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Gelenkblutungen

  • Winfried Mohr
Chapter

Zusammenfassung

Bevorzugt treten Hämorrhagien im Kniegelenk auf: Direkten einmaligen Traumen mit Kapseleinrissen oder transchondralen Knochenfrakturen folgt ein Hämarthros. Indirekte Traumen, besonders Sportunfälle, führen zu Kreuzbandrupturen mit hämorrhagischen Ergüssen [5, 12, 45].

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Literatur

  1. 1.
    Abell JM, Bailey RW (1960) Hemophilic pseudotumor. Arch Surg 81:569–581PubMedGoogle Scholar
  2. 2.
    Arnold WD, Hilgartner MW (1977) Hemophilic arthropathy. J Bone Joint Surg [Am] 59:287–305Google Scholar
  3. 3.
    Barthels M (1980) Die Situation der hämophilen Patienten heute. Die gelben Hefte 20:144–150Google Scholar
  4. 4.
    Bokelmann W (1881) Ueber die Natur und Bedeutung der haemophilen Gelenkaffectionen. Med Diss, Universität Göttingen, Dieterichsche Univ.-Buchdruckerei. W. Fr. KästnerGoogle Scholar
  5. 5.
    Casteleyn PP, Handelberg F, Opdecam P (1988) Traumatic haemarthrosis of the knee. J Bone Joint Surg [Br] 70:404–406Google Scholar
  6. 6.
    Cazzola M, Bergamaschi G, Dezza L, Arosio P (1990) Manipulations of cellular iron metabolism for modulating normal and malignant cell proliferation: Achievements and prospect. Blood 75:1903–1919PubMedGoogle Scholar
  7. 7.
    Chiari H (1934) Die „blutigen“ Gelenkerkrankungen. In: Lubarsch O, Henke F (Hrsg) Handbuch der speziellen Pathologie und pathologischen Anatomie, Bd 9,2. Springer, Berlin, S 1–11Google Scholar
  8. 8.
    Cobb WB (1984) Septic polyarthritis in a hemophiliac. J Rheumatol 11:87–89PubMedGoogle Scholar
  9. 9.
    Cottier H (1980) Pathogenese. Ein Handbuch für die ärztliche Fortbildung. Springer, Berlin Heidelberg New YorkGoogle Scholar
  10. 10.
    Du Bois (1838) Observation remarquable d’hémorrhaphilie (disposition héréditaire aux hémorragies); suivé de re’flexions. Gazette Médicale de Paris. 6:43–44Google Scholar
  11. 11.
    Elias MM, Comin EJ, Grosman ME, Galeazzi SA, Rodriguez Garay EA (1987) Possible mechanism of unconjugated bilirubin toxicity on renal tissue. Comp Biochem Physiol [A] 87:1003–1007CrossRefGoogle Scholar
  12. 12.
    Eiskjær S, Larsen ST, Schmidt MB (1988) The significance of hemarthrosis of the knee in children. Arch Orthop Trauma Surg 107:96–98PubMedCrossRefGoogle Scholar
  13. 13.
    Fabry G (1989) Early changes in the ground substance of articular cartilage in experimental hemarthrosis in dogs, measured by the fixed-charge density method. Arch Orthop Trauma Surg 108:76–91PubMedCrossRefGoogle Scholar
  14. 14.
    France MP, Gupta SK (1991) Nonhemophilic hemosiderotic synovitis of the shoulder. A case report. Clin Orthop 262:132–136PubMedGoogle Scholar
  15. 15.
    Freund E (1925) Die Gelenkerkrankung der Bluter. Virchows Arch 256:158–188CrossRefGoogle Scholar
  16. 16.
    Gaary E, Gorlin JB, Jaramillo D (1996) Pseudotumor and arthropathy in the knees of a hemophiliac. Skeletal Radiol 25:85–87PubMedCrossRefGoogle Scholar
  17. 17.
    Gamble JG, Bellah J, Rinsky LA, Glader B (1991) Arthropathy of the ankle in hemophilia. J Bone Joint Surg [Am] 73:1008–1015Google Scholar
  18. 18.
    Grandidier L (1855) Die Haemophilie oder die Bluterkrankheit. Otto Wigand, LeipzigGoogle Scholar
  19. 19.
    Hale WB, Moorthy AV, Middleton SW (1980) Hemarthrosis from heparin therapy. JAMA 244:30PubMedCrossRefGoogle Scholar
