Skip to main content
SpringerLink
Log in
Book cover

Progress in Botany pp 51–70Cite as

Extranuclear Inheritance: Cytoplasmic Linear Double-Stranded DNA Killer Elements of the Dairy Yeast Kluyveromyces lactis

  • Chapter

Part of the book series: Progress in Botany ((BOTANY,volume 62))

Abstract

Plasmids were originally considered to be extra-chromosomal, autonomously replicating, covalently closed, circular, double-stranded DNA (dsDNA) elements restricted to prokaryotes (Lederberg 1952). However, the detection of the 2-μm circular plasmid in the yeast Saccharomyces cerevisiae (Sinclair et al. 1967) required broadening of the definition, because the occurrence of extra-chromosomal DNA was no longer limited to bacteria. Subsequently, similar circular dsDNA elements were also found in filamentous fungi (Esser et al. 1986) and other yeast genera, such as Zygosaccharomyces (Tohe and Utatsu 1985) and Kluyveromyces (Falcone et al. 1986).

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   259.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   329.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   329.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Baldan C, Murray JAH, Ghiara P, Cesareni G, Galeotti CL (1987) A novel leader peptide which allows efficient secretion of a fragment of human interleukin 1β in Saccharomyces cerevisiae. EMBO J 6:229–234

    Google Scholar 

  • Bisaillon M, Lemay K (1997) Viral and cellular enzymes involved in synthesis of mRNA cap structure. Virology 236:1–7

    Article  PubMed  CAS  Google Scholar 

  • Bolen PL, Eastman EM, Cihak PL, Hayman CT (1994) Isolation and sequence analysis of a gene from linear DNA plasmid pPac1–2 of Pichia acaciae that shows similarity to a killer toxin gene of Kluyveromyces lactis. Yeast 10:403–414

    Article  PubMed  CAS  Google Scholar 

  • Butler AR, White JH, Stark MJR (1991a) Analysis of the response of Saccharomyces cerevisiae cells to Kluyveromyces lactis toxin. J Gen Microbiol 137:1749–1757

    Article  PubMed  CAS  Google Scholar 

  • Butler AR, Porter M, Stark MJR (1991b) Intracellular expression of Kluyveromyces lactis toxin γ-subunit mimics treatment with exogenous toxin and distinguishes two classes of toxin-resistant mutants. Yeast 7:617–625

    Article  PubMed  CAS  Google Scholar 

  • Butler AR, O’Donnell RW, Martin VJ, Gooday GW, Stark MJR (1991c) Kluyveromyces lactis toxin has an essential chitinase activity. Eur J Biochem 199:483–488

    Article  PubMed  CAS  Google Scholar 

  • Butler AR, White JH, Folawiyo Y, Edlin A, Gardiner D, Stark MJR (1994) Two Saccharomyces cerevisiae genes which control sensitivity to Gl arrest induced by Kluyveromyces lactis toxin. Mol Cell Biol 14:6306–6316

    Article  PubMed  CAS  Google Scholar 

  • Cong YS, Yarrow D, Li YY, Fukuhara H (1994) Linear DNA plasmids from Pichia etchellsii, Debaryomyces hansenii and Wingea robertsiae. Microbiology 140:1327–1335

    Article  PubMed  CAS  Google Scholar 

  • Cos T, Ford R, Trilla JA, Duran A, Cabib E, Roncero C (1998) Molecular analysis of Chs3p participation in chitin synthase III activity. Eur J Biochem 256:419–426

    Article  PubMed  CAS  Google Scholar 

  • Cross FR, Tinkelenberg AH (1991) A potential positive feedback loop controlling CLN1 and CLN2 gene expression at the start of the yeast cell cycle. Cell 65:875–883

    Article  PubMed  CAS  Google Scholar 

  • Esser K, Kück U, Lang-Hinrichs C, Lemke P, Osiewacz HD, Tudzynski P (1986) Plasmids of eukaryotes, fundamentals and application. Springer, Berlin Heidelberg New York

