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Männliche Gonaden

  • R. Ochsenkühn
  • E. Nieschlag

Zusammenfassung

Infertilität und Hypogonadismus stellen Symptome unterschiedlicher Erkrankungen mit zahlreichhen möglichen Ursachen dar. Beide Symptome sind das Erscheinungsbild einer Unterfunktion der Gonaden. Hypogonadismus geht regelmäßig mit einer Infertilität einher, wohingegen eine Infertilität isoliert vorkommen kann. Die Gründer der männlichen Infertilität und des liegen auf unterschiedlichen Niveaus des Organismus. Ursächlich kommen Störungen des Hodens, der Hypophyse oder des Hypothalmus in Betracht, der z. B. durch genetische, endokrine, entzüundliche,altersassoziierte oder umweltbedingte Vorgänge zurgrunde liegen können.

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Literatur

Literatur zu Abschn. 6.1

  1. Drews U. (1995) Morphologische Entwicklung der Sexualorgane. Gynäkologe 28(1):5–11PubMedGoogle Scholar
  2. Ergün S., Stingl J., Holstein A.F. (1994) Segmental angioarchitecture of the testicular lobule in man. Andrologia 26: 143–150PubMedCrossRefGoogle Scholar
  3. Gustafson M.L., Donahoe P.K. (1994) Male sex determination: current concepts of male sexual differentiation. Ann Rev Med 45: 505–524PubMedCrossRefGoogle Scholar
  4. Thews G., Mutschier E., Vaupel P. (1989) Fortpflanzungsorgane und Schwangerschaft. In: Thews G., Mutschier E., Vaupel P. (Hrsg) Anatomie, Physiologie, Pathophysiologie des Menschen, Wissenschaftliche Verlags gesellschaft mbH, Stuttgart, S 581–603Google Scholar

