Abstract
Purines can influence motility secretion and absorption in a variety of direct and indirect ways. They can be released from intrinsic enteric nerves, sympathetic nerves, or sensory-motor nerves during axon reflexes, to act directly on smooth muscle purinoceptors mediating relaxation or contraction or on epithelial cell receptors. They can act on prejunctional nerve terminals to modify transmitter release from motor and inhibitory neural control pathways. They can participate in synaptic transmission in myenteric and submucosal ganglia that are involved in control of gastrointestinal motility, mucosal secretion and absorption. They can act on blood vessels or interstitial cells of Cajal thereby indirectly modulating motility patterns. They can act on sensory nerve endings in the gut wall to initiate local and/or central reflex activity that alters gastrointestinal motility and secretory patterns.
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Burnstock, G. (2001). Purinergic Signalling in Gut. In: Abbracchio, M.P., Williams, M. (eds) Purinergic and Pyrimidinergic Signalling II. Handbook of Experimental Pharmacology, vol 151 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56921-0_6
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