    Google Scholar 

  • Falcone C, Saliola M, Chen XJ, Frontali L, Fukuhara H (1986) Analysis of a 1.6-micron circular plasmid from the yeast Kluyveromyces drosophilarum: structure and molecular dimorphism. Plasmid 15:248–252

    Article  PubMed  CAS  Google Scholar 

  • Fukada K, Maebuchi M, Takata H, Gunge N (1997) The linear plasmid pDHL1 from Debaryomyces hansenii encodes a protein highly homologous to the pGKL1 plasmid DNA-polymerase. Yeast 13:613–620

    Article  Google Scholar 

  • Fukuhara H (1995) Linear DNA plasmids of yeasts. FEMS Microbiol Lett 131:1–9

    Article  PubMed  CAS  Google Scholar 

  • Gunge N (1986) Linear DNA killer plasmids from the yeast Kluyveromyces. Yeast 2:153–162

    Article  PubMed  CAS  Google Scholar 

  • Gunge N (1995) Plasmid DNA and the killer phenomenon in Kluyveromyces. In: Kück U (ed) Genetics and biotechnology. The Mycota, vol 2. Springer, Berlin Heidelberg New York, pp 189–209

    Chapter  Google Scholar 

  • Gunge N, Sakaguchi K (1981) Intergenic transfer of deoxyribonucleic acid killer plasmids, pGKLl and pGKL2 from Kluyveromyces lactis into Saccharomyces cerevisiae. J Bacteriol 147:155–160

    PubMed  CAS  Google Scholar 

  • Gunge N, Tamaru, A, Ozawa F, Sakaguchi K (1981) Isolation and characterization of linear deoxyribonucleic acid plasmids from Kluyveromyces lactis and the plasmid-associated killer character. J Bacteriol 145:382–390

    PubMed  CAS  Google Scholar 

  • Gunge N, Murata K, Sakaguchi K (1982) Transformation of Saccharomyces cerevisiae with linear DNA killer plasmids from Kluyveromyces lactis. J Bacteriol 151:462–464

    PubMed  CAS  Google Scholar 

  • Gunge N, Fukuda K, Takahashi S, Meinhardt F (1995) Migration of the yeast linear DNA plasmid from the cytoplasm into nucleus in Saccharomyces cerevisiae. Curr Genet 28:280–288

    Article  PubMed  CAS  Google Scholar 

  • Hishinuma F, Hirai K (1991) Genome organization of the linear plasmid, pSKL, isolated from Saccharomyces kluyveri. Mol Gen Genet 226:97–106

    Article  PubMed  CAS  Google Scholar 

  • Hishinuma F, Nakamura K, Hirai K, Nishizawa R, Gunge N, Maeda T (1984) Cloning and nucleotide sequence of the DNA killer plasmids from yeast. Nucleic Acids Res 12:7581–7597

    Article  PubMed  CAS  Google Scholar 

  • Julius D, Brake A, Blair A, Kunisawa R, Thorner J (1984) Isolation of the putative structural gene for lysine-arginine-cleaving endopeptidase required for processiong of yeast pre-pro-alpha factor. Cell 37:1075–1089

    Article  PubMed  CAS  Google Scholar 

  • Kämper J, Meinhardt F, Gunge N, Esser K (1989a) In vivo construction of linear vectors based on killer plasmids from Kluyveromyces lactis: Selection of a nuclear gene results in attachments of telomeres. Mol Cell Biol 9:3931–3937

    PubMed  Google Scholar 

  • Kämper J, Meinhardt F, Gunge N, Esser K (1989b) New recombinant linear DNA-elements derived from Kluyveromyces lactis killer plasmids. Nucleic Acids Res 17:1781

    Article  PubMed  Google Scholar 

  • Kämper J, Esser K, Gunge N, Meinhardt F (1991) Heterologous gene expression on the linear DNA killer plasmid from Kluyveromyces lactis. Curr Genet 19:109–118

