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Histopathologische Differenzierung der Darmpolypen

  • Chapter
Molekularmedizinische Grundlagen von hereditären Tumorerkrankungen

Part of the book series: Molekulare Medizin ((MOLMED))

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Zusammenfassung

Bei einer Vielzahl hereditärer Syndrome des Magen-Darm-Trakts entwickeln sich Darmpolypen. Histopathologisch lassen sich grundsätzlich 3 Formen unterscheiden:

  1. 1.

    Syndrome mit epithelialen Polypen: Die epithelialen Polypen werden nochmals unterteilt in Neoplasien, d.h. die Adenome, und nichtneoplastische Formen, nämlich die hyperplastischen Polypen. Außerdem gibt es gemischte, adenomatös-hyperplastische Polypen bzw. Serrated Adenomas, die ebenfalls zu dem neoplastischen Typ der epithelialen Polypen gehören. Die meisten hereditären gastrointestinalen Syndrome sind mit der Entwicklung von Adenomen assoziiert. Polyposen, die mit der Entwicklung von hyperplastischen Polypen oder Serrated Adenomas einhergehen, sind sehr selten und zumeist nicht hereditär.

  2. 2.

    Syndrome mit hamartomatösen Polypen: Zu den hamartomatösen Polypen zählen Peutz-Jeghers-Polypen und juvenile Polypen. Sie sind durch die Proliferation und Disorganisation reifen ortsständigen Gewebes charakterisiert, wobei sowohl epitheliale als auch mesenchymale Elemente beteiligt sein können (Fenoglio-Preiser 1889 b). Hamartomatöse Polypen gelten nicht als neoplastisch, in ihnen können sich aber Neoplasien entwickeln (Foley et al. 1988).

  3. 3.

    Syndrome mit mesenchymalen Polypen: Die mesenchymalen Polypen können prinzipiell aus jedem Zelltyp des Mesenchyms (glatte Muskelzellen, Nervenzellen, Fettgewebezellen, Endothel usw.) hervorgehen. In Verbindung mit hereditären Syndromen wurden v.a. neurogene Polypen (Damiani et al. 1998, Shekitka u. Sobin 1994) und angiomatöse Polypen beschrieben (Sharma u. Howden 1998, Kjeldsen u. Kjeldsen 2000)

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Literatur

  • Arai T, Kino I (1995) Role of apoptosis in modulation of the growth of human colorectal tubular and villous adeno mas. J Pathol 176:37–44

    Article  PubMed  CAS  Google Scholar 

  • Boardman LA, Thibodeau SN, Schaid DJ et al. (1998) Increased risk for cancer in patients with the Peutz-Jeghers syndrome. Ann Intern Med 128:896–899

    PubMed  CAS  Google Scholar 

  • Borchard F, Heilmann KL, Hermanek P et al. (1991) Definition und klinische Bedeutung der Dysplasie im Verdauungstrakt. Ergebnisse einer Sitzung der Arbeitsgemeinschaft Gastroenterologische Pathologie der Deutsehen Gesellschaft für Pathologie am 25.11.1989 in Kronberg. Pathologe 12:50–56

    PubMed  CAS  Google Scholar 

  • Bosari S, Moneghini L, Graziani D et al. (1995) bcl-2 oncoprotein in colorectal hyperplastic polyps, adenomas, and adenocarcinomas. Hum Pathol 26:534–540

    Article  PubMed  CAS  Google Scholar 

  • Bosman FT (1999) The hamartoma-adenoma-carcinoma sequence. J Pathol 188:1–2

    Article  PubMed  CAS  Google Scholar 

  • Brensinger JD, Laken SJ, Luce MC et al. (1998) variable phenotype of familial adenomatous polyposis in pedigrees with 3′ mutation in the APC gene. Gut 43:548–552

    Article  PubMed  CAS  Google Scholar 

  • Burke AP, Sobin LH (1989) The pathology of Cronkhite-Canada polyps. A comparison to juvenile polyposis. Am J SurgPathol 13:940–946

