Skip to main content
SpringerLink
Log in

Assembly of the Plasminogen System on Cell Surfaces

  • Chapter
Book cover Fibrinolytics and Antifibrinolytics

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 146))

Abstract

The contribution of the plasminogen system to fibronolysis is subject sophisticated and multifaceted regulatory mechanisms. Plasminogen activators, inhibitors of these activators and of plasmin, play critical roles in the initiation, propagation, and control of fibrinolysis. Additionally, the fibrin surface, per se, is an important regulator of its own degradation by providing specific binding sites for several components of the plasminogen system (plasminogen, tPA, α2-antiplasmin). Aberrations in any of these regulatory mechanisms can upset the delicate balance between thrombus formation and dissolution, resulting in thrombotic or bleeding tendencies.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Adelman B, Rizk A, Hanners E (1988) Plasminogen interactions with platelets in plasma. Blood 72:1530–1535

    PubMed  CAS  Google Scholar 

  • Albrecht JC, Nicholas J, Cameron KR, Newman C, Fleckenstein B, Honess RW (1992) Herpesvirus saimiri has a gene specifying a homologue of the cellular membrane glycoprotein CD59. Virology 190:527–530

    PubMed  CAS  Google Scholar 

  • Andrade-Gordon P, Strickland S (1986) Interaction of heparin with plasminogen activators and plasminogen: Effects on the activation of plasminogen. Biochemistry 25:4033–4040

    PubMed  CAS  Google Scholar 

  • Andronicos NM, Ranson M, Bognacki J, Baber MS (1997) The human ENO1 gene product (recombinant human α-enolase) displays characteristics required for a plasminogen binding protein. Biochim Biophys Acta 1337:27–39

    PubMed  CAS  Google Scholar 

  • Appella E, Robinson EA, Ullrich SJ, Stoppelli MP, Corti A, Cassani G, Blasi F (1987) The receptor-binding sequence of urokinase. A biological function for the growthfactor module of proteases. J Biol Chem 262:4437–4440

    PubMed  CAS  Google Scholar 

  • Bajpai A, Baker JB (1985) Urokinase binding sites on human foreskin cells. Evidence for occupancy with endogenous urokinase. Biochem Biophys Res Commun 133:994–1000

    PubMed  CAS  Google Scholar 

  • Barnathan ES, Kuo A, Rosenfeld L, Karikó K, Leski M, Robbiati F, Nolli ML, Henkin J, Cines DB (1990) Interaction of single-chain urokinase-type plasminogen activator with human endothelial cells. J Biol Chem 265:2865–2872

    PubMed  CAS  Google Scholar 

  • Bauer PI, Machovich R, Buki K, Csonka E, Koch S, Horvath I (1984) Interaction of plasmin with endothelial cells. Biochem J 218:119–124

    PubMed  CAS  Google Scholar 

  • Beebe DP (1987) Binding of tissue plasminogen activator to human umbilical vein endothelial cells. Thromb Res 46:241–254

    PubMed  CAS  Google Scholar 

  • Beebe DP, Miles LA, Plow EF (1989) A linear amino acid sequence involved in the interaction of t-PA with its endothelial cell receptor. Blood 74:2034–2037

    PubMed  CAS  Google Scholar 

  • Beebe DP, Wood LL, Moos M (1990) Characterization of tissue plasminogen activator binding proteins isolated from endothelial cells and other cell types. Thromb Res 59:339–350

    PubMed  CAS  Google Scholar 

  • Behrendt N, Ploug M, Patthy L, Houen G, Blasi F, Danø K (1991) The ligand-binding domain of the cell surface receptor for urokinase-type plasminogen activator. J Biol Chem 266:7842–7847

    PubMed  CAS  Google Scholar 

  • Behrendt N, Rønne E, Danø K (1996) Domain interplay in the urokinase receptor. Requirement for the third domain in high affinity ligand binding and demonstration of ligand contact sites in distinct receptor domains. J Biol Chem 271:22885–22894

    PubMed  CAS  Google Scholar 

  • Berge A, Sjöbring U (1993) PAM, a novel plasminogen-binding protein from Streptococcus pyogenes. J Biol Chem 268:25417–25424

    PubMed  CAS  Google Scholar 

  • Besser D, Verde P, Nagamine Y, Blasi F (1997) Signal transduction and the u-PA/u-PAR system. Fibrinolysis 10:215–237

    Google Scholar 

  • Bizik J, Trancikova D, Felnerova D, Verheijen JH, Vaheri A (1997) Spatial orientation of tissue-type plasminogen activator bound at the melanoma cell surface. Biochem Biophys Res Commun 239:322–328

    PubMed  CAS  Google Scholar 

  • Blasi F (1997) uPA, uPAR, PAI-1: key intersection of proteolytic, adhesive and chemotactic highways? Immunol Today 18:415–417

    PubMed  CAS  Google Scholar 

  • Boffa MB, Wang W, Bajzar L, Nesheim ME (1998) Plasma and recombinant thrombinactivable fibrinolysis inhibitor (TAFI) and activated TAFI compared with respect to glycosylation, thrombin/thrombomodulin-dependent activation, thermal stability, and enzymatic properties. J Biol Chem 273:2127–2135

    PubMed  CAS  Google Scholar 

  • Bohuslav J, Horejsí V, Hansmann C, Stöckl J, Weidle UH, Majdic O, Bartke I, Knapp W, Stockinger H (1995) Urokinase plasminogen activator receptor, β2-integrins, and Src-kinases within a single receptor complex of human monocytes. J Exp Med 181:1381–1390

    PubMed  CAS  Google Scholar 

  • Børglum AD, Byskov A, Ragno P, Roldan AL, Tripputi P, Cassani G, Danø K, Blasi F, Kruse TA (1992) Assignment of the urokinase-type plasminogen activator receptor gene (PLAUR) to chromosome 19ql3.1–ql3.2. Am J Hum Genet 50:492–497

    PubMed  Google Scholar 

  • Boyle MDP, Lottenberg R (1997) Plasminogen activation by invasive human pathogens. Thromb Haemost 77:1–10

    PubMed  CAS  Google Scholar 

  • Bugge TH, Flick MJ, Daugherty CC, Degen JL (1995) Plasminogen deficiency causes severe thrombosis but is compatible with development and reproduction. Genes Dev 9:794–807

    PubMed  CAS  Google Scholar 

  • Bürgle M, Koppitz M, Riemer C, Kessler H, König B, Weidle UH, Kellermann J, Lottspeich F, Graeff H, Schmitt M, Goretzki L, Reuning U, Wilhelm O, Magdolen V (1997) Inhibition of the interaction of urokinase-type plasminogen activator (uPA) with its receptor (uPAR) by synthetic peptides. Biol Chem 378:231–237

    PubMed  Google Scholar 

  • Burtin P, Chavanel G, Andre-Bougaran J, Gentile A (1987) The plasmin system in human adenocarcinomas and their metastases. A comparative immunofluorescence study. Int J Cancer 39:170–178

    PubMed  CAS  Google Scholar 

  • Burtin P, Fondanèche M-C (1988) Receptor for plasmin on human carcinoma cells. J Natl Cancer Inst 80:762–765

    PubMed  CAS  Google Scholar 

  • Busso N, Masur SK, Lazega D, Waxman S, Ossowski L (1994) Induction of cell migration by pro-urokinase binding to its receptor: Possible mechanism for signal transduction in human epithelial cells. J Cell Biol 126:259–270

    PubMed  CAS  Google Scholar 

  • Camacho M, Fondanèche M-C, Burtin P (1989) Limited proteolysis of tumor cells increases their plasmin-binding ability. FEBS Lett 245:21–24

    PubMed  CAS  Google Scholar 

  • Cao D, Mizukami IF, Garni-Wagner BA, Kindzelskii AL, Todd RF, III, Boxer LA, Petty HR (1995) Human urokinase-type plasminogen activator primes neutrophils for superoxide anion releases. Possible roles of complement receptor type III and calcium. J Immunol 154:1817–1829

