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Purinergic and Pyrimidinergic Signalling II pp 281–300Cite as

P2 Receptors in the Respiratory System

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 151 / 2))

Abstract

As in other tissues, it is now well established that nucleotides are released into the extracellular fluid of the respiratory tract during normal homeostatic as well as pathologic conditions to act on cell surface P2 purinergic receptors. Both the ligand gated ion channel P2X subtype and the G-protein coupled P2Y subtype have been identified and shown to provide important regulatory functions in essentially all cell components of the respiratory system. Taken together these functions appear to enhance respiratory host defense by accelerating mucociliary clearance, facilitating inflammation and possibly aiding tissue repair. The evidence that supports each of these functions is reviewed below.

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  1. Skokie Discovery Biology, Pharmacia Discovery Research, 4901 Searle Parkway, Room J-322A, Skokie, Illinois, 60077, USA

    C. D. Wegner

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  1. Institute of Pharmacological Sciences, University of Milan, Via Balzaretti, 9, 20133, Milan, Italy

    Maria Pia Abbracchio

  2. Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Medical School, Searle 8-477 (S-215) 303 East Chicago Avenue, Chicago, IL, 60611

    Michael Williams

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Wegner, C.D. (2001). P2 Receptors in the Respiratory System. In: Abbracchio, M.P., Williams, M. (eds) Purinergic and Pyrimidinergic Signalling II. Handbook of Experimental Pharmacology, vol 151 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56921-0_8

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  • DOI: https://doi.org/10.1007/978-3-642-56921-0_8

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