  20. 20.
    Handelsman JE, Lurie A (1975) Pathological changes in the juvenile haemophilic knee. S Afr J Surg 13:243–249PubMedGoogle Scholar
  21. 21.
    Harris BK, Ross HA (1974) Hemarthrosis as the presenting manifestation of myeloproliferative disease. Arthritis Rheum 17:696–697CrossRefGoogle Scholar
  22. 22.
    Higuchi M, Kochhan L, Schwaab R, Egli H, Brackmann H-H, Horst J, Olek K (1989) Molecular defects in hemophilia A: Identification and characterization of mutations in the factor VIII gene and family analysis. Blood 74:1045–1051PubMedGoogle Scholar
  23. 23.
    Hough AJ, Banfield WG, Sokoloff L (1976) Cartilage in hemophilic arthropathy. Ultrastructural and microanalytical studies. Arch Pathol Lab Med 100:91–96PubMedGoogle Scholar
  24. 24.
    Hoyer LW (1994) Hemophilia A. N Engl J Med 330:38–47PubMedCrossRefGoogle Scholar
  25. 25.
    Katz AL, Alepa FP (1976) Hemarthrosis secondary to heparin therapy. Arthritis Rheum 19:966PubMedCrossRefGoogle Scholar
  26. 26.
    Kirkpatrick CJ, Mohr W, Haferkamp O (1982) Alterations in chondrocyte morphology, proliferation and binding of 35S04 due to Fe (III), Fe (II), ferritin and haemoglobin in vitro. Virchows Arch Abt B Zellpath 38:297–306Google Scholar
  27. 27.
    Klein GE, Raith J, Passler J, Szolar DH, Sorantin E, Hausegger KA (1997) Spontaneous recurrent hemarthrosis of the knee joint: Endo vascular treatment of a ruptured aneurysm with platinum microcoils. J Bone Joint Surg [Am] 79:594–596Google Scholar
  28. 28.
    Klofkorn RW, Lightsey AL (1979) Hemarthrosis associated with Glanzmann’s thrombasthenia. Arthritis Rheum 22:1390–1393PubMedCrossRefGoogle Scholar
  29. 29.
    König F (1892) Die Gelenkerkrankungen bei Blutern mit besonderer Berücksichtigung der Diagnose. Sammlung klinischer Vorträge Nr 36, 6. Heft der 2. Serie. Breitkopf und Härtel, Leipzig, S 233–242Google Scholar
  30. 30.
    Lebert M (1837) Recherches sur les causes, les symptômes et le traitement des hémorrhagies constitutionelles. Archives Générales de Medecine, Journal complémentaire des sciences médicales. 15:36–63Google Scholar
  31. 31.
    Louthrenoo W, Abrahm J, Schumacher HR (1991) Hemarthrosis in patients with acquired factor VIII inhibitor. J Rheumatol 18:104–105PubMedGoogle Scholar
  32. 32.
    Macfarlane JD, Kroon HM, Caekebeke-Peerlinck KMJ (1989) Arthropathy in von Willebrand’s disease. Clin Rheumatol 8:98–102PubMedCrossRefGoogle Scholar
  33. 33.
    Madhok R, Bennett D, Sturrock RD, Forbes CD (1988) Mechanisms of joint damage in an experimental model of hemophilic arthritis. Arthritis Rheum 31:1148–1155PubMedCrossRefGoogle Scholar
  34. 34.
    Madhok R, York J, Sturrock RD (1991) Haemophilic arthritis. Ann Rheum Dis 50:588–591PubMedCrossRefGoogle Scholar
  35. 35.
    Maroudas A (1970) Distribution and diffusion of solutes in articular cartilage. Biophys J 10:365–379PubMedCrossRefGoogle Scholar
  36. 36.
    McLaughlin GE, McCarty DJ, Segal BL (1966) Hemarthrosis complicating anticoagulant therapy. Report of three cases. JAMA 196:1020–1021PubMedCrossRefGoogle Scholar
  37. 37.
    Miler I, Indrová M, Bubeník J, Vondráek J (1985) The in vitro cytotoxic effect of bilirubin on human lymphocytes and granulocytes. Folia Microbiol 30:272–276CrossRefGoogle Scholar
  38. 38.
    Mohr W (1984) Gelenkkrankheiten. Diagnostik und Pathogenese makroskopischer und histologischer Strukturveränderungen. Thieme, Stuttgart New YorkGoogle Scholar
