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Tissue-Type Plasminogen Activator (tPA)

  • Chapter
Fibrinolytics and Antifibrinolytics

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 146))

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Abstract

Cardiovascular diseases, comprising acute myocardial infarction (AMI), stroke, and venous thromboembolism have, as their immediate underlying cause, thrombosis of critically situated blood vessels with loss of blood flow to vital organs. One approach to the treatment of thrombosis consists of the pharmacologic dissolution of the blood clot via the intravenous infusion of plasminogen activators, which activate the blood fibrinolytic system.

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Authors
  1. D. Collen
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Editors and Affiliations

  1. FRAT — Hôpital Nestlé 2077, CHUV, CH-1011, Lausanne, Switzerland

    F. Bachmann

  2. Chemin Praz Mandry 20, CH-1052, Le Mont, Switzerland

    F. Bachmann

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© 2001 Springer-Verlag Berlin Heidelberg

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Collen, D. (2001). Tissue-Type Plasminogen Activator (tPA). In: Bachmann, F. (eds) Fibrinolytics and Antifibrinolytics. Handbook of Experimental Pharmacology, vol 146. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56637-0_8

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  • DOI: https://doi.org/10.1007/978-3-642-56637-0_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-63029-3

  • Online ISBN: 978-3-642-56637-0

  • eBook Packages: Springer Book Archive

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