    Article  PubMed  Google Scholar 

  • Kawamoto S, Arai N, Kobayashi M, Kawahara K, Iwahashi H, Tanabe C, Hatori H, Ohno T, Nakamura T (1990) Isolation and characterization of mutants of Saccharomyces cerevisiae resistant to killer toxin of Kluyveromyces lactis. J Ferment Bioeng 70:222–227

    Article  CAS  Google Scholar 

  • Kawamoto S, Nomura M, Ohno T (1992) Cloning and characterization of SKT5, a Saccharomyces cerevisiae gene that affects protoplast regeneration and resistance to killer toxin of Kluyveromyces lactis. J Ferment Bioeng 74:199–208

    Article  CAS  Google Scholar 

  • Kawamoto S, Sasaki T, Itahashi S, Hatsuyama Y, Ohno T (1993) A mutant allele skt5 affecting protoplast regeneration and killer toxin resistance has double mutations in its wild type structural gene in Saccharomyces cerevisiae. Biosci Biotech Biochem 57:1391–1393

    Article  CAS  Google Scholar 

  • Kempken F, Hermanns J, Osiewacz HD (1992) Evolution of linear plasmids. J Mol Evol 35:502–513

    Article  PubMed  CAS  Google Scholar 

  • Kikuchi Y, Hirai K, Hishinuma F (1984) The yeast DNA killer plasmids, pGKLl and pGKL2, possess terminally attached proteins. Nucleic Acids Res 12:5685–5692

    Article  PubMed  CAS  Google Scholar 

  • Kishida M, Tokunaga M, Katayose Y, Yajima H, Kawamura-Watabe A, Hishinuma F (1996) Isolation and genetic characterization of pGKL killer-insensitive mutants (iki) from Saccharomyces cerevisiae. Biosci Biotech Biochem 60:798–801

    Article  CAS  Google Scholar 

  • Kitada K, Hishinuma F (1987) A new linear DNA plasmid isolated from the yeast Saccharomyces kluyveri. Mol Gen Genet 206:377–381

    Article  CAS  Google Scholar 

  • Larsen M, Gunge N, Meinhardt F (1998) Kluyveromyces lactis killer plasmid pGKL2: Evidence for a viral like capping enzyme encoded by ORF3. Plasmid 40:243–246

    Article  PubMed  CAS  Google Scholar 

  • Leberer E, Thomas DY, Whiteway M (1997) Pheromone signalling and polarized morphogenesis in yeast. Curr Opin Genet Dev 7:59–66

    Article  PubMed  CAS  Google Scholar 

  • Lederberg J (1952) Cell genetics and hereditary symbiosis. Physiol Rev 32:403–430

    PubMed  CAS  Google Scholar 

  • Luke MM, Delia Seta F, Di Como CJ, Sugimoto H, Kobayashi R, Arndt KT (1996) The SAP, a new family of proteins, associate and function positively with the Sit4 phosphatase. Mol Cell Biol 16:2744–2755

    PubMed  CAS  Google Scholar 

  • McNeel DG, Tamanoi F (1991) Terminal recognition factor 1, a novel DNA binding protein recognizing the terminal sequences of the pGKL linear DNA plasmids. Proc Natl Acad Sci USA 88:11398–1140

    Article  PubMed  CAS  Google Scholar 

  • Meinhardt F, Rohe M (1993) Extranuclear inheritance: linear protein-primed replicating genomes in plants and microorganisms. Prog Bot 54:318–333

    Google Scholar 

  • Meinhardt F, Kempken F, Kämper J, Esser K (1990) Linear plasmids among eukaryotes. Fundamentals and application. Curr Genet 17:89–95

    Article  CAS  Google Scholar 

  • Meinhardt F, Larsen M, Wodara C, Schickel J (1994) A novel approach to express a heterologous gene on linear killer plasmids: Expression of the bacterial aph gene from a cytoplasmic promoter without in-phase fusion to the plasmid open reading frame. Plasmid 32:318–327

