Abstract
Atherosclerosis accounts for about half of both morbidity and mortality in Western countries; its pathogenesis, however, is only incompletely understood. Cardiovascular risk factors such as hyperlipidemia, hypertension, diabetes mellitus and tobacco consumption are associated with atherogenesis. These risk factors induce progressive vascular injury and lead to vascular dysfunction resulting in atherosclerotic changes (Ross 1993). Features of dysfunctional arteries include platelet activation and aggregation, monocyte adhesion and invasion, vascular smooth muscle cell (VSMC) proliferation and migration, insudation of lipid substances and formation of extracellular matrix (Fig. 4.1). Accumulation of VSMC and monocytes, as well as deposition of matrix and lipids, indeed represent the main features of neointima formation during atherogenesis (Ross 1993).
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Tanner, F.C., Lüscher, T.F. (2000). Pathophysiology of Intimal Hyperplasia. In: Zeitler, E. (eds) Radiology of Peripheral Vascular Diseases. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56956-2_4
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DOI: https://doi.org/10.1007/978-3-642-56956-2_4
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