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Osteoporose

  • Chapter
Molekularmedizinische Grundlagen von Endokrinopathien

Part of the book series: Molekulare Medizin ((MOLMED))

Zusammenfassung

Das Skelettsystem ist der Stabilisator des Organismus und gleichzeitig ein großes Reservoir für die Aufrechterhaltung der Kalziumhomöostase und des Serumkalziumspiegels. Das „Material Knochen“ setzt sich aus anorganischen und organischen Bestandteilen zusammen, sein Aufbau, seine Erhaltung und seine Anpassung an veränderte Belastung werden durch Zellen aus 2 verschiedenen Geweben gewährleistet. Mesenchymale und myeloische Zellen regulieren den Knochen in einem komplizierten Zusammenspiel. Es resultiert ein Gewebe, das dem Leben unter dem Einfluss der Schwerkraft auf der Erde in allen Alltagssituationen gerecht wird. Mit dem Alter tritt bei allen Menschen ein als normal akzeptierter Verlust an Knochenmasse ein. Individuelle Disposition zu frühzeitigem Verlust an Knochenmasse bedingt einen frühzeitigen Funktionsverlust des Knochens und führt zur Brüchigkeit des Knochens auch unter Alltagsbedingungen.

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Literatur

  • Abu-Amer Y, Tondravi MM (1997) NF-κB and bone: the breaking point. Nat Med 3:1189–1190

    Article  PubMed  CAS  Google Scholar 

  • Adachi JD, Bensen WG, Bianchi F et al. (1996) Vitamin D and calcium in the prevention of corticosteroid induced osteoporosis: a 3 year followup. J Rheumatol 23:995–1000

    PubMed  CAS  Google Scholar 

  • Adachi JD, Bensen WG, Brown J et al. (1997) Intermittent etidronate therapy to prevent corticosteroid-induced osteoporosis. N Engl J Med 337:382–387

    Article  PubMed  CAS  Google Scholar 

  • Adamski J, Leenders F, Carstensen JF et al. (1997) Steroids, fatty acyl-CoA and sterols are substrates of 80 kDa multi-functional protein. Steroids 62:1–5

    Article  Google Scholar 

  • Ammann P, Rizzoli R, Bonjour JP et al. (1997) Transgenic mice expressing soluble tumor necrosis factor-receptor are protected against bone loss caused by estrogen deficiency. J Clin Invest 99:1699–1703

    Article  PubMed  CAS  Google Scholar 

  • Anderson FH, Francis RM, Selby PL, Cooper C (1998) Sex hormones and osteoporosis in men. Calcif Tissue Int 62:185–188

    Article  PubMed  CAS  Google Scholar 

  • Arai H, Miyamoto K-I, Taketani Y et al. (1997) A vitamin D receptor gene polymorphism in the translation initiation codon: effect on protein activity and relation to bone mineral density in Japanese women. J Bone Miner Res 12:915–921

    Article  PubMed  CAS  Google Scholar 

  • Avecilla LS (1998) Professional certification and site accreditation in bone densitometry. J Clin Densitometry 1:81–89

    Article  CAS  Google Scholar 

  • Avitabile M, Campagna NE, Magri GA et al. (1991) Correlation between serum glutathione reductases and bone densitometry values. Boll Soc Hai Biol Sper 67:931–937

    CAS  Google Scholar 

  • Balikian P, Burbank K, Houde J et al. (1998) Bone mineral density and broadband ultrasound attenuation with estrogen treatment of postmenopausal women. J Clin Densitometry 1:14–19

    Article  Google Scholar 

  • Bikle DD (1997) Biochemical markers in the assessment of bone disease. Am J Med 103:427–436

    Article  PubMed  CAS  Google Scholar 

  • Bilezikian JP (1998) Estrogens and postmenopausal osteoporosis: was Albright right after all? J Bone Miner Res 13:774–776

    Article  PubMed  CAS  Google Scholar 

  • Bilezikian JP, Morishima A, Bell J, Grumbach MM (1998) Increased bone mass as a result of estrogen therapy in a man with aromatase deficiency. N Engl J Med 339:599–603

    Article  PubMed  CAS  Google Scholar 

  • Blake GM, Gluer CC, Fogelman I (1997) Bone densitometry: current status and future prospects. Br J Radiol 70:S177–S186

    PubMed  Google Scholar 

  • Blake GM, Patel R, Fogelman I (1998) Peripheral or axial bone density measurements? J Clin Densitometry 1:55–64

    Article  CAS  Google Scholar 

  • Blumsohn A, Eastell R (1995) Age-related factors. In: Riggs BL, Melton LJ (eds) Osteoporosis. Lippincott-Raven, Philadelphia, pp 161–182

    Google Scholar 

  • Bodine PV, Henderson RA, Green J et al. (1998) Estrogen receptor-alpha is developmentally regulated during osteoblast differentiation and contributes to selective responsiveness of gene expression. Endocrinology 139:2048–2057

    Article  PubMed  CAS  Google Scholar 

  • Bowcock AM, Ray A, Erlich H, Sehgal PB (1989) Rapid detection and sequencing of alleles in the 3’flanking region of the interleukin-6 gene. Nucleic Acids Res 17:6855–6864

    Article  PubMed  CAS  Google Scholar 

  • Bucay N, Sarosi I, Dunstan CR et al. (1998) Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification. Genes Dev 12:1260–1268

    Article  PubMed  CAS  Google Scholar 

  • Buelke-Sam J, Bryant HU, Francis PC (1998) The selective estrogen receptor modulator, raloxifene: an overview of nonclinical pharmacology and reproductive and developmental testing. Reprod Toxicol 12:217–221

    Article  PubMed  CAS  Google Scholar 

  • Burstein AH, Reilly DT, Martens MJ (1976) Aging of bone tissue: mechanical properties. J Bone J Surg Am 57:82–86

    Google Scholar 

  • Caerzasio J, Palmer G, Bonjour JP (1998) Fluoride: mode of action. Bone 22:585–589

    Article  Google Scholar 

  • Canalis E (1996) Regulation of bone remodeling. In: Favus MJ (ed) Primer on the metabolie bone diseases and disorders of mineral metabolism. Lippincott-Raven, Philadelphia, pp 29–34

    Google Scholar 

  • Canalis E, Hock JM, Raisz LG (1994) Parathyroid hormone: anabolic and catabolic effects on bone and interactions with growth factors. In: Bilezikian JP, Marcus R, Levine MA (eds) The parathyroids. Raven Press, New York, pp 65–82

