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Neuroendokrine Tumoren des Gastrointestinaltraktes

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Book cover Klinische Endokrinologie und Stoffwechsel

Zusammenfassung

Bereits im Jahre 1967 fasste Pearse Zellen unter dem Begriff APUD Zellsysteme zusammen (“amine and precursor uptake and decarboxylation”), die die Fähigkeit besitzen, aromatische Amine zu synthetisieren, Vorstufen der Amine aufzunehmen und Aminosäuren mittels eines Enzyms zu den entsprechenden Aminen zu decarboxylieren. Aufgrund der Beobachtung, dass die in diesen Zellen synthetisierten Peptidhormone auch im Zentralnervensystem von funktioneller Bedeutung sind und immunhistochemische Markerenzyme ebenfalls in bei den Zellsystemen nachweisbar sind, wurde der erweiterte Terminus des neuroendokrinen Systems eingeführt. Das diffuse neuroendokrine System umschließt hierbei die neuroendokrinen Zellen, die nicht in makroskopisch kompakten Organen zusammengelagert sind. Im Bereich des Gastrointestinaltraktes konnten mittlerweile 15 verschiedene Zelltypen des diffusen neuro endokrinen Systems sowie eine Reihe der von ihnen produzierten Hormone identifiziert werden.

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Authors
  1. M. Engelbach
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  2. J. Beyer
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Editors and Affiliations

  1. Medizinische Klinik IV, Universitätsklinikum Tübingen, Otfried-Müller-Straße 10, 72076, Tübingen, Deutschland

    Peter P. Nawroth

  2. Abteilung Innere Medizin I, Medizinische Universitätsklinik und Poliklinik Heidelberg, Bergheimer Straße 58, 69115, Heidelberg, Deutschland

    Reinhard Ziegler

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Engelbach, M., Beyer, J. (2001). Neuroendokrine Tumoren des Gastrointestinaltraktes. In: Nawroth, P.P., Ziegler, R. (eds) Klinische Endokrinologie und Stoffwechsel. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56784-1_14

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  • DOI: https://doi.org/10.1007/978-3-642-56784-1_14

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  • Print ISBN: 978-3-642-62970-9

  • Online ISBN: 978-3-642-56784-1

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