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Pankreasmanifestation

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Cystische Fibrose

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Zusammenfassung

Die cystische Fibrose ist die häufigste Ursache einer exokrinen Pankreasinsuffizienz im Kindes- und Jugendalter und gleichzeitig die häufigste hereditäre Pankreaserkrankung [26]. Im Gegensatz zur Lungenbeteiligung beginnt die Pankreaserkrankung meistens bereits in utero. Bei Geburt sind ca. 50%, mit einem Jahr ca. 80% der betroffenen Kinder pankreasinsuffizient. So sind es im jungen Kindesalter meistens die Zeichen der Malassimilation mit ihren Folgen, die eine CF vermuten lassen und zur Diagnose führen

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Literature

  1. Abman SH, Reardon MC, Accurso FJ, Hammond KB, Sokol RJ (1985) Hypoalbuminemia at diagnosis as a marker for severe respiratory course in infants with cystic fibrosis identified by newborn Screening. J Pediatr 107:933–935

    Article  PubMed  CAS  Google Scholar 

  2. Anderson D (1938) Cystic fibrosis of the pancreas and its relation to celiac disease. Am J Dis Child 56:344–399

    Google Scholar 

  3. Barraclough M, Taylor CJ (1996) Twenty-four hour ambulatory gastric and duodenal pH profiles in cystic fibrosis: effect of duodenal hyperacidity on pancreatic enzyme function and fat absorption. J Pediatr Gastroenterol Nutr 23:45–50

    Article  PubMed  CAS  Google Scholar 

  4. Benabdeslam H, Garcia I, Bellon G, Gilly R, Revol A (1998) Biochemical assessment of the nutritional Status of cystic fibrosis patients treated with pancreatic enzyme extracts. Am J Clin Nutr 67:912–918

    PubMed  Google Scholar 

  5. Benini L, Caliari S, Bonafante F et al. (1992) Near infrared reflectance measurement of nitrogen faecal losses. Gut 33:749–752

    Article  PubMed  CAS  Google Scholar 

  6. Benini L, Caliari S, Guidi GC et al. (1989) Near infrared spectroscopy for fecal measurement: comparison with conventional gravimetric and titrimeteric methods. Gut 30:1344–1347

    Article  PubMed  CAS  Google Scholar 

  7. Bines JE, Jacobowitz Israel E (1991) Hypoproteinemia, anemia, and failure to thrive in an infant. Gastroenterology 101:848–856

    PubMed  CAS  Google Scholar 

  8. Bonin A, Roy CC, Lasalle R, Weber A, Morin CL (1973) Fecal chymotrypsin: a reliable index of exocrine pancreatic function in children. J Pediatr 83:594–600

    Article  PubMed  CAS  Google Scholar 

  9. Borowitz DS, Grand RJ, Durie PR (1995) Use of pancreatic enzyme Supplements for patients with cystic fibrosis in the context of fibrosing colonopathy. Consensus Committee. J Pediatr 127:681–684

    Article  PubMed  CAS  Google Scholar 

  10. Bronstein MN, Sokol RJ, Abman SH, Chatfield BA, Hammond KB, Hambidge KM, Stall CD, Accurso FJ (1992) Pancreatic insufficiency, growth, and nutrition in infants identified by newborn Screening as having cystic fibrosis. J Pediatr 120:533–540

    Article  PubMed  CAS  Google Scholar 

  11. Campbell CA, Forrest J, Musgrove C (1994) High-strength pancreatic enzyme Supplements and large-bowel stricture in cystic fibrosis. Lancet 343:109

    Article  PubMed  CAS  Google Scholar 

  12. Chamarthy LM, Reinstein LJ, Schnapf B, Good RA, Bahna SL (1998) Desensitization to pancreatic enzyme intolerance in a child with cystic fibrosis. Pediatrics 102:313

    Article  Google Scholar 

  13. Cleghorn G, Benjamin L, Corey M, Forstner G, Dati F, Durie P (1985) Age-related alterations of immunoreactive pancreatic lipase and cationic trypsinogen in young children with cystic fibrosis. J Pediatr 107:377–381

    Article  PubMed  CAS  Google Scholar 

  14. Cleghorn G, Benjamin L, Corey M, Forstner G, Dati F, Durie P (1986) Serum immunoreactive pancreatic lipase and cationic trypsinogen for the assessment of exocrine pancreatic function in older patients with cystic fibrosis. Pediatrics 77:301–306