  39. 39.
    Mohr W (1993) Pathogenese der Arthropathie. In: Scharrer I, Schramm W (Hrsg) 23. Hämophilie-Symposion Hamburg 1992. Springer, Berlin Heidelberg New York London Paris Tokyo Hong Kong Barcelona Budapest, S 83–94Google Scholar
  40. 40.
    Mohr W, Wessinghage D (1992) Zur Pathogenese von Knorpelläsionen bei intraartikulären Blutungen. Aktuel Rheumatol 17:123–127CrossRefGoogle Scholar
  41. 41.
    Mohr W, Kirkpatrick CJ, Köhler G (1982) Arthropathie bei Hämophilie. Ihr morphologisches Erscheinungsbild und experimentelle Untersuchungen zur Pathogenese der Knorpeldestruktion. Aktuel Rheumatol (Sonderheft 3) 7:179–183CrossRefGoogle Scholar
  42. 42.
    Moller DE, Goldstein K (1987) Hemarthrosis and idiopathic thrombocytopenic purpura. J Rheumatol 14:382–383PubMedGoogle Scholar
  43. 43.
    Morris CJ, Blake DR, Wainwright AC, Steven MM (1986) Relationship between iron deposits and tissue damage in the synovium: an ultrastructural study. Ann Rheum Dis 45:21–26PubMedCrossRefGoogle Scholar
  44. 44.
    Niibayashi H, Shimizu K, Suzuki K, Yamamoto S, Yasuda T, Yamamuro T (1995) Proteoglycan degradation in hemarthrosis. Intraarticular, autologous blood injection in rat knees. Acta Orthop Scand 66:73–79PubMedCrossRefGoogle Scholar
  45. 45.
    Noyes FR, Bassett RW, Grood ES, Butler DL (1980) Arthroscopy in acute traumatic hemarthrosis of the knee. Incidence of anterior cruciate tears and other injuries. J Bone Joint Surg [Am] 62:687–695Google Scholar
  46. 46.
    Okada Y, Nakanishi I, Munehiro C, Umeda S, Ichizen H, Duda S (1984) The presence of siderosomes in synovioblasts (B cells) of chronic spontaneous hemarthrosis. Histologic, electron microscopic, and roentgenographic electron microanalysis studies of three cases. Arch Pathol Lab Med 108:968–972PubMedGoogle Scholar
  47. 47.
    Otto JC (1803) An account of an hemorrhagic disposition existing in certain families. Medical Repository 6:1–4Google Scholar
  48. 48.
    Parsons JR, Zingler BM, McKeon JJ (1987) Mechanical and histological studies of acute joint hemorrhage. Orthopedics 10:1019–1026PubMedGoogle Scholar
  49. 49.
    Ris H-B, Klaiber C (1989) Hemarthrosis of the ankle secondary to false aneurysm caused by impingement from an osteophyte. A case report. J Bone Joint Surg [Am] 71:935–937Google Scholar
  50. 50.
    Rodriguez-Merchán EC (1998) Management of the orthopaedic complications of haemophilia. J Bone Joint Surg [Br] 80:191–196Google Scholar
  51. 51.
    Roosendahl G, Vianen ME, van den Berg HM, Lafeber FPJG, Bijlsma JWJ (1997) Cartilage damage as a result of hemarthrosis in a human in vitro model. J Rheumatol 24:1350–1354Google Scholar
  52. 52.
    Roosendahl G, Vianen ME, vd Berg HM, Lafeber FPJG, Bijlsma JWJ (1997) Effect of blood on cartilage: A canine in vivo and in vitro study. Blood (Suppl 1) 90:48b (Abstr 2913)Google Scholar
  53. 53.
    Roosendahl G, Vianen ME, Wenting MJG, van Rinsum AC, van den Berg HM, Lafeber FPJG, Bijlsma JWJ (1998) Iron deposits and catabolic properties of synovial tissue from patients with haemophilia. J Bone Joint Surg [Br] 80:540–545CrossRefGoogle Scholar
  54. 54.
    Rosner SM, Bhogal RS (1981) Infectious arthritis in a hemophilic. J Rheumatol 8:519–521PubMedGoogle Scholar
  55. 55.
    Roy S (1968) Ultrastructure of articular cartilage in experimental hemarthrosis. Arch Pathol 86:69–76PubMedGoogle Scholar