Literatur zu Abschn. 6.2

  1. Anwar R., Gilbey S.G., New J.P., Markharn A.F. (1997) Male pseudohermaphrodltlsm resultmg from a novel mutation in the human steroid 5 alpha-reductase type 2 gene (SRD5A2). Mol Pathol 50: 51–52PubMedCrossRefGoogle Scholar
  2. Behre H.M., Kliesch S., Leifke E., Link T.M., Nieschlag E. (1997) Long-term effect of testosterone therapy on bone mineral density in hypogonadal men. J Clin Endocrinol Metab 82: 2386–2390PubMedCrossRefGoogle Scholar
  3. Behre H.M., Young C-H., Holstein A.F., Weinbauer G.F. Gassner P., Nieschlag E. (2000) Diagnostik der Infertilität und des Hypognadismus. In: Nieschlag E., Behre H.M. (Hrsg) Andrologie: Grundlagen und Klinik der reproduktiven Gesundheit des Mannes (2. Aufl.). Springer, Berlin Heidelberg New York Tokyo, pp 96–135Google Scholar
  4. Carani C., Qin K., Simoni M., Faustini-Fustini M., Serpente S., Boyd J., Korach K.S., Simpson E.R. (1997) Effect of testosterone and estradiol in a man with aromatase deficiency. N Engl J Med 337: 91–95PubMedCrossRefGoogle Scholar
  5. Christiansen K. (1998) Behavioural correlates of testosterone. In: Nieschlag E., Behre H.M. (Hrsg) Testosterone: Action-Deficiency-Substitution. Springer, Berlin Heidelberg New York Tokyo, pp 107–142CrossRefGoogle Scholar
  6. Clark P.A., Iranmanesh A., Veldhuis J.D., Rogol A.D. (1997) Comparison of pulsatile luteinizing hormone secretion between prepubertal children and young adults: evidence for a mass/amplitude-dependent difference without gender or day/night contrasts. J Clin Endocrinol Metab 82: 2950–2955PubMedCrossRefGoogle Scholar
  7. Conn P.M., Crowley W.F. Jr. (1994) Gonadotropin-releasing hormone and its analogs. Annu Rev Med 45: 391–405PubMedCrossRefGoogle Scholar
  8. Von Eckardstein A. (1998) Androgens: cardiovascular risk factors and atherosclerosis. In: Nieschlag E., Behre H.M. (Hrsg) Testosterone: Action-Deficiency-Substitution. Springer Berlin Heidelberg New York Tokyo, pp 229–258CrossRefGoogle Scholar
  9. Evans R. (1988) The steroid thyroid hormone receptor superfamily. Science 240: 889–895PubMedCrossRefGoogle Scholar
  10. Gharib S.D., Wierman M.E., Shupnik M.A., Chin W.W. (1990) Molecular biology of the pituitary gonadotropins. Endocr Rev 11: 177–199PubMedCrossRefGoogle Scholar
  11. Randall V.A. (1998) Androgens and hair. In: Nieschlag E., Behre H.M. (Hrsg) Testosterone, Action-Deficiency-Substitution.Springer, Berlin Heidelberg New York Tokyo, pp 169–186CrossRefGoogle Scholar
  12. Redmond G.P., Olson W.H., Lippman J.S., Kafrissen M.E., Jones T.M., Jonzzo J.L. (1997) Norgestimate and ethinyl estradiol m the treatment of acne vulgaris: a randomized, placebocontrolled trial. Obstet Gynecol 89: 615–622PubMedCrossRefGoogle Scholar
  13. Schlatt S., Meinhardt A., Nieschlag E. (1997) Paracrine regulation of cellular interactions m the testis: factors in search of a function. Eur J Endocrinol 137: 107–117PubMedCrossRefGoogle Scholar
  14. Shupnik M.A., Schreihofer D.A. (1997) Molecular aspects of steroid hormone action in the male reproductive axis. J Androl 18: 341–344PubMedGoogle Scholar
  15. Simoni M., Gromoll J., Nieschlag E. (1997) The follicle-stimulating hormone receptor: biochemistry, molecular biology, physiology, and pathophysiology. Endocr Rev 18: 739–773PubMedCrossRefGoogle Scholar
  16. Smith E.P., Boyd J., Frank G.R. et al. (1994) Estrogen resistance caused by a mutation m the estrogen-receptor gene in a man. N Engl J Med 331: 1056–1061PubMedCrossRefGoogle Scholar
  17. Thiboutot D., Harris G., Iles V., Cimis G., Gilliland K., Hagari S. (1995) Activity of the type 1 5 alpha-reductase exhibits regional differences in isolated sebaceous glands and whole skin. J Invest Dermatol 105: 209–214PubMedCrossRefGoogle Scholar
  18. Wang C., Alexander G., Berman N., Salehian B., Davidson T., McDonald V., Steiner B., Hull L., Callegari C., Swerdloff R.S. (1996) Testosterone replacement therapy improves mood m hypogonadal men-a clinical research center study. J Clin Endocrinol Metab 81: 3578–3583PubMedCrossRefGoogle Scholar
  19. Weinbauer G.F., Gromoll J., Simoni M., Nieschlag E. (2000) Physiologie der Hodenfunktion. In: Nieschlag E., Behre H.M. (Hrsg) Andrologie. Grundlagen und Klinik der reproduktiven Gesundheit des Mannes. Springer, Berlin Heidelberg New York Tokyo, pp 27–67Google Scholar
  20. Wu F.C.W., Farley T.M.M., Peregoudov A., Waites G.M. (1996) Effects of testosterone enanthate in normal men: experience from a multicenter contraceptive efficacy study, Fertil Steril 65: 626–636PubMedGoogle Scholar

Literatur zu Abschn. 6.3

  1. Handelsman D.J. (2000) Hypogonadismus und Infertilität bei systemischen Erkrankungen. In: Nieschlag E., Behre H.M. (Hrsg) Andrologie: Grundlagen und Klinik der reproduktiven Gesundheit des Mannes. Springer, Berlin Heidelberg New York Tokyo, pp 267–278Google Scholar
  2. Nieschlag E., von zur Mühlen A., Sippel W.G. (1993) Männliche Gonaden. In: Deutsche Gesellschaft für Endokrinologie (Hrsg) Rationale Diagnostik m der Endokrinologie. Thieme, Stuttgart, pp 186–212Google Scholar
  3. Salzbrunn A., Benson D.M., Holstein A.F., Schulze W. (1996) A new concept fur the extraction of testicular spermatozoa as a tool for assisted fertilization (ICSI). Hum Reprod 11: 752–755PubMedCrossRefGoogle Scholar
  4. Simoni M. Gromoll J., Dworniczak R. et al. (1997) Screening for deletions of the Y chromosome involving the DAZ (Veleted in Azoospermia) gene in azoospermia and severe oligozoospermia. Fertil Steril 67: 542–547PubMedCrossRefGoogle Scholar
  5. WHO:Laborhandbuch zur Untersuchung des menschlichen Ejakulates und der Spermien-Zervikalschleim-Interaktion. (1999) 4. Aufl, übersetzt von Nieschlag E et al., Springer, Berlin Heidelberg New York TokyoGoogle Scholar