    CAS  Google Scholar 

  • Burt RW, Samowitz WS (1996) Serrated adenomatous polyposis: a new syndrome? Gastroenterology 110:950–952

    Article  PubMed  CAS  Google Scholar 

  • Bussey HJ (1975) Familial polyposis coli: family studies, histopathology, differential diagnosis and results of treatment. Johns Hopkins University Press, Baltimore, pp 1–75

    Google Scholar 

  • Bussey HJ, Veale AM, Morson BC (1978) Genetics of gastrointestinal polyposis. Gastroenterology 74:1325–1330

    PubMed  CAS  Google Scholar 

  • Carney JA, Hayles AB (1977) Alimentary tract manifestations of multiple endocrine neoplasia, type 2b. Mayo Clin Proc 52:543–548

    PubMed  CAS  Google Scholar 

  • Cervoni L, Celli P, Tarantino R, Fortuna A (1995) Turcot’s syndrome: case report and review of the classification. J Neurooncol 23:63–66

    Article  PubMed  CAS  Google Scholar 

  • Chan TL, Yuen ST, Chung LP et al. (1999) Germline hMSH2 and differential somatic mutations in patients with Turcot’s syndrome. Genes Chromosomes Cancer 25:75–81

    Article  PubMed  CAS  Google Scholar 

  • Church JM, McGannon E, Null-Boiner S et al. (1992) Gastroduodenal polyps in patients with familial adenomatous polyposis. Dis Colon Rectum 35:1170–1173

    Article  PubMed  CAS  Google Scholar 

  • Cobum MC, Pricolo VE, DeLuca FG, Bland KI (1995) Malignant potential in intestinal juvenile polyposis syndromes. Ann Surg Oncol 2:386–391

    Article  Google Scholar 

  • Colton CG, Sivak MJ (1995) Flat adenomas and cancers. Gastrointest Endosc 42:182–184

    Article  PubMed  CAS  Google Scholar 

  • Cooper HS, Patchefsky AS, Marks G (1979) Adenomatous and carcinomatous changes within hyperplastic colonic epithelium. Dis Colon Rectum 22:152–156

    Article  PubMed  CAS  Google Scholar 

  • Cooper HS, Marshall C, Ruggerio F, Steplewski Z (1987) Hyperplastic polyps of the colon and rectum. An immunohistochemical study with monoclonal antibodies against blood groups antigens (sialosyl-Lea, Leb, Lex, Ley, A, B, H). Lab Invest 57:421–428

    PubMed  CAS  Google Scholar 

  • Corley DA, Uyeki TM, Cello JP (1997) Gastrointestinal bleeding and gastric outlet obstruction from Peutz-Jeghers polyposis. Diagnosis and treatment. West J Med 166:350–352

    PubMed  CAS  Google Scholar 

  • Daimaru Y, Kido H, Hashimoto H, Enjoji M (1988) Benign schwannoma of the gastrointestinal tract: a clinicopathologic andimmunohistochemical study. Hum Pathol 19:257–264

    Article  PubMed  CAS  Google Scholar 

  • Damiani S, Schildkraut P, Riguzzi P, Biasiucci A, Tardio ML, Eusebi V (1998) Gastrointestinal autonomie nerve tumor (GANT) associated with Von Recklinghausen’s disease. Pathologica 90:792–797

    PubMed  CAS  Google Scholar 

  • Deschner EE, Lipkin M (1975) Proliferative patterns in colonic mucosa in familial polyposis. Cancer 35:413–418

    Article  PubMed  CAS  Google Scholar 

  • Deschner EE, Raicht RF (1981) Kinetic and morphologic alterations in the colon of a patient with multiple polyposis. Cancer 47:2440–2445

    Article  PubMed  CAS  Google Scholar 

  • Dobbie Z, Spycher M, Hurliman R et al. (1994) Mutational analysis of the first 14 exons of the adenomatous polyposis coli (APC) gene. Eur J Cancer 30A:1709–1713

    Article  Google Scholar 

  • Driman DR (1994) Flat adenomas and flat carcinomas: do you see what I see? Gastrointest Endosc 40:106–109

