During the process of virus maturation, all the viral structural components accumulate at the cell surface in order to interact and assemble into mature virions. The majority of the negative stranded RNA viruses have been shown to assemble and bud from the cell surface (Cadd et al. 1997; Garoff et al. 1998). In contrast, viruses of the family Bunyaviridae are characterized by an unusual pattern of intracellular maturation where the bilipid envelope of the virus particles is derived from the membranes of the endoplasmic reticulum-Golgi compartment (Murphy et al. 1973; Pettersson and Melin 1996). Due to this characteristic feature, Golgi maturation has been used as one of the criteria for classification of viruses as members of the family Bunyaviridae.
KeywordsCytoplasmic Tail Hemorrhagic Fever With Renal Syndrome Hantaan Virus Hantavirus Pulmonary Syndrome Virus Maturation
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