    PubMed  CAS  Google Scholar 

  15. Cohn JA, Friedman KJ, Noone PG, Knowles MR, Silverman LM, Jowell PS (1998) Relation between mutations of the cystic fibrosis gene and idiopathic pancreatitis. N Engl J Med 339:653–658

    Article  PubMed  CAS  Google Scholar 

  16. Cole SG, Rossi S, Stern A, Hofmann AF (1987) Cholesteryl octanoate breath test: preliminary studies on a new noninvasive test of human pancreatic exocrine function. Gastroenterology 93:1372–1380

    PubMed  CAS  Google Scholar 

  17. Corey M, Durie P, Moore D, Forstner G, Levison H (1989) Familial concordance of pancreatic function in cystic fibrosis. J Pediatr 115:274–277

    Article  PubMed  CAS  Google Scholar 

  18. Corey M, Gaskin K, Durie P, Levison H, Forstner G (1984) Improved prognosis in CF patients with normal fat absorption. J Pediatr Gastroenterol Nutr 3 (Suppl): S99-S105

    Article  PubMed  Google Scholar 

  19. Couper R, Durie PR (1996) Pancreatic function tests. In: Walker WA, Durie PR, Hamilton JR, Walker-Smith JA, Watkins JB (eds) Pediatric gastrointestinal disease, 2nd edn. Mosby, St. Louis, pp 1621–1634

    Google Scholar 

  20. Couper RTL, Corey M, Moore DJ, Fisher LJ, Forstner GG, Durie PR (1992) Decline of exocrine pancreatic function in cystic fibrosis patients with pancreatic sufficiency. Pediatr Res 32:179–182

    Article  PubMed  CAS  Google Scholar 

  21. Crossley JR, Smith PA, Edgar BW, Gluckman PD, Elliott RB (1981) Neonatal Screening for cystic fibrosis, using immunoreactive trypsin assay in dried blood spots. Clin Chim Acta 113:111–121

    Article  PubMed  CAS  Google Scholar 

  22. Cumming JGR, Forsyth JS, Boyd EJS, Frost GJ, Cuschieri A (1986) Diagnosis of exocrine insufficiency in cystic fibrosis by use of fluorescein dilaurate test. Arch Dis Child 61: 573–575

    Article  PubMed  CAS  Google Scholar 

  23. Darmstadt GL, Schmidt CP, Wechsler DS, Tunnessen WW, Rosenstein BJ (1992) Dermatitis as a presenting sign of cystic fibrosis. Arch Dermatol 128:1358–1364

    Article  PubMed  CAS  Google Scholar 

  24. Delchier JC, Vidon N, Girardin MFSM, Soule JC, Moulin C, Huchet B, Zylberberg P (1991) Fate of orally ingested enzymes in pancreatic insufficiency: comparison of two pancreatic enzyme preparations. Aliment Pharmacol Ther 5:365–378

    Article  PubMed  CAS  Google Scholar 

  25. Dewit O, Prentice A, Coward A, Weaver LT (1992) Starch digestion in young children with cystic fibrosis measured using a 13C breath test. Pediatr Res 32:45–49

    Article  PubMed  CAS  Google Scholar 

  26. Durie PR (1997) Inherited causes of exocrine pancreatic dysfunction. Can J Gastroenterol 11:145–152

    PubMed  CAS  Google Scholar 

  27. Durie PR, Bell L, Linton W, Corey ML, Forstner GG (1980) Effect of Cimetidine and sodium bicarbonate on pancreatic replacement therapy in cystic fibrosis. Gut 21: 778–786

    Article  PubMed  CAS  Google Scholar 

  28. Durie PR, Forstner CG (1989) Pathophysiology of the exocrine pancreas in cystic fibrosis. J R Soc Med 16: 2–10

    Google Scholar 

  29. Durie PR, Forstner GG, Gaskin KJ, Moore DJ, Cleghorn GJ, Wong SS, Corey ML (1986) Age-related alternations of immunoreactive pancreatic cationic trypsinogen in sera from cystic fibrosis patients with and without pancreatic insufficiency. Pediatr Res 20:209–213

    Article  PubMed  CAS  Google Scholar 

  30. Durie PR, Goldberg DM (1986) Biochemical tests of pancreatic function in infancy and childhood. Adv Clin En-zymol 4:77–92