    PubMed  CAS  Google Scholar 

  • Carmeliet P, Moons L, Dewerchin M, Rosenberg S, Herbert JM, Lupu F, Collen D (1998) Receptor-independent role of urokinase-type plasminogen activator in pericellular plasmin and matrix metalloproteinase proteolysis during vascular wound healing in mice. J Cell Biol 140:233–245

    PubMed  CAS  Google Scholar 

  • Carmeliet P, Moons L, Ploplis V, Plow E, Collen D (1997) Impaired arterial neointima formation in mice with disruption of the plasminogen gene. J Clin Invest 99:200–208

    PubMed  CAS  Google Scholar 

  • Cesarman GM, Guevara CA, Hajjar KA (1994) An endothelial cell receptor for plasminogen/ tissue plasminogen activator (t-PA). II. Annexin II-mediated enhancement of t-PA-dependent plasminogen activation. J Biol Chem 269:21198–21203

    PubMed  CAS  Google Scholar 

  • Chapman HA, Bertozzi P, Sailor LZ, Nusrat AR (1990) Alveolar macrophage urokinase receptors localize enzyme activity to the cell surface. Am J Physiol 259:L432–L438

    PubMed  CAS  Google Scholar 

  • Chen ZL, Strickland S (1997) Neuronal death in the hippocampus is promoted by plasmin-catalyzed degradation of laminin. Cell 91:917–925

    PubMed  CAS  Google Scholar 

  • Christiansen VJ, Sims PJ, Hamilton KK (1997) Complement C5b-9 increases plasminogen binding and activation on human endothelial cells. Arterioscler Thromb Vase Biol 17:164–171

    CAS  Google Scholar 

  • Cohen RL, Xi X-P, Crowley CW, Lucas BK, Levinson AD, Shuman MA (1991) Effects of urokinase receptor occupancy on plasmin generation and proteolysis of basement membrane by human tumor cells. Blood 78:479–487

    PubMed  CAS  Google Scholar 

  • Coleman JL, Sellati TJ, Testa JE, Kew RR, Furie MB, Benach JL (1995) Borrelia burgdorferi binds plasminogen, resulting in enhanced penetration of endothelial monolayers. Infect Immun 63:2478–2484

    PubMed  CAS  Google Scholar 

  • Conese M, Blasi F (1995) Urokinase/urokinase receptor system: internalization/degradation of urokinase-serpin complexes: mechanism and regulation. Biol Chem Hoppe-Seyler 376:143–155

    PubMed  CAS  Google Scholar 

  • Conese M, Olson D, Blasi F (1994) Protease nexin-i-urokinase complexes are internalized and degraded through a mechanism that requires both urokinase receptor and β2-macroglobulin receptor. J Biol Chem 269:17886–17892

    PubMed  CAS  Google Scholar 

  • Conforti G, Dominguez-Jimenez C, Rønne Z, Høyer-Hansen G, Dejana E (1994) Cell-surface plasminogen activation causes a retraction of in vitro cultured human umbilical vein endothelial cell monolayer. Blood 83:994–1005

    PubMed  CAS  Google Scholar 

  • Correc P, Fondanèche M-C, Bracke M, Burtin P (1990) The presence of plasmin receptors on three mammary carcinoma MCF-7 sublines. Int J Cancer 46:745–750

    PubMed  CAS  Google Scholar 

  • Correc P, Zhang S, Komano O, Laurent M, Burtin P (1992) Visualization of the plasmin receptor on carcinoma cells. Int J Cancer 50:767–771

    PubMed  CAS  Google Scholar 

  • Crowley CW, Cohen RL, Lucas BK, Liu G, Shuman MA, Levinson AD (1993) Prevention of metastasis by inhibition of the urokinase receptor. Proc Natl Acad Sci USA 90:5021–5025

    PubMed  CAS  Google Scholar 

  • Cubellis MV, Andreasen P, Ragno P, Mayer M, Danø K, Blasi F (1989) Accessibility of receptor-bound urokinase to type-1 plasminogen activator inhibitor. Proc Natl Acad Sci USA 86:4828–4832

    PubMed  CAS  Google Scholar 

  • Cubellis MV, Nolli ML, Cassani G, Blasi F (1986) Binding of single-chain prourokinase to the urokinase receptor of human U937 cells. J Biol Chem 261:15819–15822

    PubMed  CAS  Google Scholar 

  • Danø K, Behrendt N, Brünner N, Ellis V, Ploug M, Dyke C (1994) The urokinase receptor: protein structure and role in plasminogen activation and cancer invasion. Fibrinolysis 8:189–203

    Google Scholar 

  • Dear AE, Medcalf RL (1998) The urokinase-type-plasminogen-activator receptor (CD87) is a pleiotropic molecule. Eur J Biochem 252:185–193

    PubMed  CAS  Google Scholar 

  • Deguchi K, Murashima S, Shirakawa S, Soria C, Soria J, Dunn F, Tobelem G (1985) The potentiating effect of platelet on plasminogen activation by tissue plasminogen activator. Thromb Res 40:853–861

    PubMed  CAS  Google Scholar 

  • Del Rosso M, Anichini E, Pedersen N, Blasi F, Fibbi G, Pucci M, Ruggiero M (1993) Urokinase-urokinase receptor interaction: non-mitogenic signal transduction in human epidermal cells. Biochem Biophys Res Commun 190:347–352

    PubMed  Google Scholar 

  • Del Rosso M, Fibbi G, Dini G, Grappone C, Pucci M, Caldini R, Magnelli L, Fimiani M, Lotti T, Panconesi E (1990) Role of specific membrane receptors in urokinase-dependent migration of human keratinocytes. J Invest Dermatol 94:310–316

    PubMed  Google Scholar 

  • Dudani AK, Ganz PR (1996) Endothelial cell surface actin serves as a binding site for plasminogen, tissue plasminogen activator and lipoprotein(a). Br J Haematol 95:168–178

    PubMed  CAS  Google Scholar 

  • Dumler I, Petri T, Schleuning W-D (1993) Interaction of urokinase-type plasminogen activator (u-PA) with its cellular receptor (u-PAR) induces phosphorylation on tyrosine of a 38kDa protein. FEBS Lett 322:37–40

    PubMed  CAS  Google Scholar 

  • Dumler I, Petri T, Schleuning W-D (1994) Induction of c-fos gene expression by urokinase-type plasminogen activator in human ovarian cancer cells. FEBS Lett 343:103–106

    PubMed  CAS  Google Scholar 

  • Dumler I, Weis A, Mayboroda OA, Maasch C, Jerke U, Haller H, Gulba DC (1998) The Jak/Stat pathway and urokinase receptor signaling in human aortic vascular smooth muscle cells. J Biol Chem 273:315–321

    PubMed  CAS  Google Scholar 

  • Duval-Jobe C, Parmely MJ (1994) Regulation of plasminogen activation by human U937 promonocytic cells, J Biol Chem 269:21353–21357

    PubMed  CAS  Google Scholar 

  • Eaton DL, Malloy BE, Tsai SP, Henzel W, Drayna D (1991) Isolation, molecular cloning, and partial characterization of a novel carboxypeptidase B from human plasma, J Biol Chem 266:21833–21838

    PubMed  CAS  Google Scholar 

  • Ellis V, Behrendt N, Danø K (1991) Plasminogen activation by receptor-bound urokinase. A kinetic study with both cell-associated and isolated receptor. J Biol Chem 266:12752–12758

    PubMed  CAS  Google Scholar 

  • Ellis V, Scully MF, Kakkar VV (1989) Plasminogen activation initiated by single-chain urokinase-type plasminogen activator. J Biol Chem 264:2185–2188

    PubMed  CAS  Google Scholar 

  • Ellis V, Whawell SA (1997) Vascular smooth muscle cells potentiate plasmin generation by both urokinase and tissue plasminogen activator-dependent mechanisms: evidence for a specific tissue-type plasminogen activator receptor on these cells. Blood 90:2312–2322

