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Molekulare Grundlagen des Diabetes insipidus centralis und renalis

  • Chapter
Molekularmedizinische Grundlagen von Endokrinopathien

Part of the book series: Molekulare Medizin ((MOLMED))

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Zusammenfassung

Der Wasserhaushalt aller Primaten und Säugetiere unterliegt einer strengen Kontrolle: Eine Erhöhung der Plasmaosmolarität um <2% oder eine Verminderung des Plasmavolumens um <10% führen zu einer vermehrten Freisetzung des antidiuretischen Hormons (ADH). Da es bei Säugetieren zudem eine Gefäßverengung hervorruft, wird es auch als Vasopressin (AVP) bezeichnet. Diese Bezeichnung hat sich international durchgesetzt. AVP ist ein zyklisches Nonapeptid (Abb. 9.1), dessen Aminosäuresequenz bei fast allen Säugetieren identisch ist. Lediglich beim Schwein findet sich an Position 8 anstelle eines Arginin-ein Lysinrest (Tabelle 9.1). Bei den Reptilien, Amphibien und Wirbellosen wird der Wasserhaushalt ebenfalls über vasopressinähnliche Peptide reguliert.

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Authors
  1. Alexander Oksche
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  2. Walter Rosenthal
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  1. Max-Delbrück-Centrum für Molekulare Medizin (MDC), Robert-Rössle-Str. 10, 13122, Berlin-Buch, Deutschland

    Detlev Ganten  & Klaus Ruckpaul  & 

  2. Abteilung für Endokrinologie, Universitätsklinikum Essen Zentrum für Innere Medizin, Hufelandstraße 55, 45122, Essen, Deutschland

    Onno E. Janssen

  3. Zentrum für Innere Medizin Abteilung Endokrinologie und Diabetologie, Klinikum der Philipps-Universität, Baldingerstraße/Lahnberge, 35033, Marburg, Deutschland

    Armin E. Heufelder

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Oksche, A., Rosenthal, W. (2001). Molekulare Grundlagen des Diabetes insipidus centralis und renalis. In: Ganten, D., Ruckpaul, K., Janssen, O.E., Heufelder, A.E. (eds) Molekularmedizinische Grundlagen von Endokrinopathien. Molekulare Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56858-9_9

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