    Article  PubMed  CAS  Google Scholar 

  • Meinhardt F, Schaffrath R, Larsen M (1997) Microbial linear plasmids (Mini Review). Appl Microbiol Biotechnol 47:329–336

    Article  PubMed  CAS  Google Scholar 

  • Meinhardt F, Tontsidou L, Jeske S, Tiggemann M, Larsen M (1998) Yeast linear plasmids: structure and gene expression. Abstracts of the 11th meeting on the Biology of Kluyveromyces. Martin Luther Universität, Halle/Saale

    Google Scholar 

  • Nasmyth K (1996) Trends Genet 12:405–412

    Article  PubMed  CAS  Google Scholar 

  • Niwa O, Sakaguchi K, Gunge N (1981) Curing of the deoxyribonucleic acid plasmids of Kluyveromyces lactis. J Bacteriol 148:988–990

    PubMed  CAS  Google Scholar 

  • Pring DR, Lewings CS III, Hu WWL, Timothy DH (1977) Unique DNA associated with mitochondria in the S-type cytoplasm of male-sterile maize. Proc Natl Acad Sci USA 72:2904–2908

    Article  Google Scholar 

  • Rohe M, Schründer J, Tudzynski P, Meinhardt F (1992) Phylogenetic relationships of linear protein primed replicating genomes. Curr Genet 21:173–176

    Article  PubMed  CAS  Google Scholar 

  • Romanos M, Boyd A (1988) A transcriptional barrier to expression of cloned toxin genes of the linear plasmid kl of Kluyveromyces lactis: evidence that native kl has novel promoters. Nucleic Acids Res 16:7333–7350

    Article  PubMed  CAS  Google Scholar 

  • Salas M, Freire R, Soengas MS, Esteban JA, Mendez J, Bravo A, Serrano M, Blasco MA, Lazaro JM, Blanco L, Gutierrez C, Hermoso JM (1995) Protein-nucleic acid interactions in bacteriophage phi 29 DNA replication. FEMS Microbiol Rev 17:73–82

    PubMed  CAS  Google Scholar 

  • Santos B, Snyder M (1997) Targeting of chitin synthase 3 to polarized growth sites in yeast requires Chs5p and Myo2p. J Cell Biol 136:95–110

    Article  PubMed  CAS  Google Scholar 

  • Schaffrath R, Meacock PA (1995) Kluyveromyces lactis killer plasmid pGKL2: molecular analysis of an essential gene, ORF5.Yeast 11:615–628

    Article  PubMed  CAS  Google Scholar 

  • Schaffrath R, Meacock PA (1996) A cytoplasmic gene-shuffle system in Kluyveromyces lactis: use of epitope tagging to detect a killer plasmid-encoded gene product. Mol Microbiol 19:545–554

    Article  PubMed  CAS  Google Scholar 

  • Schaffrath R, Meinhardt F (1998) Das Killersystem von Kluyveromyces lactis: Molekularbiologie und Biotechnik. Biospektrum 4:40–42

    Google Scholar 

  • Schaffrath R, Stark MJR, Gunge N, Meinhardt F (1992) Kluyveromyces lactis killer system: ORF1 of pGKL2 has no function in immunity expression and is dispensable for killer plasmid replication and maintenance. Curr Genet 21:357–363

    Article  PubMed  CAS  Google Scholar 

  • Schaffrath R, Soond SM, Meacock PA (1995a) Cytoplasmic gene expression in yeast: a plasmid encoded transcription system in Kluyveromyces lactis. Biochem Soc Trans 23:128

    Google Scholar 

  • Schaffrath R, Soond SM, Meacock PA (1995b) The DNA and RNA polymerase genes of yeast plasmid pGKL2 are essential loci for plasmid integrity and maintenance. Microbiology 141:2591–2599

    Article  PubMed  CAS  Google Scholar 

  • Schaffrath R, Meinhardt F, Meacock PA (1996) Yeast killer plasmid pGKL2: molecular analysis of UCS5, a cytoplasmic promoter element essential for ORF5 gene function. Mol Gen Genet 250:286–294