    PubMed  CAS  Google Scholar 

  • Estreicher A, Mühlhauser J, Carpentier J-L, Orci L, Vassalli J-D (1990) The receptor for urokinase type plasminogen activator polarizes expression of the protease to the leading edge of migrating monocytes and promotes degradation of enzyme inhibitor complexes. J Cell Biol 111:783–792

    PubMed  CAS  Google Scholar 

  • Estreicher A, Wohlwend A, Belin D, Schleuning W-D, Vassalli J-D (1989) Characterization of the cellular binding site for the urokinase-type plasminogen activator. J Biol Chem 264:1180–1189

    PubMed  CAS  Google Scholar 

  • Falcone DJ, McCaffrey TA, Haimovitz-Friedman A, Vergilio J-A, Nicholson AC (1993) Macrophage and foam cell release of matrix-bound growth factors. Role of plasminogen activation. J Biol Chem 268:11951–11958

    PubMed  CAS  Google Scholar 

  • Fazioli F, Resnati M, Sidenius N, Higashimoto Y, Appella E, Blasi F (1997) A urokinase-sensitive region of the human urokinase receptor is responsible for its chemotactic activity. EMBO J 16:7279–7286

    PubMed  CAS  Google Scholar 

  • Felez J, Chanquia CJ, Fabregas P, Plow EF, Miles LA (1993) Competition between plasminogen and t-PA for cellular binding sites. Blood 82:2433–2441

    PubMed  CAS  Google Scholar 

  • Felez J, Chanquia CJ, Levin EG, Miles LA, Plow EF (1991) Binding of tissue plasminogen activator to human monocytes and monocytoid cells. Blood 78:2318–2327

    PubMed  CAS  Google Scholar 

  • Felez J, Miles LA, Fabregas P, Jardi M, Plow EF, Lijnen RH (1996) Characterization of cellular binding sites and interactive regions within reactants required for enhancement of plasminogen activation by tPA on the surface of leukocytic cells. Thromb Haemost 76:577–584

    PubMed  CAS  Google Scholar 

  • Felez J, Miles LA, Plescia J, Plow EF (1990) Regulation of plasminogen receptor expression on human monocytes and monocytoid cell lines. J Cell Biol 111:1673–1683

    PubMed  CAS  Google Scholar 

  • Fibbi G, Ziche M, Morbidelli L, Magnelli L, Del Rosso M (1988) Interaction of urokinase with specific receptors stimulates mobilization of bovine adrenal capillary endothelial cells. Exp Cell Res 179:385–395

    PubMed  CAS  Google Scholar 

  • Fukao H, Hagiya Y, Nonaka T, Okada K, Matsuo O (1992) Analysis of binding protein for tissue-type plasminogen activator in human endothelial cells. Biochem Biophys Res Commun 187:956–962

    PubMed  CAS  Google Scholar 

  • Fuse N, Tsuchiya T, Nomomura Y, Menez A, Tamiya T (1990) Structure of the snake short-chain neurotoxin, erabutoxin c, precursor gene. Eur J Biochem 193:629–633

    PubMed  CAS  Google Scholar 

  • Ganz PR, Dupuis D, Dudani AK, Hashemi S (1991) Characterization of plasminogen binding to human capillary and arterial endothelial cells. Biochem Cell Biol 69:442–448

    PubMed  CAS  Google Scholar 

  • Goldfarb RH, Ziche M, Murano G, Liotta LA (1986) Plasminogen activators (urokinase) mediate neovascularization: Possible role in tumor angiogenesis. Semin Thromb Hemost 12:294–307

    PubMed  CAS  Google Scholar 

  • Gonias SL, Geary WA, VandenBerg SR (1989) Plasminogen binding to rat hepatocytes in primary culture and to thin slices of rat liver. Blood 75:729–736

    Google Scholar 

  • Gonzalez-Gronow M, Edelberg JM, Pizzo SV (1989) Further characterization of the cellular plasminogen binding site: Evidence that plasminogen 2 and lipoprotein(a) compete for the same site. Biochemistry 28:2374–2377

    PubMed  CAS  Google Scholar 

  • Gonzalez-Gronow M, Gawdi G, Pizzo SV (1994) Characterization of the plasminogen receptors of normal and rheumatoid arthritis human synovial fibroblasts. J Biol Chem 269:4360–4366

    PubMed  CAS  Google Scholar 

  • Gonzalez-Gronow M, Stack S, Pizzo SV (1991) Plasmin binding to the plasminogen receptor enhances catalytic efficiency and activates the receptor for subsequent ligand binding. Arch Biochem Biophys 286:625–628

    PubMed  CAS  Google Scholar 

  • Gyetko MR, Todd RF, III, Wilkinson CC, Sitrin RG (1994) The urokinase receptor is required for human monocyte chemotaxis in vitro, J Clin Invest 93:1380–1387

    PubMed  CAS  Google Scholar 

  • Hajjar KA (1991) The endothelial cell tissue plasminogen activator receptor. Specific interaction with plasminogen. J Biol Chem 266:21962–21970

    PubMed  CAS  Google Scholar 

  • Hajjar KA (1995) Cellular receptors in the regulation of plasmin generation. Thromb Haemost 74:294–301

    PubMed  CAS  Google Scholar 

  • Hajjar KA, Gavish D, Breslow JL, Nachman RL (1989) Lipoprotein(a) modulation of endothelial cell surface fibrinolysis and its potential role in atherosclerosis. Nature 339:303–305

    PubMed  CAS  Google Scholar 

  • Hajjar KA, Hamel NM (1990) Identification and characterization of human endothelial cell membrane binding sites for tissue plasminogen activator and urokinase. J Biol Chem 265:2908–2916

    PubMed  CAS  Google Scholar 

  • Hajjar KA, Hamel NM, Harpel PC, Nachman RL (1987) Binding of tissue plasminogen activator to cultured human endothelial cells. J Clin Invest 80:1712–1719

    PubMed  CAS  Google Scholar 

  • Hajjar KA, Harpel PC, Jaffe EA, Nachman RL (1986) Binding of plasminogen to cultured human endothelial cells. J Biol Chem 261:11656–11662

    PubMed  CAS  Google Scholar 

  • Hajjar KA, Jacovina AT, Chacko J (1994) An endothelial cell receptor for plasminogen/ tissue plasminogen activator. I. Identity with annexin II. J Biol Chem 269:21191–21197

    PubMed  CAS  Google Scholar 

  • Hajjar KA, Mauri L, Jacovina AT, Zhong F, Mirza UA, Padovan JC, Chait BT (1998) Tissue plasminogen activator binding to the annexin II tail domain. Direct modulation by homocysteine. J Biol Chem 273:9987–9993

    PubMed  CAS  Google Scholar 

  • Hall SW, Humphries JE, Gonias SL (1991) Inhibition of cell surface receptor-bound plasmin by α2-antiplasmin and α2-macroglobulin. J Biol Chem 266:12329–12336

    PubMed  CAS  Google Scholar 

  • Heegaard CW, Simonsen AC, Oka K, Kjoiler L, Christensen A, Madsen B, Ellgaard L, Chan L, Andreasen PA (1995) Very low density lipoprotein receptor binds and mediates endocytosis of urokinase-type plasminogen activator-type-1 plasminogen activator inhibitor complex. J Biol Chem 270:20855–20861

    PubMed  CAS  Google Scholar 

  • Hembrough TA, Vasudevan J, Allietta MM, Glass WF, II, Gonias SL (1995) A cytokeratin 8-like protein with plasminogen-binding activity is present on the external surfaces of hepatocytes, HepG2 cells and breast carcinoma cell lines. J Cell Sci 108:1071–1082

    PubMed  CAS  Google Scholar 

  • Herbert JM, Carmeliet P (1997) Involvement of u-PA in the anti-apoptotic activity of TGFb for vascular smooth muscle cells. FEBS Lett 413:401–404

    PubMed  CAS  Google Scholar 

  • Higazi AA-R, Cohen RL, Henkin J, Kniss D, Schwartz BS, Cines DB (1995) Enhancement of the enzymatic activity of single-chain urokinase plasminogen activator by soluble urokinase receptor. J Biol Chem 270:17375–17380

