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Cell Signaling by Endothelin Peptides

  • Chapter
Endothelin and Its Inhibitors

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 152))

Abstract

Endothelin (ET) peptides are surprisingly multifunctional. They control diverse physiological events such as vascular tone, cardiac, pulmonary, and renal function. Endothelins also direct phenotypic functions including cell growth, development, and differentiation. ET receptors control these events by evoking a complex, integrated network of signaling pathways. ET signaling has emerged as an important model for understanding how G protein-coupled receptors function in physiology and pathophysiology, particularly for those signals that regulate the genome.

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Authors
  1. M. S. Simonson
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  1. Department of Cardiac, Vascular and Inflammation Research, The William Harvey Research Institute St. Barthomew’s and the Royal London School of Medicine and Dentistry, Charterhouse Square, London, EC1M 6BQ, UK

    Timothy D. Warner Ph.D

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Simonson, M.S. (2001). Cell Signaling by Endothelin Peptides. In: Warner, T.D. (eds) Endothelin and Its Inhibitors. Handbook of Experimental Pharmacology, vol 152. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56899-2_5

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  • DOI: https://doi.org/10.1007/978-3-642-56899-2_5

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