Abstract
The degenerative diseases of the central nervous system (eNS) are a heterogeneous group of disorders, genetically determined or with sporadic occurrence and unknown etiology, which may affect the brain and spinal cord with different mechanisms; they may involve the whole nervous system, but often exhibit a remarkable selectivity in affecting one system or another.
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References
Adams RD, Victor M (1993) Principles of Neurology, 5th edn. McGraw-Hill, New York, pp 987-989
Aiba I, Hashizume Y, Yoshida M et al. (1997) Relationship between brainstem MRI and pathological findings in progressive supranuclear palsy-study in autopsy cases. J Neurol Sci 152:210–217
Angelini L, Nardocci N, Rumi V et al. (1992) HallervordenSpatz disease: clinical and MRI study in eleven cases diagnosed in life. J Neurol 239:417–425
Autti T, Raininko R, Vanhanen SL et al. (1996) MRI of neuronal ceroid lipofuscinosis. I Cranial MRI of 30 patients with juvenile neuronal ceroid lipofuscinosis. Neuroradiology 38:476–482
Autti T, Raininko R, Santavuori P et al. (1997) MRI of neuronal ceroid lipofuscinosis. II Postmortem MRI and histopathological study of the brain in 16 cases of neuronal ceroid lipofuscinosis of juvenile or late infantile type. Neuroradiology 39:371–377
Aylward EH, Li Q, Stine OC et al. (1997) Longitudinal change in basal ganglia volume in patients with Huntington’s disease. Neurology 48:394–399
Block W, Karitzky J, Traber F et al. (1998) Proton magnetic resonance spectroscopy of the primary motor cortex in patients with motor neuron disease: subgroup analysis and follow-up measurements. Arch Neurol 55:931–936
Borit A, Rubinstein LJ, Urich H (1975) The striatonigral degenerations: putaminal pigments and nosology. Brain 98:101–112
Braffman BH, Trojanowski JQ, Atlas SW (1991) The aging brain and neurodegenerative disorders. In: Atlas SW (nted) Magnetic resonance imaging of the brain and spine. Raven Press, New York, pp 567–624
Bürk K, Abele M, Fetter M et al. (1996) Autosomal dominant cerebellar ataxia type I. Clinical features and MRI in families with SCA 1, SCA 2 and SCA 3. Brain 119:1497–1505
Carella F, Grisoli M, Savoiardo M et al. (1995) Magnetic resonance signal abnormalities along the pyramidal tracts in amyotrophic lateral sclerosis. Ital J Neurol Sci 16:511–515
Cumings IN (1948) The copper and iron content of brain and liver in the normal and in hepato-lenticular degeneration. Brain 71:410–415
de Leon MJ, Golomb J, Convit A et al. (1993) The radiologic prediction of Alzheimer disease: the atrophic hippocampal formation. Am J Neuroradiol 14:897–906
Di Donato S (1998) The complex clinical and genetic classification of inherited ataxias. Ital J Neurol Sci 19:335–343
Drayer BP, Olanow W, Burger P et al. (1986) Parkinson plus syndrome: diagnosis using high field MR imaging of brain iron. Radiology 159:493–498
Duchen LW, Jakobs JM (1984) Nutritional deficiencies and metabolic disorders. In: Hume Adams J, Corsellis JAN, Duchen LW (eds) Greenfield’s neuropathology, 4th edn. Wiley, New York, pp 573–626
Ellis CM, Simmons A, Andrews C et al. (1998) A proton magnetic resonance spectroscopic study in ALS: correlation with clinical findings. Neurology 51:1104–1109
Engelbrecht V, Schlang G, Hefter H et al. (1995) MRI of the brain in Wilson disease: T2 signal loss under therapy. J Comput Assist Tomogr 19:635–638
Farina L, Uggetti C, Ottolini A et al. (1994) Ataxia-telangiectasia: MR and CT findings. J Comput Assist Tomogr 18:724–727
Farina L, Nardocci N, Bruzzone MG et al. (1999) Infantile neuroaxonal dystrophy: neuroradiological studies in 11 patients. Neuroradiology 41:376–380
Fearnley JM, Lees AJ (1990) Striatonigral degeneration. A clinicopathological study. Brain 113:1823–1842
Frisoni GB, Laakso MP, Beltramello A et al. (1999) Hippocampal and entorhinal cortex atrophy in frontotemporal dementia and Alzheimer’s disease. Neurology 52:91–100
Gallucci M, Splendiani A, Bozzao A et al. (1990) MR imaging of degenerative disorders of brain stem and cerebellum. Magn Reson Imaging 8:117–122
Goto S, Matsumoto S, Ushio Y et al. (1996) Subregional loss of putaminal efferents to the basal ganglia output nuclei may cause parkinsonism in striatonigral degeneration. Neurology 47:1032–1036