    PubMed  CAS  Google Scholar 

  • Higazi AA-R, Mazar A, Wang J, Quan N, Griffin R, Reilly R, Henkin J, Cines DB (1997) Soluble human urokinase receptor is composed of two active units. J Biol Chem 272:5348–5353

    PubMed  CAS  Google Scholar 

  • Hollas W, Blasi F, Boyd D (1991) Role of the urokinase receptor in facilitating extracellular matrix invasion by cultured colon cancer. Cancer Res 51:3690–3695

    PubMed  CAS  Google Scholar 

  • Hollas W, Hoosein N, Chung LWK, Mazar A, Henkin J, Karikó K, Barnathan ES, Boyd D (1992) Expression of urokinase and its receptor in invasive and non-invasive prostate cancer cell lines. Thromb Haemost 68:662–666

    PubMed  CAS  Google Scholar 

  • Høyer-Hansen G, Ploug M, Behrendt N, Rønne E, Danø K (1997) Cell-surface acceleration of urokinase-catalyzed receptor cleavage. Eur J Biochem 243:21–26

    PubMed  Google Scholar 

  • Hu LT, Pratt SD, Perides G, Katz L, Rogers RA, Klempner MS (1997) Isolation, cloning, and expression of a 70-kilodalton plasminogen binding protein of Borrelia burgdorferi. Infect Immun 65:4989–4995

    PubMed  CAS  Google Scholar 

  • Huang Y-Y, Bach ME, Lipp HP, Zhuo M, Wolfer DP, Hawkins RD, Schoonjans L, Kandel ER, Godfraind J-M, Mulligan R, Collen D, Carmeliet P (1996) Mice lacking the gene encoding tissue-type plasminogen activator show a selective interference with late-phase long-term potentiation in both Schaffer collateral and mossy fiber pathways. Proc Natl Acad Sci USA 93:8699–8704

    PubMed  CAS  Google Scholar 

  • Jackson CL, Reidy MA (1992) The role of plasminogen activation in smooth muscle cell migration after arterial injury. Ann NY Acad Sci 667:141–150

    PubMed  CAS  Google Scholar 

  • Jankun J, Merrick HW, Goldblatt PJ (1993) Expression and localization of elements of the plasminogen activation system in benign breast disease and breast cancers. J Cell Biochem 53:135–144

    PubMed  CAS  Google Scholar 

  • Jardí M, Inglés-Esteve J, Burgal M, Azqueta C, Velasco F, López-Pedrera C, Miles LA, Felez J (1996) Distinct patterns of urokinase receptor (uPAR) expression by leukemic cells and peripheral blood cells. Thromb Haemost 76:1009–1019

    PubMed  Google Scholar 

  • Jensen PH, Christensen EI, Ebbesen P, Gliemann J, Andreasen PA (1990) Lysosomal degradation of receptor-bound urokinase-type plasminogen activator is enhanced by its inhibitors in human trophoblastic choriocarcinoma cells. Cell Regulation 1:1043–1056

    PubMed  CAS  Google Scholar 

  • Jia X-C, Ny T, Hsueh AJW (1990) Synergistic effect of glucocorticoids and androgens on the hormonal induction of tissue plasminogen activator activity and messenger ribonucleic acid levels in granulosa cells. Mol Cell Endocrinol 68:143–151

    PubMed  CAS  Google Scholar 

  • Jiang YP, Pannell R, Liu JN, Gurewich V (1996) Evidence for a novel binding protein to urokinase-type plasminogen activator in platelet membranes. Blood 87:2775–2781

    PubMed  CAS  Google Scholar 

  • Karikó K, Kuo A, Boyd D, Okada SS, Cines DB, Barnathan ES (1993) Overexpression of urokinase receptor increases matrix invasion without altering cell migration in a human osteosarcoma cell line. Cancer Res 53:3109–3117

    PubMed  Google Scholar 

  • Kassam G, Choi KS, Ghuman J, Kang HM, Fitzpatrick SL, Zackson T, Zackson S, Toba M, Shinomiya A, Waisman DM (1998) The role of annexin II tetramer in the activation of plasminogen. J Biol Chem 273:4790–4799

    PubMed  CAS  Google Scholar 

  • Kim J, Yu W, Kovalski K, Ossowski L (1998) Requirement for specific proteases in cancer cell intravasation as revealed by a novel semiquantitative PCR-based assay. Cell 94:353–362

    PubMed  CAS  Google Scholar 

  • Kim S-O, Plow EF, Miles LA (1996) Regulation of plasminogen receptor expression on monocytoid cells by β1-integrin-dependent cellular adherence to extracellular matrix proteins. J Biol Chem 271:23761–23767

    PubMed  CAS  Google Scholar 

  • Kirchheimer JC, Nong Y-H, Remold HG (1988) IFN-gamma, tumor necrosis factor-α and urokinase regulate the expression of urokinase receptors on human monocytes. J Immunol 141:4229–4234

    PubMed  CAS  Google Scholar 

  • Kirchheimer JC, Remold HG (1989a) Functional characteristics of receptor-bound urokinase on human monocytes: catalytic efficiency and susceptibility to inactivation by plasminogen activator inhibitors. Blood 74:1396–1402

    PubMed  CAS  Google Scholar 

  • Kirchheimer JC, Remold HG (1989b) Endogenous receptor-bound urokinase mediates tissue invasion of human monocytes. J Immunol 143:2634–2639

    PubMed  CAS  Google Scholar 

  • Kirchheimer JC, Remold HG, Wanivenhaus A, Binder BR (1991) Increased proteolytic activity on the surface of monocytes from patients with rheumatoid arthritis. Arthritis Rheum 34:1430–1433

    PubMed  CAS  Google Scholar 

  • Klein KL, Hartmann RC (1989) Acute coronary artery thrombosis in paroxysmal nocturnal hemoglobinuria. South Med J 82:1169–1171

    PubMed  CAS  Google Scholar 

  • Kobayashi H, Shinohara H, Takeuchi K, Itoh M, Fujie M, Saitoh M, Terao T (1994) Inhibition of the soluble and the tumor cell receptor-bound plasmin by urinary trypsin inhibitor and subsequent effects on tumor cell invasion and metastasis. Cancer Res 54:844–849

    PubMed  CAS  Google Scholar 

  • Konakova M, Hucho F, Schleuning WD (1998) Downstream targets of urokinase-type plasminogen-activator-mediated signal transduction. Eur J Biochem 253:421–429

    PubMed  CAS  Google Scholar 

  • Krätzschmar J, Haendler B, Kojima S, Rifkin DB, Schleuning W-D (1993) Bovine urokinase-type plasminogen activator and its receptor: Cloning and induction by retinoic acid. Gene 125:177–183

    PubMed  Google Scholar 

  • Krieger M, Herz J (1994) Structures and functions of multiligand lipoprotein receptors macrophage scavenger receptors and LDL receptor-related protein (LRP). Annu Rev Biochem 63:601–637

    PubMed  CAS  Google Scholar 

  • Kristensen P, Eriksen J, Blasi F, Danø K (1991) Two alternatively spliced mouse urokinase receptor mRNAs with different histological localization in the gastrointestinal tract. J Cell Biol 115:1763–1771

    PubMed  CAS  Google Scholar 

  • Kristensen T, Moestrup SK, Gliemann J, Bendtsen L, Sand O, Sottrup-Jensen L (1990) Evidence that the newly cloned low-density-lipoprotein receptor related protein (LRP) is the alpha-2-macroglobulin receptor. FEBS Lett 276:151–155

    PubMed  CAS  Google Scholar 

  • Kuusela P, Ullberg M, Kronvall G, Tervo T, Tarkkanen A, Saksela O (1992) Surface-associated activation of plasminogen on gram-positive bacteria. Effect of plasmin on the adherence of staphylococcus aureus. Acta Ophthalmol [Suppl 202]:42–46

    Google Scholar 

  • Lee SW, Ellis V, Dichek D (1994) Characterization of plasminogen activation by glycosyl-phosphatidylinositol-anchored urokinase. J Biol Chem 269:2411–2418

