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Role of P2 Receptors in the Immune System

  • Chapter
Purinergic and Pyrimidinergic Signalling II

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 151 / 2))

Abstract

In many tissues, stressed or damaged cells can locally release nucleotides which, in turn, activate autocrine or paracrine signaling cascades that permit those tissues to adapt to the particular stress or injury that precipitated the release of cellular nucleotides (Schwiebert 1999). In complex organisms, the introduction of foreign material — living or nonliving — into any organ or tissue constitutes a major stress that triggers the powerful adaptive responses of the immune system. Pathogenic microorganisms that injure or kill cells of the host organism often elicit these responses. In turn, the response of the host organism often involves the killing and removal of the invading microorganisms. The immune system also provides a surveillance mechanism for identifying and eliminating any host cells that might be irreversibly damaged or diseased.

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Authors and Affiliations

  1. Department of Physiology and Biophysics, Case Western Reserve University, School of Medicine, Cleveland, Ohio, 44106, UK

    G.R. Dubyak

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  1. Institute of Pharmacological Sciences, University of Milan, Via Balzaretti, 9, 20133, Milan, Italy

    Maria Pia Abbracchio

  2. Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Medical School, Searle 8-477 (S-215) 303 East Chicago Avenue, Chicago, IL, 60611

    Michael Williams

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Dubyak, G. (2001). Role of P2 Receptors in the Immune System. In: Abbracchio, M.P., Williams, M. (eds) Purinergic and Pyrimidinergic Signalling II. Handbook of Experimental Pharmacology, vol 151 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56921-0_10

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  • DOI: https://doi.org/10.1007/978-3-642-56921-0_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-67848-9

  • Online ISBN: 978-3-642-56921-0

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