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Klinische Endokrinologie und Stoffwechsel pp 443–482Cite as

Osteoporose und metabolische Knochenerkrankungen

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Zusammenfassung

Das fertige Knochengewebe besteht aus der Knochengrundsubstanz, die vor allem aus Kollagen Typ I besteht, zusätzlich aus unterschiedlichen Eiweißen wie Sialoprotein, Osteopontin, Osteonektin o.a. Eingelagert sind auch Wachstumsfaktoren und Zytokine wie IGF-1, IGF-2 und TGF-β. Stabilisiert wird die biegsame, aber zugkräftige Grundsubstanz durch die Einlagerung des Hydroxylapatits. Griffig ist der technische Vergleich mit Eisenbeton: Das Kollagen entspricht der Eisenarmierung, das Hydroxylapatit dem Zement. Je nach mechanischer Aufgabe werden für die einzelnen Knochen kompakte Strukturen verwendet (z. B. Röhrenknochen), oder es liegt der verzweigte spongiöse, trabekuläre Knochen als Netzwerk von Streben, Stäben und Platten vor (z. B. Wirbelkörper).

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Literatur

Literatur zu Abschn. 11.1

  • Cuneo R.C., Judd S., Wallace J.D. et al. (1998) The Australian multicenter trial of growth hormone (GH) treatment in GHdeficient adults. J Clin Endocrin Metab 83: 107–118

    Article  CAS  Google Scholar 

  • Drinkwater B., Nilson K., Chesnut III C. et al.(1984) Bone mineral content of amenorrheic and eumenorrheic athletes. New Engl J Med 311: 277–281

    Article  PubMed  CAS  Google Scholar 

  • Eriksen E.F., Axelrod D.W., Meisen F. (1994) Bone Histomorphometry. New York: Raven Press, 13–20

    Google Scholar 

  • Frost H. (1991) A new direction for osteoporosis research: A review and proposal. Bone 12: 429–437

    Article  PubMed  CAS  Google Scholar 

  • Rao D.S. (1995) Bone and mineral metabolism. Bockus Gastroenterology. 5th edn, Saunders, Philadelphia, pp 464–3471

    Google Scholar 

  • Uzzan B., Campos I., Cucherat M., Nony P., Boissei J.P., Perret G.Y. (1996) Effects on bone mass oflong term treatment with thyroid hormones: a meta-analysis. J Clin Endocrinol Metab 81, 4278–4289

    Article  PubMed  CAS  Google Scholar 

  • Ziegler R. (1995) Der Knochen und seine Erkrankungen, Teil I-VI. Dtsch Med Wochenschr 120: 531–532, 571–572, 1091–1092, 1251–1252, 1367–1368, 1445–1446

    PubMed  CAS  Google Scholar 

  • Ziegler R., Scheidt-Nave C., Scharla S. (1995) Pathophysiology of osteoporosis: unresolved problems and new insights. J Nutr 125: 2033S-2037S

    Google Scholar 

Literatur zu Abschn. 11.2

  • Adachi J.D. (1997) Corticosteroid-induced osteoporosis. Am J Med Sci 313: 41–49

    Article  PubMed  CAS  Google Scholar 

  • Black D.M., Cummings S.R., Karpf D.B. et al. (1996) Randomised trial of effect of alendronate on risk of fracture in women with existing vertebral fractures. Lancet 348: 1535–1541

    Article  PubMed  CAS  Google Scholar 

  • Chapuy M.C., Arlot M.E., Delmas P.D., Meunier P.J. (1994) Effect of calcium and cholecalciferol treatment for three years on hip fractures in elderly women. BMJ 308: 1081–1082

    Article  PubMed  CAS  Google Scholar 

  • Civitelli R., Connelli S., Zacchei F. et al. (1988) Bone turnover in postmenopausal osteoporosis. Effect of calcitonin treatment. J Clin Invest 82: 1268–1274

    Article  PubMed  CAS  Google Scholar 

  • Cummings S.R., Black D.M., Nevitt M.C., et al. (1993) Bone density at various sites for prediction of hip fractures. Lancet 341: 72–75

    Article  PubMed  CAS  Google Scholar 

  • Dawson-Hughes B., Harris S.S., Krall E.A., Dallal G.E. (1997) Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older. N Engl J Med 337: 670–676

    Article  PubMed  CAS  Google Scholar 

  • Erdtsieck R.I., Pols H.A.P., Kuijk C.V. et al. (1994) Course of bone mass during and after hormonal replacement therapy with and without addition of nandrolone decanoate. J Bone Miner Res 9: 277–283

