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Vascular and Cardiac Effects of Endothelin

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Endothelin and Its Inhibitors

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 152))

Abstract

Endothelin (ET)-1, the most potent mammalian vasoconstrictor identified to date, was originally characterized as a peptide capable of producing contractile responses that were both sustained and extremely resistant to wash-out (Yanagisawa et al. 1988). Subsequently, ET-1 has been shown to contract both resistance arterioles and venous tissue in addition to conduit arteries (venous tissue generally being more sensitive than arterial vessels; Brain et al. 1988, 1989; Borges et al. 1989b; Cocks et al. 1989; D’Orleans-Juste et al. 1989). Furthermore, since subthreshold concentrations of ET-1 augment the contractile actions of norepinephrine, 5-HT, and angiotensin II, it has been proposed that ET-1 also sensitizes vessels to the actions of other “classical” circulating neurohumoral factors (MacLean and McGrath 1990; Lerman et al. 1991; Nakayama et al. 1991).

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Authors
  1. S. A. Douglas
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  2. E. H. Ohlstein
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  1. Department of Cardiac, Vascular and Inflammation Research, The William Harvey Research Institute St. Barthomew’s and the Royal London School of Medicine and Dentistry, Charterhouse Square, London, EC1M 6BQ, UK

    Timothy D. Warner Ph.D

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Douglas, S.A., Ohlstein, E.H. (2001). Vascular and Cardiac Effects of Endothelin. In: Warner, T.D. (eds) Endothelin and Its Inhibitors. Handbook of Experimental Pharmacology, vol 152. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56899-2_16

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