Literatur zu Abschn. 6.4 bis 6.73

  1. Arbeitsgemeinschaft gynäkologische Endokrinologie und Fortpflanzungsmedizin (Hrsg) (1999) Deutsches IVF-Register. Jahrbuch 1998. Bad Segeberg.Google Scholar
  2. Behre, H.M., Bohmeyer J., Nieschlag E.. (1994) Prostate volume in testosterone-treated and untreated hypogonadal men in comparison to age-matched normal eontrols. Clin Endocrinol 40: 341–349CrossRefGoogle Scholar
  3. Behre H.M., S. Kliesch, E. Leifke, T.M. Link, P.E. Peters, E. Nieschlag (1997) Long-term effect of testosterone therapy on bone mineral density in hypogonadal men. J Clin Endocrinol Metabol 82: 2386–2390Google Scholar
  4. Biller B.M., Molitch M.E., Vanee M.L. et al. (1996) Treatment of prolactin-seereting macroadenomas with the once-weekly dopamine agonist cabergoline. J Clin Endocrinol Metab 81: 2338–2343PubMedCrossRefGoogle Scholar
  5. Brocks D.R.., Meikle A.W., Boike S.C., Mazer N.A., Zariffa N., Audet P.R., Jorkasky D.K. (1996) Pharmacokinetics of testosterone in hypogonadal men after transdermal delivery: influenee of dose. J Clin Pharmacol 36: 732–739PubMedCrossRefGoogle Scholar
  6. Büchter D., Behre H.M., Kliesch S., Nieschlag E. (1998) Pulsatile GnRH or human ehorionic gonadotropin/human menopausal gonadotrop in as effective treatment for men with hypo gonadotrop in hypogonadism: a review of 42 eases. Eur J Endocrinol 139: 298–303PubMedCrossRefGoogle Scholar
  7. von Eckardstein S., Nieschlag E. (1998) Substititionstherapie mit Testosteron. Der Kassenarzt 8: 39–41Google Scholar
  8. Fukuda M., Fukuda K., Shimizu T., Yomura W., Shimizu S. (1996) Kobe earthquake and redueed sperm motility. Hum Reprod 11: 1244–1246PubMedCrossRefGoogle Scholar
  9. Glenn C.C., Driseoll D.J., Yang T.P., Nieholls R.D. (1997) Genomic imprinting: potential funetion and meehanisms revealed by the Prader-Willi and Angelman syndromes. Mol Hum Reprod 3: 321–332PubMedCrossRefGoogle Scholar
  10. Handelsman D.J. (2000) Hypogonadismus und Infertilität bei systemischen Erkrankungen. In: Nieschlag E., Behre H.M. (Hrsg) Andrologie: Grundlagen und Klinik der reproduktiven Gesundheit des Mannes, Springer, Berlin Heidelberg New York Tokyo (2. Aufl.) S 267–278Google Scholar
  11. Hauffa B.P. (1997) One-year results of growth hormone treatment of short stature in Prader-Willi syndrome. Acta Paediatr Suppl 423: 63–65CrossRefGoogle Scholar
  12. Hoorweg-Nijman J.J.G., Harvers H.M., Delemarre-van de Waal H.A. (1994) Effeet of human chorionic gonadotrop in (hCG)/ follide-stimulating hormone treatment vs. hCG alone on testicular descent: a double-blind placebo-controlled study. Eur J Endocrinol 130: 60–64PubMedCrossRefGoogle Scholar
  13. Hutson J.M., Hasthorpe S., Heyns C.F. (1997) Anatomical and functional aspects of testicular descent and cryptorchidism. Endocr Rev 18: 259–280PubMedCrossRefGoogle Scholar
  14. Kamisehke A., Behre H.M., Bergmann M., Simoni M., Schäfer T., Nieschlag E. (1998) Recombinant human FSH for treatment of male idiopathic infertility: A randomized, double-blind, placebo-controlled, dinical trial. Hum Reprod 13: 596–603CrossRefGoogle Scholar
  15. Nieschlag E., Behre H.M. (Hrsg) (2000) Andrologie: Grundlagen und Klinik der reproduktiven Gesundheit des Mannes (2. Aufl.) Springer, Berlin Heidelberg New York TokyoGoogle Scholar
  16. Nieschlag E., Lerchl A. (1996) Dedining sperm counts in European men-faet or fiction? Andrologia 28: 305–306PubMedCrossRefGoogle Scholar
  17. Nieschlag E., Brabant G., Schopohl J., Sippell W. (1997) Männliche Gonaden: Hypogonadismus, Infertilität, Pubertätsstärungen. In: Deutsche Gesellschaft für Endokrinologie (Hrsg), Rationelle Therapie in der Endokrinologie. Thieme, Stuttgart, S 317–340Google Scholar
  18. Nieschlag E., Behre H. M., Fischedick A., Hertle L. (1998) Varikozelenbehandlung im Zeitalter der Evidence-based Medicine: Arztliche Beratung so erfolgreich wie interventionelle Behandlung (Ligatur oder Embolisation). Urologe A 27: 263–269Google Scholar
  19. Nieschlag (1998) Pharmacology and dinical use of testosterone. In: Nieschlag E., Behre H.M. (Hrsg) Testosterone, Action-Deficiency-Substitution. Springer, Berlin Heidelberg New York Tokyo, S 293–328CrossRefGoogle Scholar
  20. Palermo G.D., Schlegel P.N., Sills E.S., Veeek L.L., Zaninovic N., Menendez S., Rosenwaks Z. (1998) Births after intracytoplasmic injection of sperm obtained by testicular extraction from men with nonmosaie Klinefelter’s syndrome. N Engl J Med 338: 588–590PubMedCrossRefGoogle Scholar
  21. Peterson C.M., Hatasaka J.J., Jones K.P. (1994) Ovulation in duction with gonadotropins and intrauterine insemination compared with in vitro fertilization and not therapy: a prospective, nonrandomized, cohort study and meta-analysis. Fertil Steril 62: 535–544PubMedGoogle Scholar
  22. de Roux N., Young J., Misrahi M., Genet R., Chanson P., Schaison G., Milgrom E. (1997) A family with hypogonadotropic hypogonadism and mutations in the gonadotropin-releasing hormone receptor. N Engl J Med 337: 1597–1602PubMedCrossRefGoogle Scholar
  23. Sasco A.J., Lowenfels A.B., Pasker-de Jong P. (1993) Review artide: epidemiology of male breast cancer. A meta-analysis of published case-control studies and discussion of selected aetiological factors. Int J Cancer 53: 538–549PubMedCrossRefGoogle Scholar
  24. Sorahan T., Lancashire R.J., Hulten M.A., Peck I., Stewart A.M. (1997) Childhood cancer and parental use of tobacco: deaths from 1953–1955. Br J Canc Res 75: 134–138CrossRefGoogle Scholar
  25. Vine M.F. (1996) Smoking and male reproduction: a review. Int J Androl 19: 323–337PubMedCrossRefGoogle Scholar
  26. Wang C., Alexander G., Berman N., Salehian B., Davidson T., McDonald V., Steiner B., Hull L., Callegari C., Swerdloff R.S. (1996) Testosterone replacement therapy improves mood in hypogonadal men-a dinical research center study. J Clin Endocrinol Metab 81: 3578–3583PubMedCrossRefGoogle Scholar

