Replication of Hantaviruses

  • C. B. Jonsson
  • C. S. Schmaljohn
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 256)


Hantaviruses have a genome consisting of three segments of negative-sense, single-strand RNA (reviewed in Schmaljohn 1996a). The large (L), medium (M), and small (S) genomic segments, or vRNAs, code for the viral RNA-dependent RNA polymerase (RdRp), envelope glycoproteins (Gl and G2), and nucleoprotein (N), respectively. Nonstructural proteins have not been described for hantaviruses. One of the first molecular features found to distinguish hantaviruses from other viruses in the family Bunyaviridae is the sequence of their conserved, complementary terminal nucleotides on the L, M, and S segments (Schmaljohn and Dalrymple 1983). This characteristic, and the absence of serological cross-reactivity among other members of the family, were the bases for the proposal to establish the Hantavirus genus in the family Bunyaviridae in 1986.


Hemorrhagic Fever With Renal Syndrome Rift Valley Fever Virus Terminal Nucleotide Hantavirus Infection Reverse Genetic System 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2001

Authors and Affiliations

  • C. B. Jonsson
    • 1
  • C. S. Schmaljohn
    • 2
  1. 1.Department of Chemistry and BiochemistryNew Mexico State UniversityLas CrucesUSA
  2. 2.United States Army Medical Research Institute of Infectious DiseasesFort DetrickFrederickUSA

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