    Google Scholar 

  31. Easley D, Krebs N, Jefferson M, Miller L, Erskine J, Accurso F, Hambidge KM (1998) Effect of pancreatic enzymes on zinc absorption in cystic fibrosis. J Pediatr Gastroenterol Nutr 26:136–139

    Article  PubMed  CAS  Google Scholar 

  32. Fanconi G, Uehlinger E, Knauer C (1936) Das Coeliakiesyndrom bei angeborener cystischer Pankreasfibromatose und Bronchiectasen. Wien Med Wochenschr 86: 753–756

    Google Scholar 

  33. Farrell PM, Kosorok MR, Laxova A, Shen G, Koscik RE, Bruns WT, Splaingard M, Mischler EH (1997) Nutritional benefits of neonatal Screening for cystic fibrosis. Wisconsin Cystic Fibrosis Neonatal Screening Study Group. N Engl J Med 337:9631–969

    Article  Google Scholar 

  34. Forget MT, van den Neucker A, Strik J, van Kreel B, Kuijten R (1994) The acid steatocrit: a much improved method. J Pediatr Gastroenterol Nutr 19:229–303

    Google Scholar 

  35. Forstner G, Durie PR (1996) Cystic fibrosis. In: Walker WA, Durie PR, Hamilton JR, Walker-Smith JA, Watkins JB (eds) Pediatric gastrointestinal disease, 2nd edn. Mosby, St. Louis, pp 1466–1487

    Google Scholar 

  36. Gaskin K, Gurwitz D, Durie P, Corey M, Levison H, Forstner G (1982) Improved respiratory prognosis in CF patients with normal fat absorption. J Pediatr 100:857–862

    Article  PubMed  CAS  Google Scholar 

  37. Gaskin K, Waters D, Dorney S, Gruca M, O’Halloran M, Wilcken B (1991) Assessment of pancreatic function in screened infants with cystic fibrosis. Pediatr Pulmonol Suppl 7:69–71

    Article  PubMed  CAS  Google Scholar 

  38. Gaskin KJ, Durie P, Hill RE, Lee LM, Forstner GG (1982) Colipase and maximally activated pancreatic lipase in normal subjects and patients with steatorhea. J Clin Invest 69:427–434

    Article  PubMed  CAS  Google Scholar 

  39. Gaskin KJ, Durie P, Lee L, Forstner GG (1984) Colipase and lipase secretion in childhood onset of pancreatic insufficiency: delineation of patients with steatorhea with relative colipase deficiency. Gastroenterology 86:1–7

    PubMed  CAS  Google Scholar 

  40. Greer R, Shepherd R, Cleghorn G, Bowling FG, Holt T (1991) Evaluation of growth and changes in body composition following neonatal diagnosis of cystic fibrosis. J Pediatr Gastroenterol Nutr 13:52–58

    Article  PubMed  CAS  Google Scholar 

  41. Gross V, Schoelmerich J, Denzel K, Gerok W (1989) Case report: Relapsing pancreatitis as initial manifestation of cystic fibrosis in a young man without pulmonary disease. Int J Pancreatology 4:221–228

    CAS  Google Scholar 

  42. Guarner L, Rodriguez R, Malagelada JR (1993) Fate of oral enzymes in pancreatic insufficiency. Gut 34:708–712

    Article  PubMed  CAS  Google Scholar 

  43. Gullo L, Graziano L, Babbini S, Battistini A, Lazzari R, Pezzilli R (1997) Faecal elastase 1 in children with cystic fibrosis. Eur J Pediatr 156:770–772

    Article  PubMed  CAS  Google Scholar 

  44. Hadorn B, Johansen PG, Anderson CM (1968) Pancreozymin secretin test of exocrine pancreatic function in cystic fibrosis and the significance of the result for the pathogenesis of the disease. Can Med Assoc J 98:377–385

    PubMed  CAS  Google Scholar 

  45. Hausler M, Meilicke R, Biesterfeld S, Heimann G (1998) First adult patient with fibrosing colonopathy. Am J Gastroenterol 93:1171–1172

    PubMed  CAS  Google Scholar 

  46. Heijerman HG, Lamers CB, Bakker W (1991) Omeprazole enhances the efficacy of pancreatin (pancrease) in cystic fibrosis. Ann Intern Med 114:200–201