    Article  PubMed  CAS  Google Scholar 

  • Ettinger B., Genant H.K., Cann C.E. (1985) Long-term estrogen replacement therapy prevents bone loss and fractures. Ann Intern Med 102: 319–324

    Article  PubMed  CAS  Google Scholar 

  • Farley J.R., Tarbaux N.M., Hall S.L. et al.(1988) Evidence that fluoride-stimulated 3[H] thymidine incorporation in embryonic chick calvarial cell cultures is dependent on the presence of a bone cell mitogen, sensitive to changes in the phosphate concentration, and modulated by systemic skeletal effectors. Metabolism 37: 988–995

    Article  PubMed  CAS  Google Scholar 

  • Farrerons I., Rodriguez de la Serna A., Gua[ntilde]abens N. et al. (1997) Sodium fluoride treatment is a major protector against vertebral and nonvertebral fractures when compared with other common treatments of osteoporosis: a longitudinal, observational study. Calcif Tissue Int 60: 250–254

    Article  PubMed  CAS  Google Scholar 

  • Felson D.T., Sloutskis D., Anderson J.J. et a1. (1991) Thiazide diuretics and the risk of hip fracture. Results from the Framingham Study. JAMA 265: 370–373

    Article  PubMed  CAS  Google Scholar 

  • Flicker L., Hopper J.L., Larkins R.G., Lichtenstein M., Buirski G., Wark J.D. (1997) Nandrolone decanoate and intranasal calcitonin as therapy in established osteoporosis. Osteoporosis Int 7: 29–35

    Article  CAS  Google Scholar 

  • Gallacher S.I., Anderson K., Speekenbrink T., Bessent R., Boyle I.T. (1995) A comparison ofthe effects of etidronate, pamidronate, clodronate and calcium on bone density in patients with corticosteroid-dependent lung disease. Calcif Tissue Int 56: 447

    Google Scholar 

  • Lau E.C.M., Cooper C., Wickham C., Donnan S., Barker D.J.P. (1990) Hip fracture in Hong Kong and Britain. Int J Epidemiol 19: 1119–1121

    Article  PubMed  CAS  Google Scholar 

  • Leidig G., Minne H.W., Sauer P., Wüster C., Wüster I., Lojen M., Raue F., Ziegler R. (1990) A study of complaints and their relation for vertebral destruction in patients with osteoporosis. Bone and Mineral 8: 217–229

    Article  PubMed  CAS  Google Scholar 

  • Lutkin E.G., Wahner H.W., O’Fallon W.M. et al. (1992) Treatment of postmenopausal osteoporosis with trans dermal estrogen. Ann Intern Med 117: 1–9

    Article  Google Scholar 

  • Melton L.J. III, Chrischilles E.A., Cooper C., Lane AW., Riggs B.L. (1992) How many women have osteoporosis? J Bone Miner Res 7: 1005–1010

    Article  PubMed  Google Scholar 

  • Obrant K.J., Bngner U., Johnell O., Nilsson B.E., Sernbo I. (1989) Increasing age-adjusted risk of fragility fractures: a sign of increasing osteoporosis in successive generations? Calcif Tissue Int 44: 157–167

    Article  PubMed  CAS  Google Scholar 

  • Overgaard K., Hansen M.A., Birk Jensen S., Christiansen C. (1992) Effect of salcatonin given intranasallyon bone mass and fracture rate in established osteoporosis: a dose-response study. BMJ 305: 556–561

    Google Scholar 

  • Quigley M.E.T., Martin P.L., Burnier A.M., Brooks P. (1987) Estrogen therapy arrests bone loss in elderly women. Am J Obstet Gynecol 156: 1516–1523

    PubMed  CAS  Google Scholar 

  • Ravn P., Clemmesen B., Riis B.J., Christiansen C. (1996) The effect on bone mass and bone markers of different doses of ibandronate: A new bisphosphonate for prevention and treatment of postmenopausal osteoporosis: A 1-year, randomized, double-blind, placebo-controlled dose-finding study. Bone 19: 527–533

    Article  PubMed  CAS  Google Scholar 

  • Riggs B.L., Melton L.J. III (1986) Involutional osteoporosis. N Engl J Med 314: 1676–1686

    Article  PubMed  CAS  Google Scholar 

  • Riggs B.L., O’Fallon W.M., Lane A., Hodgson S.F. et al. (1994) Clinical trial of fluoride therapy in postmenopausal osteoporotic women: extended observations and additional analysis. J Bone Miner Res 9: 265–275