    PubMed  CAS  Google Scholar 

  • Lee SW, Khan ML, Dichek D (1992) Expression of an anchored urokinase in the apical endothelial cell membrane. J Biol Chem 267:13020–13029

    PubMed  CAS  Google Scholar 

  • Lijnen HR, Van Hoef B, De Cock F, Collen D (1989) The mechanism of plasminogen activation and fibrin dissolution by single chain urokinase-type plasminogen activator in a plasma milieu in vitro. Blood 73:1864–1872

    PubMed  CAS  Google Scholar 

  • Lo SK, Ryan TJ, Gilboa N, Lai L, Malik AB (1989) Role of catalytic and lysine-binding sites in plasmin-induced neutrophil adherence to endothelium. J Clin Invest 84:793–801

    PubMed  CAS  Google Scholar 

  • Lottenberg R (1997) A novel approach to explore the role of plasminogen in bacterial pathogenesis. Trends Microbiol 5:466–47

    PubMed  CAS  Google Scholar 

  • Lottenberg R, Broder CC, Boyle MDP, Kain SJ, Schroeder BL, Curtiss I (1992) Cloning, sequence analysis, and expression in Escherichia coli of a streptococcal plasmin receptor. J Bacteriol 174:5204–5210

    PubMed  CAS  Google Scholar 

  • Lu H, Li H, Mirshahi SS, Soria C, Soria J, Menashi S (1993) Comparative study of fibrinolytic activity on U937 line after stimulation by interferon gamma, 1,25 dihydroxyvitamin D3 and their combination. Thromb Res 69:353–359

    PubMed  CAS  Google Scholar 

  • Lund LR, Rønne E, Roldan AL, Behrendt N, Rømer J, Blasi F, Danø K (1991a) Urokinase receptor mRNA level and gene transcription are strongly and rapidly increased by phorbol myristate acetate in human monocyte-like U937 cells. J Biol Chem 266:5177–5181

    PubMed  CAS  Google Scholar 

  • Lund LR, Rømer J, Rønne E, Ellis V, Blasi F, Danø K (1991b) Urokinase-receptor biosynthesis, mRNA level and gene transcription are increased by transforming growth factor β1 in human A549 lung carcinoma cells. EMBO J 10:3399–3407

    PubMed  CAS  Google Scholar 

  • Manchanda N, Schwartz BS (1991) Single chain urokinase. Augmentation of enzymatic activity upon binding to monocytes. J Biol Chem 266:14580–14584

    PubMed  CAS  Google Scholar 

  • Mandriota SJ, Seghezzi G, Vassalli JD, Ferrara N, Wasi S, Mazzieri R, Mignatti P, Pepper MS (1995) Vascular endothelial growth factor increases urokinase receptor expression in vascular endothelial cells. J Biol Chem 270:9709–9716

    PubMed  CAS  Google Scholar 

  • Meissauer A, Kramer MD, Schirrmacher V, Brunner G (1992) Generation of cell surface-bound plasmin by cell-associated urokinase-type or secreted tissue-type plasminogen activator: A key event in melanoma cell invasiveness in vitro. Exp Cell Res 199:179–190

    PubMed  CAS  Google Scholar 

  • Menoud PA, Debrot S, Schowing J (1989) Mouse neural crest cells secrete both urokinase-type and tissue-type plasminogen activators in vitro. Development 106:685–690

    PubMed  CAS  Google Scholar 

  • Merenmies J, Pihlaskari R, Laitinen J, Wartiovaara J, Rauvala H (1991) 30-kDa heparinbinding protein of brain (amphoterin) involved in neurite outgrowth. Amino acid sequence and localization in the filopodia of the advancing plasma membrane. J Biol Chem 266:16722–16729

    PubMed  CAS  Google Scholar 

  • Miles LA, Dahlberg CM, Levin EG, Plow EF (1989a) Gangliosides interact directly with plasminogen and urokinase and may mediate binding of these fibrinolytic components to cells. Biochemistry 28:9337–9343

    PubMed  CAS  Google Scholar 

  • Miles LA, Dahlberg CM, Plescia J, Felez J, Kate K, Plow EF (1991) Role of cell-surface lysines in plasminogen binding to cells: identification of alpha-enolase as a candidate plasminogen receptor. Biochemistry 30:1682–1691

    PubMed  CAS  Google Scholar 

  • Miles LA, Dahlberg CM, Plow EF (1988a) The cell-binding domains of plasminogen and their function in plasma. J Biol Chem 263:11928–11934

    PubMed  CAS  Google Scholar 

  • Miles LA, Fless GM, Levin EG, Scanu AM, Plow EF (1989b) A potential basis for the thrombotic risks associated with lipoprotein(a). Nature 339:301–303

    PubMed  CAS  Google Scholar 

  • Miles LA, Fless GM, Scanu AM, Baynham P, Sebald MT, Skocir P, Curtiss LK, Levin EG, Hoover-Plow JL, Plow EF (1995a) Interaction of Lp(a) with plasminogen binding sites on cells. Thromb Haemost 73:458–465

    PubMed  CAS  Google Scholar 

  • Miles LA, Ginsberg MH, White JG, Plow EF (1986) Plasminogen interacts with human platelets through two distinct mechanisms. J Clin Invest 77:2001–2009

    PubMed  CAS  Google Scholar 

  • Miles LA, Levin EG, Plescia J, Collen D, Plow EF (1988b) Plasminogen receptors, urokinase receptors, and their modulation on human endothelial cells, Blood 72:628–635

    PubMed  CAS  Google Scholar 

  • Miles LA, Plow EF (1985) Binding and activation of plasminogen on the platelet surface. J Biol Chem 260:4303–4311

    PubMed  CAS  Google Scholar 

  • Miles LA, Plow EF (1987) Receptor mediated binding of the fibrinolytic components, plasminogen and urokinase, to peripheral blood cells. Thromb Haemost 58:936–942

    PubMed  CAS  Google Scholar 

  • Miles LA, Plow EF (1990) Lp(a): an interloper into the fibrinolytic system? Thromb Haemost 63:331–335

    PubMed  CAS  Google Scholar 

  • Moestrup SK, Nielsen S, Andreasen P, Jorgensen KE, Nykjaer A, Rolgaard H, Gliemann J, Christensen EJ (1993) Epithelial glycoprotein-330 mediates endocytosis of plasminogen activator-plasminogen activator inhibitor type-1 complexes. J Biol Chem 268:16564–16570

    PubMed  CAS  Google Scholar 

  • Møller LB, Ploug M, Blasi F (1992) Structural requirements for glycosylphosphatidylinositol anchor attachment in the cellular receptor for urokinase plasminogen activator. Eur J Biochem 208:493–500

    PubMed  Google Scholar 

  • Møller LB, Pöllänen J, Rønne E, Pedersen N, Blasi F (1993) N-linked glycosylation of the ligand-binding domain of the human urokinase receptor contributes to the affinity for its ligand. J Biol Chem 268:11152–11159

    PubMed  Google Scholar 

  • Morimoto K, Mishima H, Nishida T, Otori T (1993) Role of urokinase type plasminogen activator (u-PA) in corneal epithelial migration. Thromb Haemost 69:387–391

    PubMed  CAS  Google Scholar 

  • Nakajima K, Nagata K, Hamanoue M, Takemoto N, Shimada A, Kohsaka S (1993) Plasminogen-binding protein associated with the plasma membrane of cultured embryonic rat neocortical neurons. FEBS Lett 333:223–228

    PubMed  CAS  Google Scholar 

  • Nakajima K, Nagata K, Kohsaka S (1994) Plasminogen mediates an interaction between microglia and dopaminergic neurons. Eur Neurol 34 [Suppl 3]:10–16

    PubMed  Google Scholar 

  • Needham GK, Nicholson S, Angus B, Farndon JR, Harris AL (1988) Relationship of membrane-bound-tissue type and urokinase type plasminogen activators in human breast cancers to estrogen and epidermal growth factor receptors. Cancer Res 48:6603–6607