    Article  PubMed  CAS  Google Scholar 

  • Elster K, Eidt H, Ottenjann R, Rosch W, Seifert E (1977) Drusenkörperzysten, eine polypoide Läsion der Magenschleimhaut. Dtsch Med Wochenschr 102:183–187

    Article  PubMed  CAS  Google Scholar 

  • Entius MM, Westerman AM, Velthuysen ML van et al. (1999) Molecular and phenotypic markers of hamartomatous polyposis syndromes in the gastrointestinal tract. Hepatogastroenterology 46:661–666

    PubMed  CAS  Google Scholar 

  • Fenoglio-Preiser C (1985) Tumors of the large and small intestine. Armed Forces Institute of Pathology, Washington, DC

    Google Scholar 

  • Fenoglio-Preiser CM (1989a) Epithelial and neuroendocrine tumors of the large intestine. In: Fenoglio-Preiser CM (Hrsg) Gastrointestinal pathology: an atlas and text. Raven Press, New York, pp 910–957

    Google Scholar 

  • Fenoglio-Preiser CM (1989b) Polyposis syndromes. In: Fenoglio-Preiser CM (Hrsg) Gastrointestinal pathology: an atlas and text. Raven Press, New York, pp 717–745

    Google Scholar 

  • Fernandes C, Silva A, Coelho A, Campos M, Pontes F (1999) Blue rubber bleb naevus: case report and literature review. Eur J Gastroenterol Hepatol 11:455–457

    Article  PubMed  CAS  Google Scholar 

  • Fluckiger R, Wegmann W, Huber A (1996) Tumor des gastrointestinalen autonomen Nervensystems (GAN-Tumor oder Plexosarkom). Chirurg 67:371–379

    PubMed  CAS  Google Scholar 

  • Foley TR, McGarrity TJ, Abt AB (1988) Peutz-Jeghers syndrome: a clinicopathologic survey of the “Harrisburg family” with a 49-year follow-up. Gastroenterology 95:1535–1540

    PubMed  CAS  Google Scholar 

  • Foulkes WD (1995) A tale of four syndromes: familial adenomatous polyposis, Gardner syndrome, attenuated APC and Turcot syndrome. QJM 88:853–863

    PubMed  CAS  Google Scholar 

  • Franzin G, Zamboni G, Scarpa A, Dina R, Iannucci A, Novelli P (1984) Hyperplastic (metaplastic) polyps of the colon. A histologic and histochemical study. Am J Surg Pathol 8:687–698

    Article  Google Scholar 

  • Fraser GM, Niv Y (1993) Hyperplastic polyp and colonic neoplasia. Is there an association? J Clin Gastroenterol 16:278–280

    Article  PubMed  CAS  Google Scholar 

  • Friedl W, Meuschel S, Caspari R et al. (1996) Attenuated familial adenomatous polyposis due to a mutation in the 3′ part of the APC gene. A clue for understanding the function of the APC protein. Hum Genet 97:579–584

    Article  PubMed  CAS  Google Scholar 

  • Fulcheri E, Baracchini P, Pagani A, Lapertosa G, Bussolati G (1991) Significance of the smooth muscle cell component in Peutz-Jeghers and juvenile polyps. Hum Pathol 22:1136–1140

    Article  PubMed  CAS  Google Scholar 

  • Giardiello FM, Welsh SB, Hamilton SR et al. (1987) Increased risk of cancer in the Peutz-Jeghers syndrome. N Engl J Med 316:1511–1514

    Article  PubMed  CAS  Google Scholar 

  • Grigioni WF, Alainpi G, Martinelli G, Piccaluga A (1981) Atypical juvenile polyposis. Histopathology 5:361–376

    Article  PubMed  CAS  Google Scholar 

  • Hamilton SR (1992) The adenoma-adenocarcinoma sequence in the large bowel: variations on a theme. J Cell Biochem [Suppl] 1992:41–46

    Article  Google Scholar 

  • Harach HR, Soubeyran I, Brown A, Bonneau D, Longy M (1999) Thyroid pathologic findings in patients with Cowden disease. Ann Diagn Pathol 3:331–340

