Abstract
Epstein-Barr virus (EBV) is the first virus that was identified in a human neoplastic cell in 1963 Epstein 1994). More than 90% of the world population is infected with EBV before adolescence, and it is thought that a small population develops EBV-associated malignancy in an endemic manner, such as Burkitt’s lymphoma in equatorial Africa Osato 1998) and nasopharyngeal carcinoma (NPC) in Southern China Raab-Traub 1992). However, recent advances in molecular biological techniques have demonstrated that an unexpectedly wide variety of neoplasms in the general population is associated with EBV infection (Anagnostopoulos and Hummel 1996), among which EBV-associated gastric carcinoma (EBVaGC) is the most common with a worldwide distribution. In Japan, for example, more than 5,000 patients are estimated to develop gastric carcinoma annually in association with EBV (less than 10% of total gastric cancer) (Fukayama et al. 1998).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Anagnostopoulos I, Hummel M (1996) Epstein-Barr virus in tumours. Histopathology 29:297–315
Arikawa J, Tokunaga M, Tashiro Y, Tanaka S, Sato E, Harabuchi K, Yamamoto A, Toyohira O, Tuchimochi A (1997a) Epstein-Barr virus-positive multiple early gastric cancers and dysplastic lesions: a case report. Pathol Int 47:730–734
Arikawa J, Tokunaga M, Satoh E, Tanaka S, Land CE (1997b) Morphological characteristics of Epstein-Barr virus-related early gastric carcinoma: a case control study. Pathol Int 47:360–367
Chong J, Fukayama M, Hayashi Y, Takizawa T, Koike M, Konishi M, Kikuchi-Yanoshita R, Miyaki M (1994) Microsatellite instability in the progression of gastric carcinoma. Cancer Res 54:4595–4597
Chong J, Fukayama M, Hayashi Y, Funata N, Takizawa T, Koike M, Muraoka M, Kikuchi-Yanoshita R, Miyaki M, Mizuno S (1997) Expression of CD44 variants in gastric carcinoma with or without Epstein-Barr virus. Int J Cancer 74:450–454
Dixon MF, Genta RM, Yardley JH, Correa P, and participants in the International Workshop on the Histopathology of Gastritis, Houston 1994 (1996) Classification and grading of gastritis. The updated Sydney System. Am J Surg Pathol 20:1161–1181
Epstein A (1994) Thirty years of Epstein-Barr virus. Epstein-Barr virus Report 1:3–4
Fukayama M, Hayashi Y, Iwasaki Y, Chong J, Ooba T, Takizawa T, Koike M, Miyaki M, Mizutani S, Hirai K (1994) Epstein-Barr virus-associated gastric carcinoma and Epstein-Barr virus infection of the stomach. Lab Invest 71:73–81
Fukayama M, Chong J, Kaizaki Y (1998) Epstein-Barr virus and gastric carcinoma. Gastric Cancer 1:104–114
Gulley ML, Raphael M, Lutz CT, Ross DW, Raab-Traub N (1992) Epstein-Barr virus integration in human lymphomas and lymphoid cell lines. Cancer 70:185–191
Gulley ML, Pulitzer DR, Eagan PA, Schneider BG (1996) Epstein-Barr virus infection is an early event in gastric carcinogenesis and is independent of bcl-2 expression and p53 accumulation. Hum Pathol 27:20–27
Gutierrez MI, Judde J, Magrath IT, Bhatia KG (1996) Switching viral latency to viral lysis: a novel therapeutic approach for Epstein-Barr virus-associated neoplasia. Cancer Res 56:969–972
Imai S, Koizumi S, Sugiura M, Tokunaga M, Uemura Y, Yamamoto N, Tanaka S, Sato E, Osato T (1994) Gastric carcinoma: monoclonal epithelial malignant cells expressing Epstein-Barr virus latent infection protein. Proc Natl Acad Sci USA 91:9131–9135
Imai S, Nishikawa J, Takada K (1998) Cell-to-cell contact as an efficient mode of Epstein-Barr virus infection of diverse human epithelial cells. J Virol 72:4371–4378