Literatur zu Abschn. 6.74

  1. Bals-Pratsch M., Schweikert H.U., Nieschlag E. (1990) Androgen receptor dis order in three brothers with bifid prepenile seroturn and hypospadias. Acta Endocrinol (Copenh) 123: 271–276Google Scholar
  2. Brown T.R. (1995) Human androgen insensitivity syndrom. J Androl 16: 299–303PubMedGoogle Scholar
  3. Quigley C.A. (1998) The androgen receptor: physiology and pathophysiology. In: Testosterone, Action-Deficiency-Substitution. In: Nieschlag E., Behre H.M. (Hrsg). Springer, Berlin Heidelberg New York Tokyo, S 33–106CrossRefGoogle Scholar
  4. Kremer H., Kraaij R., Toledo S.P. et al. (1995) Male pseudohermaphroditism due to a homozygous missense mutation of the luteinizing hormone receptor gene. Nat Genet 9: 160–164PubMedCrossRefGoogle Scholar
  5. Meschede D., Behre H.M., Nieschlag E. (2000) Stärungen im Bereich der Androgenzielorgane. In: Nieschlag E., Behre H.M. (Hrsg) Andrologie: Grundlagen und Klinik der reproduktiven Gesundheit des Mannes (2. Aufl.) Springer, Berlin Heidelberg New York Tokyo, S 247–265Google Scholar
  6. van Niekerk W.A. (1976) True hermaphroditism: an analytic review with areport of 3 new cases. Am J Obstet Gynecol 126: 890–907PubMedGoogle Scholar