    Article  PubMed  CAS  Google Scholar 

  • Hayashi T, Yatani R, Apostol J, Stemmermann GN (1974) Pathogenesis of hyperplastic polyps of the colon: a hypothesis based on ultrastructure and in vitro cell kinetics. Gastroenterology 66:347–356

    PubMed  CAS  Google Scholar 

  • Hemminki A (1999) The molecular basis and clinical aspects of Peutz-Jeghers syndrome. Cell Mol Life Sci 55:735–750

    Article  PubMed  CAS  Google Scholar 

  • Herrera GA, Moraes HP de (1984) Neurogenic sarcomas in patients with neurofibromatosis (von Recklinghausen’s disease). Light, electron microscopy, and immunohistochemistry study. Virchows Arch 403:361–376

    Article  CAS  Google Scholar 

  • Hiyama T, Yokozaki H, Shimamoto F et al. (1998) Frequent p53 gene mutations in serrated adenomas of the colorectum. J Pathol 186:131–139

    Article  PubMed  CAS  Google Scholar 

  • Hizawa K, Iida M, Matsumoto T et al. (1994) Gastrointestinal manifestations of Cowden’s disease. Report of four eases. J Clin Gastroenterol 18:13–18

    Article  PubMed  CAS  Google Scholar 

  • Howe JR, Mitros FA, Summers RW (1998) The risk of gastrointestinal carcinoma in familial juvenile polyposis. Ann Surg Oncol 5:751–756

    Article  PubMed  CAS  Google Scholar 

  • Hotting I, Pott G, Stolte M (1993) Das Syndrom der Juvenilen Polyposis. Leber Magen Darm 23:107–108, 111–112

    Google Scholar 

  • Iida M, Yao T, Itoh H et al. (1985) Natural history of fundic gland polyposis in patients with familial adenomatosis coli/Gardner’s syndrome. Gastroenterology 89:1021–1025

    PubMed  CAS  Google Scholar 

  • Ikeda Y, Mori M, Yoshizumi T, Sugimachi K (1999) Cancer and adenomatous polyp distribution in the colorectum. Am J Gastroenterol 94:191–193

    Article  PubMed  CAS  Google Scholar 

  • Iwashita A, Watanabe H, Enjoji M (1989) Argyrophil and argentaffin cells in adenomas of the colon and rectum. Fukuoka Igaku Zasshi 80:114–124

    PubMed  CAS  Google Scholar 

  • Jaramillo E, Watanabe M, Rubio C, Slezak P (1997) Small colorectal serrated adenomas: endoscopic findings. Endoscopy 29:1–3

    Article  PubMed  CAS  Google Scholar 

  • Jass JR (1999) Serrated adenoma and colorectal cancer. J Pathol 187:499–502

    Article  PubMed  CAS  Google Scholar 

  • Jass JR, Williams CB, Bussey HJ, Morson BC (1988) Juvenile polyposis — a precancerous condition. Histopathology 13:619–630

    Article  PubMed  CAS  Google Scholar 

  • Jeevaratnam P, Cottier DS, Browett PJ, Van De Water NS, Pokos V, Jass JR (1996) Familial giant hyperplastic polyposis predisposing to colorectal cancer: a new hereditary bowel cancer syndrome. J Pathol 179:20–25

    Article  PubMed  CAS  Google Scholar 

  • Kaye GI, Fenoglio CM, Pascal RR, Lane N (1973) Comparative electron microscopic features of normal, hyperplastic, and adenomatous human colonic epithelium. Variations in cellular structure relative to the process of epithelial differentiation. Gastroenterology 64:926–945

    PubMed  CAS  Google Scholar 

  • Kinzler KW, Vogelstein B (1998) Landscaping the cancer terrain. Science 280:1036–1037

    Article  PubMed  CAS  Google Scholar 

  • Kjeldsen AD, Kjeldsen J (2000) Gastrointestinal bleeding in patients with hereditary hemorrhagic teleangiectasia. Am J Gastroenterol 95:415–418

