Titanium in Cardiac and Cardiovascular Applications

  • Christian Olin
Part of the Engineering Materials book series (ENG.MAT.)


Due to its unique properties, titanium and its alloys have found many applications in cardiovascular medicine. One of the earliest applications was in prosthetic heart valves and in protective cases of pacemakers. Later, titanium was used in artificial hearts and circulatory assist devices. Recently, the use of shape memory titanium-nickel (Nitinol) alloy in intravascular devices such as stents and occlusion coils has received considerable attention. An advantage of titanium in cardiovascular applications is that it is strong, inert and non-magnetic. It will produce few artifacts when studied with magnetic resonance (MR), a diagnostic modality that is getting increasingly common. A disadvantage is that it is not sufficiently radio-opaque in finer structures.


Heart Valve Leave Ventricular Assist Device Prosthetic Heart Valve Mechanical Heart Valve Artificial Heart 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Davey TB, Smeloff EA (1977) Development of a cardiac valve substitute: the Smeloff-Cutter prosthesis. Med Instrum 11(2):95–97Google Scholar
  2. 2.
    Wada J, Komatsu S, Kamata K (1972) Cardiac valve replacement with Wada-Cutter prosthesis. Ann Thorac Surg 14(l):38–46CrossRefGoogle Scholar
  3. 3.
    Kaster RL, Tanaka S, Carlson RG, Lillehei CW (1970) Initial laboratory development and evaluation of the cageless free-floating pivoting-disc prosthetic heart valve. Adv Biomed Eng Med Phys 3:261–371Google Scholar
  4. 4.
    DeWall RA, Caffarena Raggio JM, Dittrich H, Guilmet D, Morea M, Thevenet A (1989) The Omni design: evolution of a valve. J Thorac Cardiovasc Surg (5 Pt 2):999–1006; discussion 1006–1007Google Scholar
  5. 5.
    Hall KV (1992) The Medtronic-Hall valve: a design in 1977 to improve the results of valve replacement. Eur J Cardiothorac Surg 6 Suppl l:S64–67CrossRefGoogle Scholar
  6. 6.
    Akins CW (1996) Medtronic-Hall prosthetic aortic valve. Semin Thorac Cardiovasc Surg 8(3):242–248Google Scholar
  7. 7.
    Arm P, Rinaldi S, Stacchino C, Vallana F (1996) Wear assessment in bileaflet heart valves. J Heart Valve Dis 5 Suppl l:S133–43; discussion 144–148Google Scholar
  8. 8.
    Carpentier A, Deloche A, Dauptain J, et al (1971) A new reconstructive operation for correction of mitral and tricuspid insufficiency. J Thorac Cardiovasc Surg 61:1Google Scholar
  9. 9.
    Covalesky VA, McAllister M, Chandrasekaran K, McCormick DJ, Mintz GS, Kutalek SP (1993) Visualization of implantable defibrillator patches by two-dimensional echocardiography. J Clin Ultrasound 21(5):313–316CrossRefGoogle Scholar
  10. 10.
    Schaldach M, Hubmann M, Weikl A, Hardt R (1990) Sputter-deposited TiN electrode coatings for superior sensing and pacing performance. Pacing Clin Electrophysiol 13(12 Pt 2): 1891–1895CrossRefGoogle Scholar
  11. 11.
    Rintoul TC, Butler KC, Thomas DC, Carriker JW, Maher TR, Kiraly RJ, Massiello A, Himley SC, Chen JF, Fukamachi K, et al (1993) Continuing development of the Cleveland Clinic-Nimbus total artificial heart. ASAIO J 39(3):M168–171CrossRefGoogle Scholar
  12. 12.
    Frazier OH (1994) First use of an untethered, vented electric left ventricular assist device for long-term support. Circulation 89(6):2908–2914CrossRefGoogle Scholar
