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Wachstum

  • G. Binder
  • T. Haak
  • M. B. Ranke
  • K. H. Usadel

Zusammenfassung

Wachstumshormon (Syn. Somatotropin, somatotropes Hormon = STH, growth hormone = GH) ist ein einkettiges Peptidhormon aufgebaut aus 191 Aminosäuren (AS) ohne Zuckerreste, welches über 2 Disulfidbrücken in seine Tertiärstruktur gefaltet ist. Diese besteht aus 4 α-Helices, die antiparallel angeordnet sind. Wachstumshormon ist das Produkt des GH-1(GH-N)-Gens, welches zusammen mit Genen für humanes Chorionsomatomammotropin (hCS) und dem nur in der Plazenta exprimierten GH-2(GH-V)-Gen auf dem langen Arm des Chromosoms 17 lokalisiert ist. Neben GH mit einem Molekulargwicht von 22 kD (ca. 90%) entsteht durch alternatives Splicing eine Pro tein variante (20 kD, ca. 10%), dem die AS 32-46 der 22-kD-Form fehlen. Darüber hinaus existieren im Blut in geringeren Konzentrationen, jedoch individuell variierend, weitere GH-Varianten und Oligomere (z. B. „big“ GH) mit unterschiedlicher biologischer Aktivität. Die Expression des GH-1-Gens ist fast ausschließlich auf die somatotropen Zellen der Adenohypophyse beschränkt, welche ca. 90% ihrer Zellmasse ausmachen.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2001

Authors and Affiliations

  • G. Binder
  • T. Haak
  • M. B. Ranke
  • K. H. Usadel

There are no affiliations available

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