    Article  PubMed  Google Scholar 

  47. Iacono G, Carroccio A, Cavataio F, Montalto G, Mancuso C, Balsamo V, Notarbartolo A (1990) Steatocrit test: normal range and physiological variations in infants. J Pediatr Gastroenterol Nutr 11:53–57

    Article  PubMed  CAS  Google Scholar 

  48. Imrie J, Fagan D, Sturgess J (1979) Quantitative evaluation of the development of the exocrine pancreas in cystic fibrosis and control subjects. Am J Pathol 95:697–708

    PubMed  CAS  Google Scholar 

  49. Jeejeebhoy KN, Ahmed S, Kozak G (1970) Determination of fecal fats containing both medium and long chain triglycerides and fatty acids. Clin Biochem 3:157–163

    PubMed  CAS  Google Scholar 

  50. Kerem E, Corey M, Kerem B-S, Rommens J, Markiewicz D, Levison H, Tsui LC, Durie P (1990) The relation between genotype and phenotype in cystic fibrosis — analysis of the most common mutation (Delta F508). N Engl J Med 323:1517–1522

    Article  PubMed  CAS  Google Scholar 

  51. Kerem E, Nissim RM, Argaman Z et al. (1997) A missense cystic fibrosis transmembrane conductance regulator mutation with variable phenotype. Pediatrics 100:E5

    Article  PubMed  CAS  Google Scholar 

  52. Khouri MR, Huang G, Shiau YF (1989) Sudan stain of fecal fat: new insight into an old test. Gastroenterology 96: 421–427

    PubMed  CAS  Google Scholar 

  53. Koletzko S, Corey M, Ellis L, Spino M, Stringer DA, Durie RP (1990) Effects of cisapride in patients with cystic fibrosis and distal intestinal obstuction Syndrome. J Pediatr 117:815–822

    Article  PubMed  CAS  Google Scholar 

  54. Koletzko S, Haisch M, Seeboth I, Braden B, Hengels K, Koletzko B, Hering P (1995) Isotope-selective non-dispersive infrared spectrometry for detection of Helicobacter pylori infection with 13C-urea breath test. Lancet 345:961–962

    Article  PubMed  CAS  Google Scholar 

  55. Koletzko S, Koletzko B (1993) Zystische Fibrose: Normalernährung oder Ernährungstherapie. In: Koletzko B (Hrsg) Ernährung chronisch kranker Kinder und Jugendlicher. Springer, Berlin Heidelberg New York Tokio, 167–190

    Chapter  Google Scholar 

  56. Koletzko S, Koletzko B, Reinhardt D (1994) Aktuelle Aspekte der Ernährungstherapie bei zystischer Fibrose. Monatsschr Kinderheilkd 142:432–445

    Google Scholar 

  57. Koletzko S, Reinhardt D (2001) Nutritional challenges in infants with cystic fibrosis. Early Hum Dev (in press)

    Google Scholar 

  58. Koletzko S, Stringer D, Cleghorn GJ, Durie PR (1989) Lavage treatment of distal intestinal obstuction Syndrome in children with cystic fibrosis. Pediatrics 83:727–733

    PubMed  CAS  Google Scholar 

  59. Kopelman H, Corey M, Gaskin K, Durie P, Weizman Z, Forstner G (1988) Impaired chloride secretion, as well as bicarbonate secretion, underlies the fluid secretory defect in the cystic fibrosis pancreas. Gastroenterology 95: 349–355

    PubMed  CAS  Google Scholar 

  60. Kopelman H, Durie P, Gaskin K, Weizman Z, Forstner G (1985) Pancreatic fluid secretion and protein hyper-concentration in cystic fibrosis. N Engl J Med 312:329–334

    Article  PubMed  CAS  Google Scholar 

  61. Kopelman H, Forstner G, Durie P, Corey M (1989) Origins of chloride and bicarbonate secretory defects in the cystic fibrosis pancreas, as suggested by pancreatic function studies on control and CF subjects with preserved pancreatic function. Clin Invest Med 12:207–211

    PubMed  CAS  Google Scholar 

  62. Kristidis P, Bozon D, Corey M, Markiewicz D, Rommens J, Tsui L-C, Durie P (1992) Genetic determination of exocrine pancreatic function in cystic fibrosis. N Engl J Med 323:1517–1522