Grisoli M, Fetoni V, Savoiardo M et al. ( 1995) MRI in corticobasal degeneration. Eur J Neurol 2:547–552
Hammans SR (1996) The inherited ataxias and the new genetics. J Neurol Neurosurg Psychiatry 61:327–332
Harris GJ, Pearlson GD, Peyser CE et al. (1992) Putamen volume reduction on magnetic resonance imaging exceeds caudate changes in mild Huntington’s disease. Ann Neurol 31:69–75
Harris GJ, Aylward EH, Peyser CE et al. (1996) Single photon emission computed tomographic blood flow and magnetic resonance volume imaging of basal ganglia in Huntington’s disease. Arch Neurol 53:316–324
Hirai T, Korogi Y, Sakamoto Y et al. (1996) T2 shortening in the motor cortex: effect of aging and cerebrovascular diseases. Radiology 199:799–803
Hurko O (1997) Recent advances in heritable ataxias. Ann Neurol 41:4–6
Ibanez V, Pietrini P, Alexander GE et al. (1998) Regional glucose metabolic abnormalities are not the result of atrophy in Alzheimer’s disease. Neurology 50:1585–1593
Inoue E, Hori S, Narumi Y et al. (1991) Portal-systemic encephalopathy: presence of basal ganglia lesions with high signal intensity on MR images. Radiology 179:551–555
Jack CR, Petersen RC, O’Brien PC et al. (1992) MR-based hippocampal volumetry in the diagnosis of Alzheimer’s disease. Neurology 42:183–188
Kalra S, Cashman NR, Genge A et al. (1998) Recovery of Nacetylaspartate in corticomotor neurons of patients with ALS after riluzole therapy. Neuroreport 9:1757–1761
Kato Y, Matsumura K, Kinosade Y et al. (1997) Detection of pyramidal tract lesions in amyotrophic lateral sclerosis with magnetization-transfer measurements. Am J Neuroradiol 18:541–1547
Kitagaki H, Mori E, Hirono N et al. (1997) Alteration of white matter MR signal intensity in frontotemporal dementia. Am J Neuroradiol 18:367–378
Kitagaki H, Mori E, Yamaji S et al. (1998) Frontotemporal dementia and Alzheimer disease: evaluation of cortical atrophy with automated hemispheric surface display generated with MR images. Radiology 208:431–439
Klockgether T, Skalej M, Wedekind D et al. (1998) Autosomal dominant cerebellar ataxia type I. MRI-based volume try of posterior fossa structures and basal ganglia in spinocerebellar ataxia types 1,2 and 3. Brain 121:1687–1693
Kraft E, Schwarz J, Trenkwalder C et al. (1999) The combination of hypo intense and hyperintense signal changes on T2-weighted magnetic resonance imaging sequences. A specific marker of multiple system atrophy? Arch Neurol 56:225–228
Laakso MP, Partanen K, Riekkinen P et al. (1996) Hippocampal volumes in Alzheimer’s disease, Parkinson’s disease with and without dementia, and in vascular dementia: an MRI study. Neurology 46:678–681
Litvan I, Agid Y, Jankovic J et al. (1996) Accuracy of clinical criteria for the diagnosis of progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome). Neurology 46:922–930
Litvan I, Agid Y, Goetz C et al. (1997) Accuracy of the clinical diagnosis of corticobasal degeneration: a clinicopathologic study. Neurology 48:119–125
Magalhaes ACA, Caramelli P, Menezes JR et al. (1994) Wilson’s disease: MRI with clinical correlation. Neuroradiology 36:97–100
Mascalchi M, Salvi F, Piacentini S et al. (1994) Friedreich’s ataxia: MR findings involving the cervical portion of the spinal cord. AJR 163:187–191
Miller BL, Moats RA, Shonk T et al. (1993) Alzheimer disease: depiction of increased cerebral myo-inositol with proton MR spectroscopy. Radiology 187:433–437
Murata Y, Kawakami H, Yamaguchi S et al. (1998a) Characteristic magnetic resonance imaging findings in spinocerebellar ataxia 6. Arch Neurol 55:1348–1352
Murata Y, Yamaguchi S, Kawakami H et al. (1998b) Characteristic magnetic resonance imaging findings in MachadoJoseph disease. Arch Neurol 55:33–37
Nardocci N, Verga ML, Binelli S et al. (1995) Neuronal ceroidlipofuscinosis: a clinical and morphological study of 19 patients. Am J Med Genetics 57:137–141
Nardocci N, Zorzi G, Farina L et al. (1999) Infantile neuroaxonal dystrophy. Clinical spectrum and diagnostic criteria. Neurology 52:1472–1478
Oba H, Araki T, Ohtomo K et al. (1993) Amyotrophic lateral sclerosis: T2 shortening in motor cortex at MR imaging. Radiology 189:843–846
Oliva D, Carella M, Savoiardo M et al. (1993) Clinical and magnetic resonance features of the classic and akinetic-rigid variants of Huntington’s disease. Arch Neurol 50:17–19
