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Endothelin and Its Inhibitors pp 323–356Cite as

The Involvement of Endothelins in Cerebral Vasospasm and Stroke

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 152))

Abstract

Endothelin-1 (ET-1) is a 21 amino acid peptide which has a high degree of structural homology with the other members of the ET family, ET-2 and ET-3 (Inoue et al. 1989; Yanagisawa et al. 1988). ET-1 is the most potent mammalian vasoconstrictor identified to date, being approximately one order of magnitude greater in potency than either angiotensin II, vasopressin or norepinephrine. The discovery of the existence of vasoconstrictor peptides of the endothelin family in the mid- to late 1980s, let to a great deal of excitement over their potential role in cardiovascular homeostasis and their possible therapeutic potential. The isolation, purification and sequencing of the endothelins has since allowed the development of both peptide and non peptide antagonists selective for endothelin receptors (see Chap. 9).

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Authors
  1. O. Touzani
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  2. J. McCulloch
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  1. Department of Cardiac, Vascular and Inflammation Research, The William Harvey Research Institute St. Barthomew’s and the Royal London School of Medicine and Dentistry, Charterhouse Square, London, EC1M 6BQ, UK

    Timothy D. Warner Ph.D

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Touzani, O., McCulloch, J. (2001). The Involvement of Endothelins in Cerebral Vasospasm and Stroke. In: Warner, T.D. (eds) Endothelin and Its Inhibitors. Handbook of Experimental Pharmacology, vol 152. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56899-2_13

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