    PubMed  CAS  Google Scholar 

  • Nguyen DH, Hussaini IM, Gonias SL (1998) Binding of urokinase-type plasminogen activator to its receptor in MCF-7 cells activates extracellular signal-regulated kinase 1 and 2 which is required for increased cellular motility. J Biol Chem 273:8502–8507

    PubMed  CAS  Google Scholar 

  • Niedbala MJ, Picarella MS (1992) Tumor necrosis factor induction of endothelial cell urokinase-type plasminogen activator mediated proteolysis of extracellular matrix and its antagonism by gamma-interferon. Blood 79:678–687

    PubMed  CAS  Google Scholar 

  • Niedbala MJ, Sartorelli AC (1990) Plasminogen activator mediated degradation of subendothelial extracellular matrix by human squamous carcinoma cell lines. Cancer Communications 2:189–199

    PubMed  CAS  Google Scholar 

  • Nielsen LS, Kellerman GM, Behrendt N, Picone R, Danø K, Blasi F (1988) A 55 000–60 000 Mr receptor protein for urokinase-type plasminogen activator. Identification in human tumor cell lines and partial purification. J Biol Chem 263:2358–2363

    PubMed  CAS  Google Scholar 

  • Nusrat AR, Chapman HA (1991) An autocrine role for urokinase in phorbol estermediate differentiation of myeloid cell lines. J Clin Invest 87:1091–1097

    PubMed  CAS  Google Scholar 

  • Nykjaer A, Conese M, Christensen EI, Olson D, Cremona O, Gliemann J, Blasi F (1997) Recycling of the urokinase receptor upon internalization of the uPA:serpin complexes. EMBO J 16:2610–2620

    PubMed  CAS  Google Scholar 

  • Nykjaer A, Møller B, Todd RF, III, Christensen T, Andreasen PA, Gliemann J, Petersen CM (1994) Urokinase receptor: an activation antigen in human T lymphocytes. J Immunol 152:505–516

    PubMed  CAS  Google Scholar 

  • Odekon LE, Sato Y, Rifkin DB (1992) Urokinase-type plasminogen activator mediates basic fibroblast growth factor-induced bovine endothelial cell migration independent of its proteolytic activity. J Cell Physiol 150:258–263

    PubMed  CAS  Google Scholar 

  • Ossowski L, Clunie G, Masucci M-T, Blasi F (1991a) In vivo paracrine interaction between urokinase and its receptor: effect on tumor cell invasion. J Cell Biol 115:1107–1112

    PubMed  CAS  Google Scholar 

  • Ossowski L, Russo-Payne H, Wilson EL (1991b) Inhibition of urokinase-type plasminogen activator by antibodies: The effect on dissemination of a human tumor in the nude mouse. Cancer Res 51:274–281

    PubMed  CAS  Google Scholar 

  • Palfree RGE (1991) The urokinase-type plasminogen activator receptor is a member of the Ly-6 superfamily. Immunol Today 12:170–171

    PubMed  CAS  Google Scholar 

  • Pancholi V, Fischetti VA (1998) α-enolase, a novel strong plasmin(ogen) binding protein on the surface of pathogenic streptococci. J Biol Chem 273:14503–14515

    PubMed  CAS  Google Scholar 

  • Parkkinen J, Raulo E, Merenmies J, Nolo R, Kajander EO, Baumann M, Rauvala H (1993) Amphoterin, the 30-kDa protein in a family of HMGl-type polypeptides. Enhanced expression in transformed cells, leading edge localization, and interactions with plasminogen activation. J Biol Chem 268:19726–19738

    PubMed  CAS  Google Scholar 

  • Parkkinen J, Rauvala H (1991) Interactions of plasminogen and tissue plasminogen activated (t-PA) with amphoterin. Enhancement of t-PA-catalyzed plasminogen activation by amphoterin. J Biol Chem 266:16730–16735

    PubMed  CAS  Google Scholar 

  • Pepper MS, Sappino A-P, Stöcklin R, Montesano R, Orci L, Vassalli J-D (1993) Upregulation of urokinase receptor expression on migrating endothelial cells. J Cell Biol 122:673–684

    PubMed  CAS  Google Scholar 

  • Picone R, Kajitaniak EL, Nielsen LS, Behrendt N, Mastronicola MR, Cubellis MV, Stoppelli MP, Pedersen S, Danø K, Blasi F (1989) Regulation of urokinase receptors in monocyte-like U937 cells by phorbol ester phorbol myristate acetate. J Cell Biol 108:693–702

    PubMed  CAS  Google Scholar 

  • Pittman RN, Ivins JK, Buettner HM (1989) Neuronal plasminogen activators: Cell surface binding sites and involvement in neurite outgrowth. J Neurosci 9:4269–4286

    PubMed  CAS  Google Scholar 

  • Plesner T, Behrendt N, Ploug M (1997) Structure, function and expression on blood and bone marrow cells of the urokinase-type plasminogen activator receptor, uPAR. Stem Cells 15:398–408

    PubMed  CAS  Google Scholar 

  • Ploplis VA, Carmeliet P, Vazirzadeh S, Van Vlaenderen I, Moons L, Plow EF, Collen D (1995) Effects of disruption of the plasminogen gene in mice on thrombosis, growth and health. Circulation 92:2585–2593

    PubMed  CAS  Google Scholar 

  • Ploplis VA, French EL, Carmeliet P, Collen D, Plow EF (1998) Plasminogen deficiency differentially affects recruitment of inflammatory cell populations in mice. Blood 91:2005–2009

    PubMed  CAS  Google Scholar 

  • Ploug M, Ellis V (1994) Structure-function relationships in the receptor for urokinasetype plasminogen activator. Comparison to other members of the Ly-6 family and snake venom α-neurotoxins. FEBS Lett 349:163–168

    PubMed  CAS  Google Scholar 

  • Ploug M, Ellis V, Danø K (1994) Ligand interaction between urokinase-type plasminogen activator and its receptor probed with 8-anilino-1-naphthalenesulfonate. Evidence for a hydrophobic binding site exposed only on the intact receptor. Biochemistry 33:8991–8997

    PubMed  CAS  Google Scholar 

  • Ploug M, Kjalke M, Rønne E, Weidle U, Høyer-Hansen G, Danø K (1993) Localization of the disulfide bonds in the NH2-terminal domain of the cellular receptor for human urokinase-type plasminogen activator. A domain structure belonging to a novel superfamily of glycolipid-anchored membrane proteins. J Biol Chem 268:17539–17546

    PubMed  CAS  Google Scholar 

  • Ploug M, Ostergaard S, Hansen LB, Holm A, Danø K (1998) Photoaffinity labeling of the human receptor for urokinase-type plasminogen activator using a decapeptide antagonist. Evidence for a composite ligand-binding site and a short interdomain separation. Biochemistry 37:3612–3622

    PubMed  CAS  Google Scholar 

  • Ploug M, Plesner T, Rønne E, Ellis V, Høyer-Hansen G, Hansen NE, Danø K (1992) The receptor for urokinase-type plasminogen activator is deficient on peripheral blood leukocytes in patients with paroxysmal nocturnal hemoglobinuria. Blood 79:1447–1455

    PubMed  CAS  Google Scholar 

  • Ploug M, Rahbek-Nielsen H, Nielsen PF, Roepstorff P, Dan0ø K (1998) Glycosylation profile of a recombinant urokinase-type plasminogen activator receptor expressed in Chinese hamster ovary cells. J Biol Chem 273:13933–13943

    PubMed  CAS  Google Scholar 

  • Ploug M, Rønne E, Behrendt N, Jensen AL, Blasi F, Danø K (1991) Cellular receptor for urokinase plasminogen activator. Carboxyl-terminal processing and membrane anchoring by glycosyl-phosphatidylinositol, J Biol Chem 266:1926–1933

    PubMed  CAS  Google Scholar 

  • Plow EF, Freaney DE, Plescia J, Miles LA (1986) The plasminogen system and cell surfaces: Evidence for plasminogen and urokinase receptors on the same cell type. J Cell Biol 103:2411–2420