Literatur zu Abschn. 6.75

  1. Abel A., Danek A., Borasio G.D., Witt T.N. (1996) X chromosomal bulbospinal neuropathy (X-BSN, Kennedy syndrome): an illness with repetitive triplet sequences. Case report, differential diagnosis and molecular genetics aspects. Nervenarzt 67: 1011–1019PubMedCrossRefGoogle Scholar
  2. Adler R.A. (1992) Clinical review 33: Clinically important effects of alcohol on endocrine function. J Clin Endocrinol Metab 74: 957–960PubMedCrossRefGoogle Scholar
  3. Braunstein G.D. (1993) Gynecomastia. N Engl J Med 328: 490–495PubMedCrossRefGoogle Scholar
  4. Casanova D., Magalon G. (1997) Surgical treatment of gynecomastia. J Chir (Paris) 134: 76–79Google Scholar
  5. Lee K.O., Chua D.Y., Cheah J.S. (1990) Oestrogen and progesterone receptors in men with bilateralor unilateral pubertal macromastia. Clin Endocrinol 32: 101–105CrossRefGoogle Scholar
  6. Mathur R., Braunstein G.D. (1997) Gynecomastia: pathomechanisms and treatment strategies. Horm Res 48: 95–102PubMedCrossRefGoogle Scholar
  7. Riemel A., Grzeszczak W., Koziak H., Moczulski D. (1996) Circadian rhythm of lutropin and follitropin in patients with chronic renal failure. Pol Arch Med Wewn 95: 313–322PubMedGoogle Scholar
  8. Sasco A.J., Lowenfels A.B., Pasker-de-Jong P. (1993) Review artide: epidemiology of male breast cancer. A meta-analysis of published case-control studies and discussion of selected aetiological factors. Int J Cancer 53: 538–549PubMedCrossRefGoogle Scholar

Literatur Abschn. 6.16

  1. Purvis K., Christiansen E. (1993) Infection in the male reproductive tract. Impact, diagnosis and treatment in relation to male infertility. Int J Androl 16: 1–13PubMedCrossRefGoogle Scholar

Literatur zu Abschn. 6.17

  1. van Ahlen H., Hertle L. (2000) Störungen der Samendeposition. In: Nieschlag E., Behre H.M. (Hrsg) Andrologie: Grundlagen und Klinik der reproduktiven Gesundheit des Mannes (2. Aufl.) Springer, Berlin Heidelberg New York Tokyo, S 211–245Google Scholar
  2. Boolell M., Allen M.J., Ballard S.A. et al. (1996) Sildenafil: an orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction. Int J Impot Res 8: 47–52PubMedGoogle Scholar
  3. Diemont W.L., Meuleman E.J. (1997) Neurological testing in erectile dysfunction. J Androl 18: 345–350PubMedGoogle Scholar
  4. Granata A.R., Rochira V., Lerchl A., Marrama P., Carani C. (1997) Relationship between sleep-related erections and testosterone levels in men. J Androl 18: 522–527PubMedGoogle Scholar
  5. Gupta R., Kirschen J., Barrow R.C. 2nd, Eid J.F. (1997) Predictors of success and risk factors for attrition in the use of intracavernous injection. J Urol 157: 1681–1686PubMedCrossRefGoogle Scholar
  6. Lewis R.W., Witherington R. (1997) External vacuum therapy for erectile dysfunction: use and results. World J Urol 15: 78–82PubMedCrossRefGoogle Scholar
  7. Munoz M.M., Bancroft J., Marshall I. (1993) The performance of the Rigiscan in the measurement of penile tumescence and rigidity. Int J Impot Res 5: 69–76PubMedGoogle Scholar
  8. Padma-Nathan H., Hellstrom W.J., Kaiser F.E. et al. (1997) Treatment of men with erectile dysfunction with trans urethral alprostadil. Medicated Urethral System for Erection (MUSE) Study Group. N Engl J Med 336: 1–7PubMedCrossRefGoogle Scholar
  9. Rampin O., Bernabe J., Giuliano F. (1997) Spinal control of penile erection. World J Urol 15: 2–13PubMedCrossRefGoogle Scholar
  10. Rolf C., Nieschlag E. (1998) Sildenafil (Viagra) bei erektiler Dysfunktion. Effektive Behandlung mit beachtenswerten Wechselwirkungen. Dtsch Med Wochensehr 123: 1356–1361CrossRefGoogle Scholar
  11. Vogt H.J., Brandl P., Kockott G., Schmitz J.R., Wiegand M.H., Schadrack J., Gierend M. (1997) Double-blind, placebo-controlled safety and efficacy trial with yohimbine hydrochloride in the treatment of nonorganic erectile dysfunction. Int J Impot Res 9: 155–161PubMedCrossRefGoogle Scholar
  12. Weinbauer G.F., Gromoll J., Simoni M., Nieschlag E. (2000) Physiologie der Hodenfunktion. In: Nieschlag E., Behre H.M. (Hrsg) Andrologie: Grundlagen und Klinik der reproduktiven Gesundheit des Mannes (2. Aufl.) Springer, Berlin Heidelberg New York Tokyo, S 27–67Google Scholar
  13. Stravynski A., Gaudette G., Lesage A., Arbel N., Petit P., Clerc D., Fabian J., Lamontagne Y., Langlois R., Lipp O., Sidoun P. (1997) The treatment of sexually dysfunetional men without partners: a eontrolled study of three behavioural group approaches. Br J Psychiatry 170: 338–344PubMedCrossRefGoogle Scholar