    Google Scholar 

  • Carani C, Qin K, Simoni M et al. (1997) Effect of testosterone and oestradiol in a man with aromatase deficiency. N Engl J Med 337:91–95

    Article  PubMed  CAS  Google Scholar 

  • Carling T, Kindmark A, Hellman P, Holmberg L, Akerstrom G, Rastad J (1997) Vitamin D receptor alleles b, a, and T: risk factors for sporadic primary hyperparathyroidism (HPT) but not HPT of uremia or MEM-1. Biochem Biophys Res Commun 231:329–332

    Article  PubMed  CAS  Google Scholar 

  • Carter DR, Hayes WC (1977) The compressive behavior of bone as a two-phase porous structure. J Bone J Surg Am 59:954–962

    CAS  Google Scholar 

  • Christenson RH (1997) Biochemical markers of bone metabolism: an overview. Clin Biochem 30:573–593

    Article  PubMed  CAS  Google Scholar 

  • Cooper GS, Umbach DM (1996) Are vitamin D receptor polymorphisms associated with bone mineral density? A meta-analysis. J Bone Miner Res 11:1841–1849

    Article  PubMed  CAS  Google Scholar 

  • Cosman F, Lindsay R (1998) Is parathyroid hormone a therapeutic option for osteoporosisi A review of the clinical evidence. Calcif Tissue Int 62:475–480

    Article  PubMed  CAS  Google Scholar 

  • Cummings SR, Browner WS, Bauer D, Stone K, Ensrud K, Jamal S (1998) Endogenous sex and calcitropic hormones and the risk of hip and vertebral fractures in older women: the study of osteoporotic fractures research group. N Engl J Med 339:733–738

    Article  PubMed  CAS  Google Scholar 

  • Cutler GB Jr (1997) The role of estrogen in bone growth and maturation during childhood and adolescence. J Steroid Biochem Mol Biol 61:141–144

    Article  PubMed  CAS  Google Scholar 

  • Dawson-Hughes B, Harris SS, Krall EA, Dallal GE (1997) Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older. N Engl J Med 337:670–676

    Article  PubMed  CAS  Google Scholar 

  • Dempster DW, Cosman F, Parisien M, Shen V, Lindsay R (1993) Anabolic actions of parathyroid hormone on bone. Endocr Rev 14:690–709

    PubMed  CAS  Google Scholar 

  • Derynck R, Rhee L, Chen EY, Tilburg AV (1987) Intron-exon structure of the human transforming growth factor-β precursor gene. Nucleic Acids Res 15:3188–3189

    Article  PubMed  Google Scholar 

  • Dohi Y, Iki M, Ohgushi H et al. (1998) A novel polymorphism in the promoter region for the human osteocalcin gene: the possibility of a correlation with bone mineral density in postmenopausal Japanese women. J Bone Miner Res 13:1633–1639

    Article  PubMed  CAS  Google Scholar 

  • Dreher I, Schütze N, Baur A et al. (1998) Selenoproteins are expressed in fetal human osteoblast-like cells. Biochem Biophys Res Commun 245:101–107

    Article  PubMed  CAS  Google Scholar 

  • Ducy P, Desbois C, Boyce B et al. (1996) Increased bone formation in osteocalcin deficient mice. Nature 382:448–452

    Article  PubMed  CAS  Google Scholar 

  • Duda RJ, O’Brien JF, Katzmann JA, Peterson JM, Mann KG, Riggs BL (1988) Concurrent assays of circulating bone GLA protein and bone alkaline phosphatase: effects of age, sex and metabolic bone disease. J Clin Endocrinol Metab 66:951–957

    Article  PubMed  CAS  Google Scholar 

  • Eastell R, Boyle IT, Compston J et al. (1998) Management of male osteoporosis: report of the UK consensus group. Q J Med 91:71–92

    Article  CAS  Google Scholar 

  • Eisman JA (1995) Vitamin D receptor gene alleles and osteoporosis: an affirmative view. J Bone Miner Res 10:1289–1293

    Article  PubMed  CAS  Google Scholar 

  • Erlebacher A, Derynck R (1996) Increased expression of TGF-beta 2 in osteoblasts results in an osteoporosis-like phenotype. J Cell Biol 132:195–210

    Article  PubMed  CAS  Google Scholar 

  • Ettinger B (1998) Overview of estrogen replacement therapy: a histo rie al perspective. Proc Soc Exp Biol Med 217:2–5

    PubMed  CAS  Google Scholar 

  • Ettinger B, Pressman A, Sklarin P, Bauer DC, Cauley JA, Cummings SR (1998) Associations between low levels of serum estradiol, bone density, and fractures among elderly women: the study of osteoporotic fractures. J Clin Endocrinol Metab 83:2239–2243

    Article  PubMed  CAS  Google Scholar 

  • Evans DM, Ralston SH (1996) Nitrie oxide and bone. J Bone Miner Res 11:300–305

    Article  PubMed  CAS  Google Scholar 

  • Fardellone P, Brazier M, Kamel S et al. (1998) Biochemical effects of calcium supplementation in postmenopausal women: influence of dietary calcium intake. Am J Clin Nutr 67:1273–1278

    PubMed  CAS  Google Scholar 

  • Feldman D (1997) Androgen and vitamin D receptor polymorphisms: the long and short of prostate cancer risk. J Natl Cancer Inst 89:109–111

    Article  PubMed  CAS  Google Scholar 

  • Feretti JL, Schiessl H, Frost HM (1998) On new opportunities for absorptiometry. J Clin Densitometry 1:41–54

    Article  Google Scholar 

  • Fisher JE, Rogers MJ, Halasy JM et al. (1999) Alendronate mechanism of action: geranygeraniol, an intermediate of the mevalonate pathway, prevents inhibition of osteoclast. formation, bone resorption, and kinase activation in-vitro. Proc Natl Acad Sci USA 96:133–138

    Article  PubMed  CAS  Google Scholar 

  • Fleisch H (1998) Bisphosphonates: mechanism of action. Endocr Rev 19:80–100

    Article  PubMed  CAS  Google Scholar 

  • Franeis RM (1997) Is there a differential response to alfacaleidol and vitamin D in the treatment of osteoporosis? Calcif Tissue Int 60:11–114

    Article  Google Scholar 

  • Fraser JH, Helfrich MH, Wallace HM, Ralston SH (1996) Hydrogen peroxide, but not superoxide, stimulates bone resorption in mouse calvariae. Bone 19:223–226

