Wear of Titanium 6–4 Alloy in Laboratory Tests and in Retrieved Human Joint Replacements

  • Harry A. McKellop
  • Tord Rostlund
  • Edward Ebramzadeh
  • Augusto Sarmiento
Part of the Engineering Materials book series (ENG.MAT.)


During the period from 1975 to 1985, a variety of joint replacement prostheses were introduced clinically that included a bearing surface of titanium-6% alumi-num-4% vanadium alloy (Ti-6A1-4V) articulating against an acetabular component of ultra-high molecular weight (UHMW) polyethylene. Hip prostheses included the STH, the DF-80, the Six Ti-28 and the Six Ti-32 (Zimmer, Inc. Warsaw, IN), the Stanmore (Zimmer GB), the ES-30 (Biomet, Inc., Warsaw, IN) and the APR (Intermedics, Inc., Austin, TX). Titanium alloy knee prostheses included the Miller/Galante (Zimmer) and the Natural Knee (Intermedics). The suitability of this combination of bearing materials was initially questioned because, in some laboratory wear tests, titanium alloy underwent severe abrasive-corrosive wear, characterized by extensive scoring of the metal surface and the release of large amounts of finely divided metallic particles that blackened the opposing polymer and the lubricant [1-8].


Titanium Alloy Wear Rate Acetabular Component Cement Mantle PMMA Particle 
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  1. 1.
    Galante JO, Rostoker W (1973) Wear in Total Hip Prostheses. Acta Orthopaedica Scandinavica, Supplement No. 145, Munksgaard, CopenhagenGoogle Scholar
  2. 2.
    McKellop H, Clarke IC, Markolf KL, Amstutz HC (1979) Wear properties of new high strength alloys for prosthetic joints. Transactions of the 25th Annual Meeting, Orthopaedic Research Society, San Francisco, p 71Google Scholar
  3. 3.
    McKellop H, Kirkpatrick J, Markolf K, Amstutz H (1980) Abrasive wear of Ti-6AL-4V prostheses by acrylic cement particles. Transactions of the 26th Annual Meeting, Orthopaedic Research Society, Atlanta, Georgia, p 96Google Scholar
  4. 4.
    McKellop H, Clarke IC, Markolf KL, Amstutz HC (1981) Friction and wear properties of polymer, metal, and ceramic prosthetic joint materials evaluated on a multichannel screening device. J Biomed Mater Res 15:619–653CrossRefGoogle Scholar
  5. 5.
    Rostoker W, Galante JO (1976) Some new studies of the behavior of UHMWPE. J Biomed Mater Res 10:303–310CrossRefGoogle Scholar
  6. 6.
    Swanson SAV, Freeman MAR, Heath JC (1973) Laboratory tests on joint replacement pros-theses. J Bone Joint Surg 55B:759–773Google Scholar
  7. 7.
    Buchanan RA, Rigney ED Jr, Williams JM (1987) Ion implantation of surgical Ti6A14V for improved resistance to wear-accelerated corrosion. J Biomed Mater Res 21:355–366CrossRefGoogle Scholar
  8. 8.
    Buchanan RA, Rigney ED Jr, Williams JM (1987) Wear-accelerated corrosion of Ti-6Al-4V and nitrogen-ion-implanted Ti-6A14V: Mechanisms and influence of fixed-stress magnitude. J Biomed Mater Res 21:367–377CrossRefGoogle Scholar
  9. 9.
    Clarke IC, McKellop HA, McGuire P, Okuda R, Sarmiento A (1983) Wear of Ti-6A14V implant alloy and ultrahigh molecular weight polyethylene combinations. In: Luckey HA, Kubli F Jr (eds) Titanium Alloys in Surgical Implants, ASTM STP 796. ASTM, Philadelphia, pp 136–146Google Scholar
  10. 10.
    Agins HJ, Alcock NW, Bansal M, Salvati EA, Wilson PD, Pellicci PM, Bullough P (1988) Metallic wear in failed titanium-alloy total hip replacements. A histological and quantitative analysis. J Bone Joint Surg 70-A(3):347–356Google Scholar
  11. 11.