    Google Scholar 

  63. Lembcke B, Braden B, Stein J (1994) Diagnostik der Steatorrhö. Z Gastroenterol 32:256–261

    PubMed  CAS  Google Scholar 

  64. Marcus MS, Sondel SA, Farell PM, Laxova A, Carey PM, Langhough R, Mischler EH (1991) Nutritional Status of infants with cystic fibrosis associated with early diagnosis and intervention. Am J Clin Nutr 54:578–585

    PubMed  CAS  Google Scholar 

  65. Marino CR, Matovcik LM, Gorelick FS, Cohn JA (1991) Localization of the cystic fibrosis transmembrane conductance regulator in pancreas. J Clin Invest 88:712

    Article  PubMed  CAS  Google Scholar 

  66. Meyer JH, Elashoff J, Porter-Fink V, Dressman J, Amidon GL (1988) Human postprandial gastric emptying of 1–3 millimeter spheres. Gastroenterology 94:1315–1325

    PubMed  CAS  Google Scholar 

  67. Monzon CM, Woodruff CW (1986) Anemia and edema as presenting signs in cystic fibrosis: case report. J Med 17:135–141

    PubMed  CAS  Google Scholar 

  68. Munch R, Brägger CP, Altorfer J, Hoppe B, Shmerling DH, Ammann R (1998) Faecal immunoreactive lipase: a simple diagnostic test for cystic fibrosis. Eur J Pediatr 157:282–286

    Article  PubMed  CAS  Google Scholar 

  69. Mundlos S, Kühnelt P, Adler G (1990) Monitoring enzyme replacement treatment in exocrine pancreatic insufficiency using the cholesteryl octanoate breath test. Gut 31: 1324–1328

    Article  PubMed  CAS  Google Scholar 

  70. Murphy MS, Eastham EJ, Nelson R, Aynsley-Green A (1990) Non-invasive assessment of intraluminal lipolysis using a 13C02 breath test. Arch Dis Child 65:574–578

    Article  PubMed  CAS  Google Scholar 

  71. Neis P, Zeub F (1981) Über die Anwendbarkeit von Fluoresceindilaurat zur exokrinen Pankreasfunktionsprüfung bei Kindern. Monatsschr Kinderheilkd 129: 347–348

    PubMed  CAS  Google Scholar 

  72. Neumeister V, Henker J, Kaltenborn G, Sprossig C, Jaross W (1997) Simultaneous determination of fecal fat, nitrogen, and water by near-infrared reflectance spectroscopy. J Pediatr Gastroenterol Nutr 25:388–393

    Article  PubMed  CAS  Google Scholar 

  73. Newcomer AD, Hofmann AF, DiMagno EP, Thomas PJ, Carlson GL (1979) Triolein breath test: a sensitive and specific test for fat malabsorption. Gastroenterology 76:6–13

    PubMed  CAS  Google Scholar 

  74. Nielsen OH, Larsen BF (1982) The incidence of anemia, hypoproteinemia, and edema in infants as presenting Symptoms of cystic fibrosis: a retrospective survey of the frequency of this Symptom complex in 130 patients with cystic fibrosis. J Pediatr Gastroenterol Nutr 1:355–359

    Article  PubMed  CAS  Google Scholar 

  75. Parad RB (1996) Heterogeneity of phenotype in two cystic fibrosis patients homozygous for the CFTR exon 11 mutation G551D. J Med Genet 33:711–713

    Article  PubMed  CAS  Google Scholar 

  76. Park RW, Grand RJ (1981) Gastrointestinal manifestations of cystic fibrosis: a review. Gastroenterology 81: 1143–1161

    PubMed  CAS  Google Scholar 

  77. Pedroli G, Liechti GS, Mauri S, Birrer P, Kraemer R, Foletti JC, Bianchetti MG (1995) Chronic metabolic alkalosis: not uncommon in young children with severe cystic fibrosis. Am J Nephrol 15:245–250

    Article  PubMed  CAS  Google Scholar 

  78. Reid CJ, Hyde K, Ho SB, Harris A (1997) Cystic fibrosis of the pancreas: involvement of MUC6 mucin in obstruction of pancreatic ducts. Mol Med 3:403–411

    Article  PubMed  CAS  Google Scholar 

  79. Robinson P, Sly PD (1990) Placebo-controlled trial of misoprostol in cystic fibrosis. J Pediatr Gastroenterol Nutr 11:37–40