    Article  PubMed  CAS  Google Scholar 

  • Frediani B, Allegri A, Bisogno S, Marcolongo R (1998) Effects of combined treatment with calcitriol plus alendronate on bone mass and bone turnover in postmenopausal osteoporosis — two years of continuous treatment. Clin Drug Invest 15:235–244

    Article  CAS  Google Scholar 

  • Frost HM (1987) The mechanostat: a proposed pathogenic mechanism of osteoporosis and the bone mass effects of mechanical and nonmechanical agents. Bone 2:73–85

    CAS  Google Scholar 

  • Gallagher J, Riggs BL, Eisman J, Hamstra A, Arnaud S, DeLuca H (1979) Intestinal calcium absorption and serum vitamin D metabolites in normal subjects and osteoporotic patients. J Clin Invest 66:729–736

    Article  Google Scholar 

  • Gambien F, Ricard S, Troesch A et al. (1996) Polymorphism of the transforming growth factor-ßl gene in relation to myocardial infarction and blood pressure. Hypertension 28:881–887

    Article  Google Scholar 

  • Germari L, Becherini L, Masi L et al. (1998) Vitamin D and estrogen receptor allelic variants in Italien postmenopausal women: evidence of multiple gene contribut ion to bone mineral density. J Clin Endocrinol Metab 83:939–944

    Article  Google Scholar 

  • Gilsanz V (1998) Phenotype and genotype of osteoporosis. TEM 9:184–190

    PubMed  CAS  Google Scholar 

  • Giovannucei E, Rimm EB, Wolk A et al. (1998) Calcium and fructose intake in relation to risk of prostate cancer. Cancer Res 58:442–447

    Google Scholar 

  • Gong Y, Vikkula M, Boon L et al. (1996) Osteoporosis-pseu doglioma syndrome, a disorder affecting skeletal strengh and vision, is assigned to chromosome region 11qI2-13. Am J Hum Genet 59:146–151

    PubMed  CAS  Google Scholar 

  • Grant SFA, Reid DM, Blake RH, Fogelman I, Ralston SH (1996) Reduced bone density and osteoporosis associated with a polymorphic Spl bin ding site in the collagen type I alpha 1 gene. Nat Genet 14:203–205

    Article  PubMed  CAS  Google Scholar 

  • Gross C, Eccleshall TR, Malloy PI. Villa ML, Marcus R, Feldman D (1996) The presence of a polymorphism at the translation initiation site of the vitamin D receptor gene is associated with low bone mineral density in postmenopausal Mexical-American women. J Bone Miner Res 11:1850–1855

    Article  PubMed  CAS  Google Scholar 

  • Gross C, Krishnan AV, Malloy PJ, Sccleshall TR, Zhao X-Y, Feldman D (1998) The vitamin D receptor start codon polymorphism: a functional analysis of Fokl variants. J Bone Miner Res 13:1691–1699

    Article  PubMed  CAS  Google Scholar 

  • Halloran BP, Portale A, Lonergan ET, Morris Jr RC (1990) Production and metabolic clearance of 1,25-dihydroxyvitamin D in men: effect of advancing age. J Clin Endocrinol Metab 70:3180–3188

    Article  Google Scholar 

  • Hansen MA, Hassager C, Jensen SB, Christiansen C (1992) Is heritability a risk factor for postmenopausal osteoporosis? J Bone Miner Res 9:1037–1043

    Google Scholar 

  • Harris SA, Tau KR, Turner RT, Spelsberg TC (1996) Estrogens and progestins. In: Bilezikian JP, Raissz LG, Rodan GA (eds) Principles of bone biology. Acedemic Press, New York London, pp 507–520

    Google Scholar 

  • Haussier MR, Whitfield GK, Haussier CA et al. (1998) The nuclear vitamin D receptor: biological and molecular regulatory properties revealed. J Bone Miner Res 13:325–349

    Article  Google Scholar 

  • Heaney C, Shalev H, Elbedour K et al. (1998) Human autosomal recessive osteoporosis map s to 11q13, a position predicted by comparative mapping of the murine osteosclerosis (oc) mutation. Hum Mol Genet 7:1407–1410

    Article  PubMed  CAS  Google Scholar 

  • Hesseltine SM, Baylink DJ, Libanati CR (1998) Comparison of rates of change in bone density as measured by dualenerg y X-ray absorptiometry and quantitative computed tomography in osteoporotic females treated with fluoride. J Clin Densitometry 1:13–17

    Article  CAS  Google Scholar 

  • Hofbauer LC, Dunstan CR, Speisberg TC, Riggs BL, Khosla S (1998) Osteoprotegerin production by human osteoblast lineage cells is stimulated by vitamin D, bone morphogenic protein-2 and cytokines. Biochem Biophys Res Commun 250:776–781

    Article  PubMed  CAS  Google Scholar 

  • Hogan BLM (1996) Bone morphogenic proteins: multifunctional regulators of vertebrate development. Genes Dev 10:1580–1594

    Article  PubMed  CAS  Google Scholar 

  • Holick MF (ed) (1999) Vitamin D-physiology, molecular biology and clinical applications. Humana Press, Totowa, NJ

    Google Scholar 

  • Horwood NJ, Elliot J, Martin TJ, Gillespie MT (1998) Osteotropic agents regulate the expression of osteoclast differentiation factor and osteoprotegerin in osteoblastic stromal cells. Endocrinology 139:4743–4746

    Article  PubMed  CAS  Google Scholar 

  • Hosking D, Chilvers CED, Christiansen C et al. (1998) Prevent ion of bone loss with alendronate in postmenopausal women under 60 years of age. N Engl J Med 338:485–492

    Article  PubMed  CAS  Google Scholar 

  • Hui SL, Slemenda CS, Johnston CC (1988) Age and bone mass as predictors of fracture in a prospective study. J Clin Invest 81:1804–1809

    Article  PubMed  CAS  Google Scholar 

  • Ingles SA, Ross RK, Yu MC et al. (1997a) Association of prostate cancer risk with genetic polymorphisms in vitamin D receptor and androgen receptor. J Natl Cancer Inst 89:166–170

    Article  PubMed  CAS  Google Scholar 

  • Ingles SA, Haile RW, Henderson B, Kolonel L, Coetzee GA (1997b) Association of vitamin D receptor genetic polymorphism with breast cancer risk in African-American and Hispanic women. In: Norman A, Bouillon R, Thomasset M (eds) Vitamin D: chemistry, biology and clinical applications of the steroid hormone. Printing and Reprographics, University of California, Riverside, CA, pp 813–814