Literatur zu Abschn. 6.18

  1. Merke D.P., Cutler G.B. Jr. (1996) Evaluation and management of precoeious puberty. Arch Dis Child 7: 269–271CrossRefGoogle Scholar
  2. Nieschlag E., Brabant G., Schopohl J., Sippel W. (1997) Männliche Gonaden: Hypogonadismus, Infertilität, Pubertätsstörungen. In: Deutsche Gesellschaft für Endokrinologie (Hrsg) Rationale Therapie in der Endokrinologie einschließlich Diabetologie und Stoffwechsel. Thieme, Stuttgart, S 317–341Google Scholar
  3. Rosen D., Kelch R.P. (1995) Precocious and delayed puberty. In: Becker K.L. (eds) Principles and practiee of endocrinology and metabolism. Lippincott, Philadelphia, S 830–842Google Scholar
  4. Gromoll J., Partsch C.J., Simoni M., Nordhoff V., Sippell W.G., Nieschlag E., Saxena B.B. (1998) A mutation in the first transmembrane domain of the lutropin receptor causes male precoeious puberty. J Clin Endocrinol Metab 83: 476–480PubMedCrossRefGoogle Scholar
  5. Sippell W.G., German/Dutch Central Precoeious Puberty Study Group. (1994) Diagnosis and treatment of central precocious puberty-can final height be improved? Horm Res 41 Suppl 2: 14–15PubMedCrossRefGoogle Scholar

Literatur zu Abschn. 6.19

  1. Bosl G.J., Motzer R.J. (1997) Testicular germ-cell cancer. N Engl J Med 337: 242–253PubMedCrossRefGoogle Scholar
  2. Buetow S.A. (1995) Epidemiology of testicular cancer. Epidemiol Rev 17: 433–449PubMedGoogle Scholar
  3. Dieckmann K.P., Loy V. (1995) Testikuläre intraepitheliale Neoplasie-die Präkanzerose der germinalen Hodentumoren. In: Schnorr D., Loening S., Weißbaeh L. (Hrsg) Hodentumoren. Blackwell, Berlin, S 27–31Google Scholar
  4. Farkas L., Baki M., Pusztai C. (1995) Therapy of gonadal stromal cell testieular tumours. Int J Nephrol 27: 597–601CrossRefGoogle Scholar
  5. Giwercman A., von der Maase H., Shakkebaeek N.E. (1993) Epidemiological and clinical aspects of carcinoma in situ of the testis. Eur Urol 23: 104–114PubMedGoogle Scholar
  6. Horwich A., Sleijfer D.T., Fossa S.D. et al. (1997) Randomized trial of bleomyein, etoposide, and cisplatin compared with bleomycin, etoposide, and carboplatin in good-prognosis metastatic nonseminomatous germ cell cancer: a Multiinstitutional Medical Research Council/European Organization for Research and Treatment of Cancer Trial. J Clin Oncol 15: 1844–1852PubMedGoogle Scholar
  7. Mene M.P., Finkelstein L.H., Manfrey S.J., Belkhoff L.H. (1996) Metastatic Sertoli cell carcinoma of the testis. J Am Osteopath Assoc 96: 612–614PubMedGoogle Scholar
  8. Meng F.J., Zhou Y., Skakkebaek N.E., Marks A., Giwercman A. (1996) Detection and enrichment of carcinoma-in-situ cells in semen by an immunomagnetic method using monoclonal antibody M2 A. Int J Androl 19: 365–370PubMedCrossRefGoogle Scholar
  9. Mostofi F.K. (1979) Comparison of various clinical and pathological classifications of tumors of the testes. Semin Oncol 6: 26–30PubMedGoogle Scholar
  10. Singh S.D., Lansing A.M. (1996) Familial cardiac myxoma-a comprehensive review of reported cases. J Ky Med Assoc 94: 96–104PubMedGoogle Scholar
  11. Young S., Gooneratne S., Straus F.H. 2nd, Zeller W.P., Bulun S.E., Rosenthal I.M. (1995) Feminizing Sertoli eell tumors in boys with Peutz-Jeghers syndrome. Am J Surg Pathol 19: 50–58PubMedCrossRefGoogle Scholar

