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Familiäres Pankreaskarzinom

  • Detlef K. Bartsch
  • Matthias Rothmund
Part of the Molekulare Medizin book series (MOLMED)

Zusammenfassung

Pankreaskarziome sind in 85–90% der Fälle duktale Adenokarzinome, d.h. Tumoren, die aus den duktalen Zellen des adulten exokrinen Pankreas entstehen. Die duktalen Pankreaskarzinome stellen in zunehmenden Maß ein öffentliches Gesundheitsproblem dar. Ihre Inzidenz nahm von 1990–1995 zu, während bei nahezu allen anderen soliden Tumoren ein Rückgang zu verzeichnen war (Koch 1996). Die Häufigkeit des duktalen Pankreaskarzinoms beläuft sich auf etwa 11000 Neuerkrankungen pro Jahr in Deutschland und die Prognose ist mit einer 5-Jahres-Überlebensrate von <5% extrem schlecht (Robert-Koch-Institut 1995). Die Letalität des duktalen Pankreaskarzinoms entspricht nahezu seiner Inzidenz, wobei jeder 6. Krebstod in Deutschland inzwischen durch ein duktales Pankreaskarzinom verursacht wird. Allerdings werden von einigen Zentren 5-Jahres-Überlebensraten von bis zu 40% beschrieben, wenn eine Tumorresektion im UICC-Stadium 1 durch-geführt werden konnte (Yeo u. Cameron 1998).

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Copyright information

© Springer-Verlag Berlin Heidelberg 2001

Authors and Affiliations

  • Detlef K. Bartsch
    • 1
  • Matthias Rothmund
    • 2
  1. 1.Klinik für Allgemeinchirurgie Familiäre Pankreaskarzinome Nationale FallsammlungPhilipps-Universität MarburgMarburg
  2. 2.Klinik für AllgemeinchirurgiePhilipps-Universität MarburgMarburg

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