Iwasaki Y, Chong J, Hayashi Y, Ikeno R, Arai K, Kitamura M, Koike M, Hirai K, Fukayama M (1998) Establishment and characterization of a human Epstein-Barr-associated gastric carcinoma in SCID mice. J Virol 72:8321–8326
Japanese Research Society for Gastric Cancer (1995) Japanese classification of gastric carcinoma. Kanahara, Tokyo
Jing X, Nakamura Y, Nakamura M, Yokoi T, Shan L, Taniguchi E, Kakudo K (1997) Detection of Epstein-Barr virus DNA in gastric carcinoma with lymphoid stroma. Viral Immunol 10:49–58
Kaizaki Y, Sakurai S, Chong J, Fukayama M (1999) Atrophic gastritis, Epstein-Barr virus-associated gastric carcinoma. Gastric Cancer 2:101–108
Kuzushima K, Nakamura S, Nakamura T, Yamamura Y, Yokoyama N, Fujita M, Kiyono T, Tsurumi T (1999) Increased frequency of antigen-specific CD8 + cytotoxic T lymphocytes infiltrating an Epstein-Barr virus-associated gastric carcinoma. J Clin Invest 104:163–171
Lauren P (1965) The two histological main types of gastric carcinoma: diffuse and so-called intestinal type carcinoma. Acta Pathol Microbiol Scand (A) 64:31–49
Matsunou H, Konishi F, Hori H, Ikeda T, Sasaki K, Hirose Y, Yamamichi N (1996) Characteristics of Epstein-Barr virus-associated gastric carcinoma with lymphoid stroma in Japan. Cancer 77: 1998–2004
Ohfuji S, Osaki M, Tsujitani S, Ikeguchi M, Sairenji T, Ito H (1996) Low frequency of apoptosis in Epstein-Barr virus-associated gastric carcinoma with lymphoid stroma. Int J Cancer 68:710–715
Nishikawa J, Imai S, Oda T, Kojima T, Okita K, Takada K (1999) Epstein-Barr virus promote epithelial cell growth in the absence of EBNA2 and LMP1 expression. J Virol 73:1286–1292
Osato T (1998) Epstein-Barr virus infection and oncogenesis. In: Osato T, Takada K, Tokunaga M (eds) Epstein-Barr virus and human cancer. Japan Scientific Societies Press, Tokyo, pp 3–16
Raab-Traub N, Flynn K (1986) The structure of the termini of the Epstein-Barr virus as a marker of clonal cellular proliferation. Cell 47:833–839
Raab-Traub N (1992) Epstein-Barr virus and nasopharyngeal carcinoma. Cancer Biol 3:297–307
Sugiura M, Imai S, Tokunaga M, Koizumi S, Uchizawa M, Okamoto K, Osato T (1996) Transcriptional analysis of Epstein-Barr virus gene expression in EBV-positive gastric carcinoma: unique viral latency in the tumor cells. Br J Cancer 74:625–631
Takano Y, Kato Y, Saegusa M, Mori S, Shiota M, Masuda M, Mikami T, Okayasu I (1999) The role of Epstein-Barr virus in the oncogenesis of EBV ( + ) gastric carcinoma. Virchows Arch 434:17–22
Tokunaga M, Land CE, Uemura Y, Tokudome T, Tanaka S, Sato E (1993) Epstein-Barr virus in gastric carcinoma. Am J Pathol 143:1250–1254
Yanai H, Takada K, Shimizu N, Mizugaki Y, Tada M, Okita K (1997) Epstein-Barr virus infection in non-carcinomatous gastric epithelium. J Pathol 183:293–298
Yoshiyama H, Imai S, Shimizu N, Takada K (1997) Epstein-Barr virus infection of human gastric carcinoma cells: implication of the existence of a new virus receptor different from CD21. J Virol 71:5688–5691
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2001 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Fukayama, M., Chong, JM., Uozaki, H. (2001). Pathology and Molecular Pathology of Epstein-Barr Virus-Associated Gastric Carcinoma. In: Takada, K. (eds) Epstein-Barr Virus and Human Cancer. Current Topics in Microbiology and Immunology, vol 258. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56515-1_6
Download citation
DOI: https://doi.org/10.1007/978-3-642-56515-1_6
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-62568-8
Online ISBN: 978-3-642-56515-1
eBook Packages: Springer Book Archive