    Lombardi AN Jr, Mallory TH, Vaughn BK, Drouillard P (1989) Aseptic loosening in total hip arthroplasty secondary to osteolysis induced by wear debris from titanium-alloy modular femoral heads. J Bone Joint Surg 71-A(9):1337–1342Google Scholar
  12. 12.
    Black J, Sherk H, Bonini J, Rostoker WR, Schajowicz F, Galante JO (1990) Metallosis associated with a stable titanium-alloy femoral component in total hip replacement. J Bone Joint Surg 72-A(l):126–130Google Scholar
  13. 13.
    Salvati E, Huo M, Buly R (1991) Cemented total hip replacement: Long-term results and future outlook. In: Tullos HS (ed) Advances in Total Hip Reconstruction. AAOS Instructional Course Lectures, XL, American Academy of Orthopaedic Surgeons, pp 121–134Google Scholar
  14. 14.
    Clarke IC (1982) Wear- screening tests and joint simulation studies vs. materials selection and prosthesis design. In: Bourne JR (ed) Critical Reviews in Biomedical Engineering. CRC Press, Boca Raton 8(1):29–91Google Scholar
  15. 15.
    Wright KWJ (1982) Friction and wear of materials and joint replacement prostheses. In: Williams DF (ed) Biocompatibility of Orthopaedic Implants, Vol. 1. CRC Press, Boca Raton, Chap 5, pp 141–161Google Scholar
  16. 16.
    McKellop HA, Clarke IC (1984) Evolution and evaluation of materials-screening machines and joint simulators in predicting in vivo wear phenomena. In: Ducheyne P, Hastings G (eds) Functional Behavior of Orthopaedic Biomaterials, Vol. II. CRC Press, Boca Raton, pp 51–85Google Scholar
  17. 17.
    Dumbleton J (1981) Tribology of Natural and Artificial Joints, Vol. 3. Tribology Series, Elsevier, Amsterdam, Chap 1Google Scholar
  18. 18.
    Mittlmeier T, Walter A 1987 The influence of prosthesis design on wear and loosening phenomena. CRC Critical Reviews in Biocompatibility, CRC Press, Boca Raton3(4)319419Google Scholar
  19. 19.
    Davidson JA, Schwartz G 1987 Wear, creep, and frictional heat of femoral implant articulating surfaces and the effect on long-term performance - Part I, A review. J Biomed Mater Res, Appl Biomater 21(A3):261285Google Scholar
  20. 20.
    20.McKellop H, Clarke IC, Markolf KL, Amstutz HC 1978 Wear characteristics of UHMW polyethylene: A method for accurately measuring extremely low wear rates. J Biomed Mater Res12895927CrossRefGoogle Scholar
  21. 21.
    21.1999 ASTM F 73298 Standard practice for reciprocating pin-on-flat evaluation of friction and wear properties of polymeric materials for use in total joint prostheses. Annual Book of ASTM Standards, Vol. 13.01: Medical Devices; Emergency Medical Services, ASTM, Philadelphia , pp 192198Google Scholar
  22. 22.
    Walker PS, Gold BL (1973) Comparison of the bearing performance of normal and artificial human joints, Transaction ASME. Journal of Lubrication Technology, pp 334341Google Scholar
  23. 23.
    Linn FC (1967) Lubrication of animals joints - I: The arthrotripsometer. J Bone Joint Surg 49-A:10791098Google Scholar
  24. 24.
    McKellop HA, Clarke IC (1985) Degradation and wear of ultra-high-molecular-weight polyethylene. In: Fraker AC, Griffin CD (eds) Corrosion and Degradation of Implant Materials: Second Symposium. ASTM STP 859, ASTM, Philadelphia, pp 351368CrossRefGoogle Scholar
  25. 25.
    McKellop HA, Rostlund TV (1990) The wear behavior of ion-implanted Ti-6A14V against UHMW Polyethylene. J Biomed Mater Res 24:14131425CrossRefGoogle Scholar
  26. 26.