    Article  PubMed  CAS  Google Scholar 

  • Konishi F, Morson BC (1982) Pathology of colorectal adenomas: a colonoscopic survey. J Clin Pathol 35:830–841

    Article  PubMed  CAS  Google Scholar 

  • Kraus C, Gunther K, Vogler A, Hohenberger W, Pfeiffer RA, Ballhausen WG (1998) Rapid RT-PCR-based protein truncation test in the screening for 5′-located mutations of the APC gene. Mol Cell Probes 12:143–147

    Article  PubMed  CAS  Google Scholar 

  • Kubota O, Kino I (1995) Depressed adenomas of the colon in familial adenomatous polyposis. Histology, immunohistochemical detection of proliferating cell nuclear antigen (PCNA), and analysis of the background mucosa. Am J Surg Pathol 19:318–327

    Article  PubMed  CAS  Google Scholar 

  • Lin HJ, Tsai YT, Lee SD et al. (1987) The Cronkhite-Canada syndrome with focus on immunity and infection. Report of a case. J Clin Gastroenterol 9:568–570

    Article  PubMed  CAS  Google Scholar 

  • Lipkin M, Blattner WE, Fraumeni JF Jr, Lynch HT, Deschner E, Winawer S (1983) Tritiated thymidine (phi p, phi h) labeling distribution as a marker for hereditary predisposition to colon cancer. Cancer Res 43:1899–1904

    PubMed  CAS  Google Scholar 

  • Lloyd KM, Dennis M (1963) Cowden’s disease: a possible new syndrome with multiple system involvement. Ann Intern Med 58:136–142

    PubMed  Google Scholar 

  • Longacre TA, Fenoglio-Preiser CM (1990) Mixed hyperplastic adenomatous polyps/serrated adenomas. A distinct form of colorectal neoplasia. Am J SurgPathol 14:524–537

    CAS  Google Scholar 

  • Lorenz R, Gulotta U, Becker K, Bottermann P, Vogel GE, Classen M (1986) New observations in a case of Cronkhite-Canada syndrome. Z Gastroenterol 24:85–92

    PubMed  CAS  Google Scholar 

  • Lowichik A, White FV, Timmons CF et al. (2000) Bannayan-Riley-Ruvalcaba syndrome: spectrum of intestinal pathology including juvenile polyps. Pediatr Dev Pathol 3:155–161

    Article  PubMed  CAS  Google Scholar 

  • Lynch HT, Lynch JF (1998) Genetics of colonic cancer. Digestion 59:481–492

    Article  PubMed  CAS  Google Scholar 

  • Lynch HT, Smyrk T, McGinn T et al. (1995) Attenuated familial adenomatous polyposis (AFAP). A phenotypically and genotypically distinctive variant of FAR Cancer 76:2427–2433

    CAS  Google Scholar 

  • Malhotra R, Sheffield A (1988) Cronkhite-Canada syndrome associated with colon carcinoma and adenomatous changes in C-C polyps. Am J Gastroenterol 83:772–776

    PubMed  CAS  Google Scholar 

  • Marsh DJ, Dahia PL, Caron S et al. (1998a) Germline PTEN mutations in Cowden syndrome-like families. J Med Genet 35:881–885

    Article  PubMed  CAS  Google Scholar 

  • Marsh DJ, Dahia PL, Coulon Vet al. (1998b) Allelic imbalance, including deletion of PTEN/MMACI, at the Cowden disease locus on 10q22-23, in hamartomas from patients with Cowden syndrome and germline PTEN mutation. Genes Chromosomes Cancer 21:61–69

    Article  PubMed  CAS  Google Scholar 

  • McGarrity TJ, Kulin HE, Zaino RJ (2000) Peutz-Jeghers syndrome. Am J Gastroenterol 95:596–604

    Article  PubMed  CAS  Google Scholar 

  • Mendelsohn G, Diamond MP (1984) Familial ganglioneuromatous polyposis of the large bowel. Report of a family with associated juvenile polyposis. Am J Surg Pathol 8:515–520

