubMed  CAS  Google Scholar 

  498. Sugiyama M, Tsukazaki T, Yonekura A, Matsuzaki S, Yamashita S, Iwasaki K (1996) Localisation of apoptosis and expression of apoptosis related proteins in the synovium of patients with rheumatoid arthritis. Ann Rheum Dis 55:442–449

    Article  PubMed  CAS  Google Scholar 

  499. Syrovets T, Tippler B, Rieks M, Simmet T (1997) Plasmin is a potent and specific chemoattractant for human peripheral monocytes acting via a cyclic guanosine monophosphate-dependent pathway. Blood 89:4574–4583

    PubMed  CAS  Google Scholar 

  500. Takashima T, Kawai K, Hirohata K, Miki A, Mizoguti H, Cooke TDV (1989) Inflammatory cell changes in Haversian canals. A possible cause of osteoporosis in rheumatoid arthritis. J Bone Joint Surg [Br] 71:671–676

    CAS  Google Scholar 

  501. Taranta A (1962) Occurrence of rheumatic-like subcutaneous nodules without evidence of joint or heart disease. Report of a case. N Engl J Med 266:13–16

    Article  PubMed  CAS  Google Scholar 

  502. Tauro B (1995) Eosinophilic synovitis. A new entity? J Bone Joint Surg [Br] 77:654–656

    CAS  Google Scholar 

  503. Tetlow LC, Woolley DE (1995) Distribution, activation and tryptase/chymase phenotype of mast cells in the rheumatoid lesion. Ann Rheum Dis 54:549–555

    Article  PubMed  CAS  Google Scholar 

  504. Tetlow LC, Woolley DE (1995) Mast cells, cytokines, and metalloproteinases at the rheumatoid lesion: dual immunolocalisation studies. Ann Rheum Dis 54:896–903

    Article  PubMed  CAS  Google Scholar 

  505. Tetlow LC, Woolley DE (1996) Eosinophils are an insignificant cellular component of rheumatoid synovium in patients with late stage disease: comparative distributions with mast cells and macrophages. Ann Rheum Dis 55:548–551

    Article  PubMed  CAS  Google Scholar 

  506. Thaxter TH, Mann RA, Anderson CE (1965) Degeneration of immobilized knee joints in rats. Histological and autoradiographic study. J Bone Joint Surg [Am] 47:567–585

    CAS  Google Scholar 

  507. Thevenon A, Cocheteux P, Duquesnoy B, Mestdagh M, Lecomte-Houcke M, Delcambre B (1987) Subacromial bursitis with rice bodies as a presenting feature of seronegative rheumatoid arthritis. Arthritis Rheum 30:715–716

    Article  PubMed  CAS  Google Scholar 

  508. Thomas R, Davis LS, Lipsky PE (1994) Rheumatoid synovium is enriched in mature antigen-presenting dendritic cells. J Immunol 152:2613–2623

    PubMed  CAS  Google Scholar 

  509. Thompson K, Wright S, Sheron N (1996) Chemotactic and suppressor cytokine networks. Hepato-Gasteroenterol 43:15–31

    CAS  Google Scholar 

  510. Thompson M, Bywaters EGL (1962) Unilateral rheumatoid arthritis following hemiplegia. Ann Rheum Dis 21:370–377

    Article  PubMed  CAS  Google Scholar 

  511. Thurner J (1984) Traumatische Gelenkerkrankungen. In: Doerr W, Scifert G (Hrsg) Spezielle pathologische Anatomie, 18/I. Pathologie der Gelenke und Weichteiltumoren I. Springer, Berlin Heidelberg New York, S 549–621 [561]

    Google Scholar 

  512. Thurston TJ (1982) Distribution of nerves in long bones as shown by silver impregnation. J Anat 134:719–728

    PubMed  CAS  Google Scholar 

  513. Tobetto K, Nakai K, Akatsuka M, Yasui T, Ando T, Hirano S (1993) Inhibitory effects of hyaluronan on neutrophilmediated cartilage degradation. Connect Tissue Res 29:181–190

    Article  PubMed  CAS  Google Scholar 

  514. Tomatsu T, Imai N, Takeuchi N, Takahashi K, Kimura N (1992) Experimentally produced fractures of articular cartilage and bone. The effects of shear forces on the pig knee. J Bone Joint Surg [Br] 74:457–462

    CAS  Google Scholar 

  515. Trias A (1961) Effect of persistent pressure on the articular cartilage. J Bone Joint Surg [Br] 43:376–386

    Google Scholar 

  516. Trudel G, Jabi M, Uhthoff HK (1998) Intraarticular tissue proliferation after immobility: Methods of assessment and preliminary results in rat knee joints. J Rheumatol 25:945–950

