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Tumor Biology of Mucosa-Associated Lymphoid Tissue Lymphomas

  • Conference paper
Gastrointestinal Lymphoma

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 156))

Abstract

Extranodal lymphomas arising at mucosal sites exhibit clinicopathological features that suggest a closer relationship of these tumors to the structure and function of mucosa-associated lymphoid tissue (MALT) than to lymph nodes. The factors that induce MALT in these tissues are operative in early MALT lymphoma development and the progressive independence on T-cell help defines late stages of MALT lymphoma genesis.

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References

  1. Banchereau J, Bazan F, Blanchard D, Briere F, Galizzi JP, van Kooten C, Liu YJ, Rousset F, Saeland S (1994) The CD40 antigen and its ligand. Annu Rev Immunol 12:881–922

    Article  PubMed  CAS  Google Scholar 

  2. Bayerdorffer E, Neubauer A, Rudolph B, Thiede C, Lehn N, Eidt S, Stolte M (1995) Regression of primary gastric lymphoma of mucosa-associated lymphoid tissue type after cure of Helicobacter pylori infection. MALT Lymphoma Study Group. Lancet 345:1591–1594

    CAS  Google Scholar 

  3. Caligaris Cappio F (1996) B-chronic lymphocytic leukemia: a malignancy of anti-self B cells. Blood 87:2615–2620

    PubMed  CAS  Google Scholar 

  4. Cyster JG, Goodnow CC (1995) Antigen-induced exclusion from follicles and anergy are separate and complementary processes that influence peripheral B cell fate. Immunity 3:691–701

    Article  PubMed  CAS  Google Scholar 

  5. Du M, Diss TC, Xu C, Peng H, Isaacson PG, Pan L (1996) Ongoing mutation in MALT lymphoma Immunoglobulin gene suggests that antigen stimulation plays a role in the clonal expansion. Leukemia 10:1190–1197

    PubMed  CAS  Google Scholar 

  6. Dunn Walters DK, Isaacson PG, Spencer J (1995) Analysis of mutations in immunoglobulin heavy chain variable region genes of microdissected marginal zone (MGZ) B cells suggests that the MGZ of human spleen is a reservoir of memory B cells. J Exp Med 182:559–566

    Article  PubMed  CAS  Google Scholar 

  7. Enno A, O’Rourke JL, Howlett CR, Jack A, Dixon MF, Lee A (1995) MALToma-like lesions in the murine gastric mucosa after long-term infection with Helicobacter felis. A mouse model of Helicobacter pylori-induced gastric lymphoma. Am J Pathol 147:217–222

    CAS  Google Scholar 

  8. Eris JM, Basten A, Brink R, Doherty K, Kehry MR, Hodgkin PD (1994) Anergic self-reactive B cells present self antigen and respond normally to CD40-dependent T-cell signals but are defective in antigen-receptor-mediated functions. Proc Natl Acad Sci USA 91:4392–4396

    Article  PubMed  CAS  Google Scholar 

  9. Fischbach W, Tacke W, Greiner A, Müller Hermelink HK (1997) Regression of immunoproliferative small intestinal disease after eradication of Helicobacter pylori. Lancet 349:31–32

    Article  PubMed  CAS  Google Scholar 

  10. Fisher GH, Rosenberg FJ, Straus SE, Dale JK, Middleton LA, Lin AY, Strober W, Lenardo MJ, Puck JM (1995) Dominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome. Cell 81:935–946

    Article  PubMed  CAS  Google Scholar 

  11. Galibert L, Burdin N, de Saint Vis B, Garrone P, van Kooten C, Banchereau J, Rousset F (1996) CD40 and B cell antigen receptor dual triggering of resting B lymphocytes turns on a partial germinal center phenotype. J Exp Med 183:77–85

    Article  PubMed  CAS  Google Scholar 

  12. Gause WC, Halvorson MJ, Lu P, Greenwald R, Linsley P, Urban JF, Finkelman FD (1997) The function of costimulatory molecules and the development of IL-4 producing T cells. Immunol Today 18:115–120

    Article  PubMed  CAS  Google Scholar 

  13. Goodnow CC (1996) Balancing immunity and tolerance: deleting and tuning lymphocyte repertoires. Proc Natl Acad Sci USA 93:2264–2271