    Article  PubMed  CAS  Google Scholar 

  • Michaels RD, Shakir KM (1993) Association of multinodular goiter with breast carcinoma: Cowden’s disease. J Endocrinol Invest 16:909–911

    PubMed  CAS  Google Scholar 

  • Miettinen M, Sarlomo-Rikala M, Lasota J (1998) Gastrointestinal stromal tumours. Ann Chir Gynaecol 87:278–281

    PubMed  CAS  Google Scholar 

  • Morson B (1976) Polyps and cancer of the large bowel. West J Med 125:93–99

    PubMed  CAS  Google Scholar 

  • Morson BC (1977) Polyps and cancer of the large bowel. In: Yardley JH (ed) The gastrointestinal tract. Williams & Wilkins, Baltimore, pp 101–108

    Google Scholar 

  • Muto T, Kamiya J, Sawada T et al. (1985) Small “flat adenoma” of the large bowel with special reference to its clinicopathologic features. Dis Colon Rectum 28:847–851

    Article  PubMed  CAS  Google Scholar 

  • Myers BM (1993) Treatment of colonic bleeding in Klippel-Trenaunay syndrome with combined partial colectomy and endoscopic laser. Dig Dis Sci 38:1351–1353

    Article  PubMed  CAS  Google Scholar 

  • Nucci MR, Robinson CR, Longo P, Campbell P, Hamilton SR (1997) Phenotypic and genotypic characteristics of aberrant crypt foci in human colorectal mucosa. Hum Pathol 28:1396–1407

    Article  PubMed  CAS  Google Scholar 

  • Paraf F, Sasseville D, Watters AK et al. (1995) Clinicopathological relevance of the association between gastrointestinal and sebaceous neoplasms: the Muir-Torre syndrome. Hum Pathol 26:422–427

    Article  PubMed  CAS  Google Scholar 

  • Pilarski RT, Brothman AR, Benn P, Shulman Rosengren S (1999) Attenuated familial adenomatous polyposis in a man with an interstitial deletion of chromosome arm 5q. Am J Med Genet 86:321–324

    Article  PubMed  CAS  Google Scholar 

  • Place RJ, Simmang CL (1999) Hyperplastic-adenomatous polyposis Syndrome. J Am Coll Surg 188:503–507

    Article  PubMed  CAS  Google Scholar 

  • Rappaport LB, Sperling HV, Stavrides A (1986) Colon cancer in the Cronkhite-Canada syndrome. J Clin Gastroenterol 8:199–202

    Article  PubMed  CAS  Google Scholar 

  • Rex DK, Alikhan M, Cummings O, Ulbright TM (1999) Accuracy of pathologic interpretation of colorectal polyps by general pathologists in community practice. Gastrointest Endosc 50:468–474

    Article  PubMed  CAS  Google Scholar 

  • Romao Z, Pontes J, Lopes H et al. (1999) Endosonography in the diagnosis of “blue rubber bleb nevus syndrome”: an uncommon cause of gastrointestinal tract bleeding. J Clin Gastroenterol 28:262–265

    Article  PubMed  CAS  Google Scholar 

  • Sawada T, Muto T (1995) Familial adenomatous polyposis: should patients undergo surveillance of the upper gastro intestinal tract? Endoscopy 27:6–11

    Article  PubMed  CAS  Google Scholar 

  • Schlemper RJ, Itabashi M, Kato Y et al. (1998) Differences in the diagnostic criteria used by Japanese and Western pathologists to diagnose colorectal carcinoma. Cancer 82:60–69

    Article  PubMed  CAS  Google Scholar 

  • Schlemper RJ, Borchard F, Dixon W et al. (2000) International comparability of the pathological diagnosis for early-cancer of the digestive tract: Munich meeting. J Gastroenterol [Suppl 12] 35:102–110

    Google Scholar 

  • Scully RE (1970) Sex cord tumor with annular tubules a distinctive ovarian tumor of the Peutz-Jeghers syndrome. Cancer 25:1107–1121

    Article  PubMed  CAS  Google Scholar 

  • Shanna VK, Howden CW (1998) Gastrointestinal and hepatic manifestations of hereditary hemorrhagic teleangiectasia. Dig Dis Sci 16:169–174

