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Hantaviruses pp 15–32Cite as

Replication of Hantaviruses

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 256))

Abstract

Hantaviruses have a genome consisting of three segments of negative-sense, single-strand RNA (reviewed in Schmaljohn 1996a). The large (L), medium (M), and small (S) genomic segments, or vRNAs, code for the viral RNA-dependent RNA polymerase (RdRp), envelope glycoproteins (Gl and G2), and nucleoprotein (N), respectively. Nonstructural proteins have not been described for hantaviruses. One of the first molecular features found to distinguish hantaviruses from other viruses in the family Bunyaviridae is the sequence of their conserved, complementary terminal nucleotides on the L, M, and S segments (Schmaljohn and Dalrymple 1983). This characteristic, and the absence of serological cross-reactivity among other members of the family, were the bases for the proposal to establish the Hantavirus genus in the family Bunyaviridae in 1986.

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Authors and Affiliations

  1. Department of Chemistry and Biochemistry, New Mexico State University, Box 30001, Las Cruces, NM, 88003, USA

    C. B. Jonsson

  2. United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD, 21702, USA

    C. S. Schmaljohn

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  1. C. B. Jonsson
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Editors and Affiliations

  1. Molecular Virology, Virology Division, USAMRIID, 1425 Porter Street, Ft. Detrick, Frederick, MD, 21702-5011, USA

    Connie S. Schmaljohn Ph.D.

  2. Molecular Biology Section, Special Pathogens Branch, Division of Viral and Rickettsial Disease, Centers for Disease Control and Prevention (CDC), Atlanta, GA, 30333, USA

    Stuart T. Nichol Ph.D.

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Jonsson, C.B., Schmaljohn, C.S. (2001). Replication of Hantaviruses. In: Schmaljohn, C.S., Nichol, S.T. (eds) Hantaviruses. Current Topics in Microbiology and Immunology, vol 256. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56753-7_2

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