    PubMed  CAS  Google Scholar 

  517. Tscherne H (1996) Pseudarthrosen. Orthopäde 25:385

    Article  PubMed  CAS  Google Scholar 

  518. Turner FC (1941) Sarcomas at sites of subcutaneously implanted bakelite disks in rats. J Natl Cancer Inst 2:81–83

    CAS  Google Scholar 

  519. Uehlinger E (1974) Skelettveränderungen bei entzündlich-rheumatischen Erkrankungen vom pathologischanatomischen Standpunkt. Verh Dtsch Ges Rheumatol 3:157–162

    PubMed  CAS  Google Scholar 

  520. Uhlin-Hansen L, Wik T, Kjellén L, Berg E, Forsdahl F, Kolset SO (1993) Proteoglycan metabolism in normal and inflammatory human macrophages. Blood 82: 2880–2889

    PubMed  CAS  Google Scholar 

  521. Utsinger PD (1975) Synovial fluid lymphocytes in rheumatoid arthritis. Arthritis Rheum 18:595–602

    Article  Google Scholar 

  522. Vaishnaw AK, McNally JD, Elkon KB (1997) Apoptosis in the rheumatic diseases. Arthritis Rheum 40:1917–1927

    Article  PubMed  CAS  Google Scholar 

  523. van Boxel JA, Paget SA (1975) Predominantly T-cell infiltrate in rheumatoid synovial membranes. N Engl J Med 293:517–520

    Article  PubMed  Google Scholar 

  524. van de Loo AAJ, Arntz OJ, Bakker AC, van Lent PLEM, Jacobs MJM, van den Berg WB (1995) Role of interleukin 1 in antigen-induced exacerbations of murine arthritis. Am J Pathol 146:239–249

    PubMed  Google Scholar 

  525. van de Putte LBA, Meijer CJLM, Lafeber GJM, Kleinjan R, Cats A (1976) Lymphocytes in rheumatoid and nonrheumatoid synovial fluids. Nonspecifity of high T-cell and low B-cell percentages. Ann Rheum Dis 35:451–455

    Article  Google Scholar 

  526. van de Putte LBA, van Lent PLEM, van den Berg WB (1990) Neutrophile Granulozyten und Knorpelzerstörung. In: Mohr W, Emmert KH (Hrsg) Gelenkzerstörung bei entzündlichen rheumatischen Erkrankungen. Steinkopff, Darmstadt, S. 57–63

    Google Scholar 

  527. van Dinther-Janssen ACHM, Pals ST, Scheper R, Breedveld F, Meijer CJLM (1990) Dendritic cells and high endothelial venules in the rheumatoid synovial membrane. J Rheumatol 17:11–17

    PubMed  Google Scholar 

  528. van Lent PLEM, van den Bersselaar L, van de Putte LBA, van den Berg WB (1990) Immobilization aggravates cartilage damage during antigen-induced arthritis in mice. Attachment of polymorphonuclear leukocytes to articular cartilage. Am J Pathol 136:1407–1416

    PubMed  Google Scholar 

  529. van Lent PLEM, van den Hoek AEM, van den Bersselaar LAM et al. (1994) Early cartilage degradation in cationic immune complex arthritis in mice: relative role of interleukin 1, the polymorphonuclear cell (PMN) and PMN elastase. J Rheumatol 21:321–329

    PubMed  Google Scholar 

  530. van Lent PLEM, van de Loo FAJ, Holthuysen AEM, van Bersselaa LAM, Vermeer H, van den Berg WB (1995) Major role for interleukin 1 but not for tumor necrosis factor in early cartilage damage in immune complex arthritis in mice. J Rheumatol 22:2250–2258

    PubMed  Google Scholar 

  531. Verma R, Gupta SP, Katju V (1983) Place of synovial fluid examination and needle biopsy of synovial membrane in diagnosis of monoarticular joint diseases. Indian J Orthop 17:8–13

    Google Scholar 

  532. Virchow (1886) Verhandlungen ärztlicher Gesellschaften. 1) Discussion über Arthropathia tabidorum. Berl Klin Wochenschr 23:852–855

    Google Scholar 

  533. Volkmann R (1882) Die chronischen fungösen und purulenten Gelenkentzündungen. In: Pitha, v Billroth (Hrsg) Handbuch der allgemeinen und speciellen Chirurgie mit Einschluss der topographischen Anatomie, Operations-und Verbandlehre. Zweiter Band. Zweite Abtheilung. Enke, Stuttgart, S 520–555