    Article  PubMed  CAS  Google Scholar 

  • Schaffrath R, Stark MJR, Struhl K (1997a) Toxin mediated cell cycle arrest in yeast: the killer phenomenon of Kluyveromyces lactis. Bioforum Int 2:83–85

    Google Scholar 

  • Schaffrath R, Stark MJR, Struhl K (1997b) Zymocin-mediated G1-cell cycle arrest: analysis of killer toxin insensitive (KTI) Saccharomyces cerevisiae mutants. Eur J Cell Biol 72 (Suppl 44):39

    Google Scholar 

  • Schaffrath R, Meinhardt F, Meacock PA (1997c) ORF7 of yeast plasmid pGKL2: analysis of gene expression in vivo. Curr Genet 31:190–192

    Article  PubMed  CAS  Google Scholar 

  • Schaffrath R, Meinhardt F, Meacock PA (1999) Genetic manipulation of Kluyveromyces lactis linear DNA plasmids: gene targeting and plasmid shuffles. FEMS Microbiol Lett 172:201–210

    Article  Google Scholar 

  • Schickel J, Helmig C, Meinhardt F (1996) Kluyveromyces lactis killer system: analysis of cytoplasmic promoters of linear plasmids. Nucleic Acids Res 24:1879–1886

    Article  PubMed  CAS  Google Scholar 

  • Schründer J, Meinhardt F (1995a) An extranuclear expression system for analysis of cytoplasmic promoters of yeast linear killer plasmids. Plasmid 33:139–151

    Article  PubMed  Google Scholar 

  • Schründer J, Meinhardt F (1995b) Extrachromosomal inheritance: yeast linear killer plasmids as a tool in genetic engineering. Prog Bot 56:332–353

    Article  Google Scholar 

  • Schründer J, Gunge N, Meinhardt F (1996) Extranuclear expression of the bacterial xylose isomerase (xylA) and the UDP-glucose dehydrgenase (hasB) genes in yeast with Kluyveromyces lactis linear killer plasmids as vectors. Curr Microbiol 33:323–330

    Article  PubMed  Google Scholar 

  • Sinclair JH, Stevens BJ, Sanghavi P, Rabinovitz M (1967) Mitochondrial satellite and circular DNA filaments in yeasts. Science 156:1234–1237

    Article  PubMed  CAS  Google Scholar 

  • Stam JC, Kwakman J, Meijer M, Stuitje AR (1986) Efficient isolation of the linear DNA killer plasmids of Kluyveromyces lactis: evidence for location and expression in the cytoplasm and characterization of their terminally bound proteins. Nucleic Acids Res 14:6871–6884

    Article  PubMed  CAS  Google Scholar 

  • Stark MJR (1996) Yeast protein serine/threonine phosphatases: multiple roles and diverse regulation. Yeast 12:1647–1675

    Article  PubMed  CAS  Google Scholar 

  • Stark MJR, Boyd A (1986) The killer toxin of Kluyveromyces lactis: characterization of the toxin subunits and identification of the genes which encode them. EMBO J 5:1995–2002

    PubMed  CAS  Google Scholar 

  • Stark MJR, Boyd A, Mileham AJ, Romanos MA (1990) The plasmid encoded killer system of Kluyveromyces lactis: a review. Yeast 6:1–29

    Article  PubMed  CAS  Google Scholar 

  • Sugisaki Y, Gunge N, Sakaguchi K, Yamasaki M, Tamura G (1983) Kluyveromyces lactis killer toxin inhibits adenylate cyclase of sensitive yeast cells. Nature 304:464–466

    Article  Google Scholar 

  • Sugusaki Y, Gunge N, Sakaguchi K, Yamasaki M, Tamura G (1984) Characterization of a novel killer toxin encoded by a double stranded linear DNA killer plasmid of Kluyveromyces lactis. Eur J Biochem 141:241–245

    Article  Google Scholar 

  • Sugusaki Y, Gunge N, Sakaguchi K, Yamasaki M, Tamura G (1985) Transfer of DNA killer plasmids from Kluyveromyces lactis to Kluyveromyces fragilis and Candida pseudotropicalis. J Bacteriol 164:1373–1375