    Google Scholar 

  • Iotsova V, Caamano J, Loy J, Yang Y, Lewin A, Bravo R (1997) Osteopetrosis in mice lacking NF-κB1 and NFκB2. Nat Med 3:1285–1289

    Article  PubMed  CAS  Google Scholar 

  • Ishida Y, Heersehe JNM (1998) Glucocorticoid-induced osteoporosis: both in-vitro and in vivo concentrations of glucocorticoids higher than physiological levels attenuate osteoblast differentiation. J Bone Miner Res 13:1822–1826

    Article  PubMed  CAS  Google Scholar 

  • Jakob F, Siggelkow H, Homann D, Köhrle J, Adamski J, Schütze N (1997) Local estradiol metabolism in osteoblast-and osteoclast-like cells. J Steroid Biochem Mol Biol 61:167–174

    Article  PubMed  CAS  Google Scholar 

  • Jakob F, Schütze N, Adamski J (in press) Local estrogen metabolism in bone. Trends Steroid Res

    Google Scholar 

  • Johnson RS, Spiegelman BM, Papaioannou V (1992) Pleiotropic effects of a null mutation in the c-fos proto-oncogene. Cell 71:577–586

    Article  PubMed  CAS  Google Scholar 

  • Johnson ML, Gong G, Kimberling W, Recker SM, Kimmel DB, Recker RR (1997) Linkage of a gene causing high bone mass to human chromosome 11 (11q12–13). Am J Hum Genet 60:1326–1332

    Article  PubMed  CAS  Google Scholar 

  • Jouanny P, Guillemin F, Kuntz C, Jeandel C, Pourel J (1995) Environmental and genetic factors affecting bone mass. Similarity of bone density among members of healthy families. Arthritis Rheum 38:61–67

    Article  PubMed  CAS  Google Scholar 

  • Kanis JA, Melton LF, Christiansen C, Johnston CC, Khaltaev N (1994) The diagnosis of osteoporosis. J Bone Miner Res 9:1137–1141

    Article  PubMed  CAS  Google Scholar 

  • Kanis JA, McCloskey EV, Takats D de, Bernard J, Zhang DM (1997) Treatment of osteoporosis with Vitamin D. Osteoporosis Int [Suppl 3] 7:5140–5146

    Google Scholar 

  • Karaplis AC, Deckelbaum RA (1998) Role of PTHrP and PTH-1 receptor in endochondral bone development. Front Biosci 3:D795–803

    PubMed  CAS  Google Scholar 

  • Katagiri T, Boorla S, Frendo J-L, Hogan BLM, Karsenty G (1998) Skeletal abnormalities in double heterozygous Bmp4 and Bmp7 mice. Dev Genet 22:340–348

    Article  PubMed  CAS  Google Scholar 

  • Kawaguchi H, Pilbeam CC, Vargas SJ, Morse EE, Lorenzo JA, Raisz LG (1995) Ovariectomy enhances and estrogen replacement inh ibits the activity of bone marrow factors that stimulate prostagiandin production in cultured mouse calvariae. J Clin Invest 96:539–548

    Article  PubMed  CAS  Google Scholar 

  • Kawaguchi H, Nemoto K, Raisz LG et al. (1996) Interleukin4 inhibits prostagiandin G/H synthase-2 and cytosolic phospholipase A2 production in neonatal mouse parietal bone cultures. J Bone Miner Res 11:358–366

    Article  PubMed  CAS  Google Scholar 

  • Keen RW, Woodford-Richens KL, Lanchbury JS, Spector TD (1998) Allelic variation at the interleukin-1 receptor antagonist gene is associated with early postmenopausal bone loss at the spine. Bone 23:367–371

    Article  PubMed  CAS  Google Scholar 

  • Khosla S, Melton III LJ, Atkinson EJ, O’Fallon WM, Klee GG, Riggs BL (1998) Relationship of serum sex steroid levels and bone turnover markers with bone mineral density in men and women: a key role for bioavailable estrogen. J Clin Endocrinol Metab 83:2266–2274

    Article  PubMed  CAS  Google Scholar 

  • Kimble RB, Matayoshi AB, Vannice JL, Kung VT, Williams C, Pacifici R (1995) Simultaneous block of interleukin-l and tumor necrosis factor is required to completely prevent bone loss in the early postovariectomy period. Endocrinology 136:3054–3061

    Article  PubMed  CAS  Google Scholar 

  • Kingsley DM (1994) The TGF-α superfamily: new members, new receptors, and new genetic tests of function in different organisms. Genes Dev 8:133–146

    Article  PubMed  CAS  Google Scholar 

  • Kireeva ML, Lam SC-T, Lau LF (1998) Adhesion of human umbilical vein endothelial cells to the immdiate early gene product cyr61 is mediated through integrin αβ 3. J Biol Chem 273:3090–3096

    Article  PubMed  CAS  Google Scholar 

  • Klein RF, Mitchell SR, Phillips TJ, Belknap JK, Orwoll ES (1998) Quantitative trait loci affecting peak bone mineral density in mice. J Bone Miner Res 13:1648–1656

    Article  PubMed  CAS  Google Scholar 

  • Kobayashi S, Inoue S, Hosoi T, Ouchi Y, Shiraka M, Orimo H (1996) Association of bone mineral density with polymorphism of the estrogen receptor gene. J Bone Miner Res 11:306–311

    Article  PubMed  CAS  Google Scholar 

  • Koller DL, Rodriguez LA, Christian JC et al. (1998) Linkage of a QTL cont ributing to normal variation in bone mineral density to chromosome 11q12–13. J Bone Miner Res 13:1903–1908

    Article  PubMed  CAS  Google Scholar 

  • Komori T, Kishimoto T (1998) Cbfal in bone development. Curr Opin Genet Dev 8:494–499

    Article  PubMed  CAS  Google Scholar 

  • Kong YY, Yoshida H, Sarosi I et al. (1999) OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature 397:315–323

    Article  PubMed  CAS  Google Scholar 

  • Korach KS, Couse JF, Curtis SW et al. (1996) Estrogen receptor gene disruption: molecular characterzation and experimental and clinical phenotypes. Recent Prog Horm Res 51:186–188

    Google Scholar 

  • Kotowitcz M, Klee G, Kao P et al. (1990) Relationship between serum intact PTH and bone remodelling in type I osteoporosis: evidence that skeletal sensitivity is increased. Osteoporosis 1:14–20