    Article  PubMed  CAS  Google Scholar 

  • Scheidt-Nave C., Felsenberg D., Kragl G., Brucker T., LeidigBruckner G., Wüster C., Ziegler R. (1998) Vertebrale Deformität als Index der osteoporotischen Wirbelfraktur-eine externe Konstruktvalidierung anhand von Knochendichtemessdaten. Medizinische Klinik 93(Suppl. II):46–55

    Article  PubMed  Google Scholar 

  • Seilers T.A., Mink P.I., Cerhan J.R. et al. (1997) The role of hormone replacememnt therapy in the risk for breast cancer and total mortality in women with a family history of breast cancer. Ann Intern Med 127: 973–980

    Article  Google Scholar 

  • Storm T., Kollerup G., Thamsborg G., Genant H.K., Sorensen O.H. (1996) Five years of clinical experience with intermittent cyclical etidronate for postmenopausal osteoporosis. J Rheumatol 23: 1560–1564

    PubMed  CAS  Google Scholar 

  • Thiebaud D., Burckhardt P., Melchior J. et al. (1994) Two years’s effectiveness of intravenous pamidronate (APD) versus oral fluoride for osteoporosis occurring in the postmenopause. Osteoporosis Int 4: 76–83

    Article  CAS  Google Scholar 

  • Tilyard M.W., Spears G.F.S., Thomson J., Dovey S. (1991) Treatment of postmenopausal osteoporosis with calcitriol or calcium. J Engl J Med 326: 357–362

    Article  Google Scholar 

  • Ziegler R. (1995) Der Knochen und seine Erkrankungen, Teil I-VI. Dtschmed Wschr 120: 531–532, 571–572, 1091–1092, 1251–1252, 1367–1368, 1445–1446

    CAS  Google Scholar 

Literatur zu Abschn. 11.3

  • Glorieux F.H. (1996) Hypophosphatemic vitamin D-resistant rickets. In: Favus M.J. (ed) Primer on the metabolic bone diseases and dis orders of mineral metabolism. 3rd edn, Lippincott & Raven, Philadelphia, pp 316–319

    Google Scholar 

  • Kruse K. (1990) Metabolische Osteopathien im Kindesalter. Internist 31: 745–755

    PubMed  CAS  Google Scholar 

  • Offermann G., Manhold C. (1978) Osteomalazie bei türkischen Gastarbeitern in Deutschland. Inn Med 5: 103–108

    Google Scholar 

  • Sparagana M. (1987) Tumor-induced osteomalacia: long-term follow-up of two patients cured by removal of their tumors. J Surg Oncol 36: 198–205

    Article  PubMed  CAS  Google Scholar 

Literatur zu Abschn. 11.4

  • Cartwright E.I., Gordon M.T., Freemont A.I., Anderson D.C., Sharpe P.T. (1993) Paramyxovirus and Paget’s disease. J Med Virol 40: 133–141

    Article  PubMed  CAS  Google Scholar 

  • Grauer A., Klar B., Scharia S., Ziegler R. (1994) Long-term efficacy of intravenous pamidronate in Paget’s disease of bone. Seminars in Arthritis and Rheumatism 23: 283–284 Paget J (1877) On a form of chronic inflammation ofbone (osteitis deformans). Med Chir Trans 60: 37

    Article  PubMed  CAS  Google Scholar 

  • Rebel A., Bregeon C., Basle M., Kalkani K., Patezour A., Filmon R. (1975) Osteoclastic inclusions in Paget’s disease of bone. Rev Rhum Mal Osteoartic 42: 637–641

    PubMed  CAS  Google Scholar 

  • Roux C., Gennari C., Farrerons J. et al. (1995) Comparative prospective double-blind, multicenter study of the efficacy of tiludronate and etidronate in the treatment of Paget’s disease of bone. Arthritis Rheum 38: 851–858

    Article  PubMed  CAS  Google Scholar 

  • Schmorl G. (1932) Über Ostitis deformans Paget. Virch Arch Path Anat 283: 694

    Google Scholar 

  • Ziegler R. (1990) M. Paget des Skeletts. Internist 31: 763–768

    PubMed  CAS  Google Scholar 

  • Ziegler R., Holz G., Rotzier B., Minne H. (1985) Paget’s disease of bone in West Germany: Prevalence and distribution. Clin Orthop 194: 199–204

    PubMed  Google Scholar 

Literatur zu Abschn. 11.5

  • Albers-Schönberg H. (1904) Röntgenbilder einer seltenen Knochenerkrankung. Münch Med Wochenschr 51: 365

    Google Scholar 

  • Coccia P.F., Krivit W., Cervenka J. et al. (1980) Successful bonemarrow transplantation for infantile malignant osteopetrosis. N Engl J Med 302: 701–708

