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The Titanium-Bone Cell Interface In Vitro: The Role of the Surface in Promoting Osteointegration

  • Chapter
Titanium in Medicine

Part of the book series: Engineering Materials ((ENG.MAT.))

Abstract

One of the major advances in the use of metals for long-term implants was the serendipitous use of titanium (Ti). The nonreactive properties of this metal [1] made it an ideal material for the aerospace industry. Many of these same properties made it equally ideal for use in the body. Unlike stainless steel, Ti forms a surface oxide that prevents leaching of ions [2]. The oxide is biocompatible in that there is little, if any, immune response [3]. Early literature noted the lack of an immune response and defined Ti as biologically inert [4]. While we now know that Ti is not inert, there is no question that it is exceptionally well-tolerated by the body. Consequently, Ti has become the material of choice for dental implants [5] (See Chaps. 24 and 25) and cardiovascular stents [6] (See Chap. 26), and its alloys are commonly used in orthopaedics where greater strength is needed [7] (See Chap. 21).

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Authors and Affiliations

  1. Orthopaedics, San Antonio, Texas, USA

    Barbara D. Boyan, David D. Dean, Christoph H. Lohmann, Victor L. Sylvia & Zvi Schwartz

  2. Periodontics, San Antonio, Texas, USA

    Barbara D. Boyan, David L. Cochran & Zvi Schwartz

  3. Biochemistry, San Antonio, Texas, USA

    Barbara D. Boyan

  4. Department of Orthopaedics, Georg-August-Universität, Göttingen, Germany

    Christoph H. Lohmann

  5. Hadassah Faculty of Dental Medicine, Department of Periodontology, Hebrew University, Jerusalem, Israel

    Zvi Schwartz

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Boyan, B.D., Dean, D.D., Lohmann, C.H., Cochran, D.L., Sylvia, V.L., Schwartz, Z. (2001). The Titanium-Bone Cell Interface In Vitro: The Role of the Surface in Promoting Osteointegration. In: Titanium in Medicine. Engineering Materials. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56486-4_17

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