    Rostlund T, McKellop H, Albrektsson B, Albrektsson T (1989) Wear of ion-implanted pure titanium against UHMWPE, Biomaterials 10:176181CrossRefGoogle Scholar
  27. 27.
    Lausmaa J, Rostlund T. McKellop H (1990) A surface spectroscopic study of nitrogen ion-implanted Ti and Ti-6A14V wear against UHMWPE. Surf Interface Anal, 15:328336CrossRefGoogle Scholar
  28. 28.
    McKellop HA, Sarmiento A, Schwinn C, Ebramzadeh E (1990) In Vivo wear of titanium-alloy hip prostheses. J Bone Joint Surg 72A(4):512517Google Scholar
  29. 29.
    Mirra JM, Amstutz HC, Matos M, Gold R (1976) The pathology of the joint tissues and its clinical relevance in prosthesis failure. Clinical Orthopaedics and Related Research 117:221240Google Scholar
  30. 30.
    Betts F, Wright T, Salvati E, Boskey A, Bansal M (1992) Cobalt alloy metal debris in periar-ticular tissues from total hip revision arthroplasties. Clinical Orthopaedics and Related Research 276:7582Google Scholar
  31. 31.
    Nasser S, Campbell PA, Kilgus DJ, Kossovsky N, Amstutz HC (1990) Cementless total joint arthroplasty prostheses with titanium alloy articular surfaces: A human retrieval analysis. Clinical Orthopaedics and Related Research 261:171185Google Scholar
  32. 32.
    McKellop H, Clarke IC, Markolf KL, Amstutz HC (1977) Polyethylene wear in prosthetic joints. In: Dowson D, Wright V (eds) Evaluation of Artificial Joints. The Biological Engineering Society. F. S. Moore, London, pp 109134Google Scholar
  33. 33.
    McKellop H, Campbell P, Park SH, Schmalzried T, Grigoris P, Amstutz H, Sarmiento A (1995) The origin of sub-micron polyethylene wear debris in total hip arthroplasty. Clinical Orthopaedics and Related Research 311:320Google Scholar
  34. 34.
    Dobbs HS, Scales JT (1983) Behavior of commercially pure titanium and Ti-318 (Ti-6AI-4V) in orthopaedic implants. In: Luckey HA, Kubli F Jr (eds) Titanium Alloys in Surgical Implants. ASTM STP 796, ASTM, Philadelphia, pp 173186CrossRefGoogle Scholar
  35. 35.
    Zych G, Latta LL, Mnaymneh W (1983) Preliminary, clinical analysis of mechanical performance of the STH titanium alloy total hip replacement. In: Luckey HA, Kubli F Jr (eds) Titanium Alloys in Surgical Implants. ASTM STP 796, ASTM, Philadelphia, pp 151172CrossRefGoogle Scholar
  36. 36.
    Solar RJ, Korostoff E (1979) In vitro corrosion testing of titanium surgical implant alloys: An approach to understanding titanium release from implants. J Biomed Mater Res 13:217250CrossRefGoogle Scholar
  37. 37.
    Buchert P, Vaughn B, Mallory T, Engh C, Bobyn JD (1986) Excessive metal release due to loosening and fretting of sintered particles on porous-coated hip prostheses. J Bone Joint Surg 68-A(4):606609Google Scholar
  38. 38.
    Pazzaglia UE, Ceciliani L, Wilkinson MJ, Dell’Orbo C (1985) Involvement of metal particles in loosening of metal-plastic total hip prostheses. Arch Orthopaedic Trauma Surgery 104:164174CrossRefGoogle Scholar
  39. 39.
    Witt JD, Swann M (1991) Metal wear and tissue response in failed titanium alloy total hip replacements. J Bone Joint Surg 73-B(4):559563Google Scholar
  40. 40.
    Issac GH, Atkinson JR, Dowson D (1986) The role of cement in the long term performance and premature failure of Charnley low friction arthroplasties. Engineering in Medicine 15:1922Google Scholar
  41. 41.
