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Zellbiologie

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Cystische Fibrose

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Zusammenfassung

Dem Krankheitsbild der cystischen Fibrose liegt auf zellulärer Ebene eine schwere Störung des Elektrolyttransports des Epithelgewebes des Epithelgewebes zugrunde. Bereits 1953 beschrieben diSant’Agnese und Mitarbeiter einen exzessiven Salzverlust bei Kindern mit Mukoviszidose während sommerlicher Hitzeperioden über den Schweiß [58], eine Beobachtung, diezur Bestimmung der Natrium- und Chloridionen-konzentrationen im Schweiß als diagnostischer Standard bis heute führte [71]. Da die bei der CF betroffenen Organe, wie Schweißdrüsen, Tracheobron-chialsystem, Pankreas, Speicheldrüsen, Nebenhoden und Darm, epitheliale Organe darstellen und die Sekrete dieser Organe abnorm eingedickt bzw. dehydriert sind, wurde die Forschung auf den Elektrolyt- und Wassertransport von CF-Epithelgewebe fokussiert

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  1. S. Gallati
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  2. R. Kraemer
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  4. C. Randak
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  1. Kinderklinik und Poliklinik im Dr. von Haunerschen Kinderspital der Ludwig-Maximilians-Universität, Lindwurmstr. 4, 80337, München, Deutschland

    Dietrich Reinhardt

  2. Abteilung für Kinder- und Jugendheilkunde, Wilhelminenspital der Stadt Wien, Montlearstr. 37, 1171, Wien, Österreich

    Manfred Götz

  3. Inselspital, Medizinische Universitäts-Kinderklinik, Freiburgstr. 23, 3010, Bern, Schweiz

    Richard Kraemer  & Martin H. Schöni  & 

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Gallati, S., Kraemer, R., Kunzelmann, K., Randak, C., Schöni, M.H., Tümmler, B. (2001). Zellbiologie. In: Reinhardt, D., Götz, M., Kraemer, R., Schöni, M.H. (eds) Cystische Fibrose. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56796-4_2

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