    Google Scholar 

  534. Voytek A, Gristina AG, Barth E, Myrvik Q, Switalski L, Hook M, Speziale P (1988) Staphylococcal adhesion to collagen in intra-articular sepsis. Biomaterials 9:107–110

    Article  PubMed  CAS  Google Scholar 

  535. Waalen K, Thoen J, Førre Ø, Hovig T, Teigland J, Natvig JB (1986) Rheumatoid synovial dendritic cells as stimulators in allogeneic and autologous mixed leukocyte reactions-comparison with autologous monocytes as stimulator cells. Scand J Immunol 23:233–241

    Article  PubMed  CAS  Google Scholar 

  536. Walker ER, Boyd RD, Wu DD, Lukoschek M, Burr DB, Radin EL (1991) Morphologic and morphometric changes in synovial membrane associated with mechanically induced osteoarthrosis. Arthritis Rheum 34:515–524

    Article  PubMed  CAS  Google Scholar 

  537. Wallberg-Jonsson S, Rantapää-Dahlqvist S, Nordmark L, Rânby M (1996) Mobilization of fibrinolytic enzymes in synovial fluid and plasma of rheumatoid arthritis and spondyloarthropathy and their relation to radiological destruction. J Rheumatol 23:1704–1709

    PubMed  CAS  Google Scholar 

  538. Ward M (1974) Frostbite. Br Med J 1:67–70

    Article  PubMed  CAS  Google Scholar 

  539. Washburn B (1962) Frostbite. What it is-how to prevent it-emergency treatment. N Engl J Med 266:974–989

    Article  PubMed  CAS  Google Scholar 

  540. Wei L, Svensson O, Hjerpe A (1997) Correlation of morphologic and biochemical changes in the natural history of spontaneous osteoarthrosis in Guinea pigs. Arthritis Rheum 40:2075–2083

    Article  PubMed  CAS  Google Scholar 

  541. Weibel RE, Benor DE (1996) Chronic arthropathy and musculoskeletal symptoms associated with rubella vaccines. A review of 124 claims submitted to the national vaccine injury compensation program. Arthritis Rheum 39:1529–1534

    Article  PubMed  CAS  Google Scholar 

  542. Weichselbaum A (1878) Die feineren Veränderungen des Gelenkknorpels bei fungöser Synovitis und Caries der Gelenkenden. Arch Pathol Anat Physiol Klin Med (Virchows Arch) 73:461–475

    Article  Google Scholar 

  543. Weinberg JB, Pippen AMM, Greenberg CS (1991) Extravascular fibrin formation and dissolution in synovial tissue of patients with osteoarthritis and rheumatoid arthritis. Arthritis Rheum 34:996–1005

    Article  PubMed  CAS  Google Scholar 

  544. Weiner SR, Bassett LW, Reichman RP (1985) Protective effect of poliomyelitis on psoriatic arthritis. Arthritis Rheum 28:703–706

    Article  PubMed  CAS  Google Scholar 

  545. Wikaningrum R, Highton J, Parker A et al. (1998) Pathogenic mechanisms in the rheumatoid nodule. Comparison of proinflammatory cytokine production and cell adhesion molecule expression in rheumatoid nodules and synovial membranes from the same patient. Arthritis Rheum 41:1783–1797

    Article  PubMed  CAS  Google Scholar 

  546. Wild A, Mohr W, Wolf HP (1981) Untersuchungen an 3H-Prolin-vormarkiertem Knorpel bei der Adjuvansarthritis der Ratte. Verh Dtsch Ges Rheumatol 7:469–471

    CAS  Google Scholar 

  547. Wilkinson LS, Pitsillides AA, Edwards JCW (1993) Giant cells in arthritic synovium. Ann Rheum Dis 52:182–184

    Article  PubMed  CAS  Google Scholar 

  548. Willert HG, Otte P (1980) Der Gelenkschmerz-Differenzierung arthrogener und osteogener Schmerzkomponenten. In: Thorn H (Hrsg) Diagnose und Therapie des Schmerzes. Medizinische Literarische Verlagsgesellschaft mbH, Ülzen, S 80–88

    Google Scholar 

  549. Williams RC (1974) Rheumatoid arthritis as a systemic disease. In: Smith LH (ed) Major problems in internal medicine, vol 4. W B Saunders Company, Philadelphia London Toronto

    Google Scholar 

  550. Williams RJ, Smith RL, Schurman DJ (1990) Septic arthritis. Staphylococcal induction of chondrocyte proteolytic activity. Arthritis Rheum 33:533–541