    Article  Google Scholar 

  • Shekitka KM, Sobin LH (1994) Ganglioneuromas of the gastrointestinal tract. Relation to Von Recklinghausen disease and other multiple tumor syndromes. Am J Surg Pathol 18:250–257

    Article  PubMed  CAS  Google Scholar 

  • Shepherd NA, Bussey HJ, Jass JR (1987) Epithelial displacement in Peutz-Jeghers polyps. A diagnostic pitfall. Am J Surg Pathol 11:743–749

    Article  PubMed  CAS  Google Scholar 

  • Shibata C, Sasaki I, Naito H et al. (1999) Turcot syndrome with colonic obstruction and small intestinal invagination: report of a case. Surg Today 29:785–788

    Article  PubMed  CAS  Google Scholar 

  • Soravia C, Berk T, Madlensky L et al. (1998) Genotype-phenotype correlations in attenuated adenomatous polyposis coli. Am J Hum Genet 62:1290–1301

    Article  PubMed  CAS  Google Scholar 

  • Spigelman AD, Arese P, Phillips RK (1995) Polyposis: the Peutz-Jeghers syndrome. Br J Surg 82:1311–1314

    Article  PubMed  CAS  Google Scholar 

  • Spiro L, Otterud B, Stauffer D (1992) Linkage of a variant or attenuated form of adenomatous polyposis coli to the adenomatous polyposis coli (APC) locus. Am J Hum Genet 51:92–95

    Google Scholar 

  • Stratakis CA, Kirschner LS, Taymans SE et al. (1998) Carney complex, Peutz-Jeghers syndrome, Cowden disease, and Bannayan-Zonana syndrome share cutaneous and endocrine manifestations, but not genetic loci. J Clin Endocrinol Metab 83:2972–2976

    Article  PubMed  CAS  Google Scholar 

  • Sumner NW, Wasserman NF, McClain CJ (1981) Giant hyperplastic polyposis of the colon. Dig Dis Sci 26:85–89

    Article  PubMed  CAS  Google Scholar 

  • Symonds D (1974) Paneth cell metaplasia in diseases of the colon and rectum. Arch Pathol 97:343–347

    PubMed  CAS  Google Scholar 

  • Teoh HH, Delahunt B, Isbister WH (1989) Dysplastic and malignant areas in hyperplastic polyps of the large intestine. Pathology 21:138–142

    Article  PubMed  CAS  Google Scholar 

  • Thomas HJ, Whitelaw SC, Cottrell SE et al. (1996) Genetic mapping of hereditary mixed polyposis syndrome to chromosome 6q. Am J Hum Genet 58:770–776

    PubMed  CAS  Google Scholar 

  • Torlakovic E, Snover DC (1996) Serrated adenomatous polyposis in humans. Gastroenterology 110:748–755

    Article  PubMed  CAS  Google Scholar 

  • UICC — International Union Against Cancer (1997) TNM classification of malignant tumours, 5th edn. Wiley, New York, pp 1–213

    Google Scholar 

  • Van der Luijt RB, Meera Khan P, Vasen HF et al. (1996) Germline mutations in the 3′ part of APC exon 15 do not result in truncated proteins and are associated with attenuated adenomatous polyposiscoli. Hum Genet 98:727–734

    Article  PubMed  Google Scholar 

  • Vogelstein B, Fearon ER, Hamilton SR et al. (1988) Genetic alterations during colorectal-tumor development. N Engl J Med 319:525–532

    Article  PubMed  CAS  Google Scholar 

  • Walon C, Kartheuser A, Michils G et al. (1997) Novel germline mutations in the APC gene and their phenotypic spectrum in familial adenomatous polyposis kindreds. Hum Genet 100:601–605

    Article  PubMed  CAS  Google Scholar 

  • Wang ZJ, Taylor F, Churchman M, Norbury G, Tomlinson I (1998) Genetic pathways of colorectal carcinogenesis rarely involve the PTEN and LKB1 genes outside the inherited hamartoma syndromes. Am J Pathol 153:363–366