    PubMed  CAS  Google Scholar 

  • Plow EF, Herren T, Redlitz A, Miles LA, Hoover-Plow JL (1995) The cell biology of the plasminogen system. FASEB J 9:939–945

    PubMed  CAS  Google Scholar 

  • Pöllänen J (1989) Down-regulation of plasmin receptors on human sarcoma cells by glucocorticoids. J Biol Chem 264:5628–5632

    PubMed  Google Scholar 

  • Quax P, Frisdal E, Pedersen N, Bonavaud S, Thibert P, Martelly I, Verheijen JH, Blasi F (1992) Modulation of activities and RNA level of the components of the plasminogen activation system during fusion of human myogenic satellite cells in vitro. Dev Biol 151:166–175

    PubMed  CAS  Google Scholar 

  • Quax PHA, Grimbergen JM, Lansink M, Bakker AHF, Blatter MC, Belin D, Van Hinsbergh VWM, Verheijen JH (1998) Binding of human urokinase-type plasminogen activator to its receptor: residues involved in species specificity and binding. Arterioscler Thromb Biol 18:693–701

    CAS  Google Scholar 

  • Rabbani SA, Mazar AP, Bernier SM, Haq M, Bolivar I, Henkin J, Goltzman D (1992) Structural requirements for the growth factor activity of the amino-terminal domain of urokinase. J Biol Chem 267:14151–14156

    PubMed  CAS  Google Scholar 

  • Rabbani SA, Gladu J, Mazar AP, Henkin J, Goltzman D (1997) Induction in human osteoblastic cells (SaOS2) of the early response genes fos, jun, and myc by the amino terminal fragment (ATF) of urokinase. J Cell Physiol 172:137–145

    PubMed  CAS  Google Scholar 

  • Rabbani SA, Rajwans N, Achbarou A, Murthy KK, Goltzman D (1994) Isolation and characterization of multiple isoforms of the rat urokinase receptor in osteoblasts. FEBS Lett 338:69–74

    PubMed  CAS  Google Scholar 

  • Ranson M, Andronicos NM, O’Mullane MJ, Baker MS (1998) Increased plasminogen binding is associated with metastatic breast cancer cells: differential expression of plasminogen binding proteins. Br J Cancer 77:1586–1597

    PubMed  CAS  Google Scholar 

  • Redlitz A, Fowler BJ, Plow EF, Miles LA (1994) The role of an enolase-related molecule in plasminogen binding to cells. Eur J Biochem 227:407–415

    Google Scholar 

  • Redlitz A, Nicolini FA, Malycky JL, Topol EJ, Plow EF (1996) Inducible carboxypeptidase activity. A role in clot lysis in vivo. Circulation 93:1328–1330

    PubMed  CAS  Google Scholar 

  • Redlitz A, Plow EF (1995) Receptors for plasminogen and t-PA: an update. Baillieres Clin Haematol 8:313–327

    PubMed  CAS  Google Scholar 

  • Redlitz A, Tan AK, Eaton DL, Plow EF (1995) Plasma carboxypeptidases as regulators of the plasminogen system. J Clin Invest 96:2534–2538

    PubMed  CAS  Google Scholar 

  • Reich R, Miskin R, Tsafriri A (1985) Follicular plasminogen activator: involvement in ovulation. Endocrinology 116:516–521

    PubMed  CAS  Google Scholar 

  • Reuning U, Bang NU (1992) Regulation of the urokinase-type plasminogen activator receptor on vascular smooth muscle cells is under the control of thrombin and other mitogens. Arterioscler Thromb 12:1161–1170

    PubMed  CAS  Google Scholar 

  • Ringdahl U, Svensson M, Wistedt AC, Renné T, Kellner R, Müller-Esterl W, Sjöbring U (1998) Molecular co-operation between protein PAM and streptokinase for plasmin acquisition by Streptococcus pyogenes. J Biol Chem 273:6424–6430

    PubMed  CAS  Google Scholar 

  • Roldan AL, Cubellis MV, Masucci M-T, Behrendt N, Lund LR, Danø K, Appella E, Blasi F (1990) Cloning and expression of the receptor for human urokinase plasminogen activator, a central molecule in cell surface, plasmin dependent proteolysis. EMBO J 9:467–474

    PubMed  CAS  Google Scholar 

  • Rønne E, Behrendt N, Ellis V, Ploug M, Danø K, Høyer-Hansen G (1991) Cell-induced potentiation of the plasminogen activation system is abolished by a monoclonal antibody that recognizes the NH2-terminal domain of the urokinase receptor. FEBS Lett 288:233–236

    PubMed  Google Scholar 

  • Ryan TJ, Lai L, Malik AB (1992) Plasmin generation induces neutrophil aggregation: Dependence on the catalytic and lysine binding sites. J Cell Physiol 151:255–261

    PubMed  CAS  Google Scholar 

  • Sakata Y, Okada M, Noro A, Matsuda M (1988) Interaction of tissue-type plasminogen activator and plasminogen activator inhibitor 1 on the surface of endothelial cells. J Biol Chem 263:1960–1969

    PubMed  CAS  Google Scholar 

  • Sakharov DV, Plow EF, Rijken DC (1997) On the mechanism of the antifibrinolytic activity of plasma carboxypeptidase B. J Biol Chem 272:14477–14482

    PubMed  CAS  Google Scholar 

  • Saksela O, Rifkin DB (1988) Cell-associated plasminogen activation: Regulation and physiological functions. Annu Rev Cell Biol 4:93–126

    PubMed  CAS  Google Scholar 

  • Sanzo MA, Howard SC, Wittwer AJ, Cochrane HM (1990) Binding of tissue plasminogen activator to human aortic endothelial cells. Biochem J 269:475–482

    PubMed  CAS  Google Scholar 

  • Sappino A-P, Huarte J, Belin D, Vassalli J-D (1989) Plasminogen activators in tissue remodeling and invasion: mRNA localization in mouse ovaries and implanting embryos. J Cell Biol 109:2471–2479

    PubMed  CAS  Google Scholar 

  • Schlechte W, Murano G, Boyd D (1989) Examination of the role of the urokinase receptor in human colon cancer mediated laminin degradation. Cancer Res 49:6064–6069

    PubMed  CAS  Google Scholar 

  • Schleef RR, Podor TJ, Dunne E, Mimuro J, Loskutoff DJ (1990) The majority of type 1 plasminogen activator inhibitor associated with cultured human endothelial cells is located under the cells and is accessible to solution-phase tissue-type plasminogen activator. J Cell Biol 110:155–163

    PubMed  CAS  Google Scholar 

  • Schwartz-Albiez R, Heidtmann H-H, Wolf D, Schirrmacher V, Moldenhauer G (1992) Three types of human lung tumour cell lines can be distinguished according to surface expression of endogenous urokinase and their capacity to bind exogenous urokinase. Br J Cancer 65:51–57

    PubMed  CAS  Google Scholar 

  • Shapiro RL, Duquette JG, Nunes I, Roses DF, Harris MN, Wilson EL, Rifkin DB (1997) Urokinase-type plasminogen activator-deficient mice are predisposed to staphylococcal botryomycosis, pleuritis, and effacement of lymphoid follicles. Am J Pathol 150:359–369

    PubMed  CAS  Google Scholar 

  • Shea TB, Beermann ML (1992) Regulation of neuronal migration and neuritogenesis by distinct surface proteases. Relative contribution of plasmin and a thrombin-like protease. FEBS Lett 307:190–194

    PubMed  CAS  Google Scholar 

  • Sillaber C, Baghestanian M, Hofbauer R, Virgolini I, Bankl HC, Fureder W, Agis H, Willheim M, Leimer M, Scheiner O, Binder BR, Kiener HP, Bevec D, Fritsch G, Majdic O, Kress HG, Gadner H, Lechner K, Valent P (1997) Molecular and functional characterization of the urokinase receptor on human mast cells. J Biol Chem 272:7824–7832

