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Epstein-Barr Virus Infection of Human Epithelial Cells

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Book cover Epstein-Barr Virus and Human Cancer

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 258))

Abstract

Much attention has been given to the close association of Epstein-Barr virus (EBV) with human epithelial cancers following the first detection of the virus in nasopharyngeal carcinoma (NPC) tissues (zur Hausen et al. 1970). Related examinations confirmed the regular presence of the viral genome in poorly differentiated and undiíferentiated subtypes of NPC, irrespective of its local and ethnic incidence rate, thereby suggesting a strong etiological link of EBV to the tumor (reviewed in Klein 1979). Additionally, oral hairy leukoplakia (OHL) in AIDS patients and lymphoepithelioma-like carcinoma histologically resembling EBV-positive NPC at sites other than nasopharynx, such as the lung or salivary gland, have also been categorized as EBV-associated human epithelial proliferative lesions (for review, see Rickinson and Kieff 1996). The first report by Burke et al. (1990) suggesting that EBV infection was a pathogenetic factor in primary gastric carcinoma of the lymphoepithelioma type evoked further studies on this subject (Min et al. 1991; Shibata et al. 1991; Niedobitek et al. 1992). The subsequent accumulation of evidence has emphasized a novel etiological link of EBV to gastric carcinoma, including a common type of the tumors (Shibata and Weiss 1992; Tokunaga et al. 1993; Fukayama et al. 1994; Imai et al. 1994; Ott et al. 1994; Uemura et al. 1994). Based on a number of worldwide epidemiological surveys, it was estimated that gastric carcinoma is the most frequent of the EBV-associated human malignancies (for reviews, see Osato and Imai 1996; Levin and Levine 1998)

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Authors and Affiliations

  1. Department of Microbiology, Kochi Medical School, Kohasu, Okoh-cho, Nankoku, Kochi, 783-8505, Japan

    S. Imai & M. Kuroda

  2. First Department of Internal Medicine, Yamaguchi University School of Medicine, 1144 Kogushi, Ube, Yamaguchi, 755-8505, Japan

    J. Nishikawa

  3. Department of Tumor Virology, Institute for Genetic Medicine, Hokkaido University, N15 W7, Kita-ku, Sapporo, 060-8638, Japan

    K. Takada

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  1. S. Imai
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  2. J. Nishikawa
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  3. M. Kuroda
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  4. K. Takada
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  1. Institute for Genetic Medicine, Department of Tumor Virology, Hokkaido University, N15 W7, Kita-Ku, 060-8638, Sapporo, Japan

    Kenzo Takada

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Imai, S., Nishikawa, J., Kuroda, M., Takada, K. (2001). Epstein-Barr Virus Infection of Human Epithelial Cells. In: Takada, K. (eds) Epstein-Barr Virus and Human Cancer. Current Topics in Microbiology and Immunology, vol 258. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56515-1_11

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