    Article  PubMed  CAS  Google Scholar 

  • Wang ZJ, Ellis I, Zauber P et al. (1999) Allelic imbalance at the LKB1 (STK11) locus in tumours from patients with Peutz-Jeghers' syndrome provides evidence for a hamartoma-(adenorna)-carcinoma sequence. J Pathol 188:9–13

    Article  PubMed  CAS  Google Scholar 

  • Watanabe H, Enjoji M, Yao T, Iida M, Ohsato K (1977) Accompanying gastro-enteric lesions in familial adenomatosis coli. Acta Pathol Jpn 27:823–839

    PubMed  CAS  Google Scholar 

  • Watanabe H, Enjoji M, Yao T, Ohsato K (1978) Gastric lesions in familial adenomatosis coli: their incidence and histologic analysis. Hum Pathol 9:269–283

    Article  PubMed  CAS  Google Scholar 

  • Westerman AM, Van Velthuysen ML, Bac DJ, Schouten WR, Wilson JH (1997) Malignancy in Peutz-Jeghers syndrome? The pitfall of pseudo-invasion. J Clin Gastroenterol 25:387–390

    Article  PubMed  CAS  Google Scholar 

  • Whitelaw SC, Murday VA, Tomlinson IP et al. (1997) Clinical and molecular features of the hereditary mixed polyposis syndrome. Gastroenterology 112:327–334

    Article  PubMed  CAS  Google Scholar 

  • Williams GT, Arthur JF, Bussey HJR, Morson BC (1980) Metaplastic polyps and polyposis of the colorectum. Histopathology 4:155–170

    Article  PubMed  CAS  Google Scholar 

  • Wu TT, Rezai B, Rashid A et al. (1997) Genetic alterations and epithelial dysplasia in juvenile polyposis syndrome and sporadic juvenile polyps. Am J Pathol 150:939–947

    PubMed  CAS  Google Scholar 

  • Yao T, Kouzuki T, Kajiwara M, Matsui N, Oya M, Tsuneyoshi M (1999) “Serrated” adenoma of the colorectum, with reference to its gastric differentiation and its malignant potential. J Pathol 187:511–517

    Article  PubMed  CAS  Google Scholar 

  • Zigman AF, Lavine JE, Jones MC, Boland CR, Carethers JM (1997) Localization of the Bannayan-Riley-Ruvalcaba syndrome gene to chromosome 10q23. Gastroenterology 113:1433–1437

    Article  PubMed  CAS  Google Scholar 

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  1. Chirurgische Klinik und Poliklinik, Technische Universität München Klinikum rechts der Isar, Ismaninger Straße 22, 81675, München

    Dr. James Mueller & Dr. Elke Mueller

  2. Institut für Pathologie, Klinikum Bayreuth, Preuschwitzer Straße 101, 95445, Bayreuth

    Prof. Dr. Manfred Stolte

Authors
  1. Dr. James Mueller
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  2. Dr. Elke Mueller
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  3. Prof. Dr. Manfred Stolte
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Editors and Affiliations

  1. Max-Delbrück-Centrum für Molekulare Medizin (MDC), Robert-Rössle-Str. 10, 13122, Berlin-Buch

    Detlev Ganten  & Klaus Ruckpaul  & 

  2. Medizinische Universitätsklinik, Knappschaftskrankenhaus, In der Schornau 23-25, 44892, Bochum-Langendreer

    Stephan A. Hahn  & Wolff Schmiegel  & 

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© 2001 Springer-Verlag Berlin Heidelberg

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Mueller, J., Mueller, E., Stolte, M. (2001). Histopathologische Differenzierung der Darmpolypen. In: Ganten, D., Ruckpaul, K., Hahn, S.A., Schmiegel, W. (eds) Molekularmedizinische Grundlagen von hereditären Tumorerkrankungen. Molekulare Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56889-3_9

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  • DOI: https://doi.org/10.1007/978-3-642-56889-3_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-63219-8

  • Online ISBN: 978-3-642-56889-3

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