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Hereditäres nichtpolypöses kolorektales Karzinom (HNPCC)

  • Andreas Unger
  • Gabriela Möslein
Part of the Molekulare Medizin book series (MOLMED)

Zusammenfassung

Das kolorektale Karzinom ist in den westlichen Industrielandern eine der haufigsten Krebserkrankungen. In der Bundesrepublik Deutschland erkranken jahrlich >50000 Personen an Dickdarmkrebs; in den USA sind es etwa 160000 (Parker 1996). Eine Korrelation zwischen der Anzahl an einem kolorektalen Karzinom erkrankter Familienangehoriger und deren Alter bei der Diagnose und dem eigenen kolorektalen Karzinomrisiko fliefit in die WHO-Vorsorgeempfehlungen von 1995 ein (Tabelle 8.3.1).
Tabelle 8.3.1.

Risiken fur Angehorige von Patienten mit einem Kolonkarzinom, selbst daran zu erkranken

Verwandte

Risiko

1 erstgradig verwandter, >45 Jahre, betroffen

1:17

1 erstgradig und 1 zweitgradig Verwand ter betroffen

1:12

Infant mortality rate/lOOO

73

1 erstgradig Verwandter, <45 Jahre. betroffen

1:10

Life expectancy

62

2 erstgradig Verwandte betroffen

1:2

3 erstgradig Verwandte betroffen

1:2

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Copyright information

© Springer-Verlag Berlin Heidelberg 2001

Authors and Affiliations

  • Andreas Unger
    • 1
  • Gabriela Möslein
    • 1
  1. 1.Klinik für Allgemein- und UnfallchirurgieHeinrich-Heine-Universität DüsseldorfDüsseldorf

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