    Article  PubMed  Google Scholar 

  551. Winchester RJ, Litwin SD, Koffler D, Kunkel HG (1971) Observations on the eosinophilia of certain patients with rheumatoid arthritis. Arthritis Rheum 14:650–665

    Article  PubMed  CAS  Google Scholar 

  552. Wojtys EM, Beaman DN, Glover RA, Janda D (1990) Innervation of the human knee joint by substance-P fibers. Arthroscopy 6:254–263

    Article  PubMed  CAS  Google Scholar 

  553. Woolley DE (1995) Mast cells in the rheumatoid lesionringleaders or innocent bystanders? Ann Rheum Dis 54:533–534

    Article  CAS  Google Scholar 

  554. Woolley DE, Tetlow LC (1997) Observations on the microenvironmental nature of cartilage degradation in rheumatoid arthritis. Ann Rheum Dis 56:151–161

    Article  PubMed  CAS  Google Scholar 

  555. Woolley DE, Brinckerhoff CE, Mainardi CL, Vater CA, Evanson JM, Harris ED (1979) Collagenase production by rheumatoid synovial cells: morphological and immunohistochemical studies of the dendritic cell. Ann Rheum Dis 38:262–270

    Article  PubMed  CAS  Google Scholar 

  556. Wyke B (1981) The neurology of joints: a review of general principles. Clin Rheum Dis 7:223–239

    Google Scholar 

  557. Wyllie JC (1983) Histopathology of the subchondral bone lesions in rheumatoid arthritis. J Rheumatol (Suppl 11) 10:26–28

    Google Scholar 

  558. Wyllie JC, Haust MD, More RH (1966) The fine structure of synovial lining cells in rheumatoid arthritis. Lab Invest 15:519–529

    PubMed  CAS  Google Scholar 

  559. Xie DL, Meyers R, Homandberg GA (1993) Release of elastase from monocytes adherent to a fibronectin-gelatin surface. Blood 81:186–192

    PubMed  CAS  Google Scholar 

  560. Young LHY, Joag SV, Lin PY, Luo S-F, Zheng LM, Liu C-C, Young JD-E (1992) Expression of cytolytic mediators by synovial fluid lymphocytes in rheumatoid arthritis. Am J Pathol 140:1261–1268

    PubMed  CAS  Google Scholar 

  561. Youssef PP, Kraan M, Breedveld F et al. (1998) Quantitative microscopic analysis of inflammation in rheumatoid arthritis synovial membrane samples selected at arthroscopy compared with samples obtained blindly by needle biopsy. Arthritis Rheum 41:663–669

    Article  PubMed  CAS  Google Scholar 

  562. Zetkin M, Kiihtz E-H, Fichtel K (1964) Wörterbuch der Medizin. VEB Verlag Volk und Gesundheit, Berlin

    Google Scholar 

  563. Ziegler E (1906) Lehrbuch der allgemeinen Pathologie und pathologischen Anatomie, 2. Band, 11. Auflage. Gustav Fischer, Jena

    Google Scholar 

  564. Ziegler E (1941) Rheumatismus nodosus als einzige Manifestation der rheumatischen Krankheit. Arch Kinderheilk 122:1–6

    Google Scholar 

  565. Ziff M (1989) Role of endothelium in chronic inflammation. Springer Semin Immunopathol 11:199–214

    Article  PubMed  CAS  Google Scholar 

  566. Ziff M (1990) Rheumatoid arthritis-its present and future. J Rheumatol 17:127–133

    PubMed  CAS  Google Scholar 

  567. Ziff M (1990) The rheumatoid nodule. Arthritis Rheum 33:761–767

    Article  PubMed  CAS  Google Scholar 

  568. Zimmermann M (1980) Die physiologischen Grundlagen der Schmerzempfindung und Schmerztherapie. In: Thom H (Hrsg) Diagnose und Therapie des Schmerzes. Medizinische Literarische Verlagsgesellschaft mbH, Ülzen, S 28–44

    Google Scholar 

  569. Zschäbitz A (1988) Selective destruction of the calcified zone in a patient with seronegative rheumatoid arthritis. J Rheumatol 15:1009–1011

    PubMed  Google Scholar 

  570. Zvaifler NJ, Firestein GS (1994) Pannus and pannocytes. Alternative models of joint destruction in rheumatoid arthritis. Arthritis Rheum 37:783–789

    Article  PubMed  CAS  Google Scholar 

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    Professor Dr. med. Winfried Mohr

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Mohr, W. (2000). Reaktionsformen des organisierten Bindegewebes. In: Gelenkpathologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-57071-1_3

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