The Titanium-Bone Cell Interface In Vitro: The Role of the Surface in Promoting Osteointegration

  • Barbara D. Boyan
  • David D. Dean
  • Christoph H. Lohmann
  • David L. Cochran
  • Victor L. Sylvia
  • Zvi Schwartz
Part of the Engineering Materials book series (ENG.MAT.)


One of the major advances in the use of metals for long-term implants was the serendipitous use of titanium (Ti). The nonreactive properties of this metal [1] made it an ideal material for the aerospace industry. Many of these same properties made it equally ideal for use in the body. Unlike stainless steel, Ti forms a surface oxide that prevents leaching of ions [2]. The oxide is biocompatible in that there is little, if any, immune response [3]. Early literature noted the lack of an immune response and defined Ti as biologically inert [4]. While we now know that Ti is not inert, there is no question that it is exceptionally well-tolerated by the body. Consequently, Ti has become the material of choice for dental implants [5] (See Chaps. 24 and 25) and cardiovascular stents [6] (See Chap. 26), and its alloys are commonly used in orthopaedics where greater strength is needed [7] (See Chap. 21).


MG63 Cell Matrix Vesicle Titanium Implant Biomed Mater Ocean Thermal Energy Conversion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2001

Authors and Affiliations

  • Barbara D. Boyan
    • 1
    • 2
    • 3
  • David D. Dean
    • 1
  • Christoph H. Lohmann
    • 1
    • 4
  • David L. Cochran
    • 2
  • Victor L. Sylvia
    • 1
  • Zvi Schwartz
    • 1
    • 2
    • 5
  1. 1.OrthopaedicsSan AntonioUSA
  2. 2.PeriodonticsSan AntonioUSA
  3. 3.BiochemistrySan AntonioUSA
  4. 4.Department of OrthopaedicsGeorg-August-UniversitätGöttingenGermany
  5. 5.Hadassah Faculty of Dental Medicine, Department of PeriodontologyHebrew UniversityJerusalemIsrael

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