  13. 13.
    Capek P, Kadipasaoglu KA, Radovancevic B, Furusho N, Clubb FJ Jr, Myers TJ, Duncan JM, McAllister HA Jr, Frazier OH (1992) Human intraperitoneal response to a left ventricular assist device with a Ti-6Al-4V alloy surface. ASAIO J 38(3):M543–549CrossRefGoogle Scholar
  14. 14.
    Yamazaki K, Kormos RL, Litwak P, Tagusari O, Mori T, Antaki JF, Kameneva M, Watach M, Gordon L, Mukuo H, Umezu M, Tomioka J, Outa E, Griffith BP, Koyanagai H (1997) Long-term animal experiments with an intraventricular axial flow blood pump. ASAIO J 43(5):M696–700CrossRefGoogle Scholar
  15. 15.
    Kaufman GM, Ash SR (1984) Intravenous transcutaneous vascular access device. Trans Am Soc Artif Intern Organs 30:458–462Google Scholar
  16. 16.
    Biffi R, de Braud F, Orsi F, Pozzi S, Mauri S, Goldhirsch A, Nole F, Andreoni B (1998) Totally implantable central venous access ports for long-term chemotherapy. A prospective study analyzing complications and costs of 333 devices with a minimum follow-up of 180 days. Ann Oncol 9(7):767–773CrossRefGoogle Scholar
  17. 17.
    Blackshear PJ, Rohde TD, Prosl F, Buchwald H (1979) The implantable infusion pump: a new concept in drug delivery. Med Prog Technol 30;6(4):149–161Google Scholar
  18. 18.
    Oku T, Sutton C, Kambic HE, Harasaki H, Nose Y (1988) A titanium-nickel alloy intravascular endoprosthesis. In vitro studies. ASAIO Trans 34(3):399–403Google Scholar
  19. 19.
    Rickers C, Hamm C, Stern H, Hofmann T, Franzen O, Schrader R, Sievert H, Schranz D, Michel-Behnke I, Vogt J, Kececioglu D, Sebening W, Eicken A, Meyer H, Matthies W, Kleber F, Hug J, Weil J (1998) Percutaneous closure of secundum atrial septal defect with a new self centering device (“angel wings”). Heart 80(5):517–521Google Scholar
  20. 20.
    Thanopoulos BD, Tsaousis GS, Konstadopoulou GN, Zarayelyan AG (1999) Transcatheter closure of muscular ventricular septal defects with the amplatzer ventricular septal defect occluder: initial clinical applications in children. J Am Coll Cardiol 33(5):1395–1399CrossRefGoogle Scholar
  21. 21.
    Lim MC, Tan HC, Choo MH (1994) The new titanium Greenfield vena cava filter: initial experience and review. Singapore Med J 35(6):622–625Google Scholar
  22. 22.
    Grabitz RG, Neuss MB, Coe JY, Handt S, Redel DA, von Bernuth G (1996) A small interventional device to occlude persistently patent ductus arteriosus in neonates: evaluation in piglets. J Am Coll Cardiol 28(4):1024–1030CrossRefGoogle Scholar
  23. 23.
    Leppaniemi A, Wherry D, Pikoulis E, Hufnagel H, Waasdorp C, Fishback N, Rich N (1997) Arterial and venous repair with vascular clips: comparison with suture closure. J Vasc Surg 26(l):24–28CrossRefGoogle Scholar
  24. 24.
    Pikoulis E, Burris D, Rhee P, Nishibe T, Leppaniemi A, Wherry D, Rich N (1988) Rapid arterial anastomosis with titanium clips. Am J Surg 175(6):494–496CrossRefGoogle Scholar
  25. 25.
    Nataf P, Hinchliffe P, Manzo S, Simpson J, Kirsch WM, Zhu YH, Anton T (1998) Facilitated vascular anastomoses: the one-shot device. Ann Thorac Surg 66(3):1041–1044CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2001

Authors and Affiliations

  • Christian Olin
    • 1
  1. 1.Cardiothoracic SurgeryLinköping Health UniversityLinköpingSweden

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