Literatur zu Abschn. 6.20

  1. Bordson B.L., Leonardo V.S. (1991) The appropriate upper age limit for semen donors: a review of thc genetic effects of paternal age. Fertil Steril 56: 397–401PubMedGoogle Scholar
  2. Gooren L.I. (1996) The age-related decline of androgen levels in men: clinically signifieant? Br J Urol 78: 763–768PubMedCrossRefGoogle Scholar
  3. Gray A., Feldman H.A., MeKinlay J.E., Longeope C. (1991) Age, disease, and changing sex hormone levels in middleaged men: results of the Massachusetts Male Aging Study. J Clin Endocrinol Metab 73: 1016–1025PubMedCrossRefGoogle Scholar
  4. Hajjar R.R., Kaiser F.E., Modey J.E. (1997) Outcomes of longterm testosterone replacement in older hypogonadal males: a retrospective analysis. J Clin Endocrinol Metab 82: 3793–3796PubMedCrossRefGoogle Scholar
  5. Handelsman D.J., Staraj S. (1985) Testicular size: the effects of aging, malnutrition, and illness. J Androl 6: 144–151PubMedGoogle Scholar
  6. Lagiou P., Mantzoros C.S., Tzonou A., Signorello L.B., Lipworth L., Trichopoulos D. (1997) Serum steroids in relation to benign prostatic hyperplasia. Oncology 54: 497–501PubMedCrossRefGoogle Scholar
  7. McIntosh G.C., Olshan A.F., Baird P.A. (1995) Patemal age and the risk of birth defects in offspring. Epidemiology 6: 282–288PubMedCrossRefGoogle Scholar
  8. Meston C.M. (1997) Aging and sexuality. West J Med 167: 285–290PubMedGoogle Scholar
  9. Nieschlag E., Lammers U., Freischem C.W., Langer K., Wickings E.J. (1982) Reproductive functions in young fathers and grandfathers. J Clin Endocrinol Metab 55: 676–681PubMedCrossRefGoogle Scholar
  10. Rolf C., Behre H.M., Nieschlag E. (1996) Reproductive parameters of older compared to younger men of infertile couples. Int J Androl 19: 135–142PubMedCrossRefGoogle Scholar
  11. Rolf C., Nieschlag E. (2000) Seneszenz. In: Nieschlag E., Behre H.M. (Hrsg) Andrologie: Grundlagen und Klinik der reproduktiven Gesundheit des Mannes (2. Autl.) Springer, Berlin Heidelberg New York Tokyo, S 465–479Google Scholar