    Article  PubMed  CAS  Google Scholar 

  80. Robinson PJ, Smith AL, Sly PD (1990) Duodenal pH in cystic fibrosis and its relationship to fat malabsorption. Dig Dis Sei 35:1299–1304

    Article  CAS  Google Scholar 

  81. Rosenstein BJ, Cutting GR (1998) The diagnosis of cystic fibrosis: a consensus Statement. Cystic Fibrosis Foundation Consensus Panel. J Pediatr 132:589–595

    Article  PubMed  CAS  Google Scholar 

  82. Schoenberger W, Weitzel D (1980) Diagnose der exokrinen Pankreas-Insuffizienz mit Flurescein-Dilaurat bei Patienten mit Cystischer Fibrose. Monatsschr Kinderheilkd 128:195–198

    Google Scholar 

  83. Schwarzenberg SJ, Wielinski CL, Shamieh I, Carpenter BL, Jessurun J, Weisdorf SA, Warwick WJ, Sharp HL (1995) Cystic fibrosis-associated Colitis and fibrosing colonopathy. J Pediatr 127:565–570

    Article  PubMed  CAS  Google Scholar 

  84. Sharer N, Schwarz M, Malone G, Howarth A, Painter J, Super M, Braganza J (1998) Mutations of the cystic fibrosis gene in patients with chronic pancreatitis. N Engl J Med 339:645–652

    Article  PubMed  CAS  Google Scholar 

  85. Shmerling DH, Forrer JCW, Prader A (1970) Fecal fat and nitrogen in healthy children and in children with malabsorption or maldigestion. Pediatrics 5:690–695

    Google Scholar 

  86. Shwachman H (1975) Gastrointestinal manifestations of cystic fibrosis. Pediatr Clin North Am 22:787–805

    PubMed  CAS  Google Scholar 

  87. Shwachman H, Lebenthal E, Khaw K-T (1975) Recurrent acute pancreatitis in patients with cystic fibrosis with normal pancreatic enzymes. Pediatrics 55:86–95

    PubMed  CAS  Google Scholar 

  88. Smyth RL, van Velzen D, Smyth AR, Lloyd DA, Heaf DP (1994) Strictures of ascending colon in cystic fibrosis and high-strength pancreatic enzymes. Lancet 343:85–86

    Article  PubMed  CAS  Google Scholar 

  89. Sokol RJ, Reardon MC, Accurso FJ, Stall C, Narkewicz M, Abman SH, Hammond KB (1989) Fat-soluble-vitamin Status during the first year of life in infants with cystic fibrosis identified by Screening of newborns. Am J Clin Nutr 50:1064–1071

    PubMed  CAS  Google Scholar 

  90. Sokol RJ, Reardon MC, Accurso FJ, Stall C, Narkewicz MR, Abman SH, Hammond KB (1991) Fat-soluble vitamins in infants identified by cystic fibrosis newborn Screening. Pediatr Pulmonol Suppl 7:52–55

    Article  PubMed  CAS  Google Scholar 

  91. Soldan W, Henker J, Sprossig C (1997) Sensitivity and specificity of quantitative determination of pancreatic elastase 1 in feces of children. J Pediatr Gastroenterol Nutr 24:53–55

    Article  PubMed  CAS  Google Scholar 

  92. Stein J, Jung M, Sziegoleit A, Zeuzem S, Caspary WF, Lembcke B (1996) Immunoreactive elastase I: clinical evaluation of a new noninvasive test of pancreatic func-tion. Clin Chem 42:222–226

    PubMed  CAS  Google Scholar 

  93. Stein J, Spirchez B, Lembcke B, Caspary WE (1997) Untersuchungen zur Bedeutung der Elastase-Bestimmung als einen neuen nicht-invasiven Test der exokrinen Pankreasinsuffizienz. Z Gastroenterol Suppl 1:122–129

    Google Scholar 

  94. Stevens JC, Maguiness KM, Hollingsworth J, Heilman DK, Chong SK (1998) Pancreatic enzyme supplementation in cystic fibrosis patients before and after fibrosing colonopathy. J Pediatr Gastroenterol Nutr 26:80–84

    Article  PubMed  CAS  Google Scholar 

  95. Strong TV, Boehm K, Collins FS (1994) Localization of the cystic fibrosis transmembrane conductance regulator mRNA in the human gastrointestinal tract by in situ hybridization. J Clin Invest 93:347