    Google Scholar 

  • Takeda M, Hiraishi H, Takesako T, Tanase S, Gunge N (1996) The terminal protein of the linear DNA plasmid pGKL2 shares an N-terminal domain with the plasmid encoded DNA polymerase. Yeast 12:241–246

    Article  PubMed  CAS  Google Scholar 

  • Takita M, Castilho-Valavicius B (1993) Absence of cell wall chitin in Saccharomyces cerevisiae leads to resistance to Kluyveromyces lactis killer toxin. Yeast 9:589–598

    Article  PubMed  CAS  Google Scholar 

  • Tanguy-Rougeau C, Wesolowski-Louvel M, Fukuhara H (1988) The Kluyveromyces lactis KEX1 gene encodes a subtilisin type serin proteinase. FEBS Lett 234:464–470

    Article  PubMed  CAS  Google Scholar 

  • Tohe A, Utatsu I (1985) Physical and functional structure of a yeast plasmid, pSB3, isolated from Zygosaccharomyces bisporus. Nucleic Acids Res 13:4267–4282

    Article  CAS  Google Scholar 

  • Tokunaga M, Wada N, Hishinuma F (1987a) Expression and identification of immunity determinants on linear DNA killer plasmids pGKLl and pGKL2 in Kluyveromyces lactis. Nucleic Acids Res 15:1031–1046

    Article  PubMed  CAS  Google Scholar 

  • Tokunaga M, Wada N, Hishinuma F (1987b) A novel yeast secretion vector utilizing secretion signal of killer toxin encoded on the linear plasmid pGKLl. Biochem Biophys Res Commun 144:613–619

    Article  PubMed  CAS  Google Scholar 

  • Tokunaga M, Wada N, Hishinuma F (1988) A novel yeast secretion signal isolated from 28K killer precursor protein encoded on the linear plasmid pGKLl. Nucleic Acids Res 16:7499–7511

    Article  PubMed  CAS  Google Scholar 

  • Tokunaga M, Kawamura A, Hishinuma F (1989) Expression of pGKL 28K killer subunit in Saccharomyces cerevisiae: identification of 28K subunit as a killer protein. Nucleic Acids Res 17:3435–3446

    Article  PubMed  CAS  Google Scholar 

  • Tokunaga M, Kawamura A, Kitada K, Hishinuma F (1990) Secretion of killer toxin encoded on the linear killer plasmid pGKLl from Saccharomyces cerevisiae. J Biol Chem 265 17274–17280

    PubMed  CAS  Google Scholar 

  • Tokunaga M, Kawamura A, Omori A, Hishinuama F (1992) Structure of yeast 128 kDa killer-toxin secretion secretion signal sequence. Processing of the 128 kDa killer-toxin-secretion-signal-alpha-amylase-fusion-protein. Eur J Biochem 203:415–423

    Article  PubMed  CAS  Google Scholar 

  • Tokunaga M, Kawamura A, Yonekyu S, Kishida M Hishinuma F (1993) Secretion of mouse alpha amylase from fission yeast Schizosaccharomyces pombe: presence of chymostatin sensitive protease activity in the culture medium. Yeast 9:379–387

    Article  PubMed  CAS  Google Scholar 

  • Tokunaga M, Ishibashi M, Tatsuda D, Tokunaga H (1997) Secretion of mouse alpha amylase from Kluyveromyces lactis. Yeast 13:699–706

    Article  PubMed  CAS  Google Scholar 

  • Tommasino M (1991) Killer system of Kluyveromyces lactis: the open reading frame 10 of the pGKL2 plasmid encodes a putative DNA binding protein. Yeast 7:245–252

    Article  PubMed  CAS  Google Scholar 

  • Tommasino M, Ricci S, Galeotti C (1988) Genome organizaton of the killer plasmid pGKL2 from Kluyveromyces lactis. Nucleic Acids Res 16:5863–5878

