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Molekulare Diagnostik beim hereditären Mammakarzinom

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Gen-Medizin

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Zusammenfassung

Das Mammakarzinom ist der häufigste Krebs der Frau. Ein genaues Verständnis seiner Entstehung, Progression und Metastasierung, eine verbesserte Früherkennung und eine wirksame Therapie sind wichtige Ziele der Frauenheilkunde. Die Identifizierung der für Mamma- und Ovarialkarzinome prädisponierenden Gene BRCA1 und BRCA2 hat die Basis für eine molekulare Diagnostik bei Familien mit einem hohen Erkrankungsrisiko geschaffen. Diese Arbeit zeigt die molekularen Ursachen der Entstehung der hereditären Mammakarzinome auf und beschreibt den prädiktiven Gentest, seine Anwendung, seinen Nutzen und die damit verbundenen Probleme.

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  1. U. Hamann
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Editors and Affiliations

  1. Hasenbusch 27, 48159, Münster, Deutschland

    Arnold Maria Raem

  2. Labor Prof. Enders & Partner, Rosenbergstraße 85, 70193, Stuttgart, Deutschland

    Rüdiger W. Braun

  3. Hedwigstraße 12, 48149, Münster, Deutschland

    Hermann Fenger

  4. Universität Augsburg, Universitätsstraße 10, 86159, Augsburg, Deutschland

    Wolfgang Michaelis

  5. Medizinische Klinik I Klinikum Großhadern, Ludwig-Maximilians-Universität München, Marchioninistraße 15, 81377, München, Deutschland

    Sigrid Nikol

  6. Bundesärztekammer Dezernat VI (Wissenschaft und Forschung), Herbert-Lewin-Straße 1, 50931, Köln, Deutschland

    Stefan F. Winter

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Hamann, U. (2001). Molekulare Diagnostik beim hereditären Mammakarzinom. In: Raem, A.M., Braun, R.W., Fenger, H., Michaelis, W., Nikol, S., Winter, S.F. (eds) Gen-Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56818-3_10

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  • DOI: https://doi.org/10.1007/978-3-642-56818-3_10

  • Publisher Name: Springer, Berlin, Heidelberg

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  • Online ISBN: 978-3-642-56818-3

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