    Article  PubMed  CAS  Google Scholar 

  • Helfrich M.H., Aronson D.C., Everts V., Mieremet R.H.P., Gerritsen E.J.A., Eckhardt P.G., Groot C.G., Scherft J.P. (1991) Morphologic features of bone in human osteopetrosis. Bone 12: 411–419

    Article  PubMed  CAS  Google Scholar 

  • Kahler S.G., Bums J.A., Aylsworth A.S. (1984) A mild autosomal recessive form of osteopetrosis. Am J Med Genet 17: 451–464

    Article  PubMed  CAS  Google Scholar 

  • Key L.L., Ries W.L., Schiff R. (1987) Osteopetrosis associated with interleukin-2 deficiency. J Bone Miner Res 2(Suppl. 2):85

    Google Scholar 

  • Loria-Cortes R., Quesada-Calvo E., Cordero-Chaverri E. (1977) Osteopetrosis in children. A report of 26 cases. J Pediatr 91: 43–47

    Article  PubMed  CAS  Google Scholar 

  • Teitelbaum S.L., Tonadravi M.M., Ross F.P. (1996) Osteoclast biology. In: Marms R., Feldman D., Kelsey J. (eds) Osteoporosis, Academic Press, San Diego, pp 61–94

    Google Scholar 

Literatur zu Abschn. 11.6

  • Devogelaer J.P., Malghem I., Maldague B., Nagant de Deuxchaisnes C. (1987) Radiological manifestations of bisphosphonate treatment with ADP in a child suffering from osteogenesis imperfecta. Skeletal Radiol 16: 360–363

    Article  PubMed  CAS  Google Scholar 

  • Henethorn P.S., Raducha M., Fedde K.N., Lafferty M.A., Whyte M.P. (1992) Different missen se mutations at the tissues-nonspecific alkaline phosphatase gene locus in autosomal recessively inherited forms of mild and severe hypophosphatasia. Proc Natl Acad Sci USA 89: 9924–9928

    Article  Google Scholar 

  • Liens D., Delmas P.D., Meunier P.J. (1994) Long-term effects of intravenous pamidronate in fibrous dysplasia of bone. Lancet 323: 953–954

    Article  Google Scholar 

  • Pfeilschifter I., Ziegler R. (1998) Wirkung von Pamidronat auf das Beschwerdebild und den Knochenstoffwechsel bei Patienten mit fibröser Dysplasie und McCune-Albright-Syndrom. Medizinische Klinik 99: 352–359

    Article  Google Scholar 

  • Shenker A., Weinstein L.S., Sweet D.E., Spiegel A.M. (1994) An activating Gs a mutations is present in fibrous dysplasia of bone in the McCune-Albright syndrome. J Endocrin Metab 79: 750–755

    Article  CAS  Google Scholar 

  • Stöß H., Pesch H-J., Spranger J. (1979) Therapie der Osteogenesis imperfecta mit (+)-Catechin. Dtsch Med Wochenschr 50: 1774–1778

    Article  Google Scholar 

  • Whyte M.P. (1996) Osteogenesis imperfecta. In: Favus M.J. (ed) Primer on the Metabolic bone diseases and dis orders of mineral metabolism. Lippincott & Raven, Philadelphia, pp 382–385

    Google Scholar 

  • Whyte M.P. (1996) Hypophosphatasia. In Favus M.J. (ed) Primer on the metabolic bone diseases and disorders of mineral metabolism. Lippincott & Raven, Philadelphia, pp 326–328

    Google Scholar 

  • Ziegler R., Raue F., Cotta H. et al. (1987) Osteogenesis imperfecta und juvenile Osteoporose. Behandlungsversuche mit synthetischem Humancalcitonin. Therapiewoche 37: 1895–1904

    Google Scholar 

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Authors
  1. R. Ziegler
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Editors and Affiliations

  1. Medizinische Klinik IV, Universitätsklinikum Tübingen, Otfried-Müller-Straße 10, 72076, Tübingen, Deutschland

    Peter P. Nawroth

  2. Abteilung Innere Medizin I, Medizinische Universitätsklinik und Poliklinik Heidelberg, Bergheimer Straße 58, 69115, Heidelberg, Deutschland

    Reinhard Ziegler

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Ziegler, R. (2001). Osteoporose und metabolische Knochenerkrankungen. In: Nawroth, P.P., Ziegler, R. (eds) Klinische Endokrinologie und Stoffwechsel. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56784-1_11

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  • DOI: https://doi.org/10.1007/978-3-642-56784-1_11

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