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Age-Related Macular Degeneration pp 79–83Cite as

Radiation Biology of Choroidal Neovascularisation of Age-Related Macular Degeneration

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Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

Abstract

Age-related macular degeneration (AMD) is a disorder of older people where there is progressive deterioration of central vision due to degenerative changes within the macula of the eye. The wet form of this disease is present in only one tenth of the individuals with AMD although it accounts for over 90% of those who suffer severe central visual loss (Ferris 1983). In the subgroup with wet AMD, the degenerative process results in the breakdown of the barrier between the choroid and the retina in the macular region and provokes growth of new vessels originating from the choriocapillaris (Gass 1967). These new vessels invade the sub-pigment epithelial and sub-retinal spaces and are accompanied by inflammatory cells, detached retinal pigment epithelial cells and fibroblasts. The new vessels are incompetent and leak fluid and blood, which are inimical to the health of the retinal pigment epithelium (RPE) and the photoreceptors.

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Author information

Authors and Affiliations

  1. Queen’s University of Belfast, Royal Victoria Hospital, Belfast, BT12 6BA, Northern Ireland, UK

    Usha Chakravarthy MD (Professor of Vision Science and Consultant Ophthalmologist)

  2. Indiana University Cyclotron Facility, 2401 Milo B. Sampson Lane, Bloomington, IN, 47408, USA

    Susan B. Klein MD

Authors
  1. Usha Chakravarthy MD
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  2. Susan B. Klein MD
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Editor information

Editors and Affiliations

  1. Department of Radiotherapy and Radiooncology, University Hospital Eppendorf, Martinistr.52, 20246, Hamburg, Germany

    Winfried E. Alberti MD (Professor) (Professor)

  2. Department of Ophthalmology, University Hospital Eppendorf, Martinistr.52, 20246, Hamburg, Germany

    Gisbert Richard MD (Professor) (Professor)

  3. Department of Radiation Oncology, State University of New York, Upstate Medical University, 750 East Adams Street, Syracuse, NY, 13210, USA

    Robert H. Sagerman MD, FACR (Professor) (Professor)

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© 2001 Springer-Verlag Berlin Heidelberg

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Chakravarthy, U., Klein, S.B. (2001). Radiation Biology of Choroidal Neovascularisation of Age-Related Macular Degeneration. In: Alberti, W.E., Richard, G., Sagerman, R.H. (eds) Age-Related Macular Degeneration. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56439-0_9

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  • DOI: https://doi.org/10.1007/978-3-642-56439-0_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-63071-2

  • Online ISBN: 978-3-642-56439-0

  • eBook Packages: Springer Book Archive

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