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Functions of GABAA-Receptors: Pharmacology and Pathophysiology

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Pharmacology of GABA and Glycine Neurotransmission

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 150))

Abstract

Based on the diversity of constituent subunits the structual heterogenity of GABAA-receptors is well established (see BARNARD Chap. 2, this volume). The functional significance of GABAA-receptors subtypes in vivo, however, has largely remained unknown. It is only through genetic means — gene inactivation, reduction of gene dosage, point mutations — that the functional role of GABAA-receptor subtypes is beginning to be identified. The present chapter summarizes these attempts with regard to the pharmacology and pathophysiology of GABAA-receptor subtypes.

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  1. H. Möhler
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  1. Institute of Pharmacology and Toxicology, ETH and University of Zürich, Winterthurerstr. 190, CH-8057, Zürich, Switzerland

    Hanns Möhler

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Möhler, H. (2001). Functions of GABAA-Receptors: Pharmacology and Pathophysiology. In: Möhler, H. (eds) Pharmacology of GABA and Glycine Neurotransmission. Handbook of Experimental Pharmacology, vol 150. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56833-6_3

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  • DOI: https://doi.org/10.1007/978-3-642-56833-6_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-63191-7

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