    Article  PubMed  CAS  Google Scholar 

  96. Sturgess JM (1984) Structural and developmental abnormalities of the exocrine pancreas in cystic fibrosis. Proceedings of the 5th Professional Conference of the Cana-dian Cystic Fibrosis Foundation. J Pediatr Gastroenterol Nutr 3:S55–S66

    Article  PubMed  Google Scholar 

  97. Taylor CJ (1994) Colonic strictures in cystic fibrosis. Lancet 343:615–616

    Article  PubMed  CAS  Google Scholar 

  98. Taylor CJ, Dodge CJ (1994) High-strength pancreatic enzyme Supplements and large-bowel stricture in cystic fibrosis. Lancet 343:110

    Article  PubMed  CAS  Google Scholar 

  99. Thompson GN (1988) Excessive taurine loss predisposes to taurine deficiency in cystic fibrosis. J Pediatr Gastroenterol Nutr 7:214–219

    Article  PubMed  CAS  Google Scholar 

  100. Tran TM, Van-den NA, Hendriks JJ, Forget P, Forget PP (1998) Effects of a proton-pump inhibitor in cystic fibrosis. Acta Paediatr 87:553–558

    Article  PubMed  CAS  Google Scholar 

  101. van de Kamer JK, ten Bokkel Huinink H, Weyers HA (1949) Rapid method for the determination of fat in feces. J Biol Chem 2:347–355

    Google Scholar 

  102. Vantrappen GR, Rutgeerts PJ, Ghoos YF, Hiele MI (1989) Mixed triglyceride breath test: a noninvasive test of pancreatic lipase activity in the duodenum. Gastroenterology 96:1126–1134

    PubMed  CAS  Google Scholar 

  103. Waters DL, Dorney SFA, Gaskin KJ, Gruca MA, O’Halloran M, Wilcken B (1990) Pancreatic function in infants identified as having cystic fibrosis in a neonatal Screening program. N Engl J Med 322:303–308

    Article  PubMed  CAS  Google Scholar 

  104. Watkins JB, Klein PD, Schoeller DA, Kirschner BS, Park R, Perman JA (1982) Diagnosis and differentiation of fat malabsorption in children using 13C-labeled lipids: trioctanoin, triolein, and palmitic acid breath tests. Gastroenterology 82:911–917

    PubMed  CAS  Google Scholar 

  105. Weber AM, Roy CC, Morin CL, Lasalle R (1973) Malabsorption of bile acids in children with cystic fibrosis. N Engl J Med 289:1001–1005

    Article  PubMed  CAS  Google Scholar 

  106. Weizman Z, Forstner GG, Gaskin KJ, Kopelman H, Wong S, Durie PR (1985) Bentiromide test for assessing pancreatic dysfunction using analysis of para-aminobenzoic acid in plasma and urine: studies in cystic fibrosis and Shwachman’s Syndrome. Gastroenterology 89:596–604

    PubMed  CAS  Google Scholar 

  107. Wilcken B (1987) An evaluation of Screening for cystic fibrosis in genetics and epithelial cell dysfunction. In: Riordan JR, Buchwald M (eds) Cystic fibrosis. Alan R Liss, New York, p 201

    Google Scholar 

  108. Zeng W, Lee MG, Yan M, Diaz J, Benjamin I, Marino CR, Kopito R, Freedman S, Cotton C, Muallem S, Thomas P (1997) Immuno and functional characterization of CFTR in submandibular and pancreatic acinar and duct cells. Am J Physiol 273:C442–C445

    PubMed  CAS  Google Scholar 

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  1. Kinderklinik und Poliklinik im Dr. von Haunerschen Kinderspital der Ludwig-Maximilians-Universität, Lindwurmstr. 4, 80337, München, Deutschland

    Dietrich Reinhardt

  2. Abteilung für Kinder- und Jugendheilkunde, Wilhelminenspital der Stadt Wien, Montlearstr. 37, 1171, Wien, Österreich

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    Richard Kraemer  & Martin H. Schöni  & 

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Koletzko, S. (2001). Pankreasmanifestation. In: Reinhardt, D., Götz, M., Kraemer, R., Schöni, M.H. (eds) Cystische Fibrose. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56796-4_8

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