    Article  PubMed  CAS  Google Scholar 

  • Trilla JA, Cos T, Duran A, Roncero D (1997) Characterization of CHS4 (CAL2), a gene of Saccharomyces cerevisiae involved in chitin biosynthesis and allelic to SKT5 and CSD4. Yeast 13:795–807

    Article  PubMed  CAS  Google Scholar 

  • Trilla JA, Duran A, Roncero C (1999) Chs7p, a new protein involved in the control of protein export from the endoplasmic reticulum that is specifically engaged in the regulation of chitin synthesis in Saccharomyces cerevisiae. J Cell Biol 145:1153–1163

    Article  PubMed  CAS  Google Scholar 

  • Wesolowski-Louvel M, Tanguy-Rougeau C, Fukuhara H (1988) A nuclear gene required for the expression of the linear DNA associated killer system of Kluyveromyces lactis. Yeast 4:71–81

    Article  PubMed  CAS  Google Scholar 

  • Wesolowski-Louvel M, Breunig K, Fukuhara H (1996) Kluyveromyces lactis. In: Wolf K (ed) Non-conventional yeasts in biotechnology: a handbook. Springer, Berlin Heidelberg New York, pp 139–201

    Chapter  Google Scholar 

  • White JH, Butler AR, Stark MJR (1989) Kluyveromyces lactis toxin does not inhibit yeast adenylyl cyclase. Nature 341:666–668

    Article  CAS  Google Scholar 

  • Wickner RB (1996) Double stranded RNA viruses of Saccharomyces cerevisiae. Microbiol Rev 60:250–265

    PubMed  CAS  Google Scholar 

  • Wilson DW, Meacock PA (1988) Extranuclear gene expression in yeast: evidence for a plasmid encoded RNA-polymerase of unique structure. Nucleic Acids Res 16:8097–8112

    PubMed  CAS  Google Scholar 

  • Yajima H, Tokunaga M, Nakayama-Murayama A, Hishinuma F (1997) Characterization of IKI1 and IKI3 genes conferring pGKL killer sensitivity on Saccharomyces cerevisiae. Biosci Biotech Biochem 61:704–709

    Article  CAS  Google Scholar 

  • Ziman M, Chuang JS, Schekman R (1996) Chs1p and Chs3p, two proteins involved in chitin synthesis, populate a compartment of the Saccharomyces cerevisiae endocytic pathway. Mol Biol Cell 7:1909–1919

    PubMed  CAS  Google Scholar 

  • Ziman M, Chuang JS, Tsung M, Hamamoto S, Schekman R (1998) Chs6p-dependent anterograde transport of Chs3p from the chitosome to the plasma membrane in Saccharomyces cerevisiae. Mol Biol Cell 9:1565–1576

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institut für Mikrobiologie, Westfälische Wilhelms-Universität, Corrensstraße 3, 48149, Münster, Germany

    Prof. Dr. Friedhelm Meinhardt

  2. Institut für Genetik, Martin-Luther-Universität, Domplatz 1, 06108, Halle/Saale, Germany

    Dr. Raffael Schaffrath

Authors
  1. Prof. Dr. Friedhelm Meinhardt
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Dr. Raffael Schaffrath
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Bochum, Germany

    K. Esser

  2. Darmstadt, Germany

    U. Lüttge

  3. Mainz, Germany

    J. W. Kadereit

  4. Bielefeld, Germany

    W. Beyschlag

Rights and permissions

Reprints and permissions

Copyright information

© 2001 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Meinhardt, F., Schaffrath, R. (2001). Extranuclear Inheritance: Cytoplasmic Linear Double-Stranded DNA Killer Elements of the Dairy Yeast Kluyveromyces lactis . In: Esser, K., Lüttge, U., Kadereit, J.W., Beyschlag, W. (eds) Progress in Botany. Progress in Botany, vol 62. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56849-7_4

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-56849-7_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-52378-6

  • Online ISBN: 978-3-642-56849-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation