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Durchblutungsfördernde Mittel

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Zusammenfassung

Durchblutungsfördernde Mittel werden bei peripheren und zerebralen Durchblutungsstörungen eingesetzt. Die Mehrzahl der Präparate ist nur noch für die Anwendung bei peripheren arteriellen Durchblutungsstörungen zugelassen. Diese indikative Abgrenzung ist vor allem dadurch entstanden, daß zahlreiche Herstellerfirmen ihre Präparate ab 1996 zusammen mit den Nootropika in eine neu geschaffene Indikationsgruppe „Antidementiva“ umgruppiert haben (s. ).

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Literatur

  • Adhoute G., Andreassian B., Boccalon H., Cloarec M., Di Maria G. et al. (1990): Treatment of stage II chronic arterial disease of the lower limbs with the serotonergic antagonist naftidrofuryl: results after 6 months of a controlled, multicenter study. J. Cardiovasc. Pharmacol. 16(Suppl. 3): S75–S80.

    PubMed  Google Scholar 

  • Adhoute G., Bacourt F., Barrai M., Cardon J.M., Chevalier J.M. et al. (1986): Naftidrofuryl in chronic arterial disease. Results of a six month controlled multicenter study using naftidrofuryl tablets 200 mg. Angiology 37: 160–167.

    CAS  Google Scholar 

  • Arzneimittelkommission der Deutschen Apotheker (1995): Naftidrofuryl Infusionslösung. Pharmazeut. Ztg. 140: 2222.

    Google Scholar 

  • Barradell L.B., Brogden R.N. (1996): Oral naftidrofuryl. A review of its pharmacology and therapeutic use in the management of peripheral occlusive arterial disease. Drugs Aging 8: 299–322.

    CAS  Google Scholar 

  • Bauer U. (1984): 6-Month double-blind randomised clinical trial of ginkgo biloba extract versus placebo in two parallel groups in patients suffering from peripheral arterial insufficiency. Arzneim. Forsch. 34: 716–720.

    CAS  Google Scholar 

  • Bollinger A., Frei Ch. (1977): Double-blind study of pentoxifylline against placebo in patients with intermittent claudication. Pharmatherapeutica 1: 557–563.

    Google Scholar 

  • Clifford P.C., Davies P.W., Hayne J.A., Baird R.N. (1980): Intermittent claudication: is a supervised exercise class worth while? Brit. Med. J. 280: 1503–1505.

    Article  CAS  Google Scholar 

  • Clyne C.A.C., Galland R.B., Fox M.J., Gustave R., Jantet G.H., Jamieson C.W. (1980): A controlled trial of naftidrofuryl (Praxilene) in the treatment of intermittent claudication. Br. J. Surg. 67: 347–348.

    Article  PubMed  CAS  Google Scholar 

  • Creasy T.S., McMillan P.J., Fletcher E.W.L., Collin J., Morris RJ. (1990): Is percutaneous transluminal angioplasty better than exercise for claudication?—Preliminary results from a prospective randomised trial. Eur. J. Vasc. Surg. 4: 135–140.

    Article  PubMed  CAS  Google Scholar 

  • Cummings D.M., Ballas S.K., Ellison M.J. (1992): Lack of effect of pentoxifylline on red blood cell deformability. J. Clin. Pharmacol. 32: 1050–1053.

    Article  PubMed  CAS  Google Scholar 

  • Dahllöf A.-G., Holm J., Scherstén T., Sivertsson R. (1976): Peripheral arterial insufficiency. Effect of physical training on walking tolerance, calf blood flow, and blood flow resistance. Scand. J. Rehab. Med. 8: 19–26.

    Google Scholar 

  • Dettori A.G., Pini M., Moratti A., Paolicelli M., Basevi P. et al. (1989): Acenocoumarol and pentoxifylline in intermittent claudication. A controlled clinical study. Angiology 40: 237–248.

    CAS  Google Scholar 

  • Di Perri T., Carandente O., Vittoria A., Guerrini M., Messsa G.L. (1984): Studies of the clinical pharmacology and therapeutic efficacy of pentoxifylline in peripheral obstructive arterial disease. Angiology 35: 427–435.

    Article  Google Scholar 

  • Donaldson D.R., Hall T.J., Kester R.C., Ramsden C.W., Wiggins P.A. (1984): Does oxpentifylline (’Trental’) have a place in the treatment of intermittent claudication? Curr. Med. Res. Opin. 9: 35–40.

    Article  CAS  Google Scholar 

  • Drabaek H., Petersen J.R., Winberg N., Hansen K.F., Mehlsen J. (1996): The effect of Ginkgo biloba extract in patients with intermittent claudication. Ugeskr. Laeger 158: 3928–3931.

    PubMed  CAS  Google Scholar 

  • Ekroth R., Dahllöf A.-G., Gundevall B., Holm J., Scherstén T. (1978): Physical training of patients with intermittent claudication: indications, methods, and results. Surgery 84: 640–643.

    PubMed  CAS  Google Scholar 

  • Ernst E., Kollár L., Resch K.L. (1992): Does pentoxifylline prolong the walking distance in exercised claudicants? A placebo-controlled double-blind trial. Angiology 43: 121–125.

    Article  PubMed  CAS  Google Scholar 

  • Ernst E. (1994): Pentoxifylline for intermittent claudication. A critical review. Angiology 45: 339–345.

    CAS  Google Scholar 

  • Gallus A.S., Morley A.A., Dupont P., Walsh H., Gleadow F. et al. (1985): Intermittent claudication: a double-blind study crossover trial of pentoxifylline. Aust. N. Z. J. Med. 15: 402–409.

    Article  PubMed  CAS  Google Scholar 

  • Girolami B., Bernardi E., Prins M.H., Wouter ten Cate J., Hettiarachchi R. et al. (1999): Treatment of intermittent claudication with physical training, smoking cessation, pentoxifylline, or nafronyl. Arch. Intern. Med. 159: 337–345.

    Article  PubMed  CAS  Google Scholar 

  • Heidrich H., Allenberg J., Cachovan M., Creutzig A., Diehm C. et al. (1992): Prüfrichtlinien für Therapiestudien im Fontaine-Stadium II-IV bei peripher-arterieller Verschlußkrankheit. Vasa 21: 333–337.

    PubMed  CAS  Google Scholar 

  • Hiatt W.R., Regensteiner J.G., Hargarten M.E., Wolfel E.E., Brass E.P. (1990): Benefit of exercise conditioning for patients with peripheral arterial disease. Circulation 81: 602–609.

    Article  PubMed  CAS  Google Scholar 

  • Hiatt W.R., Wolfel E.E., Meier R.H., Regensteiner J.G. (1994): Superiority of treadmill walking exercise versus strength training for patients with peripheral arterial disease. Circulation 90: 1866–1874.

    Article  PubMed  CAS  Google Scholar 

  • Housley E. (1988): Treating claudication in five words. Brit. Med. J. 296: 1483–1484.

    Article  CAS  Google Scholar 

  • Jonason T., Jonzon B., Ringqvist I., Öman-Rydberg A. (1979): Effect of physical training on different categories of patients with intermittent claudication. Acta Med. Scand. 206: 253–258.

    Article  PubMed  CAS  Google Scholar 

  • Karnik R., Valentin A., Stöllberger C., Slany J. (1988): Effects of naftidrofuryl in patients with intermittent claudication. Angiology 39: 234–240.

    Article  PubMed  CAS  Google Scholar 

  • Kiesewetter H., Blume J., Jung F., Gerhards M., Leipnitz G. (1987): Gehtraining und medikamentöse Therapie bei der peripheren arteriellen Verschlußkrankheit. Randomisierte, prospektive, placebo-kontrollierte Doppelblindstudie. Dtsch. Med. Wochenschr. 112: 873–878.

    Article  CAS  Google Scholar 

  • Kriessmann A., Neiss A. (1988): Klinischer Wirksamkeitsnachweis von Naftidrofuryl bei Claudicatio intermittens. VASA (Suppl. 24): 27–32.

    Google Scholar 

  • Larsen O.A., Lassen N.A. (1966): Effect of daily muscular exercise in patients with intermittent claudication. Lancet 2: 1093–1096.

    Article  PubMed  CAS  Google Scholar 

  • Lindgärde F., Jelnes R., Björkman H., Adielsson G., Kjellström T. et al. (1989): Conservative drug treatment in patients with moderately severe chronic occlusive peripheral arterial disease. Circulation 80: 1549–1556.

    Article  PubMed  Google Scholar 

  • Lundgren F., Dahllöf A.-G., Lundholm K., Scherstén T., Volkmann R. (1989): Intermittent claudication—surgical reconstruction or physical training? Ann. Surg. 209: 346–355.

    CAS  Google Scholar 

  • Mannarino E., Pasqualini L., Innocente S., Scricciolo V, Rignanese A., Ciuffetti G. (1991): Physical training and antiplatelet treatment in stage II peripheral arterial occlusive disease: alone or combined? Angiology 42: 513–521}.

    Article  PubMed  CAS  Google Scholar 

  • Moody A.P., Al-Khaffaf H.S., Lehert P., Harris P.L., Charlesworth D. (1994): An evaluation of patients with severe intermittent claudication and the effect of treatment with naftidrofuryl. J. Cardiovasc. Pharmacol. 23(Suppl. 3): S44–S47.

    PubMed  Google Scholar 

  • Norwegian Pentoxifylline Multicenter Trial Group (1996): Efficacy and clinical tolerance of parenteral pentoxifylline in the treatment of critical lower limb ischemia. Int. Angiol. 15: 75–80.

    Google Scholar 

  • Pedersen T.R., Kjekshus J., Pyörälä K., Olsson A.G., Cook T.J. et al. (1998): Effect of Simvastatin on ischemic signs and symptoms in the Scandinavian Simvastatin Survival Study (4S). Am. J. Cardiol. 81: 333–335.

    Article  PubMed  CAS  Google Scholar 

  • Porter J.M., Cutler B.S., Lee B.Y., Reich Th., Reichle F.A. et al. (1982): Pentoxifylline efficacy in the treatment of intermittent claudication. Multicenter controlled double-blind trial with objective assessment of chronic occlusive arterial disease patients. Am. Heart J. 104: 66–72.

    Article  PubMed  CAS  Google Scholar 

  • Quick C.R., Cotton L.T. (1982): The measured effect of stopping smoking on intermittent claudication. Brit. J. Surg. 69 (Suppl.): S24–S26.

    Article  PubMed  Google Scholar 

  • Radack K., Wyderski R.J. (1990): Conservative management of intermittent claudication. Ann. Intern. Med. 113: 135–146.

    Article  PubMed  CAS  Google Scholar 

  • Reilly D.T., Quinton D.N., Barrie W.W. (1987): A controlled trial of pentoxifylline (Trental 400) in intermittent claudication: clinical, haemostatic and rheological effects. New Zeal. Med. J. 100: 445–447.

    PubMed  CAS  Google Scholar 

  • Rieger H., Hossmann V. (1998): Medikamentöse Durchblutungssteigerung bei chronischer peripherer arterieller Verschlußkrankheit. In: Rieger H., Schoop W. (Hrsg.): Lehrbuch der Angiologie. Springer Verlag Berlin Heidelberg New York, S. 239–252.

    Google Scholar 

  • Roekaerts F., Deleers L. (1984): Trental® 400 in the treatment of intermittent claudication: results of long-term, placebo-controlled administration. Angiology 35: 396–406.

    Article  PubMed  CAS  Google Scholar 

  • Rudofsky G., Haussler K.E, Kunkel H.P., Schneider-May H., Spengel E, Symann O., Werner H.-J. (1989): Intravenous treatment of chronic peripheral occlusive arterial disease: a double-blind, placebo-controlled, randomized, multicenter trial of pentoxifylline. Angiology 40: 639–649.

    Article  PubMed  CAS  Google Scholar 

  • Scheffler A., Rieger H. (1999): Arterielle Durchblutungsstörungen. In: Paumgartner G. (Hrsg.): Therapie innerer Krankheiten. 9. Aufl., Springer Verlag Berlin Heidelberg New York, S. 257–273.

    Chapter  Google Scholar 

  • Scheffler P., de la Hamette D., Gross J., Mueller H., Schieffer H. (1994): Intensive vascular training in stage llb of peripheral arterial occlusive disease. The additive effects of intravenous prostaglandin El or intravenous pentoxifylline during training. Circulation 90: 818–822.

    CAS  Google Scholar 

  • Schoop W., Breddin K., Diehm C., Gruß J., Held K. et al. (1996): Klinische Prüfung mit Ginkgo biloba-Spezialextrakt Egb 761 bei Patienten mit peripherer arterieller Verschlußkrankheit im Stadium 11b nach Fontaine im Vergleich zu Placebo. Posterpublikation, Jahreskongress der Schweizerischen Gesellschaft für Angiologie 1.-2.11.1996.

    Google Scholar 

  • Strano A., Davi G., Avellone G., Novo S., Pinto A. (1984): Double-blind, crossover study of the clinical efficacy and the hemorheological effects of pentoxifylline in patients with occlusive arterial disease of the lower limbs. Angiology 35: 459–466.

    Article  PubMed  CAS  Google Scholar 

  • Transparenzkommission (1983): Transparenzliste für das Teilgebiet periphere arterielle Durchblutungsstörungen. Bundesanzeiger Nr. 169 vom 9.9.1983.

    Google Scholar 

  • Trübestein G., Böhme H., Heidrich H., Heinrich F., Hirche H., Maass U. et al. (1984): Naftidrofuryl in chronic arterial disease. Results of a controlled multicenter study. Angiology 35: 701–708.

    Article  PubMed  Google Scholar 

  • Völker D. (1983): Treatment of arteriopathies with pentoxifylline (Trental 400): results of a double-blind study. Pharmatherapeutica 3(suppl. 1): 136–142.

    Google Scholar 

  • Walker G.A., MacMannaford J.C. (1995): A meta-analysis of randomized, double-blind, placebo-controlled studies of the effect of buflomedil on intermittent claudication. Fundam. Clin. Pharmacol. 9: 387–394.

    Article  PubMed  CAS  Google Scholar 

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Schwabe, U. (2001). Durchblutungsfördernde Mittel. In: Schwabe, U., Paffrath, D. (eds) Arzneiverordnungs-Report 2000. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56832-9_24

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  • DOI: https://doi.org/10.1007/978-3-642-56832-9_24

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-67573-0

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