Hantaviruses pp 91-115 | Cite as

Cellular Receptors and Hantavirus Pathogenesis

  • E. R. Mackow
  • I. N. Gavrilovskaya
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 256)


Hantaviruses cause two frequently fatal human diseases, hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS) (Nolte et al. 1995; Zaki et al. 1995; Gonzalez-Scarano et al. 1996; Schmaljohn 1996). HFRS-associated hantaviruses cause vascular hemorrhage and kidney dysfunction while HPS-associated hantaviruses cause acute pulmonary edema (Lee et al. 1999; Zaki et al. 1999). Both diseases are associated with acute thrombocytopenia and changes in vascular permeability, and either disease may have pulmonary or renal components (Nolte et al. 1995; Zaki et al. 1995; Gonzalez-Scarano and Nathanson 1996; Schmaljohn 1996; Lee et al. 1999; Zaki and Nolte 1999).


Cellular Receptor Hemorrhagic Fever With Renal Syndrome Hantavirus Infection Hantaan Virus Hantavirus Pulmonary Syndrome 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2001

Authors and Affiliations

  • E. R. Mackow
    • 1
  • I. N. Gavrilovskaya
    • 2
  1. 1.Department of MedicineStony Brook UniversityStony BrookUSA
  2. 2.Northport VA Medical CenterNorthportUSA

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