    Article  Google Scholar 

  • Krall EA, Dawson-Hughes B (1993) Heritable and life-style determinants of bone mineral density. J Bone Miner Res 8:1–9

    Article  PubMed  CAS  Google Scholar 

  • Krozowski Z (1994) The short-chain alcohol dehydrogenase superfamily: variations on a common theme. J Steroid Biochem Mol Biol 51:125–130

    Article  PubMed  CAS  Google Scholar 

  • Kumar CC (1998) Signaling by integrin receptors. Oncogene 17:1365–1373

    Article  PubMed  CAS  Google Scholar 

  • Labuda M, Morgan K, Glorieux FH (1990) Mapping autosomal recessive vitamin D dependency type I to chromosome 12ql4 by linkage analysis. Am J Hum Genet 47:28–36

    PubMed  CAS  Google Scholar 

  • Lacey DL, Timms E, Tan H-L et al. (1998) Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 93:165–176

    Article  PubMed  CAS  Google Scholar 

  • Langdahl BL, Knudsen JY, Jensen HK, Gregersen N, Eriksen EF (1997) A sequence variation: 713-8delC in the transforming growth factor-beta 1 gene has higher prevalence in osteoporotic women than in normal women and is as sociated with very low bone mass in osteoporotic women and increased bone turnover in both osteoporotic and normal women. Bone 20:289–294

    Article  PubMed  CAS  Google Scholar 

  • Langdahl BL, Ralston SH, Grant SFA, Eriksen EF (1998) An Sp1 binding site polymorphism in the COU1A gene predicts osteoporotic fractures in both men and women. J Bone Miner Res 13:1384–1389

    Article  PubMed  CAS  Google Scholar 

  • Lanske B, Karaplis AC, Lee K et al. (1996) PTH/PTHrP receptor in early development and indian hedgehog-regulated bone growth. Science 273:663–666

    Article  PubMed  CAS  Google Scholar 

  • Ledger GA, Burritt MF, Kao PC, O’Fallon WM, Riggs BL, Khosla S (1995) Role of parathyroid hormone in mediating nocturnal and age-related increases in bone resorption. J Clin Endocrinol Metab 80:3304–3310

    Article  PubMed  CAS  Google Scholar 

  • Lewis DB, Liggitt HD, Elfman EL et al. (1993) Osteoporosis induced in mice by overproduction of interleukin-4. Proc Nati Acad Sci USA 90:11.618–11.622

    Article  Google Scholar 

  • Li YC, Pirro AE, Amling M et al. (1997a) Targeted ablation of the vitamin D receptor: an animal model of vitamin D-dependent rickets type II with alopecia. Proc Nati Acad Sci USA 94:9831–9835

    Article  CAS  Google Scholar 

  • Li YC, Pirro A, Amling M, Baron R, Bronson R, Demay M (1997b) Vitamin D receptor knock-out mice develop hypocalcemia, hyperparathyroidism, rickets, osteomalacia and alopecia. J Bone Miner Res [Suppl 1] 12:S123

    Google Scholar 

  • Liberman UA, Weiss SR, Bröll J et al. (1995) Effect of oral alendronate on bone mineral density and the incidence of fractures in postmenopausal osteoporosis. N Engl J Med 333:1437–1443

    Article  PubMed  CAS  Google Scholar 

  • Lim SK, Won YJ, Lee JH et al. (1997) Altered hydroxylation of estrogen in patients with postmenopausal osteopenia. J Clin Endocrinol Metab 82:1001–1006

    Article  PubMed  CAS  Google Scholar 

  • Lindsay R (1995) Estrogen deficiency. In: Riggs BL, Melton LJ (eds) Osteoporosis: etiology, diagnosis and management. Lippincott-Raven, Philadelphia, pp 133–160

    Google Scholar 

  • Lorenzo JA, Naprta A, Rao Y et al. (1998) Mice lacking the type I interleukin-1 receptor do not lose bone mass after ovariectomy. Endocrinology 139:3022–3025

    Article  PubMed  CAS  Google Scholar 

  • MacGillivray MH, Morishima A, Conte F, Grumbach M, Smith EP (1998) Pediatric endocrinology update: an overview. The essential roles of estrogens in pubertal growth, epiphyseal fusion and bone turnover: lessons from mutations in the genes for aromatase and the estrogen receptor. Horm Res [Suppl 1] 49:2–8

    Google Scholar 

  • MacLaughlin J, Holick MF (1985) Aging decreases the capacity of human skin to produce vitamin D. J Clin Invest 76:1536–1538

    Article  PubMed  CAS  Google Scholar 

  • Manolagas SC, Jilka RL (1995) Bone marrow, cytokines and bone remodeling — emerging insight s into the pathophysiology of osteoporosis. N Engl J Med 332:305–311

    Article  PubMed  CAS  Google Scholar 

  • Marcus R (1996) The nature of osteoporosis. J Clin Endocrinol Metab 81:1–5

    Article  PubMed  CAS  Google Scholar 

  • Marcus R, Madvig P, Crim M, Pont A, Kosek J (1984) Conjugated estrogens in the treatment of postmenopausal women with hyperparathyroidism. Ann Intern Med 100:633–640

    PubMed  CAS  Google Scholar 

  • Martin TJ, Udagawa N (1998) Hormonal regulation of osteoelast function. TEM 9:6–12

    PubMed  CAS  Google Scholar 

  • Masarachia P, Yamamoto M, Leu C-T, Rodan G, Duong L (1998) Histomorphometric evidence for echistatin inhibition of bone resorption in mice with secondary hyperparathyroidism. Endocrinology 139:1401–1410

    Article  PubMed  CAS  Google Scholar 

  • Masi L, Becherini L, Colli E et al. (1998) Polymorphisms of the calciton in receptor gene are associated with bone mineral density in postmenopausal Italien women. Biochem Biophys Res Commun 248:190–195

    Article  PubMed  CAS  Google Scholar 

  • Masuda H, Tsujimura A, Yoshioka M et al. (1997) Bone mass loss due to estrogen deficiency is compensated in transgenic mice overexpressing human osteoblast stimulating factor-1. Biochem Biophys Res Commun 238:528–533

    Article  PubMed  CAS  Google Scholar 

  • Mee AP, Hoyland JA, Braidman IP, Freemont AJ, Davies M, Mawer EB (1996) Demonstration of vitamin D receptor transcripts in actively resorbing osteoelasts in bone sections. Bone 18:295–299