Oppenheimer DR (1984) Diseases of the basal ganglia, cerebellum and motor neurons. In: Hume Adams J, Corsellis JAN, Duchen LW (eds) Greenfield’s neuropathology, 4th edn. Wiley, New York, pp 699–747
Osborn AG (1994) Diagnostic neuroradiology (Chapter 18: Acquired metabolic, white matter, and degenerative diseases of the brain). Mosby, St Louis, pp 748–781
Pastakia B, Polinsky R, Di Chiro G et al. (1986) Multiple system atrophy (Shy-Drager syndrome): MR imaging. Radiology 159:499–502
Perani D, Bressi S, Testa D et al. (1995) Clinical/metabolic correlations in multiple system atrophy. A fludeoxyglu cose F18 positron emission tomographic study. Arch Neurol 52:179–185
Rooney WD, Miller RG, Gelinas D et al. (1998) Decreased Nacetylaspartate in motor cortex and corticospinal tract in ALS. Neurology 50:1800–1805
Savoiardo M, Strada L, Girotti F et al.(1989) MR imaging in progressive supranuclear palsy and Shy-Drager syndrome. J Comput Assist Tomogr 13:555–560
Savoiardo M, Strada L, Girotti F et al.(1990) Olivopontocerebellar atrophy: MR diagnosis and relationship to multisystem atrophy. Radiology 174:693-696
Savoiardo M, Strada L, Oliva D et al.(1991) Abnormal MRI signal in the rigid form of Huntington’s disease. J Neurol Neurosurg Psychiatry 54:888–891
Savoiardo M, Halliday WC, Nardocci N et al. (1993) Hallervorden-Spatz disease: MR and pathologic findings. Am J Neuroradiol 14:155–162
Savoiardo M, Grisoli M (1998) Magnetic resonance imaging of movement disorders. In: Jankovic J, Tolosa E (eds) Parkinson’s disease and movement disorders. Williams & Wilkins, Baltimore, pp 967–990
Savoiardo M, Grisoli M, Girotti F (1999) Magnetic resonance imaging in CBD and related atypical parkinsonian disorders and dementias. In: Litvan I, Goetz C, Lang A (eds) Corticobasal degeneration: clinical and research aspects. “Advances in Neurology” series. Lippincott-Raven Publishers, Philadelphia, in press
Sax DS, Powsner R, Kim A et al. (1996) Evidence of cortical metabolic dysfunction in early Huntington’s disease by single-photon-emission computed tomography. Mov Disord 11:671–677
Seöls L, Kruger R, Amoiridis G et al. (1998) Spinocerebellar ataxia type 6: genotype and phenotype in German kindreds. J Neurol Neurosurg Psychiatry 64:67–73
Schrag A, Kingsley D, Phatouros C et al. (1998) Clinical usefulness of magnetic resonance imaging in multiple system atrophy. J Neurol Neurosurg Psychiatry 65:65–71
Sethi KD, Adams RJ, Loring DW et al. (1988) HallervordenSpatz syndrome: clinical and magnetic resonance imaging correlations. Ann Neurol 24:692–694
Subramony SH (1998) The inherited ataxias. In: Jankovic J, Tolosa E (eds) Parkinson’s disease and movement disorders. Williams & Wilkins, Baltimore, pp 887–907
Taylor TD, Litt M, Kramer P (1996) Homozygosity mapping of Hallervorden-Spatz syndrome to chromosome 20 p 12.3-p 13. Nat Genet 14:479–481
Testa D, Savoiardo M, Fetoni V et al. (1993) Multiple system atrophy. Clinical and MR observations on 42 cases. Ital J Neurol Sci 14:211–216
Vanhanen SL, Rainiko R, Santavuori P (1994) Early differential diagnosis of infantile neuronal ceroid lipofuscinosis, Rett syndrome and Krabbe disease by CT and MR. Am J Neuroradiol 15:1443–1453
van Wassenaer-van Hall HN, van den Heuvel AG, Jansen GH et al. (1995) Cranial MR in Wilson disease. Abnormal white matter in extrapyramidal and pyramidal tracts. Am J Neuroradiol 16:2021–2027
van Wassenaer-van Hall HN, van den Heuvel AG, Algra A et al. (1996) Wilson disease: findings at MR imaging and CT of the brain with clinical correlation. Radiology 198:531–536
Vymazal J, Righini A, Brooks RA et al. (1999) T1 and T2 in the brain of healthy subjects, patients with Parkinson disease, and patients with multiple system atrophy: relation to iron content. Radiology 211:489–495
Waragai M (1997) MRI and clinical features in amyotrophic lateral sclerosis. Neuroradiology 39:847–851
Yagishita A, Oda M (1996) Progressive supranuclear palsy: MRI and pathological findings. Neuroradiology 38:560–566
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Savoiardo, M., Grisoli, M. (2001). Degenerative Diseases. In: Demaerel, P. (eds) Recent Advances in Diagnostic Neuroradiology. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56662-2_15
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DOI: https://doi.org/10.1007/978-3-642-56662-2_15
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