    Article  PubMed  CAS  Google Scholar 

  14. Goodnow CC, Cyster JG, Hartley SB, Bell SE, Cooke MP, Healy JI, Akkaraju S, Rathmell JC, Pogue SL, Shokat KP (1995) Self-tolerance checkpoints in B lymphocyte development. Adv Immunol 59:279–368

    Article  PubMed  CAS  Google Scholar 

  15. Greiner A, Knorr C, Qin Y, Schultz A, Marx A, Kroczek RA, Müller Hermelink HK (1998) CD40 Ligand and Autoantigen are involved in the pathogenesis of low-grade Bcell lymphomas of mucosa-associated lymphoid tissue (MALT-type). Dev Immunol 6:187–195

    Article  PubMed  CAS  Google Scholar 

  16. Greiner A, Knorr C, Qin Y, Sebald W, Schimpl A, Banchereau J, Müller Hermelink HK (1997) Low-grade B cell lymphomas of mucosa-associated lymphoid tissue (MALT-type) require CD40-mediated signaling and Th2-type cytokines for in vitro growth and differentiation. Am J Pathol 150:1583–1593

    PubMed  CAS  Google Scholar 

  17. Greiner A, Marx A, Heesemann J, Leebmann J, Schmausser B, Müller Hermelink HK (1994) Idiotype identity in a MALT-type lymphoma and B cells in Helicobacter pylori associated chronic gastritis. Lab Invest 70:572–578

    PubMed  CAS  Google Scholar 

  18. Ho WY, Cooke MP, Goodnow CC, Davis MM (1994) Resting and anergic B cells are defective in CD28-dependent costimulation of naive CD4+ T cells. J Exp Med 179:1539–1549

    Article  PubMed  CAS  Google Scholar 

  19. Hussell T, Isaacson PG, Crabtree JE, Dogan A, Spencer J (1993a) Immunoglobulin specificity of low-grade B cell gastrointestinal lymphoma of mucosa-associated lymphoid tissue (MALT) type. Am J Pathol 142:285–292

    PubMed  CAS  Google Scholar 

  20. Hussell T, Isaacson PG, Spencer J (1993b) Proliferation and differentiation of tumor cells from B-cell lymphoma of mucosa-associated lymphoid tissue in vitro. J Pathol 169:221–227

    Article  PubMed  CAS  Google Scholar 

  21. Hyjek E, Isaacson PG (1988) Primary B cell lymphoma of the thyroid and its relationship to Hashimoto’s thyroiditis. Hum Pathol 19:1315–1326

    Article  PubMed  CAS  Google Scholar 

  22. Hyjek E, Smith WJ, Isaacson PG (1988) Primary B-cell lymphoma of salivary glands and its relationship to myoepithelial sialadenitis. Hum Pathol 19:766–776

    Article  PubMed  CAS  Google Scholar 

  23. Isaacson PG, Wright DH (1983) Malignant lymphoma of mucosa-associated lymphoid tissue A distinctive type of B-cell lymphoma. Cancer 52:1410–1416

    Article  PubMed  CAS  Google Scholar 

  24. Jacobson BA, Panka DJ, Nguyen KA, Erikson J, Abbas AK, Marshak Rothstein A (1995) Anatomy of autoantibody production: dominant localization of antibody-producing cells to T cell zones in Fas-deficient mice. Immunity 3:509–519

    Article  PubMed  CAS  Google Scholar 

  25. Korthauer U, Graf D, Mages HW, Briere F, Padayachee M, Malcolm S, Ugazio AG, Notarangelo LD, Levinsky RJ, Kroczek RA (1993) Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM. Nature 361:539–541

    Article  PubMed  CAS  Google Scholar 

  26. Liu YJ, Barthelemy C, Bouteiller O de, Arpin C, Durand I, Banchereau J (1995) Memory B cells from human tonsils colonize mucosal epithelium and directly present antigen to T cells by rapid up-regulation of B7-1 and B7-2. Immunity 2:239–248

    Article  PubMed  CAS  Google Scholar 

  27. MacLennan IC (1994) Germinal centers. Annu Rev Immunol 12:117–139

    Article  PubMed  CAS  Google Scholar 

  28. Negrini R, Savio A, Poiesi C, Appelmelk BJ, Buffoli F, Paterlini A, Cesari P, Graffeo M, Vaira D, Franzin G (1996) Antigenic mimicry between Helicobacter pylori and gastric mucosa in the pathogenesis of body atrophic gastritis. Gastroenterology 111:655–665