    Article  PubMed  CAS  Google Scholar 

  • Melton LJ, Atkinson EJ, O’Fallon WM, Wahner HW, Riggs BL (1993) Long term fracture prediction by bone mineral assessed at different skeletal sites. J Bone Miner Res 8:1227–1233

    Article  PubMed  Google Scholar 

  • Meunier PJ, Sebert JL, Reginster JY et al. (1998) Fluoride salts are no better at preventing new vertebral fractures than calcium-vitamin D in postmenopausal osteoporosis: the FAVO Study. Osteoporosis Int 8:4–12

    Article  CAS  Google Scholar 

  • Miyaura C, Onoe Y, Ohta H et al. (1995) Interleukin-13 inhi bit s bone resorption by suppressing cyclooxigenase-2 (COX2) mRNA expression and prostagiandin production in osteoblasts. J Bone Miner Res 10:S158

    Google Scholar 

  • Mizuno A, Amizuka N, Irie K et al. (1998) Severe osteoporosis in mice lacking osteoelastogenesis inhibitory factor/ osteoprotegerin. Biochem Biophys Res Commun 247:610–615

    Article  PubMed  CAS  Google Scholar 

  • Morishima A, Grumbach MM, Simpson ER, Fisher C, Qin K (1995) Aromatase deficiency in male and fernale siblings caused by a novel mutation and the physiological role of estrogens. J Clin Endocrinol Metab 80:3689–3698

    Article  PubMed  CAS  Google Scholar 

  • Morrison NA, Yeoman R, Kelly PJ, Eisman JA (1992) Contribution of trans-acting factor alleles to normal physiological variability: vitamin D receptor polymorphisms and circulating osteocalcin. Proc Nati Acad Sci USA 89:6665–6669

    Article  CAS  Google Scholar 

  • Morrison NA, Qi JC, Tokita A et al. (1994) Prediction of bone density from vitamin D receptor alleles. Nature 367:284–287

    Article  PubMed  CAS  Google Scholar 

  • Morrison NA, Qi JC, Tokita A et al. (1997) Prediction of bone density from vitamin D receptor alleles [correction]. Nature 387:106

    CAS  Google Scholar 

  • Mundy GR (1996) Bone-resorbing cells. In: Favus MJ (ed) Primer on the metabolic bone diseases and disorders of mineral metabolism. Lippincott-Raven, New York, pp 1623

    Google Scholar 

  • Murray RE, McGuigan F, Grant SFA, Reid DM, Ralston SH (1997) Polymorphisms of the interieukin-6 gene are associated with bone mineral density. Bone 21:89–92

    Article  PubMed  CAS  Google Scholar 

  • Murrills RJ, Stein LS, Fey CP, Dempster DW (1990) The effects of parathyroid hormone (PTH) and PTH-related peptide on osteoelast resorption of bone slices in-vitro: an analysis of pit size and the resorption focus. Endocrinology 127:2648–2653

    Article  PubMed  CAS  Google Scholar 

  • Nakano Y, Watanabe K, Moromoto I et al. (1995) Interleukin-4 inhibits spontaneous and par athyroid horrnone-related protein-stimulated osteoelast formation in mice. J Bone Miner Res 9:1533–1529

    Article  Google Scholar 

  • Need AG, Morris HA, Horowitz M, Nordin BEC (1997) The response to calcitriol therapy in postmenopausal osteoporotic women is a function of initial calcium absorptive status. Calcif Tissue Int 61:6–9

    Article  PubMed  CAS  Google Scholar 

  • Nijweide PJ, Burger EH, Klein Nulend J. Van der Olas A (1996) The osteocyte. In: Bilezikian JP, Raissz LG, Rodan GA (eds) Principles of bone biology. Acedemic Press, New York London, pp 115–126

    Google Scholar 

  • Nussbaum SR, Potts Jr JT (1994) Advances in immunoassays for parathyroid hormone: clinical applications in skeletal disorders of bone and mineral metabolism. In: Bilezikian JP, Marcus R, Levine M (eds) The parathyroids. Raven Press, New York, pp 157–170

    Google Scholar 

  • Orwoll ES, Klein RF (1995) Osteoporosis in men. Endocr Rev 16:87–116

    PubMed  CAS  Google Scholar 

  • Pacifici R, Vannice JL, Rifas L, Kimble RB (1993) Monocytic secretion of interleukin-1 receptor antagonist in normal and osteoporotic women: effects of menopause and estrogen/ progesterone therapy. J Clin Endocrinol Metab 77:1135–1141

    Article  PubMed  CAS  Google Scholar 

  • Pak CYC, Sakhaee K, Rubin CD, Zerwekh JE (1997) Sustained-release sodium fluoride in the management of established postmenopausal osteoporosis. Am J Med Sci 313:23–32

    Article  PubMed  CAS  Google Scholar 

  • Peacock M (1995) Vitamin D receptor gene alleles and osteoporosis: a contrasting view, J Bone Miner Res 10: 1294–1297

    Article  PubMed  CAS  Google Scholar 

  • Pearce SH, Thakker RV (1997) The calcium-sensing receptor: insights into extracellular calcium homeostasis in health and disease. J Endocrinol 154:371–378

    Article  PubMed  CAS  Google Scholar 

  • Pereira RF, Hume EL, Halford KW, Prockop DJ (1995) Bone fragility in transgenic mice expressing a mutated gene for type 1 pro collagen (COL1A1) parallels the age-dependent phenotype of human osteogenesis imperfecta. J Bone Miner Res 10:1837–1843

    Article  PubMed  CAS  Google Scholar 

  • Pocock NA, Eisman JA, Hopper JL, Yeates MG, Sambrook PN, Eberl S (1987) Genetic determinants of bone mass in adults: a twin study. J Clin Invest 80:706–710

    Article  PubMed  CAS  Google Scholar 

  • Porter JC, Hogg N (1998) Integrins take partners: cross-talk between integrins and other membrane receptors. Trends Cell Biol 8:390–396

    Article  PubMed  CAS  Google Scholar 

  • Prank K, Nowlan S, Harms HM et al. (1995) Time series prediction of plasma hormone concentration: evidence for differences in predictability of parathyroid hormone secretion between osteoporotic patients and normal controls. J Clin Invest 95:2910–2919

    Article  PubMed  CAS  Google Scholar 

  • Prins SH, Jorgensen HL, Jorgensen LV, Hassager C (1998) The role of quantitative ultrasound in the assessment of bone: a review. Clin Physiol 18:3–17

    Article  PubMed  CAS  Google Scholar 

  • Prochop DJ, Kivirikko KI (1995) Collagens: molecular biology, diseases, and potentials for therapy. Annu Rev Biochem 64:403–434