  56. 56.
    Roy S, Ghadially FN (1967) Ultrastructure of synovial membrane in human hemarthrosis. J Bone Joint Surg [Am] 49:1636–1646Google Scholar
  57. 57.
    Safran MR, Johnston-Jones K, Kabo JM, Meals RA (1994) The effect of experimental hemarthrosis on joint stiffness and synovial histology in a rabbit model. Clin Orthop 303:280–288PubMedGoogle Scholar
  58. 58.
    Schramm W (1992) Todesursachen und Aids-Erkrankungen Hämophiler in der Bundesrepublik Deutschland (Umfrageergebnisse September 1992). In: Scharrer I, Schramm W (Hrsg) 23. Hämophilie-Symposion Hamburg 1992. Springer, Berlin Heidelberg New York London Paris Tokyo Hong Kong Barcelona Budapest, S 9–14Google Scholar
  59. 59.
    Siame JL, DuQuesnoy B, Thevenon A, Delcambre B (1981) Hemarthrosis and thrombocythemia. J Rheumatol 8: 521–522PubMedGoogle Scholar
  60. 60.
    Speer DP (1984) Early pathogenesis of hemophilic arthropathy. Evolution of the subchondral cyst. Clin Orthop 185:250–265PubMedGoogle Scholar
  61. 61.
    Sugita K, Sato T, Nakajima H (1987) Effects of pH and hypoglycemia on bilirubin cytotoxicity in vitro. Biol Neonate 52:22–25PubMedCrossRefGoogle Scholar
  62. 62.
    Tate GA, Schumacher HR, Reginato AJ, Algeo SB, Gratwick GM, Di Battista WT (1992) Synovial fluid crystals derived from erythrocyte degradation products. J Rheumatol 19:1111–1114PubMedGoogle Scholar
  63. 63.
    Tessier JE, Salimi Z, Restrepo GL, Samuels LD, Joist JH (1988) Experimental hemarthrosis in dogs: Progressive synovitis monitored with technetium-99m pyrophosphate joint imaging. Haemostasis 18:83–90PubMedGoogle Scholar
  64. 64.
    Thakker S, McGehee W, Quismorio FP (1986) Arthropathy associated with factor XIII deficiency. Arthritis Rheum 29:808–811PubMedCrossRefGoogle Scholar
  65. 65.
    Thaler MM (1971) Bilirubin toxicity in hepatoma cells. Nature 230:218–219Google Scholar
  66. 66.
    Tilmann (1900) Zur Frage der Blutergelenke. Dtsch Ärztezeitung, S 421–424Google Scholar
  67. 67.
    Tuddenham EGD, Schwaab R, Seehafer J et al. (1994) Haemophilia A: database of nucleotide substitutions, deletions, insertions and rearrangements of the factor VIII gene, second edition. Nucleic Acids Res 22:3511–3533PubMedCrossRefGoogle Scholar
  68. 68.
    van’t Veer C, Golden NJ, Kalafatis M, Simioni P, Bertina RM, Mann KG (1997) An in vitro analysis of the combination of hemophilia A and factor vLEIDEN. Blood 90:3067–3072Google Scholar
  69. 69.
    Vassilopoulou-Sellin R, Oyedeji CO, Samaan NA (1989) Bilirubin inhibits cartilage metabolism and growth in vitro. Metabolism 38:759–762PubMedCrossRefGoogle Scholar
  70. 70.
    Wennberg RP (1991) Cellular basis of bilirubin toxicity. N Y State J Med 91:493–496PubMedGoogle Scholar
  71. 71.
    Wild JH, Zvaifler NJ (1976) Hemarthrosis associated with sodium warfarin therapy. Arthritis Rheum 19:98–102PubMedCrossRefGoogle Scholar
  72. 72.
    Wilkins RM, Wiedel JD (1983) Septic arthritis of the knee in a hemophiliac. J Bone Joint Surg [Am] 65:267–268Google Scholar
  73. 73.
    Zeman DH, Roberts ED, Shoji H, Miwa T (1991) Experimental haemarthrosis in Rhesus monkeys: Morphometric, biochemical and metabolic analyses. J Comp Pathol 104:129–139PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2000

Authors and Affiliations

  • Winfried Mohr
    • 1
  1. 1.Universität Ulm Abt. PathologieUlmGermany

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