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Familiäres Nierenkarzinom

  • Chapter
Molekularmedizinische Grundlagen von hereditären Tumorerkrankungen

Part of the book series: Molekulare Medizin ((MOLMED))

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Zusammenfassung

Familiäre Nierenkarzinome kommen selten vor. Als Rarität erschienen sie zunächst ohne weitere Bedeutung. Im Verlauf der 80er und der 90er Jahre hat die wissenschaftliche Erforschung der hereditären Nierentumoren jedoch Meilensteine gesetzt: Es gelangen die Kartierung und in jüngster Zeit die Identifizierung von pathogenetisch relevanten Genen. Dies hat zu einem völlig neuen Verständnis der Entstehung aller, d.h. auch der sporadischen Nierenkarzinome geführt. Nierenkarzinome lassen sich somit nicht nur morphologisch, sondern in zunehmendem Maß auch molekularbiologisch charakterisieren. Inwieweit Therapieoptionen und Prognose auch unter diesen neuen Aspekten überdacht werden müssen, lässt sich allerdings bislang nur für hereditäre Nierenkarzinome sagen.

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  1. Albert-Ludwigs-Universität Medizinische Universitätsklinik, Abteilung Innere Medizin, Hugstetter Straße 55, 79106, Freiburg im Breisgau

    Prof. Dr. Hartmut P. H. Neumann

  2. Klinik für Allgemeinchirurgie, Martin-Luther-Universität Halle-Wittenberg, Ernst-Grube-Str. 40, 06097, Halle

    Dr. Oliver Gimm

  3. Friedrich-Miescher-Institut, Maulbeerstraße 66, 4058, Basel, Schweiz

    Dr. Wilhelm Krek

  4. Van Andel Research Institute, 333 Bostwick NE, Grand Rapids, MI, 49503, USA

    Prof. Dr. Bin Tean Teh

  5. Laboratory of Immunobiology, NCI-Frederick Cancer Research and Development Center, Building 560, Room 12-71, Frederick, Maryland, 21702, USA

    Prof. Dr. Berton Zbar

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Neumann, H.P.H., Gimm, O., Krek, W., Teh, B.T., Zbar, B. (2001). Familiäres Nierenkarzinom. In: Ganten, D., Ruckpaul, K., Hahn, S.A., Schmiegel, W. (eds) Molekularmedizinische Grundlagen von hereditären Tumorerkrankungen. Molekulare Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56889-3_17

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