    Article  Google Scholar 

  • Quarles LD (1997) Cation sensing receptors in bone: a novel paradigm for regulating bone remodeling? J Bone Miner Res 12:1971–1974

    Article  PubMed  CAS  Google Scholar 

  • Ralston SH (1997) The genetics of osteoporosis Q J Med 90:247–251

    Article  CAS  Google Scholar 

  • Reginster JY, Deroisy R, Bruwier M, Franchimont P (1992) Calcitonin metabolism in senile (type 11) osteoporosis. Osteoporosis Int 2:141–145

    Article  CAS  Google Scholar 

  • Reinholt FP, Hultenby K, Oldberg C, Heinegard D (1990) Osteopontin — a possible anchor of osteoclasts to bone. Proc Natl Acad Sci USA 8:4473–4475

    Article  Google Scholar 

  • Rifkin BR, Gay CV (1992) Biology and physiology of the osteoclast. CRC-Press, Boca Raton, USA

    Google Scholar 

  • Riggs BL, Melton LJ (1993) Evidence for two distinct syndromes of involutional osteoporosis. Am J Med 75:899–901

    Article  Google Scholar 

  • Riggs BL, Mamstra A, DeLuca H (1981) Assessment of 25hydroxyvitamin D 1-alpha hydroxylase reserve in postmenopausal osteoporosis by administration of parathyroid extract. J Clin Endocrinol Metab 53:833–835

    Article  PubMed  CAS  Google Scholar 

  • Riggs BL, Khosla S, Melton LJ (1998) A unitary model for involutional osteoporosis: estrogen deficiency causes both type I and type II osteoporosis in postmenopausal women and contributes to bone loss in aging men. J Bone Min Res 13:763–773

    Article  CAS  Google Scholar 

  • Rittling SR, Matsumoto HN, McKee MD et al. (1998) Mice lacking osteopontin show normal development and bone structure but displayaltered osteoclast formation in-vitro. J Bone Miner Res 13:1101–1111

    Article  PubMed  CAS  Google Scholar 

  • Rogers J, Mahaney MC, Beamer WG, Donahue LR, Rosen CJ (1997a) Beyond one gene-one disease: alternative strategies for deciphering genetic determinants of osteoporosis. Calcif Tissue Int 60:225–228

    Article  PubMed  CAS  Google Scholar 

  • Rogers MI, Watts DI, Russell RGG (1997b) Overview of bisphosphonates. Cancer 80:1652–1660

    Article  PubMed  CAS  Google Scholar 

  • Rosen CJ, Donahue LR, Hunter SJ (1994) Insulin-like growth factors and bone: the osteoporosis connection. Proc Soc Exp Biol Med 206:83–102

    Article  PubMed  CAS  Google Scholar 

  • Rosen CJ, Kurland ES, Vereault D et al. (1998) Association between serum insulin growth factor-I (IGF-I) and a simple sequence repeat in IGF-I gene: implications for genetic studies of bone mineral density. J Clin Endocrinol Metab 83:2286–2290

    Article  PubMed  CAS  Google Scholar 

  • Rüther U, Garber C, Komitowski D, Müller R, Wagner EF (1987) Deregulated c-fos expression interferes with normal bone development in transgenic mice. Nature 325: 412–416

    Article  PubMed  Google Scholar 

  • Saag KG, Emkey R, Schnitzer TJ et al. (1998) Alendronate for the prevent ion and treatment of glucocorticoid-induced osteoporosis. N Engl J Med 339:292–299

    Article  PubMed  CAS  Google Scholar 

  • Sano M, Inoue S, Hosoi T et al. (1995) Association of estrogen receptor dinucleotide repeat polymorphism with osteoporosis. Biochem Biophys Res Commun 217:378–383

    Article  PubMed  CAS  Google Scholar 

  • Schütze N, Jakob F (in press) 1,25(OH)2-Vitamin D3 dependent early gene regulation. Trends Steroid Res

    Google Scholar 

  • Schütze N, Lechner A, Groll C et al. (1998a) The human analogue of murine cysteine rich protein 16 is a 1α,25-dihydroxyvitamin D3 responsive immediate early gene in human fetal osteoblasts: regulation by cytokines, growth factors and serum. Endocrinology 139:1761–1770

    Article  PubMed  Google Scholar 

  • Schütze N, Bachthaler M, Lechner A, Köhrle J, Jakob F (1998b) Identification by differential display PCR of the selenoprotein thioredoxin reductase as a 1α,25(OH)2-vitamin D3-responsive gene in human osteoblasts — regulation by selenite. Biofactors 7:299–310

    Article  PubMed  Google Scholar 

  • Seeman E, Hopper JL, Bach LA et al. (1989) Reduced bone mass in daughters of women with osteoporosis. N Engl J Med 320:554–558

    Article  PubMed  CAS  Google Scholar 

  • Seeman E, Szmukler GI, Formica C, Tsalamandaris C, Mestrovic R (1992) Osteoporosis in anorexia nervosa: the influence of peak bone density, bone loss, oral contraceptive use and exercise. J Bone Miner Res 7:1467–1474

    Article  PubMed  CAS  Google Scholar 

  • Seibel MJ, Baylink DJ, Farley JR et al. (1997) Basic science and clinical utility of biochemical markers of bone turnover — a congre ss report. Exp Clin Endocrinol Diabetes 105:125–133

    Article  PubMed  CAS  Google Scholar 

  • Silverberg SJ, Shane E, Clemens TL et al. (1986) The effect of oral phosphate on major indices of skeletal metabolism in normal subjects. J Bone Miner Res 1:333–338

    Google Scholar 

  • Silverberg SJ, Shane E, Cruz L dela, Segre GV, Clemens TL, Bilezikian JP (1989) Abnormalities in parathyroid hormone secretion and 1,25-dihydroxyvitamin D3 formation in women with osteoporosis. N Engl J Med 320:277–281

    Article  PubMed  CAS  Google Scholar 

  • Simonet WS, Lacey DL, Dunstan CR et al. (1997) Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell 89:309–319

    Article  PubMed  CAS  Google Scholar 

  • Skorey K, Ly HD, Kelly J et al. (1997) How does alendronate inhibit prote in-tyrosine phosphatases? J Biol Chem 272:22.472–22.480

    Article  Google Scholar 

  • Smith DM, Nance WE, Kang KW, Christian JC, Johnston CC (1973) Genetic factor s in determining bone mass. J Clin Invest 52:2800–2808