Literatur zu Abschn. 6.27

  1. Amichai B., Grunwald M.H., Sobel R. (1997) 5 α-reductase inhibitors-a new ho pe in dermatology? Int J Dermatol 36: 182–184PubMedCrossRefGoogle Scholar
  2. Bergfeld W.F. (1995) Androgenetic alopecia: an autosomal dominant disorder. Am J Med 98(1 A):95S–98SPubMedCrossRefGoogle Scholar
  3. Demark-Wahnefried W., Lesko S.M., Conaway M.R., Robertson C.N., Clark R.V., Lobaugh B., Mathias B.J., Strigo T.S., Paulson D.F. (1997) Serum androgens: associations with prostate cancer risk and hair patterning. J Androl 18: 495–500PubMedGoogle Scholar
  4. Drake L.A., Dinehart S.M., Farmer E.R. et al. (1996) Guidelines of care for androgenetic alopecia. American Academy of Dermatology. J Am Acad Dermatol 35(3 Pt 1):465–469PubMedCrossRefGoogle Scholar
  5. Hamilton J.B. (1942) Male hormone stimulation is prerequisite and an incitement in common baldness. Am J Anat 71: 451CrossRefGoogle Scholar
  6. Kaufman K.D. (1996) Androgen metabolism as it affects hair growth in androgenetic alopecia. Dermatol Clin 4: 697–711Google Scholar
  7. Norwood O.T. (1975) Male pattern baldness: classification and incidence. South Med J 68: 1359–1365PubMedCrossRefGoogle Scholar
  8. Rubin M.B. (1997) Androgenetic alopecia. Battling a losing proposition. Postgrad Med 102: 129–131PubMedCrossRefGoogle Scholar
  9. Sawaya M.E., Price V.H. (1997) Different levels of 5a-reductase type land II, aromatase, and androgen receptor in hair follicles of women and men with androgenetic alopecia. J Invest Dermatol 109: 296–300PubMedCrossRefGoogle Scholar
  10. Shrank A.B. (1995) Minoxidil over the counter. BMJ 311: 526PubMedCrossRefGoogle Scholar

Literatur Abschn. 6.22

  1. Schlatterer K., von Werder K., Stalla G.K. (1996) Multistep treatment concept of transsexual patients. Exp Clin Endocrinol Diabetes 104: 413–419PubMedCrossRefGoogle Scholar
  2. Benjamin (1953) Transvestism and transsexualism. Int J Sexol 7: 12–14Google Scholar
  3. Bakker A., van Kersten P.J.M., Gooren L.J.G., Bezemer P.D. (1993) The prevalence of transsexualism in the Netherlands. Acta Psychiatr Scand 87: 237–238PubMedCrossRefGoogle Scholar
  4. Bosinski H.A.G., Sohn M., Löffler D., Wille R., Jakse G. (1994) Aktuelle Aspekte qer Begutachtung und Operation Transsexueller. Dtsch Arztebl 91: 552–555Google Scholar
  5. Diederichs P. (1993) Der eigene Körper als Fremder. In: Streek U. (Hrsg) Das Fremde in der Psychoanalyse. Pfeiffer, München, S 324–336Google Scholar
  6. Eicher W. (1995) Operative Therapie bei intersexuellem, weiblichen Genitale und bei Transsexualismus. Gynäkologe 28: 40–47PubMedGoogle Scholar
  7. Gooren L.J. (1998) Androgen treatment of female-to-male transsexuals. In: Nieschlag E., Behre H.M. (Hrsg) Testosterone: Action-Deficiency-Substitution. Springer, Berlin Heidelberg New York Tokyo, pp 529–544CrossRefGoogle Scholar
  8. Hage J.J., Haumann G. (1995) Maskulinisierende Techniken bei intersexuellem männlichen Genitale und bei Frau-zuMann-Transsexualismus. Gynäkologe 28: 48–53PubMedGoogle Scholar
  9. Ratzel R. (1995) Juristische Aspekte bei Intersexualität und Transexualismus. Gynäkologe 28: 59–61PubMedGoogle Scholar
  10. Sigusch V. (1995) Leitsymptome transsexueller Entwicklung. Dtsch Arztbl 91: 1085–1088Google Scholar
  11. Zhou J.N., Hofman M.A., Gooren L.J., Swaab D.F. (1995) A sex difference in the human brain and its relation to transsexuality. Nature 378: 68–70PubMedCrossRefGoogle Scholar
  12. van Kesteren P.J., Gooren L.J., Megens J.A. (1996) An epidemiological and demographic study of transsexuals in The Netherlands. Arch Sex Behav 25: 589–600PubMedCrossRefGoogle Scholar
  13. van Kesteren P.J., Asscheman H., Megens J.A., Gooren L.J. (1997) Mortality and morbidity in trans sexual subjects treated with cross-sex hormones. Clin Endocrinol 47: 337–342CrossRefGoogle Scholar
  14. Elbers J.M., Asscheman H., Seidell J.C., Frolich M., Meinders A.E., Gooren L.J. (1997) Reversal of the sex difference in serum leptin levels upon cross-sex hormone administration in transsexuals. J Clin Endocrinol Metab 82: 3267–3270PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2001

Authors and Affiliations

  • R. Ochsenkühn
  • E. Nieschlag

There are no affiliations available

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