    Brien WW, Salvati EA, Betts F, Bullough P, Wilson PD, Wright T (1990) Metal levels in synovial fluid in well fixed and failed total hip replacements. Transaction of Orthopaedic Research Society 27Google Scholar
  42. 42.
    Dorr L, Bloebaum R, Enimanual J, Meldrum R (1990) Histologic, biochemical and ion analysis of tissues and fluids retrieved during total hip arthroplasty. Clinical Orthopaedics and Related Research 261:8295Google Scholar
  43. 43.
    Jacobs JJ, Skipor AK, Black J, Hastings C, Schavocky J, Urban RM, Galante JO (1990) Metal release and excretion from cementless titanium total knee replacements. Transactions of the Society of Biomaterials 13:199Google Scholar
  44. 44.
    McKellop H, Sarmiento A, Brien W, Park SH (1991) Interface corrosion of a modular head total hip prosthesis. J Arthroplasty 7(3):291294CrossRefGoogle Scholar
  45. 45.
    Head WC, Bauer TW, Bloebaum RD, Bobyn JD, Collier JP, Cook SD, Emerson R, Galante J, Harris WH, Jasty M, Mayor M, Stulberg B, Sumner R (1991) Techniques and results of retrieval analysis of total hip prostheses obtained at autopsy: A multi-center study of the Hip Society, Transactions Fifty-eight Annual Meeting, American Academy Orthopaedic Surgeons, Scientific Exhibit #4104Google Scholar
  46. 46.
    Mathiesen EB, Lindgren JU, Blomgren GGA, Reinholt GP (1991) Corrosion of modular hip prostheses. J Bone Joint Surg 73-B:569575Google Scholar
  47. 47.
    Lieberman J, Rimnac C, Wright T (1991) Corrosion on the Morse taper head and neck. Retrieval analysis of 25 modular femoral components. Read at the Summer Meeting of The Hip Society, New York, September 1921Google Scholar
  48. 48.
    Crowninshield R, Price H, Parr J, Gilbertson L, Lower J, Shetty R (1991) Hardness, abrasion resistance and particulate release from metallic implant surfaces. Transactions of the Orthopaedic Research Society 16:91Google Scholar
  49. 49.
    Davidson JA, Kovacs P, Lanzer L (1990) Metal ion release during articulation of ion implanted Ti-6AI-4V alloy against UHMWPE. Transactions of the Orthopaedic Research Society 15:460Google Scholar
  50. 50.
    Crowninshield R, Lower J, Gilbertson L, Jacobs C, Price H, Jones F (1990) Simulating total knee replacement wear in vitro: Comparison of Ti-6A14V and nitrogen ion implanted Ti-6AI-4V. Transactions of the Orthopaedic Research Society 15:470Google Scholar
  51. 51.
    (1990) Wear testing of total knee prostheses. Current Topics in Orthopaedic Technology, 3(1), Zimmer, Inc., WarsawGoogle Scholar
  52. 52.
    (1990) Ion implanted titanium alloy: A survey. Current Topics in Orthopaedic Technology, 3(2), Zimmer, Inc., WarsawGoogle Scholar
  53. 53.
    Rieu J, Pichat A, Rabbe L-M, Rambert A, Chabrol C, Robelet M (1991) Ion implantation effects of friction and wear of joint prosthesis materials. Biomaterials 12:139143CrossRefGoogle Scholar
  54. 54.
    Cooper JR, Fisher J, Dowson D (1993) The effect of transfer film and surface roughness on the wear of lubricated ultra-high molecular weight polyethylene. Clinical Materials and Related Research 14:295302CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2001

Authors and Affiliations

  • Harry A. McKellop
    • 1
  • Tord Rostlund
    • 2
  • Edward Ebramzadeh
    • 1
  • Augusto Sarmiento
    • 3
  1. 1.The J. Vernon Luck Center for Orthopaedic ResearchLos Angeles Orthopaedic HospitalLos AngelesUSA
  2. 2.Department of Handicap Research, Biomaterials GroupGöteborg UniversityGöteborgSweden
  3. 3.The Arthritis and Joint Replacement InstituteCoral GablesUSA

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