Abstract
A separate partial circulatory system with a defined flow via a roller pump is created by abdominal stop-flow therapy under hypoxic conditions. Forty chinchilla rabbits were subjected to intra-aortal (stop-flow therapy) or systemic therapy with 50 mg 5-FU or 5-FU-SUV-PEG liposomes. pH and pO2 were measured at regular intervals during therapy. After 20 min, the concentration of 5-FU and its active metabolite 5-FURD were determined by HPLC in different organs. The 5-FURD concentration was measured in vitro in relation to the pH value. Subsequently, another 20 chinchilla rabbits received 50 mg of 5-FU or 5-FU-SUV-PEG liposomes intra-aortally (stop-flow therapy), keeping the pH value within the physiological range by NH3 titration, and the 5-FURD concentration was determined here as well. Intra-aortal applications of 5-FU-PEG liposomes increase 5-FU tumor concentrations 40-fold and para-aortal lymph-node concentrations 100-fold compared to i.v. applications. Metabolization of 5-FU to its active metabolite 5-FURD is strongly dependent on the pH value and can be modulated.
Chapter PDF
Literatur
Eibel-Eibesfeld B, Störz V, Kummermehr J, Schalhorn A (1988) Basic investigations on interaction of 5-fluorouracil and tumor ischemia in the Treatment of liver malignances. In: Schlag P, Hohenberg P, Metzger U (ed) Combined Modality of Gstrointestinal Tract Cancer. Recent Results in Cancer Research 110, Springer Verlag Berlin: 187–195
Tannock IF (1987) Toxicity of 5-FU for aerobic and hypoxic cells in two murine tumours Cancer. Chemother Pharmacol 19: 53–56
Heidelberger C, Chaudhuari NK, Danenberg P, Mooren D, Griesbach L, Duschinsky R, Schnitzler RJ, Pleven E, Schreiner J (1957) Fluorinated pyrimidines, a new class of tumor-inhibitory compounds. Nature 179: 663–666
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2001 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Pohlen, U., Berger, G., Binnenhei, M., Reszka, R., Buhr, H.J. (2001). 5-FU-PEG-Liposomen zur intraaortalen Therapie. Ist die Metabolisierung von 5-Fluorouracil (5-FU) in Fluorourdesoxyuridin (FUDR) pH abhängig?. In: Schönleben, K., Neugebauer, E., Hartel, W., Menger, M.D. (eds) Chirurgisches Forum 2001 für experimentelle und klinische Forschung. Deutsche Gesellschaft für Chirurgie, vol 30. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56698-1_17
Download citation
DOI: https://doi.org/10.1007/978-3-642-56698-1_17
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-41718-7
Online ISBN: 978-3-642-56698-1
eBook Packages: Springer Book Archive