    Article  PubMed  CAS  Google Scholar 

  • Smith EP, Boyd J, Frank GR et al. (1994) Estrogen resistance caused by a mutation in the estrogen receptor gen in a man. N Engl J Med 331:1056–1061

    Article  PubMed  CAS  Google Scholar 

  • Soriano P, Montgomery C, Geske R, Bradley A (1991) Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in miee. Cell 64:693–702

    Article  PubMed  CAS  Google Scholar 

  • Sowers M (1998) Expanding the repertoire: the future of genetic studies. J Bone Miner Res 13:1657–1659

    Article  PubMed  CAS  Google Scholar 

  • Spotila LD, Constantinou CD, Sereda L, Ganguly A, Riggs BL, Prockop DJ (1991) Mutation in a gene for type I pro collagen (Col1A2) in a woman with postmenopausal osteoporosis: evidence for phenotypic and genotypic overlap with mils osteogenesis imperfecta. Proc Natl Acad Sci USA 88:5423–5427

    Article  PubMed  CAS  Google Scholar 

  • St-Arnaud R, Messerlian S, Moir JM, Omdahl JL, Glorieux FH (1997) The 25-hydroxyvitamin D 1-alpha-hydroxylase gene maps to the pseudovitamin D-deficiency rickets (PDDR) disease locus. J Bone Miner Res 12:1552–1559

    Article  PubMed  CAS  Google Scholar 

  • Stein GS, Lian JB, Own TA (1990) Relationship of cell growth to the regulation of tissue-specific gene expresion during osteoblast differentiation. FASEB J 4:3111–3123

    PubMed  CAS  Google Scholar 

  • Steinbeck MJ, Appel WH, Verhoeven AJ, Karnovsky MJ (1994) NADPH-oxidase expression and in situ production of superoxide by osteoelasts actively resorbing bone. J Cell Biol 126:765–772

    Article  PubMed  CAS  Google Scholar 

  • Suda T, Udagawa N Takahashi N (1996) Cells of bone: osteoelast generation. In: Bilezikian JP, Raissz LG, Rodan GA (eds) Principles of bone biology. Acedemic Press, New York London, pp 87–102

    Google Scholar 

  • Takahashi T, Wada T, Mori M, Kokai Y, Ishii S (1996) Overexpression of the granulocyte colony-stimulating factor gene leads to osteoporosis in mice. Lab Invest 74:827–834

    PubMed  CAS  Google Scholar 

  • Thomas MK, Lloyd-Jones DM, Thadhani RI et al. (1998) Hypovitaminosis D in medical patients. N Engl J Med 338:777–783

    Article  PubMed  CAS  Google Scholar 

  • Torgerson DJ, Campbell MK, Reid DM (1995) Life-style, environmental and medical factors influencing peak bone mass in women. Br J Rheumatol 34:620–624

    Article  PubMed  CAS  Google Scholar 

  • Tsukamoto K, Emi M (1998) A polymorphic CA-repeat sequence at the human calcitonin locus. J Hum Genet 43:146–147

    Article  PubMed  CAS  Google Scholar 

  • Uitterlinden AG, Burger H, Huang Q et al. (1998) Relation of alleles of the collagen type I alpha 1 gene to bone density and the risk of osteoporotic fractures in postmenopausal women. N Engl J Med 338:1016–1021

    Article  PubMed  CAS  Google Scholar 

  • Väänänen K (1996) Osteoelast function: biology and mechanisms. In: Bilezikian JP, Raissz LG, Rodan GA (eds) Principles of bone biology. Acedemic Press, New York London, pp 1103–114

    Google Scholar 

  • Wang Z-Q, Ovitt C, Grigoriades AE, Möhle-Steinlein U, Rüther U, Wagner EF (1992) Bone and hematopoietic defects in mice lacking c-fos. Nature 360:741–745

    Article  PubMed  CAS  Google Scholar 

  • Watanabe I, Tsukamoto K, Shiba T, Emi M (1998) Isolation and radiation hybrid mapping of dinueleotide repeat polymorphism at the human matrix Gla protein (MGP) locus. J Hum Genet 43:75–76

    Article  PubMed  CAS  Google Scholar 

  • Wiktor-Jedrzejczak W, Urbanowska E, Szperl M (1994) Granulocyte-macrophage colony-stimulating factor corrects macrophage deficiencies, but not osteoporosis, in the colony-stimulating factor-1-deficient op/op mouse. Endocrinology 134:1932–1935

    Article  PubMed  CAS  Google Scholar 

  • Wren BG (1998) Megatrials of hormonal replacement therapy. Drugs Aging 12:343–348

    Article  PubMed  CAS  Google Scholar 

  • Yamada Y, Miyauchi A, Goto J et al. (1998) Association of a polymorphism of the transforming growth factor-β1 gene with genetic susceptibility to osteoporosis in postmenopausal Japanese women. J Bone Miner Res 13:1569–1576

    Article  PubMed  CAS  Google Scholar 

  • Yamamoto M, Fisher JE, Gentile M et al. (1998) The integrin ligand echistatin prevents bone loss in ovariectomized miee and rats. Endocrinology 139:1411–1419

    Article  PubMed  CAS  Google Scholar 

  • Yoshida H, Hayashi S, Kunisada T et al. (1990) The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene. Nature 345: 442–444

    Article  PubMed  CAS  Google Scholar 

  • Yoshizawa T, Handa Y, Uematsu Y et al. (1997) Mice lacking the vitamin D recepto r exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning. Nat Genet 16:391–396

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. Norbert Schütze
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  2. Franz Jakob
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  1. Max-Delbrück-Centrum für Molekulare Medizin (MDC), Robert-Rössle-Str. 10, 13122, Berlin-Buch, Deutschland

    Detlev Ganten  & Klaus Ruckpaul  & 

  2. Abteilung für Endokrinologie, Universitätsklinikum Essen Zentrum für Innere Medizin, Hufelandstraße 55, 45122, Essen, Deutschland

    Onno E. Janssen

  3. Zentrum für Innere Medizin Abteilung Endokrinologie und Diabetologie, Klinikum der Philipps-Universität, Baldingerstraße/Lahnberge, 35033, Marburg, Deutschland

    Armin E. Heufelder

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Schütze, N., Jakob, F. (2001). Osteoporose. In: Ganten, D., Ruckpaul, K., Janssen, O.E., Heufelder, A.E. (eds) Molekularmedizinische Grundlagen von Endokrinopathien. Molekulare Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56858-9_5

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