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Chromosomopathien

  • Karl Sperling
  • Heidemarie Neitzel
Part of the Handbuch der Molekularen Medizin book series (HDBMOLEK, volume 7)

Zusammenfassung

Die Darstellung der ersten menschlichen Chromosomen reicht bereits in das vergangene Jahrhundert zurück, aber erst im Jahr 1956 konnte die genaue Diploidzahl mit 2 n = 46 bestimmt werden. Inzwischen gilt, dass von keiner Spezies mehr Chromosomenanalysen durchgeführt wurden als vom Menschen. Allein in Deutschland dürften es jßhrlich mehr als 100000 Untersuchungen sein. Die Entwicklung der Humanzytogenetik ist damit ein Beispiel für die enge Verknüpfung von methodischem und wissenschaftlichem Fortschritt. Heute ist es sogar möglich, im Lichtmikroskop durch die Technik der In-situ-Hybridisierung einzelne Gene und sogar Basenaustausche nachzuweisen, wodurch die Zytogenetik unmittelbaren Anschluss an die molekulare Genetik bzw. die molekulare Medizin gewonnen hat.

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© Springer-Verlag Berlin Heidelberg 2000

Authors and Affiliations

  • Karl Sperling
  • Heidemarie Neitzel

There are no affiliations available

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