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Hyper- und Hypoparathyreoidismus

  • Chapter
Molekularmedizinische Grundlagen von Endokrinopathien

Part of the book series: Molekulare Medizin ((MOLMED))

  • 171 Accesses

Zusammenfassung

Der Serumkalziumspiegel wird in engen Grenzen (2,2-2,6 mM) konstant gehalten. Die Konstanz der extrazellulären Kalziumkonzentration ist für eine Reihe von Stoffwechselvorgängen im Körper essenziell: die Modulation der Sekretion von Hormonen und anderen Substanzen, die Erregbarkeit von Nervenzellen und die Konstanz der Nervenleitfähigkeit, die Zellproliferation, die Blutgerinnung, bei der Kalzium ein Kofaktor ist, die Modulation von zahlreichen Enzymen z.B. der Glukoneogenese, der Glykogenolyse und der Mineralisierung von neu gebildeter Knochengrundsubstanz. Die Änderung der Serumkalziumkonzentration durch die Hormone der Kalziumhomöostase, Parathormon (PTH) und Vitamin-Ir-Hormon [1,25-Dihydroxycholecalciferol: 1,25(OH)2D3], innerhalb des Normbereichs dient zur Modulation dieser verschiedenen Stoffwechselfunktionen (Hurwitz 1996).

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Authors
  1. Friedhelm Raue
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  2. Tobias Schilling
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Editors and Affiliations

  1. Max-Delbrück-Centrum für Molekulare Medizin (MDC), Robert-Rössle-Str. 10, 13122, Berlin-Buch, Deutschland

    Detlev Ganten  & Klaus Ruckpaul  & 

  2. Abteilung für Endokrinologie, Universitätsklinikum Essen Zentrum für Innere Medizin, Hufelandstraße 55, 45122, Essen, Deutschland

    Onno E. Janssen

  3. Zentrum für Innere Medizin Abteilung Endokrinologie und Diabetologie, Klinikum der Philipps-Universität, Baldingerstraße/Lahnberge, 35033, Marburg, Deutschland

    Armin E. Heufelder

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Raue, F., Schilling, T. (2001). Hyper- und Hypoparathyreoidismus. In: Ganten, D., Ruckpaul, K., Janssen, O.E., Heufelder, A.E. (eds) Molekularmedizinische Grundlagen von Endokrinopathien. Molekulare Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56858-9_4

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  • DOI: https://doi.org/10.1007/978-3-642-56858-9_4

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