    PubMed  CAS  Google Scholar 

  • Silverstein RL, Friedlander RJ, Jr, Nicholas RL, Nachman RL (1988) Binding of lysplasminogen to monocytes/macrophages. J Clin Invest 82:1948–1955

    PubMed  CAS  Google Scholar 

  • Skidgel RA (1988) Basic carboxypeptidases: regulators of peptide hormone activity. Trends Pharmacol Sci 9:299–304

    PubMed  CAS  Google Scholar 

  • Skidgel RA (1995) Human carboxypeptidase N (lysine carboxypeptidase). Methods Enzymol 248:653–663

    PubMed  CAS  Google Scholar 

  • Soravia E, Grebe A, De Luca P, Helin K, Suh TT, Degan JL, Blasi F (1995) A conserved TATA-less proximal promoter drives basal transcription from the urokinase-type plasminogen activator receptor gene. Blood 86:624–635

    PubMed  CAS  Google Scholar 

  • Stahl A, Mueller BM (1994) Binding of urokinase to its receptor promotes migration and invasion of human melanoma cells in vitro. Cancer Res 54:3066–3071

    PubMed  CAS  Google Scholar 

  • Stefanovà I, Horejsi V, Ansotegui IJ, Knapp W, Stockinger H (1991) GPI-anchored cell-surface molecules complexed to protein tyrosine kinases. Science 254:1016–1019

    PubMed  Google Scholar 

  • Stephens RW, Pöllänen J, Tapiovaara H, Leung K-C, Sim P-S, Salonen E-M, Rønne E, Behrendt N, Danø K, Vaheri A (1989) Activation of pro-urokinase and plasminogen on human sarcoma cells: A proteolytic system with surface-bound reactants. J Cell Biol 108:1987–1995

    PubMed  CAS  Google Scholar 

  • Stopelli MP, Corti A, Soffientini A, Cassani G, Blasi F, Assolan RK (1985) Differentiation-enhanced binding of the amino-terminal fragment of human urokinase plasminogen activator to a specific receptor on U937 monocytes. Proc Natl Acad Sci USA 82:4939–4943

    Google Scholar 

  • Strieker RB, Wong D, Shiv DT, Reyes PT, Shuman MA (1986) Activation of plasminogen by tissue plasminogen activator on normal and thrombasthenic platelets: effects on surface proteins and platelet aggregation. Blood 68:275–280

    Google Scholar 

  • Strickland S, Reich E, Sherman MI (1976) Plasminogen activator in early embryogenesis: Enzyme production by trophoblast and parietal endoderm. Cell 9:231–240

    PubMed  CAS  Google Scholar 

  • Suh TT, Nerlov C, Danø K, Degen JL (1994) The murine urokinase-type plasminogen activator receptor gene. J Biol Chem 269:25992

    PubMed  CAS  Google Scholar 

  • Syrovets T, Tippler B, Rieks M, Simmet T (1997) Plasmin is a potent and specific chemoattractant for human peripheral monocytes acting via a cyclic guanosine monophosphate-dependent pathway. Blood 89:4574–4583

    PubMed  CAS  Google Scholar 

  • Taipale J, Koli K, Keski-Oja J (1992) Release of transforming growth factor-beta 1 from the pericellular matrix of cultured fibroblasts and fibrosarcoma cells by plasmin and thrombin. J Biol Chem 267:25378–25384

    PubMed  CAS  Google Scholar 

  • Takahashi K, Ikeo K, Gojobori T, Tanifuji M (1990) Local function of urokinase receptor at the adhesion contact sites of a metastatic tumor cell, Thromb Res 57 [Suppl 10]:55–61

    Google Scholar 

  • Todd RF III, Alvarez PA, Brott DA, Liu DY (1985) Bacterial lipopolysaccaride, phorbol myristate acetate and muramyl dipeptide stimulate the expression of a human monocyte surface antigen MoЗe. J Immunol 135:3869–3877

    PubMed  CAS  Google Scholar 

  • Vassalli J-D, Baccino D, Belin D (1985) A cellular binding site for the Mr 55,000 form of the human plasminogen activator, urokinase. J Cell Biol 100:86–92

    PubMed  CAS  Google Scholar 

  • Vaughan DE, Mendelsohn ME, Declerck PJ, Van Houtte E, Collen D, Loscalzo J (1989) Characterization of the binding of human tissue-type plasminogen activator to platelets. J Biol Chem 264:15869–15874

    PubMed  CAS  Google Scholar 

  • Verrall S, Seeds NW (1989) Characterization of 125I-tissue plasminogen activator binding to cerebellar granule neurons. J Cell Biol 109:265–271

    PubMed  CAS  Google Scholar 

  • Waltz DA, Chapman HA (1994) Reversible cellular adhesion to vitronectin linked to urokinase receptor occupancy. J Biol Chem 269:14746–14750

    PubMed  CAS  Google Scholar 

  • Waltz DA, Natkin LR, Fujita RM, Wei Y, Chapman HA (1997) Plasmin and plasminogen activator inhibitor type 1 promote cellular motility by regulating the interaction between the urokinase receptor and vitronectin. J Clin Invest 100:58–67

    PubMed  CAS  Google Scholar 

  • Wang W, Hendriks DF, Scharpé SS (1994) Carboxypeptidase U, a plasma carboxypeptidase with high affinity for plasminogen, J Biol Chem 269:15937–15944

    PubMed  CAS  Google Scholar 

  • Wang Y, Jones CJ, Dang J, Liang X, Olsen JE, Doe WF (1994) Human urokinase receptor expression is inhibited by amiloride and induced by tumor necrosis factor and phorbol ester in colon cancer cells. FEBS Lett 353:138–142

    PubMed  CAS  Google Scholar 

  • Wang YF, Tsirka SE, Strickland S, Stieg PE, Soriano SG, Lipton SA (1998) Tissue plasminogen activator (tPA) increases neuronal damage after focal cerebral ischemia in wild-type and tPA-deficient mice. Nat Med 4:228–231

    PubMed  CAS  Google Scholar 

  • Wei Y, Lukashev M, Simon DI, Bodary SC, Rosenberg S, Doyle MV, Chapman HA (1996) Regulation of integrin function by the urokinase receptor. Science 273:1551–1555

    PubMed  CAS  Google Scholar 

  • Wei Y, Waltz DA, Rao N, Drummond RJ, Rosenberg S, Chapman HA (1994) Identification of the urokinase receptor as an adhesion receptor for vitronectin. J Biol Chem 269:32380–32388

    PubMed  CAS  Google Scholar 

  • Wohn KD, Kanse SM, Deutsch V, Schmidt T, Eldor A, Preissner KT (1997) The urokinase-receptor (CD87) is expressed in cells of the megakaryoblastic lineage. Thromb Haemost 77:540–547

    PubMed  CAS  Google Scholar 

  • Wong AP, Cortez SL, Baricos WH (1992) Role of plasmin and gelatinase in extracellular matrix degradation by cultured rat mesangial cells. Am J Physiol 263:F1112–F1118

    PubMed  CAS  Google Scholar 

  • Xue W, Kindzelskii A, Todd R III, Petty H (1994) Physical association of complement receptor type З and urokinase-type plasminogen activator receptor in neutrophil membranes. J Immunol 152:4630–4640

    PubMed  CAS  Google Scholar 

Download references

Authors
  1. E. F. Plow
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. Redlitz
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S. B. Hawley
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. S. Xue
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. T. Herren
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. J. L. Hoover-Plow
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. L. A. Miles
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. FRAT — Hôpital Nestlé 2077, CHUV, CH-1011, Lausanne, Switzerland

    F. Bachmann

  2. Chemin Praz Mandry 20, CH-1052, Le Mont, Switzerland

    F. Bachmann

Rights and permissions

Reprints and permissions

Copyright information

© 2001 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Plow, E.F. et al. (2001). Assembly of the Plasminogen System on Cell Surfaces. In: Bachmann, F. (eds) Fibrinolytics and Antifibrinolytics. Handbook of Experimental Pharmacology, vol 146. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56637-0_6

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-56637-0_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-63029-3

  • Online ISBN: 978-3-642-56637-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation