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Hypothalamische und hypophysäre Erkrankungen

  • Chapter
Molekularmedizinische Grundlagen von Endokrinopathien

Part of the book series: Molekulare Medizin ((MOLMED))

  • 169 Accesses

Zusammenfassung

Erst Ende des 19. Jahrhunderts wurde zunehmend deutlich, dass es sich bei der Hypophyse nicht nur um eine „Nasenschleimdrüse“ handelt, sondern um ein Organ, das lebenswichtige, den Stoffwechsel des Organismus endokrin regulierende Substanzen ins Blut abgibt. Arbeiten zu Beginn des 20. Jahrhunderts zeigten die Bedeutung der Hypophyse für die Fortpflanzung und das Wachstum. Harvey Cushing konnte nachweisen, dass die nach ihm benannte Erkrankung auf eine Hypersekretion einer damals noch nicht identifizierten, endokrin wirksamen Substanz aus Hypophysentumoren zurückzuführen war. In den 30er Jahren wurde erstmals postuliert, dass der Hypothalamus als übergeordnete Struktur die Hypophysenfunktion reguliert; diese Hypothese wurde nach dem 2. Weltkrieg experimentell bestätigt.

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Authors
  1. Ulrich Renner
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  2. Ludwig Schaaf
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  3. Günter K. Stalla
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Editors and Affiliations

  1. Max-Delbrück-Centrum für Molekulare Medizin (MDC), Robert-Rössle-Str. 10, 13122, Berlin-Buch, Deutschland

    Detlev Ganten  & Klaus Ruckpaul  & 

  2. Abteilung für Endokrinologie, Universitätsklinikum Essen Zentrum für Innere Medizin, Hufelandstraße 55, 45122, Essen, Deutschland

    Onno E. Janssen

  3. Zentrum für Innere Medizin Abteilung Endokrinologie und Diabetologie, Klinikum der Philipps-Universität, Baldingerstraße/Lahnberge, 35033, Marburg, Deutschland

    Armin E. Heufelder

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Renner, U., Schaaf, L., Stalla, G.K. (2001). Hypothalamische und hypophysäre Erkrankungen. In: Ganten, D., Ruckpaul, K., Janssen, O.E., Heufelder, A.E. (eds) Molekularmedizinische Grundlagen von Endokrinopathien. Molekulare Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56858-9_2

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