    Article  PubMed  CAS  Google Scholar 

  29. Papadaki L, Wotherspoon AC, Isaacson PG (1992) The lymphoepithelial lesion of gastric low-grade B-cell lymphoma of mucosa-associated lymphoid tissue (MALT): an ultrastructural study. Histopathology 21:415–421

    Article  PubMed  CAS  Google Scholar 

  30. Pavlidis NA, Klouvas G, Tsokos M, Bai M, Moutsopoulos HM (1995) Cutaneous lymphocytic vasculopathy in lymphoproliferative disorders — a paraneoplastic lymphocytic vasculitis of the skin. Leuk Lymphoma 16:477–482

    Article  PubMed  CAS  Google Scholar 

  31. Qin Y, Greiner A, Hallas C, Haedicke W, Müller Hermelink HK (1997) Intraclonal offspring expansion of gastric low-grade MALT-type lymphoma: evidence for the role of antigen-driven high-affinity mutation in lymphomagenesis. Lab Invest 76:477–485

    PubMed  CAS  Google Scholar 

  32. Qin Y, Greiner A, Trunk MJ, Schmausser B, Ott MM, Müller Hermelink HK (1995) Somatic hypermutation in low-grade mucosa-associated lymphoid tissue-type B-cell lymphoma. Blood 86:3528–3534

    PubMed  CAS  Google Scholar 

  33. Rathmell JC, Cooke MP, Ho WY, Grein J, Townsend SE, Davis MM, Goodnow CC (1995) CD95 (Fas)-dependent elimination of self-reactive B cells upon interaction with CD4+ T cells. Nature 376:181–184

    Article  PubMed  CAS  Google Scholar 

  34. Santana V, Rose NR (1992) Neoplastic lymphoproliferation in autoimmune disease: an updated review. Clin Immunol Immunopathol 63:205–213

    Article  PubMed  CAS  Google Scholar 

  35. Schroder AE, Greiner A, Seyfert C, Berek C (1996) Differentiation of B cells in the nonlymphoid tissue of the synovial membrane of patients with rheumatoid arthritis. Proc Natl Acad Sci USA 93:221–225

    Article  PubMed  CAS  Google Scholar 

  36. Sprent J (1994) T and B memory cells. Cell 76:315–322

    Article  PubMed  CAS  Google Scholar 

  37. Wallace WA, Howie SE, Krajewski AS, Lamb D (1996) The immunological architecture of B-lymphocyte aggregates in cryptogenic fibrosing alveolitis. J Pathol 178:323–329

    Article  PubMed  CAS  Google Scholar 

  38. Wotherspoon AC, Doglioni C, Diss TC, Pan L, Moschini A, de Boni M, Isaacson PG (1993) Regression of primary low-grade B-cell gastric lymphoma of mucosa-associated lymphoid tissue type after eradication of Helicobacter pylori. Lancet 342:575–577

    Article  PubMed  CAS  Google Scholar 

  39. Wotherspoon AC, Ortiz Hidalgo C, Falzon MR, Isaacson PG (1991) Helicobacter pyloriassociated gastritis and primary B-cell gastric lymphoma. Lancet 338:1175–1176

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Institut für Pathologie, Universität Würzburg, Josef-Schneider Straße 2, 97080, Würzburg, Germany

    A. Greiner, C. Knörr, H. Seeberger, A. Schultz & H. K. Müller-Hermelink

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  1. A. Greiner
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  2. C. Knörr
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  3. H. Seeberger
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  4. A. Schultz
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  5. H. K. Müller-Hermelink
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Editors and Affiliations

  1. Klinikum Aschaffenburg Akademisches Lehrkrankenhaus der, Universität Würzburg Medizinische Klinik II, Am Hasenkopf 1, 63739, Aschaffenburg, Germany

    Wolfgang Fischbach

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© 2000 Springer-Verlag Berlin Heidelberg

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Greiner, A., Knörr, C., Seeberger, H., Schultz, A., Müller-Hermelink, H.K. (2000). Tumor Biology of Mucosa-Associated Lymphoid Tissue Lymphomas. In: Fischbach, W. (eds) Gastrointestinal Lymphoma. Recent Results in Cancer Research, vol 156. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-57054-4_3

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  • DOI: https://doi.org/10.1007/978-3-642-57054-4_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-62984-6

  • Online ISBN: 978-3-642-57054-4

  • eBook Packages: Springer Book Archive

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